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US20070255362A1 - Cryoprotectant for use with a cooling device for improved cooling of subcutaneous lipid-rich cells - Google Patents

Cryoprotectant for use with a cooling device for improved cooling of subcutaneous lipid-rich cells Download PDF

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Publication number
US20070255362A1
US20070255362A1 US11/741,271 US74127107A US2007255362A1 US 20070255362 A1 US20070255362 A1 US 20070255362A1 US 74127107 A US74127107 A US 74127107A US 2007255362 A1 US2007255362 A1 US 2007255362A1
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US
United States
Prior art keywords
cryoprotectant
heat exchanging
skin
cooling system
treatment device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/741,271
Other languages
English (en)
Inventor
Mitchell E. Levinson
Donald Johnson
Jessica Preciado
Edward A. Ebbers
Daniel Bucks
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeltiq Aesthetics Inc
Original Assignee
Juniper Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38649308&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20070255362(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to AU2007244765A priority Critical patent/AU2007244765A1/en
Priority to KR1020087006539A priority patent/KR101039758B1/ko
Priority to US11/741,271 priority patent/US20070255362A1/en
Priority to JP2008513848A priority patent/JP4703724B2/ja
Priority to KR1020117002538A priority patent/KR101248799B1/ko
Priority to CN201410078711.0A priority patent/CN103948468A/zh
Priority to BRPI0706055A priority patent/BRPI0706055B8/pt
Priority to CA2585214A priority patent/CA2585214C/en
Priority to PCT/US2007/067638 priority patent/WO2007127924A2/en
Application filed by Juniper Medical Inc filed Critical Juniper Medical Inc
Priority to EP07761461.8A priority patent/EP2012707B1/en
Priority to CN200780001010.5A priority patent/CN101351167B/zh
Priority to IL182989A priority patent/IL182989A/en
Assigned to JUNIPER MEDICAL, INC. reassignment JUNIPER MEDICAL, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: EBBERS, EDWARD A., JOHNSON, DONALD, LEVINSON, MITCHELL E., PRECIADO, JESSICA, BUCKS, DANIEL
Assigned to ZELTIQ AESTHETICS, INC. reassignment ZELTIQ AESTHETICS, INC. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: JUNIPER MEDICAL, INC.
Publication of US20070255362A1 publication Critical patent/US20070255362A1/en
Priority to HK09102176.3A priority patent/HK1124511A1/xx
Priority to AU2010241393A priority patent/AU2010241393B2/en
Priority to US13/747,161 priority patent/US20140005760A1/en
Priority to HK15100475.7A priority patent/HK1200080A1/xx
Priority to US16/595,466 priority patent/US12070411B2/en
Abandoned legal-status Critical Current

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Definitions

  • the present application relates to a cryoprotectant for use with treatment devices, systems, and methods for removing heat from subcutaneous lipid-rich cells.
  • Excess body fat, or adipose tissue can detract from personal appearance and athletic performance.
  • Excess adipose tissue may be present in various locations of the body, including, for example, the thigh, buttocks, abdomen, knees, back, face, arms, and other areas.
  • excess adipose tissue is thought to magnify the unattractive appearance of cellulite, which forms when subcutaneous fat protrudes into the dermis and creates dimples where the skin is attached to underlying structural fibrous strands.
  • Cellulite and excessive amounts of adipose tissue are often considered to be unappealing.
  • significant health risks may be associated with higher amounts of excess body fat. An effective way of controlling or removing excess body fat therefore is needed.
  • Liposuction is a method for selectively removing adipose tissue to “sculpt” a person's body. Liposuction typically is performed by plastic surgeons or dermatologists using specialized surgical equipment that invasively removes subcutaneous adipose tissue via suction.
  • One drawback of liposuction is that it is a surgical procedure, and the recovery may be painful and lengthy. Moreover, the procedure typically requires the injection of tumescent anesthetics, which is often associated temporary bruising. Liposuction can also have serious and occasionally even fatal complications. In addition, the cost for liposuction is usually substantial.
  • Other emerging techniques for removal of subcutaneous adipose tissue include mesotherapy, laser-assisted liposuction, and high intensity focused ultrasound.
  • Conventional non-invasive treatments for removing excess body fat typically include topical agents, weight-loss drugs, regular exercise, dieting, or a combination of these treatments.
  • topical agents such as topical agents, weight-loss drugs, regular exercise, dieting, or a combination of these treatments.
  • weight-loss drugs or topical agents are not an option when they cause an allergic or negative reaction.
  • fat loss in selective areas of a person's body cannot be achieved using general or systemic weight-loss methods.
  • Non-invasive treatment methods include applying heat to a zone of subcutaneous lipid-rich cells.
  • U.S. Pat. No. 5,948,011 discloses altering subcutaneous body fat and/or collagen by heating the subcutaneous fat layer with radiant energy while cooling the surface of the skin. The applied heat denatures fibrous septae made of collagen tissue and may destroy fat cells below the skin, and the cooling protects the epidermis from thermal damage. This method is less invasive than liposuction, but it still may cause thermal damage to adjacent tissue, and can also be painful and unpredictable.
  • U.S. Patent Publication No. 2003/0220674 also discloses methods for selective removal of lipid-rich cells, and avoidance of damage to other structures including dermal and epidermal cells.
  • a method for inducing collagen compaction, remodeling, and formation is also needed for treatment of loose or sagging skin, age- or sun-damaged skin, or a variety of other skin disorders. Therefore, a method for simultaneously removing lipid-rich cells while providing beneficial collagen effects is also needed.
  • FIG. 1 is an isometric view of a system for removing heat from subcutaneous lipid-rich cells in accordance with an embodiment of the invention.
  • FIG. 2 is a side elevation view of a coupling device in accordance with an embodiment of the invention.
  • FIG. 3 is an isometric view of a coupling device in accordance with another embodiment of the invention.
  • FIG. 4 is a flow chart illustrating a method for pre-cooling a treatment device in accordance with embodiments of the invention.
  • FIG. 5 is a flow chart illustrating a method for pre-cooling a treatment device in accordance with further embodiments of the invention.
  • FIG. 6 is a flow chart illustrating a method for protecting the skin of a subject with a cryoprotectant in accordance with further embodiments of the invention.
  • FIG. 7 is an isometric view of a treatment device for removing heat from subcutaneous lipid-rich cells in accordance with an embodiment of the invention.
  • FIGS. 8A-B are isometric views of a treatment device for removing heat from subcutaneous lipid-rich cells in accordance with a further embodiment of the invention.
  • FIG. 9 is an isometric and exploded view of a treatment device for removing heat from subcutaneous lipid-rich cells in accordance with a further embodiment of the invention.
  • FIG. 10 is an isometric and exploded view of a vibrator disposed in the treatment device for removing heat from subcutaneous lipid-rich cells in accordance with yet another embodiment of the invention.
  • subcutaneous tissue means tissue lying beneath the dermis and includes subcutaneous fat, or adipose tissue, which primarily is composed of lipid-rich cells, or adipocytes. It may be appreciated that several of the details set forth below are provided to describe the following embodiments in a manner sufficient to enable a person skilled in the relevant art to make and use the disclosed embodiments. Several of the details and advantages described below, however, may not be necessary to practice certain embodiments of the invention. Additionally, the invention may include other embodiments that are within the scope of the claims but are not described in detail with respect to the Figures.
  • FIG. 1 is an isometric view of a treatment system 100 for exchanging heat from subcutaneous lipid-rich cells of a subject 101 in accordance with an embodiment of the invention.
  • the treatment system 100 may include a treatment device 104 placed at an abdominal area 102 of the subject 101 or another area where reduction of the subcutaneous fat, or fat layer, is desired.
  • the treatment device 104 may be fastened to the subject 101 using, for example, a mechanical fastener (e.g., a belt 105 ), an adhesive (e.g., an epoxy), suction (e.g., a vacuum or reduced pressure), or any other mechanisms.
  • the treatment device 104 may be configured to heat and/or cool the subject 101 .
  • the treatment device 104 may contain a non-freezing cryoprotectant to, among other advantages, allow pre-cooling of the treatment device 104 to a temperature around or below the freezing point of water (0° C.) while preventing ice from forming.
  • a non-freezing cryoprotectant to, among other advantages, allow pre-cooling of the treatment device 104 to a temperature around or below the freezing point of water (0° C.) while preventing ice from forming.
  • the treatment system 100 may also include a coupling device (not shown in FIG. 1 ) for supplying the cryoprotectant to the treatment device 104 or the skin of the subject 101 , as described in more detail below with reference to FIG. 2 and FIG. 3 .
  • the treatment device 104 is configured to cool subcutaneous lipid-rich cells of the subject 101 .
  • the treatment system 100 may further include a fluid source 106 and fluid lines 108 a - b connecting the treatment device 104 to the fluid source 106 .
  • the fluid source 106 may remove heat from a coolant to a heat sink and provide the chilled coolant to the treatment device 104 via the fluid lines 108 a - b .
  • the circulating coolant include water, glycol, synthetic heat transfer fluid, oil, a refrigerant, and any other suitable heat conducting fluids.
  • the fluid lines 108 a - b may be hoses or other conduits constructed from polyethylene, polyvinyl chloride, polyurethane, steel, aluminum, copper and other materials that may accommodate the particular circulating coolant.
  • the fluid source 106 may be a refrigeration unit, a cooling tower, a thermoelectric chiller, or any other device capable of removing heat from a coolant or municipal water supply.
  • the treatment device 104 may also include one or more thermoelectric elements, such as Peltier-type thermoelectric elements.
  • the treatment system 100 may further include a power supply 110 and a processing unit 114 operatively coupled to the treatment device 104 via electrical cables 112 , 116 .
  • the power supply 110 may provide a direct current voltage to the treatment device 104 remove heat from the subject 101 .
  • the processing unit 114 may monitor process parameters via sensors (not shown in FIG. 1 ) placed proximate to the treatment device 104 and adjust the heat removal rate based on the process parameters.
  • the processing unit 114 may include any processor, Programmable Logic Controller, Distributed Control System, and the like.
  • the processing unit 114 may be in electrical communication with an input device 118 , an output device 120 , and/or a control panel 122 .
  • the input device 118 may include a keyboard, a mouse, a touch screen, a push button, a switch, a potentiometer, and any other device suitable for accepting user input.
  • the output device 120 may include a display screen, a printer, a medium reader, an audio device, and any other device suitable for providing user feedback.
  • the control panel 122 may include indicator lights, numerical displays, and audio devices.
  • the processing unit 114 , power supply 110 , control panel 122 , fluid source 106 , input device 118 , and output device 120 are carried by a rack 124 with wheels 126 for portability.
  • the various components may be fixedly installed at a treatment site.
  • a cryoprotectant applied to the treatment device 104 may allow the treatment device 104 to be pre-cooled prior to being applied to the subject 101 for more efficient treatment. Further, the cryoprotectant can also enable the treatment device 104 to be maintained at a desired temperature while preventing ice from forming on a surface of the treatment device 104 , and thus reduces the delay in reapplying the treatment device 104 to the subject. Yet another advantage is that the cryoprotectant may prevent the treatment device 104 from freezing to the skin of the subject. If the cryoprotectant is hygroscopic, it can adsorb moisture from the atmosphere and/or from the skin, which might otherwise form ice.
  • the treatment device 104 , the cryoprotectant, and/or other components of the treatment system 100 can be included in a kit (not shown) for removing heat from subcutaneous lipid rich cells of the subject 101 .
  • the cryoprotectant can have a freezing point in the range of about ⁇ 40° C. to about 0° C. and be configured to be applied to an interface between the treatment device 104 and the skin of the subject 101 .
  • the kit can also include instruction documentation containing information regarding how to (a) apply the cryoprotectant to a target region and/or a heat exchanging surface of the treatment device 104 and (b) reduce a temperature of the target region such that lipid rich cells in the region are affected while preserving non-lipid rich cells proximate to the heat exchanging surface.
  • FIG. 2 is a side elevation view illustrating a coupling device 502 suitable to be used in the treatment system 100 of FIG. 1 and configured in accordance with an embodiment of the invention.
  • the coupling device 502 may be placed adjacent to a treatment region 501 of the subject 101 .
  • the coupling device 502 may include attachment features 510 for releasably or fixedly attaching the coupling device 502 to a heat exchanging element 130 of the treatment device 104 ( FIG. 1 ).
  • the attachment features 510 include tensioning clips.
  • the coupling device 502 may be snapped onto the heat exchanging element 130 with the backside portion 504 facing the treatment device 104 .
  • the attachment features 510 may include screws, pins, hinges, and/or any other suitable attachment devices.
  • the coupling device 502 may include a backside portion 504 proximate to the heat exchanging element 130 , a front side portion 508 spaced apart from the backside portion 504 , and an intermediate portion 506 between the backside portion 504 and the front side portion 508 .
  • the coupling device 502 optionally may include a protective layer (e.g., a polymeric film, not shown) attached to the front side portion 508 .
  • the protective layer may isolate the front side portion 508 from the environment and may be peeled off to expose the front side portion 508 before treatment.
  • the backside portion 504 may be a film, a plate, a sheet, or other structure constructed from a metal, a metal alloy, ceramics, a polymeric material, or other suitable conductive material.
  • the backside portion 504 may transfer heat between the heat exchanging element 130 and the treatment region 501 .
  • the backside portion 504 may also isolate the heat exchanging element 130 from the treatment region 501 for sanitation purposes.
  • the intermediate portion 506 may be a reservoir constructed from a mesh, a foam material, a porous plastic and/or metal, or other materials that may at least temporarily contain a fluid and/or a gel.
  • the intermediate portion 506 contains, or is loaded with, a cryoprotectant before a treatment process begins.
  • the intermediate portion 506 may be generally empty before a treatment process begins and only loaded with cryoprotectant immediately before and/or during the treatment process.
  • the intermediate portion 506 may be pressurized with the cryoprotectant or may be at a generally atmospheric pressure during treatment.
  • the front side portion 508 may be a film constructed from a polymeric material, a plastic material, or other material that is at least partially flexible.
  • the front side portion 508 may include one or more apertures 516 in fluid communication with the intermediate portion 506 .
  • the aperture or apertures 516 may allow the cryoprotectant contained in the intermediate portion 506 to escape to the treatment region 501 of the subject 101 through capillary actions or other mechanisms.
  • the intermediate portion 506 may continually supply the cryoprotectant to the treatment region 501 during treatment.
  • the intermediate portion 506 is pre-loaded with excess cryoprotectant.
  • cryoprotectant may be supplied from the intermediate portion 506 to the skin of the subject during treatment.
  • the intermediate portion 506 may be constantly replenished to provide a continuous supply of the cryoprotectant.
  • the cryoprotectant can be absorbed by the skin in the treatment region 501 .
  • the degree of cryoprotectant absorption by the skin depends on a number of factors, the most important of which are cryoprotectant concentration, duration of contact, solubility, and the physical condition of the skin.
  • the coupling device 502 optionally may include at least one sensor 514 proximate to the front side portion 508 to measure at least one parameter of the treatment process.
  • the sensor 514 may be a temperature sensor, a pressure sensor, a transmissivity sensor, a bio-resistance sensor, an ultrasound sensor, an optical sensor, an infrared sensor, a heat flux sensor, any other desired sensors, or any combination thereof. An operator may adjust the treatment process based on the measured parameter.
  • the treatment device 104 optionally may include a supply device 520 connected to a port 515 of the coupling device 502 by a conduit 522 for supplying and/or replenishing the cryoprotectant in the intermediate portion 506 .
  • the supply device 520 is a syringe holding a volume of the cryoprotectant.
  • the supply device 520 may include a pump coupled to a cryoprotectant storage (not shown), or other suitable supply configurations.
  • a pressure sensor 524 may be used for monitoring a cryoprotectant pressure in the intermediate portion 506 .
  • the pressure sensor 524 may be operatively coupled to the conduit 522 , the intermediate portion 506 , or the supply device 520 .
  • the pressure sensor 524 may provide an electric, visual, or other signal indicating the cryoprotectant pressure in the intermediate portion 506 .
  • an operator may manually adjust the output of the supply device 520 based on the indicated pressure.
  • the signal from the pressure sensor 524 may be used as a process variable to automatically control the output of the supply device 520 .
  • a cryoprotectant may be topically applied to the skin before a treatment begins.
  • the skin then absorbs the applied cryoprotectant, which dissipates over a period of time.
  • the cryoprotectant dissipates, in conventional techniques, the skin may be subject to freezing damage.
  • the treatment system 100 may at least reduce the risk of freezing damage, or even prevent such freezing damage, during treatment.
  • Several embodiments of the treatment system 100 may also reduce the risk of air pockets that can reduce the heat transfer efficiency between the treatment region 501 and the treatment device 104 .
  • the pressure in the intermediate portion 506 decreases, and air pockets may form.
  • the air pockets may interfere with the heat transfer efficiency between the treatment region 501 and the treatment device 104 .
  • maintaining the intermediate portion 506 at a constant pressure may at least reduce the risk of air pocket formation, and thus improve the efficiency of such heat transfer.
  • FIG. 3 illustrates another embodiment, in which the coupling device 502 is incorporated into a sleeve 162 that attaches to the heat exchanging element 130 .
  • the coupling device 502 can define a first sleeve portion 164 , and the sleeve 162 can also have a second sleeve portion 166 .
  • the first sleeve portion 164 may include the backside portion 504 , the front side portion 508 , and the intermediate portion 506 ( FIG. 3 ).
  • the second sleeve portion 166 may be an isolation layer extending from the first sleeve portion 164 .
  • the second sleeve portion 166 may be constructed from latex, rubber, nylon, polyimide, polyethylene, Kevlar®, or other substantially impermeable or semi-permeable material.
  • the second sleeve portion 166 may prevent any contact between the skin of the subject and the heat exchanging element 130 .
  • the sleeve 162 may be reusable. In other embodiments, the sleeve 162 may be disposable.
  • the sleeve 162 may be provided sterile or non-sterile.
  • the sleeve is fabricated from a flex circuit material such as polyimide or polyethylene, with etched traces to connect sensors to electronics resident in, e.g., the processing unit 114 .
  • the second sleeve portion 166 may also include attachment features to affix the sleeve 162 to the treatment device 104 .
  • the second sleeve portion 166 includes four brackets 172 (identified individually as 172 a - d ), each located at a corner of the second sleeve portion 166 .
  • Individual brackets 172 include an aperture 174 (identified individually as 174 a - d ) that corresponds to an attachment point 170 of the treatment device 104 .
  • the apertures 174 of the brackets 172 may fit over the attachment point 170 such that the second sleeve portion 166 at least partially encloses the heat exchanging element 130 .
  • the second sleeve portion 166 may include brackets that may engage each other.
  • the bracket 172 a may include a pin that may engage the aperture 174 d of the bracket 172 d .
  • the second sleeve portion 166 may wrap around the treatment device 104 and be held in place by engaging the brackets 172 with each other.
  • the second sleeve portion 166 may include a flexible member (not shown, e.g., an elastic band) at an outer edge 176 of the second sleeve portion 166 that may hold the sleeve 162 over the treatment device 104 during assembly.
  • the second sleeve portion 166 may include a releasable attachment member (not shown, e.g., Velcro® or snaps) at the outer edge 176 of the second sleeve portion 166 that may hold the sleeve 162 over the treatment device 104 during assembly.
  • adhesive may hold the second sleeve portion 166 to the treatment device 104 .
  • one expected advantage of using the sleeve 162 is the improved sanitation of using the treatment device 104 .
  • the sleeve 162 may prevent cross-contamination between the skin of the subject and the heat exchanging element 130 because the sleeve 162 is substantially impermeable. Also, operating expense of the treatment device 104 may be reduced because the heat exchanging element 130 does not need to be sanitized after each use.
  • the sleeve 162 may have many additional embodiments with different and/or additional features without detracting from its operation.
  • the first and second sleeve portions 164 , 166 may be constructed from the same material (e.g., polyimide) or different materials.
  • the sleeve 162 may include an adhesive layer (not shown) that binds the sleeve 162 to the treatment device 104 .
  • FIG. 4 is a flow chart illustrating a method suitable to be performed in the treatment system 100 of FIG. 1 and in accordance with an embodiment of the invention.
  • the method may include applying a cryoprotectant to a heat exchanging element contained in a treatment device (block 10 ).
  • the cryoprotectant may be applied to the skin of a subject or both the skin and the heat exchanging element.
  • the temperature of the heat exchanging element may be reduced to a desired temperature (block 12 ). Once the temperature of the heat exchanging element is reduced to a desired temperature, for example, around or below the freezing point of water (0° C.), the heat exchanging element may be placed adjacent to the skin of a subject (block 14 ).
  • Placing the heat exchanging element adjacent to the skin of a subject reduces the temperature of a region such that lipid-rich cells in the region are selectively affected while non-lipid-rich cells in the epidermis and/or dermis are not generally affected (block 16 ).
  • the temperature of the treatment device optionally may be further reduced to a treatment temperature once the heat exchanging element is placed adjacent to the skin of a subject (block 15 ).
  • the treatment device may then be removed from the skin of the subject (block 18 ), and the process may then end (block 20 ).
  • the reduced temperature of the heat exchanging element optionally may be maintained at a desired temperature (block 22 ).
  • the heat exchanging element optionally may be placed adjacent to another region of the skin of the subject to selectively affect lipid-rich cells in a different region of the skin of the subject (block 24 ). Once the heat exchanging element is placed adjacent to another region of the skin of the subject, the lipid-rich cells are affected (block 16 ).
  • the treatment device may then be removed from the skin of the subject (block 18 ) and then the process may end (block 20 ).
  • cryoprotectant may be reapplied to the heat exchanging element, the skin of the subject, or to an interface between the treatment device and the skin of the subject (block 28 ) prior to placing the heat exchanging element on another region of the skin of the subject.
  • a cryoprotectant may be applied to the heat exchanging element, the skin of the subject, or an interface between the treatment device and the skin of the subject to prevent the formation of ice (block 10 ) as the temperature of the heat exchanging element is reduced to a desired temperature.
  • the heat exchanging element is placed adjacent to the skin of the subject in a desired region (block 14 ), and the lipid-rich cells are selectively affected (block 16 ). After a selected period of time, the heat exchanging element may then be removed from the skin of the subject (block 18 ).
  • cryoprotectant is reapplied to the heat exchanging element, the skin of the subject, and/or an interface between the treatment device and the skin of the subject (block 28 ), and the temperature of the heat exchanging element is maintained at a desired temperature (block 22 ).
  • the process of treating the selected region of the skin of the subject optionally may be repeated to selectively affect the lipid-rich cells in a region of the subject while non-lipid-rich cells in the epidermis and/or dermis are not generally affected (block 26 ).
  • FIG. 5 illustrates another method for pre-cooling the heat exchanging element by applying a cryoprotectant on the heat exchanging element prior to decreasing the temperature of the heat exchanging element to prevent icing.
  • a cryoprotectant is placed on the heat exchanging element to prevent the heat exchanging element from icing (block 50 ).
  • the heat exchanging element is then pre-cooled by decreasing the temperature to at or below 0° C. (block 52 ).
  • the heat exchanging element is applied to the skin of the subject in a first treatment region (block 54 ), to selectively affect lipid-rich cells in the treatment region (block 56 ).
  • the temperature of the heat exchanging element may be further decreased (block 68 ).
  • the heat exchanging element is then removed from the treatment region (block 58 ) and the treatment may then end (block 64 ).
  • the temperature of the heat exchanging element may be maintained at a target temperature (block 60 ), and the heat exchanging element may be applied to a second treatment region on the skin of the subject (block 62 ), to selectively affect the lipid-rich cells.
  • the temperature of the heat exchanging element may be allowed to return to an ambient temperature (block 66 ), or the temperature of the heat exchanging element may be maintained at or below 0° C. (block 60 ).
  • the temperature of the heat exchanging element may be maintained at a target temperature (block 70 ).
  • the heat exchanging element may then be applied to a second treatment region on the skin of the subject (block 72 ), or may be reapplied to the first treatment region on the skin of the subject to selectively affect the lipid-rich cells (block 54 ).
  • subcutaneous lipid-rich cells By cooling the subcutaneous tissues to a temperature lower than 37° C., subcutaneous lipid-rich cells may be selectively affected.
  • the epidermis and dermis of a subject have lower amounts of unsaturated fatty acids compared to the underlying lipid-rich cells forming the subcutaneous tissues.
  • the subcutaneous lipid-rich cells may be selectively affected while maintaining the non-lipid-rich cells in the dermis and epidermis.
  • a range for the heat exchanging elements may be from about ⁇ 20° C. to about 20° C., preferably from about ⁇ 20° C. to about 10° C., more preferably from about ⁇ 15° C. to about 5° C., more preferably from about ⁇ 10° C. to about 0° C.
  • the lipid-rich cells may be affected by affecting, shrinking, disabling, destroying, removing, killing, or otherwise being altered. Without being bound by theory, selectively affecting lipid-rich cells is believed to result from localized crystallization of highly saturated fatty acids at temperatures that do not induce crystallization in non-lipid-rich cells. The crystals may rupture the bi-lipid membrane of lipid-rich cells to selectively necrose these cells. Thus, damage of non-lipid-rich cells, such as dermal cells, may be avoided at temperatures that induce crystal formation in lipid-rich cells. Cooling is also believed to induce lipolysis (e.g., fat metabolism) of lipid-rich cells to further enhance the reduction in subcutaneous lipid-rich cells. Lipolysis may be enhanced by local cold exposure, inducing stimulation of the sympathetic nervous system.
  • lipolysis e.g., fat metabolism
  • the treatment device may selectively reduce subcutaneous lipid-rich cells without unacceptably affecting the dermis, epidermis, and/or other tissues.
  • the treatment device may simultaneously selectively reduce subcutaneous lipid-rich cells while providing beneficial effects to the dermis and/or epidermis. These effects may include: fibroplasias, neocollagenesis, collagen contraction, collagen compaction, collagen density increase, collagen remodeling, and acanthosis (epidermal thickening).
  • the heat exchanging element may be pre-cooled in advance of treatment to more efficiently treat the skin of the subject. Further, the embodiments allow the treatment device to be maintained at a temperature at or below 0° C. or at a target temperature because the cryoprotectant may prevent icing on the heat exchanging element and/or on the skin of the subject.
  • FIG. 6 is a flow chart illustrating another method suitable to be performed in the treatment system 100 of FIG. 1 and in accordance with an embodiment of the invention.
  • the method 80 of FIG. 6 may be applied separately or in combination with the methods shown in FIG. 4 and/or FIG. 5 .
  • a cryoprotectant may be applied to both the skin of the subject for protecting the skin from freezing damage and the heat exchanging surface of the treatment device for pre-cooling the treatment device.
  • the method 80 may include applying a cryoprotectant to a treatment region of the skin of the subject (block 82 ).
  • applying the cryoprotectant may include spraying or smearing the cryoprotectant onto the skin using an instrument including, e.g., a spatula, a spray bottle, and/or a coupling device as shown in FIG. 2 .
  • the cryoprotectant may be injected into the skin of the subject using, e.g., a syringe.
  • a heat exchanging element is subsequently placed adjacent to the skin of the subject (block 84 ).
  • the heat exchanging element may cool the treatment region that is in contact with the cryoprotectant to selectively affect lipid-rich cells in the region (block 86 ).
  • the cryoprotectant may be continually supplied to the skin of the subject (block 88 ).
  • the continually supplied cryoprotectant may maintain a sufficient concentration of absorbed cryoprotectant in the epidermis and/or dermis of the subject for reducing the risk of freezing damage.
  • the cryoprotectant may be continually supplied using an absorbent (e.g., a cotton pad, a gauze, or other absorbents) pre-loaded with the cryoprotectant, or using a coupling device releasably attached to the treatment device.
  • an absorbent e.g., a cotton pad, a gauze, or other absorbents
  • a decision is made to determine whether the treatment should be continued (block 90 ). The determination may be based on time, skin temperatures, and/or other parameters of the treatment process. If the treatment is continued, then the process returns to block 86 ; otherwise, the process ends.
  • the applied cryoprotectant may at least reduce the risk of freezing damage in the epidermis and/or dermis of the subject during treatment and may even prevent such freezing damage.
  • low temperatures may potentially cause damage in the epidermis and/or dermis via at least intracellular and/or extracellular ice formation.
  • Intracellular ice formation occurs when ice forms inside a cell. The ice may expand and rupture the cell as the ice grows through the cellular wall, thus causing cell death.
  • extracellular ice formation occurs, extracellular water freezes to form ice. As a result, the remaining extracellular fluid becomes concentrated with solutes.
  • the high concentration of the extracellular fluid may cause intracellular fluid to permeate through the semi-permeable cellular wall and eventually cause cell dehydration and death.
  • the high concentration of the extracellular fluid may also interrupt electrical and/or ionic interactions among neighboring cells to cause irreversible protein damage.
  • Applying a cryoprotectant may at least reduce the risk of intracellular and/or extracellular ice formation, or even prevent such ice formation, by reducing the freezing point of water in the body fluid affected by the cryoprotectant. It is believed that after the cryoprotectant is absorbed into the epidermis and/or dermis, the cryoprotectant dissolves in or otherwise combines with water of the intracellular and/or extracellular fluid to delay the onset of ice formation by lowering the freezing point of the solution in which it resides. For example, the cryoprotectant may reduce the freezing point of the body fluid from, e.g., about ⁇ 2° C.
  • the cryoprotectant may have a sufficient concentration in the body fluid such that water in the body fluid does not freeze but instead vitrifies under low temperature conditions. As a result, the onset of intracellular and/or extracellular ice formation may be prevented in these embodiments.
  • One expected advantage of several of the embodiments of the method 80 is that an operator may use lower treatment temperatures for selectively affecting lipid-rich cells of the subject without causing freezing damage to the epidermis and/or dermis of the subject.
  • the applied cryoprotectant may lower the freezing point of the skin of the subject or body fluid in the target region to at least reduce the risk of intracellular and/or extracellular ice formation at such low treatment temperatures.
  • cryoprotectant may protect the treatment region of the skin of the subject. After the cryoprotectant is applied to the skin of the subject, the cryoprotectant is believed to enter the epidermis, the dermis, and eventually the blood stream of the subject. The subject's blood stream then may carry the cryoprotectant away from the treatment region. As a result, the cryoprotectant concentration in the treatment region drops, and the freezing point of the subject's affected body fluid increases to heighten the risk of freezing damage. Accordingly, continually supplying the cryoprotectant to the skin of the subject may at least reduce or even prevent such a risk.
  • cooling the skin of the subject may increase the residence time of the cryoprotectant and may reduce local and/or systemic side effects of the cryoprotectant. It is believed that the skin of the subject absorbs the cryoprotectant at a slower rate under low temperature conditions than under normal temperature (e.g., body temperature) conditions. Thus, the reduced absorption rate may increase the amount of time it takes for the subject's blood stream to remove the cryoprotectant, and thus prolong the efficacy of the cryoprotectant. It is also believed that certain cryoprotectants at certain concentration levels may be toxic to the subject by causing, for example, denaturation of proteins (e.g., enzymes). Thus, reducing the absorption rate of the cryoprotectant may reduce the cryoprotectant concentration in deeper tissues, and thus may reduce the associated local or systemic side effects.
  • proteins e.g., enzymes
  • a cryoprotectant suitable to be used in the treatment system 100 of FIG. 1 is a substance that may protect biological tissues of a subject from freezing damage (e.g., damage due to ice formation).
  • the cryoprotectant may contain a temperature depressant along with a thickening agent, a pH buffer, a humectant, a surfactant, and/or other additives.
  • the cryoprotectant may be formulated as a liquid (e.g., an aqueous solution or a non-aqueous solution), a gel, a hydrogel, or a paste.
  • the cryoprotectant may be hygroscopic, thermally conductive, and is ideally biocompatible.
  • the cryoprotectant may be formulated to be ultrasonically acoustic to allow ultrasound to pass through the cryoprotectant, such as a water-based gel described in U.S. Pat. No. 4,002,221 issued to Buchalter and U.S. Pat. No. 4,459,854 issued to Richardson et al., the entire disclosures of which are incorporated herein by reference.
  • the temperature depressant may include polypropylene glycol (PPG), polyethylene glycol (PEG), propylene glycol, ethylene glycol, dimethyl sulfoxide (DMSO), or other glycols.
  • the temperature depressant may also include ethanol, propanol, iso-propanol, butanol, and/or other suitable alcohol compounds.
  • the temperature depressant may lower the freezing point of a solution (e.g., body fluid) to about 0° C. to ⁇ 40° C., and more preferably to about ⁇ 10° C. to ⁇ 16° C.
  • Certain temperature depressants e.g., PPG, PEG, etc.
  • the thickening agent may include carboxyl polyethylene polymer, hydroxyethyl xylose polymer, and/or other viscosity modifiers to provide a viscosity in the range of about 1 cP to about 10,000 cP, more preferably in the range of about 4,000 cP to about 8,000 cP, and most preferably from about 5,000 cP to about 7,000 cP.
  • the cryoprotectant with a viscosity in this range may readily adhere to the treatment device, the skin of the subject, and/or the interface between the treatment device and the skin of the subject during treatment.
  • the pH buffer may include cholamine chloride, cetamidoglycine, tricine, glycinamide, bicine, and/or other suitable pH buffers.
  • the pH buffer may help the cryoprotectant to have a consistent pH of about 3.5 to about 11.5, more preferably about 5 to about 9.5, and most preferably about 6 to about 7.5.
  • the pH of the cryoprotectant may be close to the pH of the skin of the subject.
  • the humectant may include glycerin, alkylene glycol, polyalkylene glycol, propylene glycol, glyceryl triacetate, polyols (e.g., sorbitol and/or maltitol), polymeric polyols (e.g., polydextrose), quillaia, lactic acid, and/or urea.
  • the humectant may promote the retention of water to prevent the cryoprotectant from drying out.
  • the surfactant may include sodium dodecyl sulfate, ammonium lauryl sulfate, sodium lauryl sulfate, alkyl benzene sulfonate, sodium lauryl ether sulfate, and other suitable surfactants.
  • the surfactant may promote easy spreading of the cryoprotectant when an operator applies the cryoprotectant to the treatment device, the skin of the subject, and/or the interface between the treatment device and the skin of the subject during treatment.
  • the cryoprotectant may also include other additives in addition to or in lieu of the ingredients described above.
  • the cryoprotectant may also include a coloring agent, perfume, emulsifier, an anesthetic agent, and/or other ingredient.
  • the cryoprotectant may include about 30% polypropylene glycol, about 30% glycerin, and about 40% ethanol. In another embodiment, the cryoprotectant may include about 40% propylene glycol, about 0.8% hydroxyethylcellulose, and about 59.2% water. In a further embodiment, the cryoprotectant may include about 50% polypropylene glycol, about 40% glycerin, and about 10% ethanol.
  • FIG. 7 is an isometric view of a treatment device 104 in accordance with one embodiment of the invention suitable for use in the treatment system 100 .
  • the treatment device 104 includes a support 128 having a first portion 129 a and a second portion 129 b , a first heat exchanging element 130 a located at the first portion 129 a , and a second heat exchanging element 130 b located at the second portion 129 b .
  • the treatment device 104 is generally configured to be a handheld unit for manual operation, and/or it may be strapped or otherwise configured to be releasably attached to the subject.
  • the first heat exchanging element 130 a and/or the second heat exchanging element 130 b may be configured to move along the support 128 and/or rotate to position the heat exchanging elements 130 a - b for applying pressure to the treatment region during operation.
  • the first and second heat exchanging elements 130 a - b may have many similar features. As such, the features of the first heat exchanging element 130 a are described below with reference symbols followed by an “a”, and corresponding features of the second heat exchanging element 130 b are shown and noted by the same reference symbol followed by a “b.”
  • the first heat exchanging element 130 a may include a housing 139 a and fluid ports 138 a - b coupled to the fluid lines 108 a - b .
  • the housing 139 a may be constructed from polymeric materials, metals, ceramics, woods, and/or other suitable materials.
  • the housing 139 a shown in FIG. 7 is generally rectangular, but it may have any other desired shape.
  • the first heat exchanging element 130 a may further include a first interface member 132 a having a first heat exchanging surface 131 a for transferring heat to/from the subject 101 .
  • a cryoprotectant (not shown) may be applied to the heat exchanging surface 131 a to prevent ice from forming thereon when the temperature is reduced to a temperature around or below the freezing point of water (0° C.).
  • the first heat exchanging surface 131 a is generally planar, but in other embodiments, the first heat exchanging surface 131 a is non-planar (e.g., curved, faceted, etc.)
  • the first interface member 132 a may be constructed from any suitable material with a thermal conductivity greater than 0.05 Watts/Meter ° Kelvin, and in many embodiments, the thermal conductivity is more than 0.1 Watts/Meter ° Kelvin.
  • suitable materials include aluminum, other metals, metal alloys, graphite, ceramics, some polymeric materials, composites, or fluids contained in a flexible membrane.
  • Portions of the first heat exchanging surface 131 a may be an insulating material with a thermal conductivity less than 0.05 Watts/Meter ° Kelvin.
  • the first heat exchanging element 130 a may also include at least one sensing element 135 a proximate to the first heat exchanging surface 131 a .
  • the sensing element 135 a may be generally flush with the heat exchanging surface 131 a . Alternatively, it may be recessed or protrude from the surface.
  • the sensing element 135 a may include a temperature sensor, a pressure sensor, a transmissivity sensor, a bio-resistance sensor, an ultrasound sensor, an optical sensor, an infrared sensor, a sensor for measuring blood flow, or any other desired sensor.
  • the sensing element 135 a may be a temperature sensor configured to measure the temperature of the first heat exchanging surface 131 a and/or the temperature of the skin of the subject.
  • the temperature sensor may be configured as a probe or as a needle that penetrates the skin during measurement.
  • suitable temperature sensors include thermocouples, resistance temperature devices, thermistors (e.g., neutron-transmutation-doped germanium thermistors), and infrared radiation temperature sensors.
  • the sensing element 135 a may be an ultrasound sensor configured to measure the thickness of a fat layer in the subject or crystallization of subcutaneous fat in the treatment region of a subject.
  • the sensing element 135 a may be an optical or infrared sensor configured to monitor an image of the treatment region to detect, for example, epidermal physiological reactions to the treatment.
  • the sensing element 135 a may be a device to measure blood flow.
  • the sensing element 135 a may be in electrical communication with the processing unit 114 via, for example, a direct wired connection, a networked connection, and/or a wireless connection.
  • the treatment device 104 may further include a mounting element 136 a that couples the first heat exchanging element 130 a to the first portion 129 a of the support 128 .
  • the mounting element 136 a may be a pin, a ball joint, a bearing, or other types of rotatable joints. Suitable bearings include, but are not limited to, ball bearings, roller bearings, thrust bearings, and journal bearings.
  • the mounting element 136 a may accordingly be configured to rotatably couple the first heat exchanging element 130 a to the support 128 .
  • the first heat exchanging element 130 a may rotate relative to the support 128 in two dimensions (indicated by arrow A) such that the angle between the first and second heat exchanging surfaces 131 a - b may be adjusted. In another embodiment, the first heat exchanging element 130 a may rotate in three dimensions relative to the support 128 (as indicated by arrows A and B).
  • a specific embodiment of the mounting element 136 a includes a first mounting base 134 a and a flange 137 a coupled to the base 134 a by a rotatable or pivotable joint.
  • the angle between the first and second heat exchanging surfaces 131 a - b may be adjusted.
  • the first and second heat exchanging elements 130 a - b may be generally parallel to each other, i.e., have an angle of generally 0° between the first and second heat exchanging surfaces 131 a - b .
  • the first and second heat exchanging elements 130 a - b may also be generally co-planar, i.e., have an angle of generally 180° between the first and second heat exchanging surfaces 131 a - b .
  • any angle of about 0° to about 180° between the first and second heat exchanging surfaces 131 a - b may be achieved.
  • the treatment device 104 may further include a shaft 133 , and the first mounting base 134 a may be attached to the shaft 133 .
  • the first mounting base 134 a may be attached to the shaft 133 .
  • at least one of the heat exchanging elements 130 a - b moves along the shaft 133 and/or the shaft 133 moves relative to the support 128 to adjust the distance between the first and second heat exchanging elements 130 a - b (shown by arrow C).
  • the shaft 133 more specifically, extends between the first and second heat exchanging elements 130 a - b to enable movement of at least one of the heat exchanging elements 130 a - b relative to the support 128 .
  • first mounting base 134 a may be fixedly attached to the shaft 133
  • a second mounting base 134 b of the second heat exchanging element 130 b is configured such that the second mounting base 134 b may slide along the shaft 133 .
  • both the first mounting base 134 a and the second mounting base 134 b may be configured to slide along the shaft 133 .
  • the shaft 133 is generally constructed from polymeric materials, metals, ceramics, woods, or other suitable materials.
  • the treatment device 104 further includes a handle 140 slidably coupled to the shaft 133 or formed as a part of the shaft 133 .
  • the handle 140 is configured to be held by a hand of an operator.
  • the handle 140 may have a grip with grooves to improve stability of the treatment device 104 when held by the operator.
  • the handle 140 further includes an actuator 142 that operates with the shaft 133 to move the second heat exchanging element 130 b relative to the shaft 133 .
  • the actuator 142 may be a lever that engages the shaft 133 to incrementally advance the second heat exchanging element 130 b in an axial motion (arrow C) along the shaft 133 .
  • an operator may hold the treatment device 104 in one hand by grasping the handle 140 . Then, the heat exchanging elements 130 a - b may be rotated via the mounting elements 136 a - b to achieve a desired orientation. The operator may place the treatment device 104 having the heat exchanging elements 130 a - b in the desired orientation proximate to the skin of the subject to remove heat from a subcutaneous region of the subject 101 . In one embodiment, the operator may clamp a portion of the skin of the subject between the heat exchanging surfaces 131 a - b when the surfaces 131 a - b are generally parallel to each other.
  • the operator may press the heat exchanging surfaces 131 a - b against the skin of the subject when the surfaces 131 a - b are generally co-planar.
  • the operator may use thermoelectric coolers to remove heat from the subcutaneous region as described below with reference to FIG. 8 .
  • the operator may also monitor and control the treatment process by collecting measurements, such as skin temperatures, from the sensing element 135 a . By cooling the subcutaneous tissues to a temperature lower than 37° C., subcutaneous lipid-rich cells may be selectively affected. The affected cells are then reabsorbed into the subject through natural processes.
  • One expected advantage of using the treatment device 104 is that the treatment device may be applied to various regions of the subject's body because the two heat exchanging elements 130 a - b may be adjusted to conform to any body contour. Another expected advantage is that by pressing the treatment device 104 against the skin of the subject, blood flow through the treatment region may be reduced to achieve efficient cooling. Yet another expected advantage is that by applying the cryoprotectant to prevent icing and to allow pre-cooling of the heat exchanging elements, the treatment duration may be shortened. Yet another expected advantage is that maintaining the temperature of the heat exchanging elements may reduce the power consumption of the device. Still another expected advantage is that the power requirement is reduced for each of the heat exchanging elements 130 a - b because heat is removed from the skin through the two heat exchanging surfaces 131 a - b instead of a single heat exchanging element.
  • the first and second heat exchanging elements 130 a - b may have many additional embodiments with different and/or additional features without detracting from the operation of both elements.
  • the second heat exchanging element 130 b may or may not have a sensing element proximate to the second heat exchanging surface 131 b .
  • the second heat exchanging element 130 b may be constructed from a material that is different from that of the first heat exchanging element 130 a .
  • the second mounting base 134 b may have a shape and/or a surface configuration different from that of the first mounting base 134 a .
  • the first heat exchanging element 130 a may be rotatable, but the second heat exchanging element 130 b may be non-rotatable.
  • the first and second heat exchanging elements 130 a - b may further include a thermoelectric cooler (not shown), such as a Peltier-type element, proximate to the interface members 132 a - b .
  • the thermoelectric cooler may be a single Peltier-type element or an array of Peltier-type elements.
  • One suitable thermoelectric cooler is a Peltier-type heat exchanging element (model # CP-2895) produced by TE Technologies, Inc. in Traverse City, Mich.
  • FIGS. 8A-B are isometric views of a treatment device 104 in accordance with embodiments of the invention suitable for use in the treatment system 100 .
  • the treatment device 104 includes a control system housing 202 and cooling element housings 204 a - g .
  • the cooling element housings 204 a - g are connected to the heat exchanging elements (not shown) by attachment means 206 .
  • the attachment means may be any mechanical attachment device such as a screw or pin as is known in the art.
  • the plurality of cooling element housings 204 a - g may have many similar features.
  • the cooling element housing 204 a may be constructed from polymeric materials, metals, ceramics, woods, and/or other suitable materials.
  • the cooling element housing 204 a shown in FIGS. 8A-B is generally rectangular, but it may have any other desired shape.
  • the treatment device 104 is shown in a first relatively flat configuration in FIG. 8A and in a second curved configuration in FIG. 8B .
  • each segment of the cooling element housings 204 a - g is rotatably connected to adjacent segments and moveable about connection 207 a - f to allow the treatment device 104 to curve.
  • the connection 207 a - f may be a pin, a ball joint, a bearing, or other type of rotatable joints.
  • the connection 207 may accordingly be configured to rotatably couple the first cooling element housing 204 a to the second cooling element housing 204 b .
  • the first cooling element housing 204 a may rotate relative to the second cooling element housing 204 b (indicated by arrow A), each adjacent moveable pair of cooling elements being such that, for example, the angle between the first and second cooling element housings 204 a and 204 b may be adjusted up to 45°.
  • the treatment device is articulated such that it may assume a curved configuration as shown in FIG. 8B , conformable to the skin of a subject.
  • the arcuate shape of the treatment device may concentrate the heat transfer in the subcutaneous region. For example, when heat exchanging surfaces are rotated about a body contour of a subject, the arcuate shape may concentrate heat removal from the skin.
  • the control system housing 202 may house a processing unit for controlling the treatment device 104 and/or fluid lines 108 a - b and/or electrical power and communication lines.
  • the control system housing 202 includes a harness port 210 for electrical and supply fluid lines (not shown for purposes of clarity).
  • the control system housing 202 may further be configured to serve as a handle for a user of the treatment device 104 .
  • the processing unit may be contained at a location other than on the treatment device.
  • the treatment device 104 may further include at each end of the treatment device 104 retention devices 208 a and 208 b .
  • the retention devices 208 a and 208 b are rotatably connected to a frame by retention device coupling elements 212 a - b .
  • the retention device coupling elements 212 a - b may be a pin, a ball joint, a bearing, or other type of rotatable joints.
  • the retention devices 208 a and 208 b may be rigidly affixed to the end portions of the cooling element housings 204 a and 204 g .
  • the retention device may attach to control system housing 202 .
  • the retention devices 208 a and 208 b are each shown as tabs 214 , each having a slot 216 therein for receiving a band or elastomeric strap (not shown for purposes of clarity) to retain the treatment device 104 in place on a subject 101 during treatment.
  • the treatment device may not contain any attached retention device and may be held in place by hand, may be held in place by gravity, or may be held in place with a band, elastomeric strap, or non-elastic fabric (e.g., nylon webbing) wrapped around the treatment device 104 and the subject 101 .
  • the cooling element housings 204 a - g have a first edge 218 and an adjacent second edge 220 of a reciprocal shape to allow the treatment device 104 to mate and, thus, configure in a flat configuration.
  • the first edge 218 and the second edge 220 are generally angular in the Figures; however, the shape could be curved, straight, or a combination of angles, curves, and straight edges that provides a reciprocal shape between adjacent segments of the cooling element housings 204 a - g.
  • FIG. 9 is an isometric and exploded view of a treatment device 104 in accordance with another embodiment of the invention.
  • the treatment device 104 may include a housing 302 , a cooling assembly 308 at least partially disposed in the housing 302 , and retention devices 318 configured for fastening the cooling assembly 308 to the housing 302 .
  • the treatment device 104 may also include a vibration member disposed in the housing 302 , as described in more detail below with reference to FIG. 10 .
  • the cooling assembly 308 may include a heat sink 312 , a thermally conductive interface member 309 , and a thermoelectric cooler 314 disposed between the heat sink 312 and the interface member 309 .
  • the thermoelectric cooler 314 may be connected to an external power supply (not shown) via connection terminals 316 .
  • the heat sink 312 includes a U-shaped fluid conduit 310 at least partially embedded in a thermally conductive portion 313 of the heat sink 312 .
  • the fluid conduit 310 includes fluid ports 138 a - b that may be coupled to a circulating fluid source (not shown) via the fluid lines 108 a - b .
  • the heat sink 312 may include a plate-type heat exchanger, a tube and shell heat exchanger, and/or other types of heat exchanging device.
  • the interface member 309 may include a plate constructed from a metal, a metal alloy, and/or other types of thermally conductive material.
  • the thermoelectric cooler 314 may be a single Peltier-type element or an array of Peltier-type elements.
  • One suitable thermoelectric cooler is a Peltier-type heat exchanging element (model # CP-2895) produced by TE Technology, Inc. in Traverse City, Mich.
  • Individual retention devices 318 may include a plate 330 and a plurality of fasteners 306 extending through a plurality of apertures 332 (two are shown for illustrative purposes) of the plate 330 .
  • the fasteners 306 are screws that may be received by the housing 302 .
  • the fasteners 306 may include bolts, clamps, clips, nails, pins, rings, rivets, straps, and/or other suitable fasteners.
  • the cooling assembly 308 is first at least partially disposed in the internal space 303 of the housing 302 .
  • the retention devices 318 are positioned proximate to the cooling assembly 308 , and the fasteners 306 are extended through the apertures 332 of the plate 330 to engage the housing 302 .
  • the fasteners 306 , the plates 330 , and the housing 302 cooperate to hold the cooling assembly 308 together.
  • thermoelectric cooler 314 By applying power to the thermoelectric cooler 314 , heat may be effectively removed from the skin of the subject to a circulating fluid in the fluid conduit 310 .
  • applying a current to the thermoelectric cooler 314 may achieve a temperature generally below 37° C. on the first side 315 a of the thermoelectric cooler 314 to remove heat from the subject via the interface member 309 .
  • the thermoelectric cooler 314 transfers the heat from the first side 315 a to the second side 315 b .
  • the heat is then transferred to the circulating fluid in the fluid conduit 310 .
  • FIG. 10 is an isometric and exploded view of a vibrator 322 disposed in the treatment device 104 of FIG. 9 .
  • the vibrator 322 may include a frame 324 , a motor 325 carried by the frame 324 , a rotating member 328 operatively coupled to the motor 325 , and a plurality of fasteners 326 (e.g., screws) for fixedly attaching the frame 324 to the housing 302 .
  • the motor 325 has an output shaft (not shown) generally centered about a body axis 327 of the motor 325 .
  • One suitable motor is a direct current motor (model # Pittman 8322S008-R1) manufactured by Ametek, Inc., of Harleysville, Pa.
  • the rotating member 328 has a generally cylindrical shape and is off-centered from the body axis 327 . In other embodiments, the motor 325 may have an off-centered shaft that is operatively coupled to the rotating member 328 .
  • applying electricity to the motor 325 may cause the rotating member 328 to rotate around the body axis 327 of the motor 325 .
  • the off-centered rotating member 328 causes the vibrator 322 to be off-balanced about the body axis 327 , and vibration in the frame 324 and the housing 302 may result.
  • a first cryoprotectant composition used in the experiments included about 30% polypropylene glycol, about 30% glycerin, and about 40% ethanol (cryoprotectant I).
  • a second cryoprotectant composition used in the experiments included about 40% propylene glycol, about 0.8% hydroxyethylcellulose, and about 59.2% water (cryoprotectant II).
  • Skin surface temperatures investigated include ⁇ 11° C., ⁇ 12° C., ⁇ 14° C., ⁇ 16° C., and ⁇ 20° C.
  • Each testing site was cleaned and shaved, and a surface thermocouple was placed on the skin of the pig to control the treatment device.
  • cryoprotectant I and cryoprotectant II significantly lowered the freezing point of the skin of the pig.
  • the surface temperature was between about ⁇ 12° C. to about ⁇ 16° C., limited or no skin freezing was observed.

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US11/741,271 2006-04-28 2007-04-27 Cryoprotectant for use with a cooling device for improved cooling of subcutaneous lipid-rich cells Abandoned US20070255362A1 (en)

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Application Number Priority Date Filing Date Title
PCT/US2007/067638 WO2007127924A2 (en) 2006-04-28 2007-04-27 Cryoprotectant for use with a treatment device for improved cooling of subcutaneous lipid-rich cells
CN200780001010.5A CN101351167B (zh) 2006-04-28 2007-04-27 促进皮下富含脂肪细胞冷却的治疗装置中所用的防冻剂
KR1020087006539A KR101039758B1 (ko) 2006-04-28 2007-04-27 피하 지질 과다 세포의 개선된 냉각을 위한 치료 장치와함께 사용하기 위한 동결 방지제
JP2008513848A JP4703724B2 (ja) 2006-04-28 2007-04-27 皮下の脂質リッチ細胞の冷却が改善された治療装置に使用する凍結防止剤
KR1020117002538A KR101248799B1 (ko) 2006-04-28 2007-04-27 피하 지질 과다 세포의 개선된 냉각을 위한 치료 장치와 함께 사용하기 위한 동결 방지제
CN201410078711.0A CN103948468A (zh) 2006-04-28 2007-04-27 促进皮下富含脂肪细胞冷却的治疗装置中所用的防冻剂
BRPI0706055A BRPI0706055B8 (pt) 2006-04-28 2007-04-27 sistema e conjunto de componentes para remover calor de células subcutâneas ricas em lipídios
CA2585214A CA2585214C (en) 2006-04-28 2007-04-27 Cryoprotectant for use with a treatment device for improved cooling of subcutaneous lipid-rich cells
EP07761461.8A EP2012707B1 (en) 2006-04-28 2007-04-27 Cryoprotectant for use with a treatment device for improved cooling of subcutaneous lipid-rich cells
AU2007244765A AU2007244765A1 (en) 2006-04-28 2007-04-27 Cryoprotectant for use with a treatment device for improved cooling of subcutaneous lipid-rich cells
US11/741,271 US20070255362A1 (en) 2006-04-28 2007-04-27 Cryoprotectant for use with a cooling device for improved cooling of subcutaneous lipid-rich cells
IL182989A IL182989A (en) 2006-04-28 2007-05-03 Cold shield for use in an improved cooling device for lipid-rich subcutaneous cells
HK09102176.3A HK1124511A1 (en) 2006-04-28 2009-03-06 Cryoprotectant for use with a treatment device for improved cooling of subcutaneous lipid-rich cells
AU2010241393A AU2010241393B2 (en) 2006-04-28 2010-11-11 Cryoprotectant for use with a treatment device for improved cooling of subcutaneous lipid-rich cells
US13/747,161 US20140005760A1 (en) 2006-04-28 2013-01-22 Cryoprotectant for use with a treatment device for improved cooling of subcutaneous lipid-rich cells
HK15100475.7A HK1200080A1 (en) 2006-04-28 2015-01-15 Cryoprotectant for use with a treatment device for improved cooling of subcutaneous lipid-rich cells
US16/595,466 US12070411B2 (en) 2006-04-28 2019-10-08 Cryoprotectant for use with a treatment device for improved cooling of subcutaneous lipid-rich cells

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US13/747,161 Abandoned US20140005760A1 (en) 2006-04-28 2013-01-22 Cryoprotectant for use with a treatment device for improved cooling of subcutaneous lipid-rich cells
US16/595,466 Active US12070411B2 (en) 2006-04-28 2019-10-08 Cryoprotectant for use with a treatment device for improved cooling of subcutaneous lipid-rich cells

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US16/595,466 Active US12070411B2 (en) 2006-04-28 2019-10-08 Cryoprotectant for use with a treatment device for improved cooling of subcutaneous lipid-rich cells

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US (3) US20070255362A1 (ko)
EP (1) EP2012707B1 (ko)
JP (1) JP4703724B2 (ko)
KR (2) KR101248799B1 (ko)
CN (1) CN103948468A (ko)
AU (1) AU2007244765A1 (ko)
BR (1) BRPI0706055B8 (ko)
CA (1) CA2585214C (ko)
HK (2) HK1124511A1 (ko)
IL (1) IL182989A (ko)
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Cited By (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070129714A1 (en) * 2005-05-20 2007-06-07 Echo Healthcare Llc Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (FAT)
US20080077211A1 (en) * 2006-09-26 2008-03-27 Juniper Medical, Inc. Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile
US20080200910A1 (en) * 2007-02-16 2008-08-21 Myoscience, Inc. Replaceable and/or Easily Removable Needle Systems for Dermal and Transdermal Cryogenic Remodeling
US7850683B2 (en) 2005-05-20 2010-12-14 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
WO2010127315A3 (en) * 2009-04-30 2011-04-21 Zeltiq Aesthetics, Inc. Device, system and method of removing heat from subcutaneous lipid-rich cells
WO2011091293A1 (en) * 2010-01-21 2011-07-28 Zeltiq Aesthetics, Inc. Compositions for use with a system for improved cooling of subcutaneous lipid-rich tissue
US20110190856A1 (en) * 2010-02-04 2011-08-04 FreezeAwayFat LLC Garment and Method for Treating Fatty Deposits on a Human Body
US8073550B1 (en) 1997-07-31 2011-12-06 Miramar Labs, Inc. Method and apparatus for treating subcutaneous histological features
US20120022518A1 (en) * 2010-07-20 2012-01-26 Zeltiq Aesthetics, Inc. Combined modality treatement systems, methods and apparatus for body contouring applications
WO2012103242A1 (en) 2011-01-25 2012-08-02 Zeltiq Aesthetics, Inc. Devices, application systems and methods with localized heat flux zones for removing heat from subcutaneous lipid-rich cells
US20120221083A1 (en) * 2011-02-27 2012-08-30 Meliza Cruzada Treatment System by Heat Extraction and Methods of Use Thereof
US8275442B2 (en) 2008-09-25 2012-09-25 Zeltiq Aesthetics, Inc. Treatment planning systems and methods for body contouring applications
US8285390B2 (en) 2007-08-21 2012-10-09 Zeltiq Aesthetics, Inc. Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue
US8298216B2 (en) 2007-11-14 2012-10-30 Myoscience, Inc. Pain management using cryogenic remodeling
US8337539B2 (en) 2006-02-22 2012-12-25 Zeltiq Aesthetics, Inc. Cooling device for removing heat from subcutaneous lipid-rich cells
US8401668B2 (en) 2007-04-19 2013-03-19 Miramar Labs, Inc. Systems and methods for creating an effect using microwave energy to specified tissue
US8406894B2 (en) 2007-12-12 2013-03-26 Miramar Labs, Inc. Systems, apparatus, methods and procedures for the noninvasive treatment of tissue using microwave energy
US8469951B2 (en) 2011-08-01 2013-06-25 Miramar Labs, Inc. Applicator and tissue interface module for dermatological device
US8523927B2 (en) 2007-07-13 2013-09-03 Zeltiq Aesthetics, Inc. System for treating lipid-rich regions
US8603073B2 (en) 2008-12-17 2013-12-10 Zeltiq Aesthetics, Inc. Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells
US20130331914A1 (en) * 2012-06-11 2013-12-12 Martin Lee Thermal therapy system and method of use
WO2013191699A1 (en) * 2012-06-21 2013-12-27 Liliana Paez Cooling device for lipid-rich cell disruption
EP2687174A1 (en) * 2012-07-19 2014-01-22 Jose Antonio Sanchez Jaime Head end for device for cool therapy and method for applying locally a cool therapy with the use of the head end
US8688228B2 (en) 2007-04-19 2014-04-01 Miramar Labs, Inc. Systems, apparatus, methods and procedures for the noninvasive treatment of tissue using microwave energy
US20140144170A1 (en) * 2012-11-29 2014-05-29 Luciano Faccin Charging device for cooling system
WO2014151850A2 (en) 2013-03-14 2014-09-25 Zeltiq Aesthetics, Inc. Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue
US9017318B2 (en) 2012-01-20 2015-04-28 Myoscience, Inc. Cryogenic probe system and method
US9066712B2 (en) 2008-12-22 2015-06-30 Myoscience, Inc. Integrated cryosurgical system with refrigerant and electrical power source
US9078634B2 (en) 2011-01-27 2015-07-14 Cryosa, Llc Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
WO2015117005A1 (en) * 2014-01-31 2015-08-06 The General Hospital Corporation Cooling device to disrupt function sebaceous glands
US20150216816A1 (en) * 2014-01-31 2015-08-06 Zeltiq Aesthetics, Inc. Compositions, treatment systems and methods for improved cooling of lipid-rich tissue
US20150216718A1 (en) * 2012-08-03 2015-08-06 Board Of Regents, The University Of Texas System Devices, systems and methods for thermoelectric heating and cooling of mammalian tissue
US9149331B2 (en) 2007-04-19 2015-10-06 Miramar Labs, Inc. Methods and apparatus for reducing sweat production
US9155584B2 (en) 2012-01-13 2015-10-13 Myoscience, Inc. Cryogenic probe filtration system
US9241763B2 (en) 2007-04-19 2016-01-26 Miramar Labs, Inc. Systems, apparatus, methods and procedures for the noninvasive treatment of tissue using microwave energy
US9241753B2 (en) 2012-01-13 2016-01-26 Myoscience, Inc. Skin protection for subdermal cryogenic remodeling for cosmetic and other treatments
US9254162B2 (en) 2006-12-21 2016-02-09 Myoscience, Inc. Dermal and transdermal cryogenic microprobe systems
US9295512B2 (en) 2013-03-15 2016-03-29 Myoscience, Inc. Methods and devices for pain management
WO2016048721A1 (en) 2014-09-25 2016-03-31 Zeltiq Aesthetics, Inc. Treatment systems, methods, and apparatuses for altering the appearance of skin
US9314290B2 (en) 2012-01-13 2016-04-19 Myoscience, Inc. Cryogenic needle with freeze zone regulation
US9314368B2 (en) 2010-01-25 2016-04-19 Zeltiq Aesthetics, Inc. Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants, and associates devices, systems and methods
US20160175193A1 (en) * 2013-08-08 2016-06-23 Classys Inc. Device for curing obesity using cooling
USD777338S1 (en) 2014-03-20 2017-01-24 Zeltiq Aesthetics, Inc. Cryotherapy applicator for cooling tissue
US9610112B2 (en) 2013-03-15 2017-04-04 Myoscience, Inc. Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis
US20170105869A1 (en) * 2015-10-19 2017-04-20 Zeltiq Aesthestics, Inc. Vascular treatment systems, cooling devices, and methods for cooling vascular structures
US9668800B2 (en) 2013-03-15 2017-06-06 Myoscience, Inc. Methods and systems for treatment of spasticity
US20170224529A1 (en) * 2014-10-15 2017-08-10 Braincool Ab Device and method for reducing the body core temperature of a patient for hypothermia treatment by cooling at least two body parts of the patient
US20170239079A1 (en) * 2016-02-18 2017-08-24 Zeltiq Aesthetics, Inc. Cooling cup applicators with contoured heads and liner assemblies
US20170319378A1 (en) * 2002-03-15 2017-11-09 The General Hospital Corporation Treatment systems for removing heat from subcutaneous lipid-rich cells and treatment systems for affecting subcutaneous lipid-rich cells
US20170326042A1 (en) * 2016-05-10 2017-11-16 Zeltiq Aesthetics, Inc. Liposomes, emulsions, and methods for cryotherapy
WO2017196548A1 (en) 2016-05-10 2017-11-16 Zeltiq Aesthetics, Inc. Skin freezing systems for treating acne and skin conditions
US20170326346A1 (en) * 2016-05-10 2017-11-16 Zeltiq Aesthetics, Inc. Permeation enhancers and methods of cryotherapy
US9844460B2 (en) 2013-03-14 2017-12-19 Zeltiq Aesthetics, Inc. Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same
WO2018060533A1 (es) * 2016-09-28 2018-04-05 High Technology Products, S.L. Dispositivo protector de la piel y tejidos para tratamientos estéticos con frío
FR3061012A1 (fr) * 2016-12-27 2018-06-29 Deleo Procede de reduction d'un volume graisseux sous-cutane par le froid utilisant un actif anticellulite
US20180271767A1 (en) * 2017-03-21 2018-09-27 Zeltiq Aesthetics, Inc. Use of saccharides for cryoprotection and related technology
US10130409B2 (en) 2013-11-05 2018-11-20 Myoscience, Inc. Secure cryosurgical treatment system
US10383787B2 (en) 2007-05-18 2019-08-20 Zeltiq Aesthetics, Inc. Treatment apparatus for removing heat from subcutaneous lipid-rich cells and massaging tissue
WO2019162539A1 (es) 2018-02-26 2019-08-29 High Technology Products, Sl Dispositivo protector de la piel y tejidos para tratamientos estéticos con frío
US10463429B2 (en) 2007-04-19 2019-11-05 Miradry, Inc. Methods, devices, and systems for non-invasive delivery of microwave therapy
US10471269B1 (en) 2015-07-01 2019-11-12 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US10478633B2 (en) 2015-07-01 2019-11-19 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US10500342B2 (en) 2017-08-21 2019-12-10 Miraki Innovation Think Tank Llc Cold slurry syringe
US10524956B2 (en) * 2016-01-07 2020-01-07 Zeltiq Aesthetics, Inc. Temperature-dependent adhesion between applicator and skin during cooling of tissue
US10555831B2 (en) * 2016-05-10 2020-02-11 Zeltiq Aesthetics, Inc. Hydrogel substances and methods of cryotherapy
US10568759B2 (en) 2014-08-19 2020-02-25 Zeltiq Aesthetics, Inc. Treatment systems, small volume applicators, and methods for treating submental tissue
US10596386B2 (en) 2016-07-01 2020-03-24 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US10624696B2 (en) 2007-04-19 2020-04-21 Miradry, Inc. Systems and methods for creating an effect using microwave energy to specified tissue
US10632321B2 (en) 2016-07-01 2020-04-28 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US10675176B1 (en) 2014-03-19 2020-06-09 Zeltiq Aesthetics, Inc. Treatment systems, devices, and methods for cooling targeted tissue
US10695576B2 (en) 2015-07-01 2020-06-30 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US10695575B1 (en) 2016-05-10 2020-06-30 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US10709894B2 (en) 2015-07-01 2020-07-14 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US10709895B2 (en) 2016-05-10 2020-07-14 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US10729496B2 (en) 2017-11-21 2020-08-04 Cutera, Inc. Dermatological picosecond laser treatment systems and methods using optical parametric oscillator
US20200261137A1 (en) * 2014-05-12 2020-08-20 Gary Kalser Cryotherapy device with cryoprotection and methods for performing cryotherapy with cryoprotection
US10779885B2 (en) 2013-07-24 2020-09-22 Miradry. Inc. Apparatus and methods for the treatment of tissue using microwave energy
WO2020215011A1 (en) * 2019-04-18 2020-10-22 Abs Global, Inc. System and process for continuous addition of cryoprotectant
US10821295B1 (en) 2015-07-01 2020-11-03 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US10888366B2 (en) 2013-03-15 2021-01-12 Pacira Cryotech, Inc. Cryogenic blunt dissection methods and devices
US10935174B2 (en) 2014-08-19 2021-03-02 Zeltiq Aesthetics, Inc. Stress relief couplings for cryotherapy apparatuses
US10952891B1 (en) 2014-05-13 2021-03-23 Zeltiq Aesthetics, Inc. Treatment systems with adjustable gap applicators and methods for cooling tissue
US11000409B2 (en) 2016-11-02 2021-05-11 Miraki Innovation Think Tank Llc Devices and methods for slurry generation
WO2021105929A3 (en) * 2019-11-26 2021-07-08 Amir Katz Cryotherapy skin growth removal device
US11076879B2 (en) 2017-04-26 2021-08-03 Zeltiq Aesthetics, Inc. Shallow surface cryotherapy applicators and related technology
US11134998B2 (en) 2017-11-15 2021-10-05 Pacira Cryotech, Inc. Integrated cold therapy and electrical stimulation systems for locating and treating nerves and associated methods
US11140987B2 (en) * 2019-02-14 2021-10-12 Deer Solutions LLC Athletic chair with adjustable heating and height
US11185690B2 (en) 2016-05-23 2021-11-30 BTL Healthcare Technologies, a.s. Systems and methods for tissue treatment
US11187224B2 (en) 2013-07-16 2021-11-30 Abs Global, Inc. Microfluidic chip
US11193879B2 (en) 2010-11-16 2021-12-07 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
CN113827545A (zh) * 2020-06-23 2021-12-24 微创医美科技(嘉兴)有限公司 辅助冷冻溶脂的防冻液注射制剂、导液器、试剂盒及冷冻溶脂系统
US11243494B2 (en) 2002-07-31 2022-02-08 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US11247063B2 (en) 2019-04-11 2022-02-15 Btl Healthcare Technologies A.S. Methods and devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy
US11247039B2 (en) 2016-05-03 2022-02-15 Btl Healthcare Technologies A.S. Device including RF source of energy and vacuum system
WO2022036271A1 (en) 2020-08-14 2022-02-17 Zeltiq Aesthetics, Inc. Multi-applicator system and method for body contouring
US11253718B2 (en) 2015-07-01 2022-02-22 Btl Healthcare Technologies A.S. High power time varying magnetic field therapy
US11253717B2 (en) 2015-10-29 2022-02-22 Btl Healthcare Technologies A.S. Aesthetic method of biological structure treatment by magnetic field
US11311327B2 (en) 2016-05-13 2022-04-26 Pacira Cryotech, Inc. Methods and systems for locating and treating nerves with cold therapy
US11320361B2 (en) 2015-02-19 2022-05-03 1087 Systems, Inc. Scanning infrared measurement system
US11324673B2 (en) 2016-11-18 2022-05-10 Miraki Innovation Think Tank Llc Cosmetic appearance of skin
US11331670B2 (en) 2018-05-23 2022-05-17 Abs Global, Inc. Systems and methods for particle focusing in microchannels
US11382790B2 (en) 2016-05-10 2022-07-12 Zeltiq Aesthetics, Inc. Skin freezing systems for treating acne and skin conditions
US11395760B2 (en) 2006-09-26 2022-07-26 Zeltiq Aesthetics, Inc. Tissue treatment methods
US11400308B2 (en) 2017-11-21 2022-08-02 Cutera, Inc. Dermatological picosecond laser treatment systems and methods using optical parametric oscillator
CN114857792A (zh) * 2022-04-21 2022-08-05 山前（珠海）医疗科技有限公司 冷冻减脂装置及其控制方法
US11415503B2 (en) 2013-10-30 2022-08-16 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
US11439532B2 (en) 2017-04-05 2022-09-13 Miraki Innovation Think Tank Llc Point of delivery cold slurry generation
US11446178B2 (en) 2017-04-05 2022-09-20 Miraki Innovation Think Tank Llc Cold slurry containment
US11446175B2 (en) 2018-07-31 2022-09-20 Zeltiq Aesthetics, Inc. Methods, devices, and systems for improving skin characteristics
US11464993B2 (en) 2016-05-03 2022-10-11 Btl Healthcare Technologies A.S. Device including RF source of energy and vacuum system
US11491342B2 (en) 2015-07-01 2022-11-08 Btl Medical Solutions A.S. Magnetic stimulation methods and devices for therapeutic treatments
US11534619B2 (en) 2016-05-10 2022-12-27 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US11534335B2 (en) 2014-10-01 2022-12-27 Cryosa, Inc. Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
US11559421B2 (en) 2015-06-25 2023-01-24 Hill-Rom Services, Inc. Protective dressing with reusable phase-change material cooling insert
US11583437B2 (en) 2018-02-06 2023-02-21 Aspen Surgical Products, Inc. Reusable warming blanket with phase change material
US11590020B2 (en) 2002-03-15 2023-02-28 The General Hospital Corporation Methods and devices for selective disruption of fatty tissue by controlled cooling
US11612758B2 (en) 2012-07-05 2023-03-28 Btl Medical Solutions A.S. Device for repetitive nerve stimulation in order to break down fat tissue means of inductive magnetic fields
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
US11806528B2 (en) 2020-05-04 2023-11-07 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
US11819451B2 (en) 2020-07-10 2023-11-21 C° Change Surgical Llc Injectable slush feed supply
US11826565B2 (en) 2020-05-04 2023-11-28 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
US11896816B2 (en) 2021-11-03 2024-02-13 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
US11986421B2 (en) 2006-09-26 2024-05-21 Zeltiq Aesthetics, Inc. Cooling devices with flexible sensors
US12064163B2 (en) 2021-10-13 2024-08-20 Btl Medical Solutions A.S. Methods and devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy
US12070411B2 (en) 2006-04-28 2024-08-27 Zeltiq Aesthetics, Inc. Cryoprotectant for use with a treatment device for improved cooling of subcutaneous lipid-rich cells
US12135270B2 (en) 2020-11-23 2024-11-05 Abs Global, Inc. Modular flow cytometry systems and methods of processing samples

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102319141B (zh) * 2011-08-23 2014-08-13 广州贝伽电子科技有限公司 一种除去人体脂肪的减肥仪
CN104095702A (zh) * 2013-04-15 2014-10-15 宁波博高国际贸易有限公司 一种冰冻消脂装置
WO2016044058A1 (en) 2014-09-15 2016-03-24 Sung Oh Cooling system for localized and non-invasive cooling treatment
KR200481035Y1 (ko) * 2014-09-23 2016-08-04 박병권 동상 방지용 패드 구조
US10382961B2 (en) * 2014-12-05 2019-08-13 Ademco Inc. System and method of preventing unauthorized SIM card usage
WO2017041022A1 (en) * 2015-09-04 2017-03-09 R2 Dermatology, Inc. Medical systems, methods, and devices for hypopigmentation cooling treatments
KR101794270B1 (ko) 2016-03-15 2017-11-08 주식회사 엔씨바이오 동상방지패드 유입액센서를 갖춘 의료용 저온기
TWI621396B (zh) * 2016-09-30 2018-04-21 臺北榮民總醫院 冷凍處理中保護生物組織的防凍劑及其製備方法
US12076270B2 (en) * 2016-10-31 2024-09-03 Elmedix Nv Whole-body hyperthermia system
CN108904036B (zh) * 2018-07-17 2024-01-12 广州复大医疗有限公司 防皮肤冻伤装置、防皮肤冻伤袋及其使用方法
US10864380B1 (en) 2020-02-29 2020-12-15 Cutera, Inc. Systems and methods for controlling therapeutic laser pulse duration
US11253720B2 (en) 2020-02-29 2022-02-22 Cutera, Inc. Dermatological systems and methods with handpiece for coaxial pulse delivery and temperature sensing
CN111233142A (zh) * 2020-03-03 2020-06-05 深圳市长隆科技有限公司 一种适用于北方冬季低温条件的高效复合碳源及其制备方法
EP3906901A1 (en) 2020-05-04 2021-11-10 High Technology Products, SL Pads and systems for treatment of a subject
CN114052887A (zh) * 2020-07-30 2022-02-18 上海微创惟美医疗科技(集团)有限公司 一种冷冻溶脂治疗组件、装置及防冻剂
CN112220551B (zh) * 2020-12-10 2021-04-16 微创医美科技(嘉兴)有限公司 一种冷冻溶脂治疗组件及装置
CN113075371B (zh) * 2021-03-22 2022-11-18 重庆医药高等专科学校 一种药物崩解仪

Citations (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US681806A (en) * 1901-05-25 1901-09-03 Armand Mignault Lung-protector.
US889810A (en) * 1908-01-04 1908-06-02 Henry Robinson Medicating and massaging appliance.
US3132688A (en) * 1963-04-08 1964-05-12 Welville B Nowak Electronic cold and/or hot compress device
US3502080A (en) * 1965-06-28 1970-03-24 Max L Hirschhorn Thermoelectrically cooled surgical instrument
US3786814A (en) * 1972-12-15 1974-01-22 T Armao Method of preventing cryoadhesion of cryosurgical instruments and cryosurgical instruments
US3942519A (en) * 1972-12-26 1976-03-09 Ultrasonic Systems, Inc. Method of ultrasonic cryogenic cataract removal
US3948269A (en) * 1973-08-31 1976-04-06 Dragerwerk Aktiengesellschaft Cryomedical device
US4140130A (en) * 1977-05-31 1979-02-20 Storm Iii Frederick K Electrode structure for radio frequency localized heating of tumor bearing tissue
US4202336A (en) * 1976-05-14 1980-05-13 Erbe Elektromedizin Kg Cauterizing probes for cryosurgery
US4266043A (en) * 1974-08-15 1981-05-05 Toyo Rubber Chemical Industrial Corporation Resilient hydrophobic foamed polymer
US4381009A (en) * 1980-01-28 1983-04-26 Bon F Del Hand-held device for the local heat-treatment of the skin
US4585002A (en) * 1985-04-22 1986-04-29 Igor Kissin Method and apparatus for treatment of pain by frequently alternating temperature stimulation
US4644955A (en) * 1982-12-27 1987-02-24 Rdm International, Inc. Circuit apparatus and method for electrothermal treatment of cancer eye
US4664110A (en) * 1985-03-18 1987-05-12 University Of Southern California Controlled rate freezing for cryorefractive surgery
US4718429A (en) * 1983-03-10 1988-01-12 Udo Smidt Method of reducing fatty deposits in the human body
US4741338A (en) * 1986-10-06 1988-05-03 Toshiaki Miyamae Thermoelectric physical remedy apparatus
US4802475A (en) * 1987-06-22 1989-02-07 Weshahy Ahmed H A G Methods and apparatus of applying intra-lesional cryotherapy
US4832022A (en) * 1986-05-26 1989-05-23 Tomsky Gosudarstvenny Universitet Im. Kuibysheva Cryogenic ultrasonic scalpel
US4906463A (en) * 1986-12-22 1990-03-06 Cygnus Research Corporation Transdermal drug-delivery composition
US4990144A (en) * 1986-08-20 1991-02-05 Smith And Nephew Associated Companies Plc Medicating impressed film wound dressing
US5007433A (en) * 1988-06-23 1991-04-16 Phywe Systeme Gmbh Stimulation device
US5084671A (en) * 1987-09-02 1992-01-28 Tokyo Electron Limited Electric probing-test machine having a cooling system
US5108390A (en) * 1988-11-14 1992-04-28 Frigitronics, Inc. Flexible cryoprobe
US5197466A (en) * 1983-01-21 1993-03-30 Med Institute Inc. Method and apparatus for volumetric interstitial conductive hyperthermia
US5207674A (en) * 1991-05-13 1993-05-04 Hamilton Archie C Electronic cryogenic surgical probe apparatus and method
US5277030A (en) * 1993-01-22 1994-01-11 Welch Allyn, Inc. Preconditioning stand for cooling probe
US5314423A (en) * 1992-11-03 1994-05-24 Seney John S Cold electrode pain alleviating tissue treatment assembly
US5497596A (en) * 1994-01-27 1996-03-12 E. I. Du Pont De Nemours And Company Method for reducing penetration of liquid through nonwoven film-fibril sheets pierced by fastening elements
US5505726A (en) * 1994-03-21 1996-04-09 Dusa Pharmaceuticals, Inc. Article of manufacture for the photodynamic therapy of dermal lesion
US5507790A (en) * 1994-03-21 1996-04-16 Weiss; William V. Method of non-invasive reduction of human site-specific subcutaneous fat tissue deposits by accelerated lipolysis metabolism
US5514105A (en) * 1992-01-03 1996-05-07 The Procter & Gamble Company Resilient plastic web exhibiting reduced skin contact area and enhanced fluid transfer properties
US5514170A (en) * 1994-08-25 1996-05-07 Mauch; Rose M. Cold pack device
US5603221A (en) * 1994-06-30 1997-02-18 State Of Israel, Ministry Of Defense, Rafael-Armaments Development Authority Multiprobe surgical cryogenic apparatus
US5628769A (en) * 1994-09-30 1997-05-13 Saringer Research, Inc. Method and devices for producing somatosensory stimulation using temperature
US5733280A (en) * 1995-11-15 1998-03-31 Avitall; Boaz Cryogenic epicardial mapping and ablation
US5741248A (en) * 1995-06-07 1998-04-21 Temple University-Of The Commonwealth System Of Higher Education Fluorochemical liquid augmented cryosurgery
US5746736A (en) * 1995-08-09 1998-05-05 Lumedics, Ltd. Cryogenic laser lithotripsy with enhanced light absorption
US5755663A (en) * 1994-08-19 1998-05-26 Novoste Corporation Apparatus for procedures related to the electrophysiology of the heart
US5755753A (en) * 1995-05-05 1998-05-26 Thermage, Inc. Method for controlled contraction of collagen tissue
US5871526A (en) * 1993-10-13 1999-02-16 Gibbs; Roselle Portable temperature control system
US5871524A (en) * 1995-05-05 1999-02-16 Thermage, Inc. Apparatus for controlled contraction of collagen tissue
US5895418A (en) * 1994-09-30 1999-04-20 Saringer Research Inc. Device for producing cold therapy
US5901707A (en) * 1995-05-19 1999-05-11 Hpl Biomedical, Inc. Silicone mask for cryosurgery and method
US6017337A (en) * 1996-11-04 2000-01-25 Pira; Luc Cryoprobe based on a peltier module
US6023932A (en) * 1997-08-25 2000-02-15 Johnston; Robert Topical cooling device
US6032675A (en) * 1997-03-17 2000-03-07 Rubinsky; Boris Freezing method for controlled removal of fatty tissue by liposuction
US6039694A (en) * 1998-06-25 2000-03-21 Sonotech, Inc. Coupling sheath for ultrasound transducers
US6041787A (en) * 1997-03-17 2000-03-28 Rubinsky; Boris Use of cryoprotective agent compounds during cryosurgery
US6051159A (en) * 1995-12-19 2000-04-18 Hao; Jie Soft ice
US6350276B1 (en) * 1996-01-05 2002-02-26 Thermage, Inc. Tissue remodeling apparatus containing cooling fluid
US6354297B1 (en) * 1998-04-16 2002-03-12 The Uniformed Services University Of The Health Sciences Method and device for destroying fat cells by induction of programmed cell death
US6377855B1 (en) * 1995-05-05 2002-04-23 Thermage, Inc. Method and apparatus for controlled contraction of collagen tissue
US20020058975A1 (en) * 1999-12-14 2002-05-16 Bieberich Mark Thomas High-efficiency cooling pads, mattresses, and sleeves
US20020062142A1 (en) * 1995-05-05 2002-05-23 Edward W. Knowlton Method and apparatus for tissue remodeling
US6519964B2 (en) * 2000-04-11 2003-02-18 Augustine Medical, Inc. Cooling devices with high-efficiency cooling features
US6523354B1 (en) * 2002-03-08 2003-02-25 Deborah Ann Tolbert Cooling blanket
US6527765B2 (en) * 2000-10-06 2003-03-04 Charles D. Kelman Cryogenic surgical system and method of use in removal of tissue
US6544248B1 (en) * 1996-08-08 2003-04-08 Starion Instruments Corporation Device for suction-assisted lipectomy and method of using same
US20030069618A1 (en) * 2001-04-26 2003-04-10 Smith Edward Dewey Method, kit and device for the treatment of cosmetic skin conditions
US6548297B1 (en) * 1994-11-09 2003-04-15 Celadon Science, Inc. Sheets of cultured epithelial cells used for wound repair and their cryopreservation
US6551349B2 (en) * 1998-03-24 2003-04-22 Innercool Therapies, Inc. Selective organ cooling apparatus
US20030077329A1 (en) * 2001-10-19 2003-04-24 Kipp James E Composition of and method for preparing stable particles in a frozen aqueous matrix
US6569189B1 (en) * 1998-04-06 2003-05-27 Augustine Medical, Inc. Tissue treatment apparatus including a bandpass filter transparent to selected wavelengths of IR electromagnetic spectrum
US20030100936A1 (en) * 2001-11-29 2003-05-29 Gregory Altshuler Method and apparatus for controlling the temperature of a surface
US20040006328A1 (en) * 1999-01-04 2004-01-08 Anderson Richard Rox Targeting of sebaceous follicles as a treatment of sebaceous gland disorders
US20040009936A1 (en) * 1999-05-03 2004-01-15 Tang De-Chu C. Vaccine and drug delivery by topical application of vectors and vector extracts
US20040030332A1 (en) * 1996-01-05 2004-02-12 Knowlton Edward W. Handpiece with electrode and non-volatile memory
US20040039312A1 (en) * 2002-02-20 2004-02-26 Liposonix, Inc. Ultrasonic treatment and imaging of adipose tissue
US6699266B2 (en) * 2001-12-08 2004-03-02 Charles A. Lachenbruch Support surface with phase change material or heat tubes
US20040049178A1 (en) * 1999-01-25 2004-03-11 Marwan Abboud Cooling system
US20040073079A1 (en) * 2002-06-19 2004-04-15 Palomar Medical Technologies, Inc. Method and apparatus for treatment of cutaneous and subcutaneous conditions
US20040074629A1 (en) * 2002-10-18 2004-04-22 Noel Thomas P. Method and thermally active convection apparatus and method for abstracting heat with circulation intermediate three dimensional--parity heat transfer elements in bi-phase heat exchanging composition
US20040093042A1 (en) * 2002-06-19 2004-05-13 Palomar Medical Technologies, Inc. Method and apparatus for photothermal treatment of tissue at depth
US6840955B2 (en) * 2000-01-27 2005-01-11 Robert J. Ein Therapeutic apparatus
US20050049661A1 (en) * 2003-09-03 2005-03-03 Koffroth Shirley B. Ice belt to reduce body temperature
US6878144B2 (en) * 1996-12-02 2005-04-12 Palomar Medical Technologies, Inc. System for electromagnetic radiation dermatology and head for use therewith
US20060030778A1 (en) * 1997-08-19 2006-02-09 Mendlein John D Ultrasonic transmission films and devices for hygienic transducer surfaces
US20060036300A1 (en) * 2004-08-16 2006-02-16 Syneron Medical Ltd. Method for lypolisis
US7005558B1 (en) * 1996-05-02 2006-02-28 Sca Hygiene Products Ab Apertured covering sheet for an absorbent article and a method of producing the covering sheet
US7022121B2 (en) * 1999-03-09 2006-04-04 Thermage, Inc. Handpiece for treatment of tissue
US20060074313A1 (en) * 2004-10-06 2006-04-06 Guided Therapy Systems, L.L.C. Method and system for treating cellulite
US20060079852A1 (en) * 2002-12-31 2006-04-13 Bubb Stephen K Externally-applied patient interface system and method
US7037326B2 (en) * 2003-03-14 2006-05-02 Hee-Young Lee Skin cooling device using thermoelectric element
US20070010861A1 (en) * 2002-03-15 2007-01-11 Anderson Richard R Methods and devices for selective disruption of fatty tissue by controlled cooling
US20070032661A1 (en) * 2005-08-03 2007-02-08 Glenmark Pharmaceuticals Limited Process for the preparation of intermediates of perindopril
US7183360B2 (en) * 2001-10-05 2007-02-27 Basf Aktiengesellschaft Method for crosslinking hydrogels with morpholine-2,3-diones
US7189252B2 (en) * 2003-03-25 2007-03-13 Krueger & Gothe Gmbh Warming/chilling apparatus
US7192426B2 (en) * 2001-05-31 2007-03-20 Endocare, Inc. Cryogenic system
US7204832B2 (en) * 1996-12-02 2007-04-17 Pálomar Medical Technologies, Inc. Cooling system for a photo cosmetic device
US7220778B2 (en) * 2003-04-15 2007-05-22 The General Hospital Corporation Methods and devices for epithelial protection during photodynamic therapy
US20080077202A1 (en) * 2006-09-26 2008-03-27 Juniper Medical, Inc. Tissue Treatment Methods
US20090118722A1 (en) * 2006-10-31 2009-05-07 Ebbers Edward A Method and apparatus for cooling subcutaneous lipid-rich cells or tissue
US20100081971A1 (en) * 2008-09-25 2010-04-01 Allison John W Treatment planning systems and methods for body contouring applications

Family Cites Families (644)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1093868A (en) 1912-03-11 1914-04-21 Henry W Jacobs Means for forming couplings or joints.
DE532976C (de) 1930-07-29 1931-09-11 Lorenz Akt Ges C Sendeeinrichtung fuer Springschreiber, bei der die Sendeschienen in der Bewegungsrichtung der Sendetasten verschoben werden
GB387960A (en) 1932-09-17 1933-02-16 William Hipon Horsfield Electro-therapeutic massaging appliance
FR854937A (fr) 1939-05-19 1940-04-27 Appareil de massage par aspiration
GB578157A (en) 1942-12-21 1946-06-18 Johnson & Johnson Improvements in and relating to surgical dressings
US2516491A (en) * 1945-10-08 1950-07-25 Henry A Swastek Massage and shampoo device
US2521780A (en) 1947-06-12 1950-09-12 Bertha A Dodd Cushion or receptacle
US2726658A (en) 1953-04-27 1955-12-13 Donald E Chessey Therapeutic cooling devices for domestic and hospital use
NL177982B (nl) 1953-04-29 Siemens Ag Infusietoestel.
US2766619A (en) 1953-06-26 1956-10-16 Tribus Myron Ice detecting apparatus
CH333982A (de) 1954-06-11 1958-11-15 Usag Ultraschall Ag Ultraschall-Bestrahlungsvorrichtung
US3093135A (en) 1962-01-29 1963-06-11 Max L Hirschhorn Cooled surgical instrument
US3133539A (en) 1962-08-06 1964-05-19 Eidus William Thermoelectric medical instrument
US3282267A (en) 1964-05-05 1966-11-01 Eidus William Thermoelectric hypothermia instrument
US3341230A (en) 1965-10-23 1967-09-12 Swivelier Company Inc Swivel unit
US3591645A (en) 1968-05-20 1971-07-06 Gulf Research Development Co Process for preparing a halogenated aromatic
US3566871A (en) 1968-06-11 1971-03-02 American Cyanamid Co Hydrophilic medical sponge and method of using same
FR1595285A (ko) 1968-12-18 1970-06-08
US3703897A (en) 1969-10-09 1972-11-28 Kendall & Co Hydrophobic non-adherent wound dressing
US3587577A (en) 1970-05-09 1971-06-28 Oleg Alexandrovich Smirnov Device for applying selective and general hypothermy to and reheating of human body through the common integuments thereof
US3702114A (en) 1970-08-26 1972-11-07 Frigitronics Of Conn Inc Liquid refrigerant spray device
US3710784A (en) 1972-04-03 1973-01-16 C Taylor Massaging device
JPS5033039Y2 (ko) 1972-09-13 1975-09-26
US4002221A (en) * 1972-09-19 1977-01-11 Gilbert Buchalter Method of transmitting ultrasonic impulses to surface using transducer coupling agent
US3827436A (en) 1972-11-10 1974-08-06 Frigitronics Of Conn Inc Multipurpose cryosurgical probe
US4269068A (en) 1974-02-21 1981-05-26 Rockwell International Corporation Ultrasonic couplant compositions and method for employing same
SU532976A1 (ru) 1974-05-05 1978-11-05 Киевский Государственный Институт Усовершенстовования Врачей Министерства Здравоохранения Ссср Устройство дл локального охлаждени ткани
US3986385A (en) 1974-08-05 1976-10-19 Rosemount Engineering Company Limited Apparatus for determining the freezing point of a liquid
US3993053A (en) 1974-08-05 1976-11-23 Murray Grossan Pulsating massage system
US4008910A (en) 1975-05-16 1977-02-22 Roche Thomas F Universal electrical swivel
US4026299A (en) 1975-09-26 1977-05-31 Vari-Temp Manufacturing Co. Cooling and heating apparatus
US4149529A (en) 1977-09-16 1979-04-17 Jobst Institute, Inc. Portable thermo-hydraulic physiotherapy device
USD260173S (en) 1978-10-13 1981-08-11 International Business Machines Corporation Electrocardiograph
US4178429A (en) 1978-11-17 1979-12-11 Scheffer Karl D Catalyst for curing resins
DE2851602A1 (de) 1978-11-29 1980-06-12 Messerschmitt Boelkow Blohm Geraet zur behandlung entzuendlicher erkrankungen
US4428368A (en) 1980-09-29 1984-01-31 Masakatsu Torii Massage device
US4470263A (en) 1980-10-14 1984-09-11 Kurt Lehovec Peltier-cooled garment
US4396011A (en) 1981-01-09 1983-08-02 Clairol Incorporated Heating pad
US4459854A (en) 1981-07-24 1984-07-17 National Research Development Corporation Ultrasonic transducer coupling member
US4528979A (en) 1982-03-18 1985-07-16 Kievsky Nauchno-Issledovatelsky Institut Otolaringologii Imeni Professora A.S. Kolomiiobenka Cryo-ultrasonic surgical instrument
JPS58187454A (ja) 1982-04-27 1983-11-01 Nippon Kayaku Co Ltd カラー液晶用色素
US4555313A (en) 1982-10-21 1985-11-26 The United States Of America As Represented By The United States Department Of Energy Method of forming a continuous polymeric skin on a cellular foam material
US4548212A (en) 1982-10-29 1985-10-22 Leung Frank K Apparatus for thermographic examinations
US4483341A (en) 1982-12-09 1984-11-20 Atlantic Richfield Company Therapeutic hypothermia instrument
US4531524A (en) 1982-12-27 1985-07-30 Rdm International, Inc. Circuit apparatus and method for electrothermal treatment of cancer eye
US4614191A (en) 1983-09-02 1986-09-30 Perler Robert F Skin-cooling probe
DE3381512D1 (de) 1983-10-26 1990-06-07 Nihon Kenkozoshin Kenkyukai Kk Ein magnetfeld hervorbringende heilvorrichtung.
JPS6094113U (ja) 1983-12-06 1985-06-27 瀧川株式会社 美容美顔機
US5158070A (en) 1983-12-14 1992-10-27 Edap International, S.A. Method for the localized destruction of soft structures using negative pressure elastic waves
EP0168483A4 (en) 1984-01-18 1987-01-20 Bailey David F MEDICAL MULTI-LAYER DISPOSABLE THERMAL BLANKET.
US4603076A (en) 1985-03-04 1986-07-29 Norwood Industries, Inc. Hydrophilic foam
US4869250A (en) 1985-03-07 1989-09-26 Thermacor Technology, Inc. Localized cooling apparatus
JPS6282977A (ja) 1985-10-07 1987-04-16 オムロン株式会社 温冷低周波治療装置
US4700701A (en) 1985-10-23 1987-10-20 Montaldi David H Sterilization method and apparatus
JPH0765230B2 (ja) 1986-09-19 1995-07-12 三菱マテリアル株式会社 金属表面における多孔質層の形成方法
GB2190842B (en) * 1986-05-05 1990-03-07 Oreal Apparatus for the cryogenic treatment of the skin
ATE66360T1 (de) 1986-05-16 1991-09-15 Termac Sa Therapeutische vorrichtung mit einer masse aus einem thermisch aktiven material.
DE3621425A1 (de) 1986-06-25 1988-01-14 Messer Griesheim Gmbh Vorrichtung zur erzeugung eines kalten behandlungsgases fuer die kryotherapie
US4880564A (en) 1986-09-29 1989-11-14 Ciba-Geigy Corporation Antifoams for aqueous systems and their use
US5018521A (en) 1986-10-24 1991-05-28 Campbell William P Method of and apparatus for increased transfer of heat into or out of the body
US4764463A (en) * 1986-10-30 1988-08-16 The University Of Tennessee Research Corporation Platelet cyropreservation
CN86200604U (en) 1987-01-10 1987-10-14 Zhichang Yang Apparatus for freezing freckle and treating some skin diseases with freezing
US4962761A (en) 1987-02-24 1990-10-16 Golden Theodore A Thermal bandage
US4846176A (en) 1987-02-24 1989-07-11 Golden Theodore A Thermal bandage
GB8706141D0 (en) 1987-03-16 1987-04-23 Thorner D Treatment of damaged limb
US4935345A (en) 1987-04-07 1990-06-19 Arizona Board Of Regents Implantable microelectronic biochemical sensor incorporating thin film thermopile
US5143063A (en) 1988-02-09 1992-09-01 Fellner Donald G Method of removing adipose tissue from the body
JPH01223961A (ja) 1988-03-02 1989-09-07 Kineshio:Kk 筋肉皮下組織の改善方法並びに皮下組織活性具
US5065752A (en) 1988-03-29 1991-11-19 Ferris Mfg. Co. Hydrophilic foam compositions
DK161260C (da) 1988-05-06 1991-12-30 Paul Verner Nielsen Flowmaaler
US4930317A (en) 1988-05-20 1990-06-05 Temperature Research Corporation Apparatus for localized heat and cold therapy
US4905697A (en) 1989-02-14 1990-03-06 Cook Pacemaker Corporation Temperature-controlled cardiac pacemaker responsive to body motion
US5024650A (en) 1989-02-15 1991-06-18 Matsushita Electric Works, Ltd. Stress dissolving refreshment system
DE8905769U1 (de) 1989-05-09 1989-07-13 Schulte, Franz-Josef, Dipl.-Ing., 59939 Olsberg Gerät zur Erzeugung von Kälte und Wärme
US5516505A (en) 1989-07-18 1996-05-14 Mcdow; Ronald A. Method for using cryogenic agents for treating skin lesions
US5200170A (en) 1989-07-18 1993-04-06 Mcdow Ronald A Medical process--use of dichlorodifluoromethane (CCl2 F2) and chlorodifluoromethane (CHClF2) as cryogens for treating skin lesions
JP2625548B2 (ja) 1989-07-19 1997-07-02 沖電気工業株式会社 画像生成方法及び画像生成装置
US5160312A (en) 1990-02-09 1992-11-03 W. R. Grace & Co.-Conn. Cryopreservation process for direct transfer of embryos
US5817149A (en) 1990-02-26 1998-10-06 Vesture Corporation Heat application method
US5339541A (en) 1990-02-26 1994-08-23 Vesture Corporation Footwear with therapeutic pad
US5575812A (en) 1990-02-26 1996-11-19 Vesture Corporation Cooling pad method
JPH03259975A (ja) 1990-03-09 1991-11-20 Matsushita Refrig Co Ltd 撥水性コーティング用組成物及び撥水性コーティング用組成物を塗布した熱交換器
FR2659851A1 (fr) 1990-03-20 1991-09-27 Karagozian Serge Appareil de massage.
US5362966A (en) 1990-06-27 1994-11-08 Rosenthal Robert D Measurement of finger temperature in near-infrared quantitative measurement instrument
US5148804A (en) 1990-06-28 1992-09-22 Hill Dennis M Device, system, and methods for applying cryotherapy
JPH0493597A (ja) 1990-08-08 1992-03-26 Matsushita Refrig Co Ltd 撥水性コーティング用組成物及び撥水性コーティング用組成物を塗布した熱交換器
US5336616A (en) * 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
GB2248183A (en) 1990-09-25 1992-04-01 Lin Ju Nin Facial sauna apparatus
US5209227A (en) 1990-09-25 1993-05-11 Richard Deutsch Thermoelectric therapy device and moisturizing device therefor
US5221726A (en) 1990-10-09 1993-06-22 Mcneil-Ppc, Inc. Hydrophilic materials useful in preparing fluid-absorbent products
US5342617A (en) 1990-12-03 1994-08-30 Medical Polymers, Inc. Water-based human tissue lubricant
US5139496A (en) 1990-12-20 1992-08-18 Hed Aharon Z Ultrasonic freeze ablation catheters and probes
JPH06505023A (ja) * 1991-03-01 1994-06-09 ザ　ダウ　ケミカル　カンパニー メソ形成性グリシジルアミン
JP3217386B2 (ja) 1991-04-24 2001-10-09 オリンパス光学工業株式会社 診断システム
US5358467A (en) 1991-05-05 1994-10-25 Anatole Milstein Method for vacuum mechanothermal stimulation of the body surface
AU2309692A (en) 1991-07-03 1993-02-11 Cryolife, Inc. Method for stabilization of biomaterials
US20010031459A1 (en) * 1991-07-08 2001-10-18 The American National Red Cross Method of preparing tissues for vitrification
DE4125463A1 (de) 1991-08-01 1993-02-04 Deutsches Inst Lebensmitteltec Verfahren und vorrichtung zur kontinuierlichen, gesteuerten strukturierung, insbesondere kristallisation von stoffsystemen in fliessfaehigem zustand, insbesondere fetthaltigen massen, wie schokolademasse
US5352711A (en) 1991-08-12 1994-10-04 The Proctor & Gamble Company Method for hydrophilizing absorbent foam materials
US5169384A (en) 1991-08-16 1992-12-08 Bosniak Stephen L Apparatus for facilitating post-traumatic, post-surgical, and/or post-inflammatory healing of tissue
US5531742A (en) 1992-01-15 1996-07-02 Barken; Israel Apparatus and method for computer controlled cryosurgery
GB9201940D0 (en) 1992-01-28 1992-03-18 S I Ind Limited Cooling or heating arrangement
IT1259424B (it) 1992-03-11 1996-03-18 Elemento di contenimento e raffreddamento da applicare ad arti interessati da traumi
US5288469A (en) 1992-03-16 1994-02-22 Envirosurgical, Inc. Surgery plume filter device
WO1993019705A1 (en) 1992-03-31 1993-10-14 Massachusetts Institute Of Technology Apparatus and method for acoustic heat generation and hyperthermia
US5954680A (en) 1992-06-19 1999-09-21 Augustine Medical, Inc. Near hyperthermic heater wound covering
DE4224595A1 (de) 1992-07-23 1994-01-27 Steindorf Susanne Ruth Vorrichtung zur Behandlung erkrankten Gewebes in Körperöffnungen und/oder an Körperöffnungen angrenzender, erkrankter Organe
EP0654987A4 (en) 1992-08-17 1995-12-13 Mehl Thomas L HAND - HELD, VERSATILE, VAPOR - PRODUCING DEVICE.
US5327886A (en) 1992-08-18 1994-07-12 Chiu Cheng Pang Electronic massage device with cold/hot compress function
WO1994007935A1 (de) 1992-10-02 1994-04-14 Beiersdorf Ag Hydrophile polyurethangelschäume, insbesondere zur behandlung von tiefen wunden, wundverbände auf basis hydrophiler polyurethangeschäume und verfahren zur herstellung
GB9222335D0 (en) 1992-10-23 1992-12-09 Unilever Plc Acyl lactylates as skin elasticity enhancing agents
DE4238291A1 (de) 1992-11-13 1994-05-19 Diehl Gmbh & Co Vorrichtung zur kleinflächigen Vereisung von Oberflächen
US5333460A (en) 1992-12-21 1994-08-02 Carrier Corporation Compact and serviceable packaging of a self-contained cryocooler system
US5386837A (en) 1993-02-01 1995-02-07 Mmtc, Inc. Method for enhancing delivery of chemotherapy employing high-frequency force fields
US6620188B1 (en) 1998-08-24 2003-09-16 Radiant Medical, Inc. Methods and apparatus for regional and whole body temperature modification
US5902256A (en) 1993-02-12 1999-05-11 Jb Research, Inc. Massage unit with replaceable hot and cold packs
US5433717A (en) 1993-03-23 1995-07-18 The Regents Of The University Of California Magnetic resonance imaging assisted cryosurgery
US5456703A (en) 1993-04-28 1995-10-10 Therabite Corporation Apparatus for application of heat/cold to target regions of the human anatomy
WO1994026216A1 (en) 1993-05-12 1994-11-24 Yablon Jeffrey S Portable therapeutic device
RU2047298C1 (ru) 1993-05-27 1995-11-10 Специализированное конструкторско-технологическое бюро "Норд" Устройство для криомассажа
US5702880A (en) 1993-06-04 1997-12-30 Biotime, Inc. Blood substitute comprising 0-5 mM K+
US5411541A (en) 1993-08-05 1995-05-02 Oansh Designs Ltd. Portable fluid therapy device
US5372608A (en) 1993-08-12 1994-12-13 Johnson; Bertrand L. Circulating chilled-fluid therapeutic device
US5334131A (en) 1993-08-20 1994-08-02 Omandam Ismael C Strap-on massager with vibratory unbalanced weight
US5891617A (en) 1993-09-15 1999-04-06 Organogenesis Inc. Cryopreservation of harvested skin and cultured skin or cornea equivalents by slow freezing
US5764794A (en) 1993-10-27 1998-06-09 Perlin; Kenneth Method and apparatus for electronically storing alphanumeric characters
GB2283678B (en) 1993-11-09 1998-06-03 Spembly Medical Ltd Cryosurgical catheter probe
US5885211A (en) 1993-11-15 1999-03-23 Spectrix, Inc. Microporation of human skin for monitoring the concentration of an analyte
JPH07194666A (ja) 1993-12-30 1995-08-01 Daisee Kogyo Kk マッサージ器及びマッサージ方法
US5472416A (en) 1994-01-10 1995-12-05 Very Inventive Physicians, Inc. Tumescent lipoplastic method and apparatus
RU2036667C1 (ru) 1994-01-24 1995-06-09 Олег Алексеевич Машков Способ лечения диссеминированного псориаза
GB2286660A (en) 1994-02-01 1995-08-23 David Thorner Peltier effect cooling apparatus for treating diseased or injured tissue
US5647868A (en) 1994-02-02 1997-07-15 Chinn; Douglas Owen Cryosurgical integrated control and monitoring system and method
US5725483A (en) 1994-02-22 1998-03-10 Podolsky; Grigory Massaging device
US5363347A (en) 1994-02-24 1994-11-08 Hap Nguyen Vending tanning timer
US5833685A (en) 1994-03-15 1998-11-10 Tortal; Proserfina R. Cryosurgical technique and devices
JPH07268274A (ja) 1994-04-01 1995-10-17 Kansai Paint Co Ltd 親水化処理用組成物および親水化処理方法
JP3263275B2 (ja) 1994-04-05 2002-03-04 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 生体組織のレーザー処理のための装置並びに火焔状斑点母斑のレーザー処理装置
US5962477A (en) 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US6230501B1 (en) 1994-04-14 2001-05-15 Promxd Technology, Inc. Ergonomic systems and methods providing intelligent adaptive surfaces and temperature control
GB2289510A (en) 1994-05-10 1995-11-22 Spembly Medical Ltd Connector
US5792080A (en) 1994-05-18 1998-08-11 Matsushita Electric Works, Ltd. Massaging apparatus having self-adjusting constant strength and non-adjust strength modes
US5672172A (en) 1994-06-23 1997-09-30 Vros Corporation Surgical instrument with ultrasound pulse generator
US5505730A (en) 1994-06-24 1996-04-09 Stuart D. Edwards Thin layer ablation apparatus
US5967976A (en) 1994-08-19 1999-10-19 Novoste Corporation Apparatus and methods for procedures related to the electrophysiology of the heart
USD362091S (en) 1994-09-09 1995-09-05 Emerson Electric Co. Combined wet/dry vacuum cleaner with detachable blower
US5486207A (en) 1994-09-20 1996-01-23 Mahawili; Imad Thermal pad for portable body heating/cooling system and method of use
US5817145A (en) 1994-11-21 1998-10-06 Augustine Medical, Inc. Wound treatment device
DE4445627A1 (de) 1994-12-21 1996-06-27 Holland Letz Horst Vorrichtung für die Thermo-Therapie
US6426445B1 (en) 1995-01-10 2002-07-30 The Procter & Gamble Company Absorbent members comprising an agglomerate of hydrogel-forming absorbent polymer and particulate hydrophilic foam
US5513629A (en) * 1995-01-20 1996-05-07 Dura Therm Inc. Microwavable heat releasing and absorbing composition and container
US5735844A (en) 1995-02-01 1998-04-07 The General Hospital Corporation Hair removal using optical pulses
US5647051A (en) 1995-02-22 1997-07-08 Seabrook Medical Systems, Inc. Cold therapy system with intermittent fluid pumping for temperature control
US5635162A (en) 1995-02-23 1997-06-03 Ultradent Products, Inc. Hemostatic composition for treating gingival area
IES950163A2 (en) 1995-03-01 1995-12-27 Shannon Cool Limited Cold therapy apparatus
US5980561A (en) 1995-03-01 1999-11-09 Kolen; Paul T. Applying thermal therapy to living tissue
US5558376A (en) 1995-03-02 1996-09-24 Engineered Transitions Co., Inc. Low profile swivel adapters
US5580714A (en) 1995-03-08 1996-12-03 Celox Laboratories, Inc. Cryopreservation solution
DE69531871T2 (de) 1995-04-28 2004-08-19 Endocare, Inc. Integriertes kryo-chirurgisches steuer- und überwachungssystem
US6470216B1 (en) 1995-05-05 2002-10-22 Thermage, Inc. Method for smoothing contour irregularities of skin surface
US5634890A (en) 1995-05-09 1997-06-03 Aquasage, Inc. Water massage therapy device and method for using the same
US5769879A (en) 1995-06-07 1998-06-23 Medical Contouring Corporation Microwave applicator and method of operation
US5965438A (en) 1995-06-07 1999-10-12 Phyton, Inc. Cryopreservation of plant cells
CA2200984A1 (en) 1995-07-25 1997-02-13 Samir S. Mitragotri Enhanced transdermal transfer using ultrasound
US5853364A (en) 1995-08-07 1998-12-29 Nellcor Puritan Bennett, Inc. Method and apparatus for estimating physiological parameters using model-based adaptive filtering
US5964749A (en) 1995-09-15 1999-10-12 Esc Medical Systems Ltd. Method and apparatus for skin rejuvenation and wrinkle smoothing
US5654546A (en) 1995-11-07 1997-08-05 Molecular Imaging Corporation Variable temperature scanning probe microscope based on a peltier device
US5755755A (en) 1995-12-13 1998-05-26 Panyard; Albert A. Therapeutic structure and method
US5634940A (en) 1995-12-13 1997-06-03 Panyard; Albert A. Therapeutic structure and methods
JPH09164163A (ja) 1995-12-15 1997-06-24 Matsushita Electric Ind Co Ltd 局部冷却・加熱器
AU1349697A (en) 1995-12-29 1997-07-28 Life Resuscitation Technologies, Inc. Total body cooling system
US7267675B2 (en) 1996-01-05 2007-09-11 Thermage, Inc. RF device with thermo-electric cooler
US7229436B2 (en) 1996-01-05 2007-06-12 Thermage, Inc. Method and kit for treatment of tissue
US7189230B2 (en) 1996-01-05 2007-03-13 Thermage, Inc. Method for treating skin and underlying tissue
US7141049B2 (en) 1999-03-09 2006-11-28 Thermage, Inc. Handpiece for treatment of tissue
US7473251B2 (en) 1996-01-05 2009-01-06 Thermage, Inc. Methods for creating tissue effect utilizing electromagnetic energy and a reverse thermal gradient
US7006874B2 (en) 1996-01-05 2006-02-28 Thermage, Inc. Treatment apparatus with electromagnetic energy delivery device and non-volatile memory
WO1997025798A1 (en) 1996-01-11 1997-07-17 Mrj, Inc. System for controlling access and distribution of digital property
US5651773A (en) 1996-01-19 1997-07-29 Perry; Larry C. Skin protector for ultrasonic-assisted liposuction and accessories
US5650450A (en) 1996-01-25 1997-07-22 Foamex L.P. Hydrophilic urethane foam
FR2744358B1 (fr) 1996-02-01 1998-05-07 Biogenie Beaute Concept Tete de massage combinant massage sous aspiration et electrotherapie
FR2745935B1 (fr) 1996-03-11 1998-05-22 Ygk Holding S A Equipement de bronzage a gestion automatisee
US5654279A (en) 1996-03-29 1997-08-05 The Regents Of The University Of California Tissue destruction in cryosurgery by use of thermal hysteresis
US6180867B1 (en) 1996-04-17 2001-01-30 General Electric Company Thermal sensor array and methods of fabrication and use
ATE234129T1 (de) 1996-06-18 2003-03-15 Alza Corp Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
US5944748A (en) 1996-07-25 1999-08-31 Light Medicine, Inc. Photodynamic therapy apparatus and methods
US5976123A (en) 1996-07-30 1999-11-02 Laser Aesthetics, Inc. Heart stabilization
US5966763A (en) 1996-08-02 1999-10-19 Hill-Rom, Inc. Surface pad system for a surgical table
US5840080A (en) 1996-08-15 1998-11-24 Der Ovanesian; Mary Hot or cold applicator with inner element
US5665053A (en) 1996-09-27 1997-09-09 Jacobs; Robert A. Apparatus for performing endermology with ultrasound
US5941825A (en) 1996-10-21 1999-08-24 Philipp Lang Measurement of body fat using ultrasound methods and devices
US5800490A (en) 1996-11-07 1998-09-01 Patz; Herbert Samuel Lightweight portable cooling or heating device with multiple applications
WO1998019529A1 (en) 1996-11-07 1998-05-14 21St Century Medicine, Inc. A method for rapid cooling and warming of biological materials
USD399493S (en) 1996-11-11 1998-10-13 Toshiba Kikai Kabushiki Kaisha Machine tool operation console
US6517532B1 (en) 1997-05-15 2003-02-11 Palomar Medical Technologies, Inc. Light energy delivery head
US20060149343A1 (en) 1996-12-02 2006-07-06 Palomar Medical Technologies, Inc. Cooling system for a photocosmetic device
US8182473B2 (en) 1999-01-08 2012-05-22 Palomar Medical Technologies Cooling system for a photocosmetic device
US5964092A (en) 1996-12-13 1999-10-12 Nippon Sigmax, Co., Ltd. Electronic cooling apparatus
EP1314400B1 (en) 1996-12-31 2007-06-20 Altea Therapeutics Corporation Microporation of tissue for delivery of bioactive agents
US6102875A (en) 1997-01-16 2000-08-15 Jones; Rick E. Apparatus for combined application of massage, accupressure and biomagnetic therapy
US5830208A (en) 1997-01-31 1998-11-03 Laserlite, Llc Peltier cooled apparatus and methods for dermatological treatment
JPH10216169A (ja) 1997-02-05 1998-08-18 Kanae Kagawa:Kk 冷感冷却シート
JPH10223961A (ja) 1997-02-10 1998-08-21 Furukawa Electric Co Ltd:The 光増幅装置
US5925026A (en) 1997-03-10 1999-07-20 Kimberly-Clark Worldwide, Inc. Apertured absorbent pads for use in absorbent articles
GB2323659A (en) 1997-03-25 1998-09-30 Paul Weatherstone Hand directable chilled air blower
NL1007696C1 (nl) 1997-05-01 1998-11-03 Inst Voor Agrotech Onderzoek Omhulde stof met gecontroleerde afgifte.
DE69825447T2 (de) 1997-05-15 2005-09-15 Palomar Medical Technologies, Inc., Burlington Gerät zur dermatologischen behandlung
US5817050A (en) 1997-05-29 1998-10-06 Klein; Jeffrey A. Liposuction cannula
CA2293388A1 (en) 1997-06-17 1998-12-23 Michael L. Barretti Method and apparatus for temperature control of biologic tissue with simultaneous irradiation
US6104959A (en) 1997-07-31 2000-08-15 Microwave Medical Corp. Method and apparatus for treating subcutaneous histological features
FR2767476B1 (fr) 1997-08-25 1999-10-15 Juliette Dubois Dispositif physiotherapeutique pour le traitement de la peau par aspiration sous vide et ultrasons
US5802865A (en) 1997-09-05 1998-09-08 The Sharper Image Evaporative personal cooler
US6113558A (en) 1997-09-29 2000-09-05 Angiosonics Inc. Pulsed mode lysis method
US6623430B1 (en) 1997-10-14 2003-09-23 Guided Therapy Systems, Inc. Method and apparatus for safety delivering medicants to a region of tissue using imaging, therapy and temperature monitoring ultrasonic system
US6224617B1 (en) 1997-10-17 2001-05-01 Angiotrax, Inc. Methods and apparatus for defibrillating a heart refractory to electrical stimuli
USD424699S (en) 1997-10-23 2000-05-09 Donald Allen Wound dressing
US6071239A (en) 1997-10-27 2000-06-06 Cribbs; Robert W. Method and apparatus for lipolytic therapy using ultrasound energy
GB9724186D0 (en) 1997-11-14 1998-01-14 British Tech Group Low temperature coatings
US6113559A (en) 1997-12-29 2000-09-05 Klopotek; Peter J. Method and apparatus for therapeutic treatment of skin with ultrasound
US6104952A (en) 1998-01-07 2000-08-15 Tu; Lily Chen Devices for treating canker sores, tissues and methods thereof
DE19800416C2 (de) 1998-01-08 2002-09-19 Storz Karl Gmbh & Co Kg Vorrichtung zur Behandlung von Körpergewebe, insbesondere von oberflächennahem Weichgewebe, mittels Ultraschall
US7458984B2 (en) 1998-01-23 2008-12-02 Innercool Therapies, Inc. System and method for inducing hypothermia with active patient temperature control employing catheter-mounted temperature sensor and temperature projection algorithm
US6251129B1 (en) 1998-03-24 2001-06-26 Innercool Therapies, Inc. Method for low temperature thrombolysis and low temperature thrombolytic agent with selective organ temperature control
IL126783A0 (en) 1998-03-05 1999-08-17 M T R E Advanced Technology Lt System and method for heat control of a living body
US6047215A (en) 1998-03-06 2000-04-04 Sonique Surgical Systems, Inc. Method and apparatus for electromagnetically assisted liposuction
WO1999047085A1 (en) 1998-03-17 1999-09-23 Kochamba Gary S Method and apparatus for stabilizing tissue
ES2640937T3 (es) 1998-03-27 2017-11-07 The General Hospital Corporation Procedimiento para el direccionamiento selectivo de glándulas sebáceas
US6031525A (en) 1998-04-01 2000-02-29 New York University Method and apparatus for writing
FR2776920B3 (fr) 1998-04-03 2000-04-28 Elie Piana Dispositif de massage a depression
US6264649B1 (en) 1998-04-09 2001-07-24 Ian Andrew Whitcroft Laser treatment cooling head
US5997530A (en) 1998-04-13 1999-12-07 The Regents Of The University Of California Apparatus and method to control atmospheric water vapor composition and concentration during dynamic cooling of biological tissues in conjunction with laser irradiations
US6375673B1 (en) 1998-04-23 2002-04-23 The Board Of Regents Of The University Of Texas System Heat transfer blanket for and method of controlling a patient's temperature
US6113626A (en) 1998-04-23 2000-09-05 The Board Of Regents Of The University Of Texas System Heat transfer blanket for controlling a patient's temperature
JP4191384B2 (ja) 1998-04-23 2008-12-03 ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティー オブ テキサス システム 患者の体温を管理するための熱伝達ブランケットとその方法
US6151735A (en) 1998-05-05 2000-11-28 Imak Corporation Zone inflatable orthopedic pillow
US20050143797A1 (en) 2003-07-18 2005-06-30 Thermotek, Inc. Compression sequenced thermal therapy system
US6015390A (en) 1998-06-12 2000-01-18 D. Krag Llc System and method for stabilizing and removing tissue
US6312453B1 (en) 1998-07-16 2001-11-06 Olympic Medical Corp. Device for cooling infant's brain
US6673098B1 (en) 1998-08-24 2004-01-06 Radiant Medical, Inc. Disposable cassette for intravascular heat exchange catheter
US6620189B1 (en) 2000-02-28 2003-09-16 Radiant Medical, Inc. Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter
US6139545A (en) 1998-09-09 2000-10-31 Vidaderm Systems and methods for ablating discrete motor nerve regions
EP1115281B9 (en) 1998-09-21 2006-05-10 21st Century Medicine, Inc. Improved cryoprotectant solutions
US6093230A (en) 1998-10-12 2000-07-25 Allegiance Corporation Filter assembly comprising two filter elements separated by a hydrophobic foam
US6059820A (en) 1998-10-16 2000-05-09 Paradigm Medical Corporation Tissue cooling rod for laser surgery
TW514521B (en) 1998-10-16 2002-12-21 Coolsystems Inc Compliant heat exchange splint and control unit
US6150148A (en) 1998-10-21 2000-11-21 Genetronics, Inc. Electroporation apparatus for control of temperature during the process
IL126723A0 (en) 1998-10-22 1999-08-17 Medoc Ltd Vaginal probe and method
DE19852948C2 (de) 1998-11-12 2002-07-18 Asclepion Meditec Ag Dermatologisches Handstück
US6887260B1 (en) 1998-11-30 2005-05-03 Light Bioscience, Llc Method and apparatus for acne treatment
US6120519A (en) 1998-12-02 2000-09-19 Weber; Paul J. Advanced fulcrum liposuction device
US7785359B2 (en) 1998-12-18 2010-08-31 Traumatec, Inc. Therapeutic cooling devices
EP1158941B1 (en) 1999-01-04 2005-10-12 Medivance, Inc. Improved cooling/heating pad and system
US6306119B1 (en) 1999-01-20 2001-10-23 Pearl Technology Holdings, Llc Skin resurfacing and treatment using biocompatible materials
US6635053B1 (en) 1999-01-25 2003-10-21 Cryocath Technologies Inc. Cooling system
EP1031346B1 (en) 1999-01-27 2002-05-02 Idea Ag Noninvasive vaccination through the skin
WO2000044346A1 (en) * 1999-02-03 2000-08-03 Gerard Hassler Lowering skin temperature
US6200308B1 (en) 1999-01-29 2001-03-13 Candela Corporation Dynamic cooling of tissue for radiation treatment
US6468297B1 (en) 1999-02-24 2002-10-22 Cryovascular Systems, Inc. Cryogenically enhanced intravascular interventions
FR2789893B1 (fr) 1999-02-24 2001-05-11 Serge Karagozian Appareil de massage combinant dermotonie et magnetotherapie
US6176869B1 (en) 1999-02-25 2001-01-23 Breg, Inc. Fluid drive mechanism for a therapeutic treatment system
AU779100B2 (en) 1999-03-09 2005-01-06 Thermage, Inc. Apparatus and method for treatment of tissue
US6678558B1 (en) 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
JP3065657U (ja) 1999-04-07 2000-02-08 樋口 登 ク―ルバンド
US6319510B1 (en) 1999-04-20 2001-11-20 Alayne Yates Gum pad for delivery of medication to mucosal tissues
ES2245305T3 (es) 1999-04-22 2006-01-01 Veridicom, Inc. Autenticacion biometrica de alta seguridad usando pares de encriptacion clave publica/clave privada.
WO2000067685A1 (en) 1999-05-12 2000-11-16 Burns Terrence R Thermoregulation systems
US20020198518A1 (en) 1999-05-26 2002-12-26 Mikus Paul W. Entry position grid for computer guided cryosurgery
US6694170B1 (en) 1999-05-26 2004-02-17 Endocare, Inc. Computer guided surgery for prostatic nerve sparing
US6139544A (en) 1999-05-26 2000-10-31 Endocare, Inc. Computer guided cryosurgery
US6643535B2 (en) 1999-05-26 2003-11-04 Endocare, Inc. System for providing computer guided ablation of tissue
US6357907B1 (en) 1999-06-15 2002-03-19 V & P Scientific, Inc. Magnetic levitation stirring devices and machines for mixing in vessels
BR0215339A (pt) 1999-06-30 2004-11-16 Thermage Inc Dispositivo de tratamento e uso do dispositivo
KR200173222Y1 (ko) 1999-07-19 2000-03-15 이강민 초음파피부마사지기
JP2003505190A (ja) 1999-08-02 2003-02-12 ランス ビー． ベッカー， 低体温状態を誘導するための方法
JP2001046416A (ja) 1999-08-10 2001-02-20 Try Company:Kk 身体冷却装置
US6548728B1 (en) 1999-08-11 2003-04-15 Medical Products, Inc. Wound dressing garment
US6290713B1 (en) 1999-08-24 2001-09-18 Thomas A. Russell Flexible illuminators for phototherapy
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
IL131834A0 (en) 1999-09-09 2001-03-19 M T R E Advanced Technology Lt Method and system for improving cardiac output of a patient
US6471693B1 (en) 1999-09-10 2002-10-29 Cryocath Technologies Inc. Catheter and system for monitoring tissue contact
US6226996B1 (en) 1999-10-06 2001-05-08 Paul J. Weber Device for controlled cooling of a surface
GB9923804D0 (en) 1999-10-08 1999-12-08 Hewlett Packard Co Electronic commerce system
WO2001032114A1 (en) 1999-11-02 2001-05-10 Wizcare Ltd. Skin-gripper
US7112712B1 (en) 1999-11-10 2006-09-26 Protex Healthcare (Uk) Limited Dressing
US6743222B2 (en) 1999-12-10 2004-06-01 Candela Corporation Method of treating disorders associated with sebaceous follicles
JP2004159666A (ja) 1999-12-21 2004-06-10 Ya Man Ltd レーザ脱毛器
JP4723707B2 (ja) 1999-12-22 2011-07-13 パナソニック電工株式会社 痩身器具
US6699237B2 (en) 1999-12-30 2004-03-02 Pearl Technology Holdings, Llc Tissue-lifting device
JP2001190586A (ja) 2000-01-11 2001-07-17 Ohiro Seisakusho:Kk 美顔器
US6551251B2 (en) 2000-02-14 2003-04-22 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Passive fetal heart monitoring system
FR2805989B1 (fr) 2000-03-10 2003-02-07 Prod Ella Bache Laboratoire Su Procede de traitement des inesthetismes de la silhouette du corps humain et dispositif pour la mise en oeuvre du procede
US6951712B2 (en) * 2000-03-14 2005-10-04 Alnis Biosciences, Inc. Cryoprotective system comprising polymeric nano- or micro-particles
KR100367639B1 (ko) 2000-03-20 2003-01-14 안문휘 경혈부의 저온 자극장치
US6311497B1 (en) 2000-03-22 2001-11-06 Young-Chun Chung Device for cold and warm formentations
US20020188478A1 (en) 2000-03-24 2002-12-12 Joe Breeland Health-care systems and methods
AU2001257136B2 (en) 2000-04-20 2005-12-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and devices for cooling body core
US20020151830A1 (en) 2000-04-28 2002-10-17 Rocky Kahn Hydrotherapy system with water pervious body support
US6494844B1 (en) 2000-06-21 2002-12-17 Sanarus Medical, Inc. Device for biopsy and treatment of breast tumors
AU2001276895A1 (en) 2000-07-13 2002-01-30 Medtronic, Inc. Non-invasive carotid cooler brain hypothermia medical device
AU2001280040A1 (en) 2000-07-31 2002-02-13 Galil Medical Ltd. Planning and facilitation systems and methods for cryosurgery
US6795728B2 (en) 2001-08-17 2004-09-21 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation
US6697670B2 (en) 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US6892099B2 (en) 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
WO2002014774A2 (en) 2000-08-17 2002-02-21 Ocean Power Corporation Heat exchange element with hydrophilic evaporator surface
US8251986B2 (en) 2000-08-17 2012-08-28 Angiodynamics, Inc. Method of destroying tissue cells by eletroporation
US6458888B1 (en) 2000-09-15 2002-10-01 Isp Investments Inc. Rheology modifier for use in aqueous compositions
US20040034321A1 (en) 2000-10-05 2004-02-19 Seacoast Technologies, Inc. Conformal pad for neurosurgery and method thereof
US6579281B2 (en) 2000-10-11 2003-06-17 Popcab, Llc Instrument stabilizer for through-a-port surgery
FR2815246B1 (fr) 2000-10-13 2003-01-24 Cryonic Medical Appareil autonome et portable de cryotherapie a usage grand public
US6540694B1 (en) 2000-10-16 2003-04-01 Sanarus Medical, Inc. Device for biopsy tumors
JP3655820B2 (ja) 2000-10-23 2005-06-02 繁雄 小林 頭部冷却加温装置
EP1201266A1 (fr) 2000-10-26 2002-05-02 Compex SA Procédé de programmation de données de stimulation électrique pour un appareil de stimulation électrique, et installation pour sa mise en oeuvre
DE10056242A1 (de) 2000-11-14 2002-05-23 Alstom Switzerland Ltd Kondensationswärmeübertrager
US6821274B2 (en) 2001-03-07 2004-11-23 Gendel Ltd. Ultrasound therapy for selective cell ablation
US7549987B2 (en) 2000-12-09 2009-06-23 Tsunami Medtech, Llc Thermotherapy device
US6626854B2 (en) 2000-12-27 2003-09-30 Insightec - Txsonics Ltd. Systems and methods for ultrasound assisted lipolysis
US6645162B2 (en) 2000-12-27 2003-11-11 Insightec - Txsonics Ltd. Systems and methods for ultrasound assisted lipolysis
EP1347711B1 (en) 2000-12-28 2006-11-15 Palomar Medical Technologies, Inc. Apparatus for therapeutic emr treatment of the skin
US6607498B2 (en) 2001-01-03 2003-08-19 Uitra Shape, Inc. Method and apparatus for non-invasive body contouring by lysing adipose tissue
US20040106867A1 (en) 2001-01-03 2004-06-03 Yoram Eshel Non-invasive ultrasonic body contouring
US7347855B2 (en) 2001-10-29 2008-03-25 Ultrashape Ltd. Non-invasive ultrasonic body contouring
US6551348B1 (en) 2001-01-26 2003-04-22 Deroyal Industries, Inc. Temperature controlled fluid therapy system
JP2002224051A (ja) 2001-01-30 2002-08-13 Yamaguchi Prefecture 無拘束型生命監視装置
US20050145372A1 (en) 2004-01-02 2005-07-07 Noel Thomas P. Method and thermally active multi-phase heat transfer apparatus and method for abstracting heat using liquid bi-phase heat exchanging composition
JP4027049B2 (ja) 2001-02-28 2007-12-26 株式会社ニデック レーザ治療装置
US6948903B2 (en) 2001-03-15 2005-09-27 Maxon Lift Corporation Unitary liftgate
JP4938177B2 (ja) 2001-03-22 2012-05-23 小林製薬株式会社 保冷・保温用パッド
JP2002290397A (ja) 2001-03-23 2002-10-04 Iryo Joho Syst Kaihatsu Center セキュア通信方法
US7083580B2 (en) 2001-04-06 2006-08-01 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery
US20020156509A1 (en) 2001-04-23 2002-10-24 Stephen Cheung Thermal control suit
US6438954B1 (en) 2001-04-27 2002-08-27 3M Innovative Properties Company Multi-directional thermal actuator
FR2823973B1 (fr) 2001-04-27 2003-12-26 Alain Meunier Appareil de massage pour l'execution d'un massage du type "evalue-presse-tire"
US6430956B1 (en) * 2001-05-15 2002-08-13 Cimex Biotech Lc Hand-held, heat sink cryoprobe, system for heat extraction thereof, and method therefore
GB0111986D0 (en) 2001-05-16 2001-07-04 Optomed As Cryosurgical apparatus and methods
CN2514795Y (zh) 2001-05-18 2002-10-09 郑晓丹 多触头冷冻美容笔
US20020188286A1 (en) 2001-06-06 2002-12-12 Quijano Rodolfo C. Methods for treating vulnerable plaque
US6551341B2 (en) 2001-06-14 2003-04-22 Advanced Cardiovascular Systems, Inc. Devices configured from strain hardened Ni Ti tubing
FR2826107A1 (fr) 2001-06-19 2002-12-20 M D I C Article refrigerant notamment pour une application en cryotherapie ou pour la conservation d'aliments
TW476644B (en) 2001-06-28 2002-02-21 Wen-Hu Liau Portable first-aid cold hot compress pack
JP3393128B1 (ja) 2001-07-18 2003-04-07 正雄 酒井 女性装着型コンドーム
CN2514811Y (zh) 2001-07-31 2002-10-09 尹旭光 电热暖脚器
US20040260210A1 (en) 2003-06-23 2004-12-23 Engii (2001) Ltd. System and method for face and body treatment
US20040260209A1 (en) 2003-06-23 2004-12-23 Engli (2001) Ltd. System and method for face and body treatment
US20030032900A1 (en) 2001-08-08 2003-02-13 Engii (2001) Ltd. System and method for facial treatment
US6438964B1 (en) 2001-09-10 2002-08-27 Percy Giblin Thermoelectric heat pump appliance with carbon foam heat sink
US6572450B2 (en) 2001-09-21 2003-06-03 Iphotonics, Inc. Roll format polishing process for optical devices
US20030062040A1 (en) 2001-09-28 2003-04-03 Lurie Keith G. Face mask ventilation/perfusion systems and method
US20030114885A1 (en) 2001-10-02 2003-06-19 Nova Richard C. System and device for implementing an integrated medical device component package
US6660027B2 (en) 2001-10-11 2003-12-09 Medivance Incorporated Patient temperature control system with fluid preconditioning
US6699267B2 (en) 2001-10-11 2004-03-02 Medivance Incorporated Patient temperature control system with fluid temperature response
US20030125649A1 (en) 2001-10-31 2003-07-03 Mcintosh Laura Janet Method and system apparatus using temperature and pressure for treating medical disorders
US6889090B2 (en) 2001-11-20 2005-05-03 Syneron Medical Ltd. System and method for skin treatment using electrical current
CA2725655C (en) 2001-11-20 2015-01-20 Western Digital Technologies, Inc. Access and control system for network-enabled devices
US6849075B2 (en) 2001-12-04 2005-02-01 Estech, Inc. Cardiac ablation devices and methods
US20030109910A1 (en) 2001-12-08 2003-06-12 Lachenbruch Charles A. Heating or cooling pad or glove with phase change material
US6755852B2 (en) 2001-12-08 2004-06-29 Charles A. Lachenbruch Cooling body wrap with phase change material
EP1627662B1 (en) 2004-06-10 2011-03-02 Candela Corporation Apparatus for vacuum-assisted light-based treatments of the skin
US7762965B2 (en) 2001-12-10 2010-07-27 Candela Corporation Method and apparatus for vacuum-assisted light-based treatments of the skin
JP2003190201A (ja) 2001-12-26 2003-07-08 Lion Corp 身体冷却用具、及び、身体加温用具
US8840608B2 (en) 2002-03-15 2014-09-23 The General Hospital Corporation Methods and devices for selective disruption of fatty tissue by controlled cooling
US6662054B2 (en) 2002-03-26 2003-12-09 Syneron Medical Ltd. Method and system for treating skin
IL163947A0 (en) 2002-03-29 2005-12-18 Univ Leland Stanford Junior Methods/devices for regulating patient's temperature
US20030236487A1 (en) 2002-04-29 2003-12-25 Knowlton Edward W. Method for treatment of tissue with feedback
US20040176667A1 (en) 2002-04-30 2004-09-09 Mihai Dan M. Method and system for medical device connectivity
USD471982S1 (en) 2002-05-03 2003-03-18 Ming-Chuan Cheng Oxygen concentrator
US20030220594A1 (en) 2002-05-24 2003-11-27 United States Manufacturing Company, Inc. Torso orthosis apparatus and method
US6746474B2 (en) 2002-05-31 2004-06-08 Vahid Saadat Apparatus and methods for cooling a region within the body
JP3786055B2 (ja) 2002-06-07 2006-06-14 ソニー株式会社 データ処理システム、データ処理装置、および方法、並びにコンピュータ・プログラム
EP1505765A4 (en) 2002-06-07 2006-10-04 Sony Corp DATA PROCESSING SYSTEM, DATA PROCESSING DEVICE, DATA PROCESSING METHOD AND COMPUTER PROGRAM
JP2004073812A (ja) 2002-06-20 2004-03-11 Ya Man Ltd マッサージ装置
EP1538980B1 (en) 2002-06-25 2017-01-18 Ultrashape Ltd. Device for body aesthetics
US6820961B2 (en) 2002-06-28 2004-11-23 Lexmark International, Inc. Stationary ink mist chimney for ink jet printer
US6969399B2 (en) 2002-07-11 2005-11-29 Life Recovery Systems Hd, Llc Apparatus for altering the body temperature of a patient
US7452712B2 (en) 2002-07-30 2008-11-18 Applied Biosystems Inc. Sample block apparatus and method of maintaining a microcard on a sample block
US7393350B2 (en) 2002-08-06 2008-07-01 Erbe Elektromedizin Gmbh Cryo-surgical apparatus and methods
US7250047B2 (en) 2002-08-16 2007-07-31 Lumenis Ltd. System and method for treating tissue
US6860896B2 (en) 2002-09-03 2005-03-01 Jeffrey T. Samson Therapeutic method and apparatus
US6789545B2 (en) 2002-10-04 2004-09-14 Sanarus Medical, Inc. Method and system for cryoablating fibroadenomas
CN1723058A (zh) 2002-10-07 2006-01-18 帕洛玛医疗技术公司 用于进行光生物刺激的设备
US8226698B2 (en) 2002-10-08 2012-07-24 Vitalwear, Inc. Therapeutic cranial wrap for a contrast therapy system
US6994151B2 (en) 2002-10-22 2006-02-07 Cooligy, Inc. Vapor escape microchannel heat exchanger
CN102698368A (zh) 2002-10-23 2012-10-03 帕洛玛医疗技术公司 与冷却剂和肤面物质联用的光治疗装置
US20040082886A1 (en) 2002-10-24 2004-04-29 Timpson Sandra Tee Therapeutic device for relieving pain and stress
GB2396109B (en) 2002-12-12 2006-04-19 Johnson & Johnson Medical Ltd Absorbent multilayer hydrogel wound dressings
CN1511503A (zh) 2002-12-30 2004-07-14 中国科学院理化技术研究所 对皮肤交替实施冷热刺激的减肥装置
US6915641B2 (en) 2003-01-14 2005-07-12 Mark R. Harvie Personal cooling and heating system
US7083612B2 (en) 2003-01-15 2006-08-01 Cryodynamics, Llc Cryotherapy system
US7410484B2 (en) 2003-01-15 2008-08-12 Cryodynamics, Llc Cryotherapy probe
US7273479B2 (en) 2003-01-15 2007-09-25 Cryodynamics, Llc Methods and systems for cryogenic cooling
EP2311398B1 (en) 2003-01-15 2015-04-15 Cryodynamics, LLC. Cryotherapy probe and system
US20050143781A1 (en) 2003-01-31 2005-06-30 Rafael Carbunaru Methods and systems for patient adjustment of parameters for an implanted stimulator
US20060234899A1 (en) 2003-03-05 2006-10-19 H.H. Brown Shoe Technologies Inc. D/B/A Dicon Technologies Hydrophilic polyurethane foam articles comprising an antimicrobial compound
EP1624787A4 (en) 2003-03-06 2010-12-15 Tria Beauty Inc METHOD AND APPARATUS FOR DETECTING SKIN CONTACT
CN2617189Y (zh) 2003-03-22 2004-05-26 仇刚强 一种防冻护手筒
US7153298B1 (en) 2003-03-28 2006-12-26 Vandolay, Inc. Vascular occlusion systems and methods
US9149322B2 (en) 2003-03-31 2015-10-06 Edward Wells Knowlton Method for treatment of tissue
US20040206365A1 (en) 2003-03-31 2004-10-21 Knowlton Edward Wells Method for treatment of tissue
GB0307963D0 (en) 2003-04-05 2003-05-14 Eastman Kodak Co A foamed material and a method of making thereof
US7659301B2 (en) 2003-04-15 2010-02-09 The General Hospital Corporation Methods and devices for epithelial protection during photodynamic therapy
US20040210287A1 (en) 2003-04-21 2004-10-21 Greene Judy L. Portable cooling or heating device for applying cryotherapy
KR20040094508A (ko) * 2003-05-02 2004-11-10 김창선 냉온 초음파 피부 관리 장치
US20070129441A1 (en) 2003-05-06 2007-06-07 University Of North Texas Health Science Center At Fort Worth Protection of cells from adverse external or intrinsic effects, cellular degeneration and death by n-acylethanolamines
US20040249427A1 (en) 2003-06-06 2004-12-09 Yunes Nabilsi Medical cooler device
US7147610B2 (en) 2003-06-19 2006-12-12 Tarek Maalouf Multiple combination heat/massage devices
JP4504099B2 (ja) 2003-06-25 2010-07-14 株式会社リコー デジタル証明書管理システム、デジタル証明書管理装置、デジタル証明書管理方法、更新手順決定方法およびプログラム
US7479104B2 (en) 2003-07-08 2009-01-20 Maquet Cardiovascular, Llc Organ manipulator apparatus
US8100956B2 (en) 2006-05-09 2012-01-24 Thermotek, Inc. Method of and system for thermally augmented wound care oxygenation
US20050043723A1 (en) 2003-08-19 2005-02-24 Schering-Plough Healthcare Products, Inc. Cryosurgery device
JP2005065984A (ja) 2003-08-25 2005-03-17 Nikon Corp マッサージ機
US20050049526A1 (en) 2003-09-03 2005-03-03 Baer Mark P. Massage devices and methods thereof
US20050065584A1 (en) 2003-09-09 2005-03-24 Schiff Jonathan D. System and method for cooling internal tissue
CA2441489A1 (en) 2003-09-12 2005-03-12 Jocelyn Tortal Inducing and contouring ice formation
US7077858B2 (en) 2003-09-22 2006-07-18 Coolhead Technologies, Inc. Flexible heat exchangers for medical cooling and warming applications
WO2005033957A1 (ja) 2003-09-30 2005-04-14 Sony Corporation コンテンツ取得方法
JP2005110755A (ja) 2003-10-03 2005-04-28 Shinko Denshi Kk 筋肉疲労解消用加熱・冷却装置
US7282036B2 (en) 2003-10-24 2007-10-16 Masatoshi Masuda Cosmetic device having vibrator
EP1527760A1 (fr) 2003-10-29 2005-05-04 Normand, Jacques Coussin thermique et son utilisation
US7613523B2 (en) 2003-12-11 2009-11-03 Apsara Medical Corporation Aesthetic thermal sculpting of skin
KR101188930B1 (ko) 2003-12-30 2012-10-08 메디시스 테크놀로지스 코포레이션 가동 제어가 있는 초음파 치료 헤드
US7857773B2 (en) 2003-12-30 2010-12-28 Medicis Technologies Corporation Apparatus and methods for the destruction of adipose tissue
WO2005065371A2 (en) 2003-12-30 2005-07-21 Liposonix, Inc. Systems and methods for the destruction of adipose tissue
US7532201B2 (en) 2003-12-30 2009-05-12 Liposonix, Inc. Position tracking device
KR20060121277A (ko) 2003-12-30 2006-11-28 리포소닉스 인코포레이티드 컴포넌트 초음파 트랜스듀서
US20050149153A1 (en) 2004-01-07 2005-07-07 Kazuo Nakase Body temperature adjuster
WO2005074627A2 (en) 2004-02-02 2005-08-18 Hydrophilix Corporation Process for controlling the density, conformation and composition of the hydrophilic layer of a polyurethane composite
JP2005237908A (ja) 2004-02-12 2005-09-08 Tamotsu Nishizaki 熱交換器を用いた冷凍手術器
EP1727503A1 (en) 2004-02-23 2006-12-06 Aqueduct Medical, Inc. Temperature-controllable device
JP4109640B2 (ja) 2004-02-25 2008-07-02 株式会社エム・アイ・ラボ 自動励振マッサージ器
US7052167B2 (en) 2004-02-25 2006-05-30 Vanderschuit Carl R Therapeutic devices and methods for applying therapy
US20060035380A1 (en) 2004-03-12 2006-02-16 L'oreal Fake-proof marking of a composition
USD546949S1 (en) 2004-03-24 2007-07-17 Maxima Air Separation Center Ltd. Device for transporting canisters of gas
JP2005312950A (ja) 2004-03-31 2005-11-10 Terumo Corp エネルギー照射用医療器具および医療用エネルギー照射装置
AU2005231470B2 (en) 2004-04-01 2011-10-06 The General Hospital Corporation Method and apparatus for dermatological treatment
WO2005107848A2 (en) 2004-04-01 2005-11-17 The General Hospital Corporation Method for dermatological treatment using chromophores
US7842029B2 (en) 2004-05-07 2010-11-30 Aesthera Apparatus and method having a cooling material and reduced pressure to treat biological external tissue
US20070179482A1 (en) 2004-05-07 2007-08-02 Anderson Robert S Apparatuses and methods to treat biological external tissue
US8571648B2 (en) 2004-05-07 2013-10-29 Aesthera Apparatus and method to apply substances to tissue
US20050251117A1 (en) 2004-05-07 2005-11-10 Anderson Robert S Apparatus and method for treating biological external tissue
JP2005323716A (ja) 2004-05-13 2005-11-24 Takeshi Shimizu 冷点刺激装置
US20050281789A1 (en) 2004-05-20 2005-12-22 Mangala Rao Transcutaneous and/or transdermal transport of materials
US20050277859A1 (en) 2004-05-27 2005-12-15 Carlsmith Bruce S Joint protection device
US7959657B1 (en) 2004-07-07 2011-06-14 Harsy Douglas R Portable thermal therapeutic apparatus and method
JP4579603B2 (ja) 2004-07-14 2010-11-10 株式会社リブドゥコーポレーション 皮膚洗浄用不織布
US7171508B2 (en) 2004-08-23 2007-01-30 Micron Technology, Inc. Dual port memory with asymmetric inputs and outputs, device, system and method
US8535228B2 (en) 2004-10-06 2013-09-17 Guided Therapy Systems, Llc Method and system for noninvasive face lifts and deep tissue tightening
US7241263B2 (en) 2004-09-30 2007-07-10 Scimed Life Systems, Inc. Selectively rotatable shaft coupler
WO2006042201A1 (en) 2004-10-06 2006-04-20 Guided Therapy Systems, L.L.C. Method and system for ultrasound tissue treatment
US20120046547A1 (en) 2004-10-06 2012-02-23 Guided Therapy Systems, Llc System and method for cosmetic treatment
US8690778B2 (en) 2004-10-06 2014-04-08 Guided Therapy Systems, Llc Energy-based tissue tightening
US20060111744A1 (en) 2004-10-13 2006-05-25 Guided Therapy Systems, L.L.C. Method and system for treatment of sweat glands
KR101328103B1 (ko) 2004-10-06 2013-11-13 가이디드 테라피 시스템스, 엘.엘.씨. 비침습적 미용 증진 방법 및 시스템
USD525592S1 (en) 2004-10-18 2006-07-25 Mold-Masters Limited Controller
US20060094988A1 (en) 2004-10-28 2006-05-04 Tosaya Carol A Ultrasonic apparatus and method for treating obesity or fat-deposits or for delivering cosmetic or other bodily therapy
JP4324673B2 (ja) 2004-11-05 2009-09-02 国立大学法人東北大学 ペルチェモジュールによる凍結治療装置
US20060122509A1 (en) 2004-11-24 2006-06-08 Liposonix, Inc. System and methods for destroying adipose tissue
US7828831B1 (en) 2004-12-06 2010-11-09 Deroyal Industries, Inc. Hot and cold fluid therapy system
US7780656B2 (en) 2004-12-10 2010-08-24 Reliant Technologies, Inc. Patterned thermal treatment using patterned cryogen spray and irradiation by light
GB2422109B (en) 2005-01-13 2007-02-21 Richard Mills Apparatus for providing a heating and cooling effect
US20090112134A1 (en) 2005-01-24 2009-04-30 Kineticure Limited Devices and method for applying vibrations to joints
WO2006086513A2 (en) 2005-02-08 2006-08-17 Carewave, Inc. Apparatus and method for using a portable thermal device to reduce accommodation of nerve receptors
US7458808B2 (en) 2005-02-22 2008-12-02 Woodlane Environmental Technology, Inc. Gel fuel log set
US20110060242A1 (en) 2005-03-01 2011-03-10 Checkpoint Surgical, Llc Systems and methods for intra-operative stimulation within a surgical field
US8801701B2 (en) 2005-03-09 2014-08-12 Sunnybrook Health Sciences Centre Method and apparatus for obtaining quantitative temperature measurements in prostate and other tissue undergoing thermal therapy treatment
US20060206040A1 (en) 2005-03-09 2006-09-14 Greenberg Ronald A aparatus and method of body contouring and skin conditioning using a mobile suction device
EP1965748A4 (en) 2005-03-09 2009-11-11 Ronald Allan Greenberg DEVICE AND METHOD FOR CONTOURING THE BODY AND CONDITIONING THE SKIN
US9581942B1 (en) 2005-03-23 2017-02-28 Shippert Enterprises, Llc Tissue transfer method and apparatus
EP1865541A4 (en) 2005-03-31 2017-06-14 Nikon Corporation Exposure method, exposure apparatus and device manufacturing method
US7975702B2 (en) 2005-04-05 2011-07-12 El.En. S.P.A. System and method for laser lipolysis
JP2008539034A (ja) 2005-04-27 2008-11-13 レイディアント メディカル インコーポレイテッド 改良型の体内から熱交換を行う装置およびその方法
US7217265B2 (en) 2005-05-18 2007-05-15 Cooltouch Incorporated Treatment of cellulite with mid-infrared radiation
US7713266B2 (en) 2005-05-20 2010-05-11 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US7850683B2 (en) 2005-05-20 2010-12-14 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US20090326621A1 (en) 2005-05-24 2009-12-31 Rizk El-Galley Surgical delivery devices and methods
CN2843367Y (zh) 2005-07-01 2006-12-06 李铁军 用于治疗皮肤赘生物的冷冻装置
US8181262B2 (en) 2005-07-20 2012-05-15 Verimatrix, Inc. Network user authentication system and method
US7955262B2 (en) 2005-07-26 2011-06-07 Syneron Medical Ltd. Method and apparatus for treatment of skin using RF and ultrasound energies
US20070032561A1 (en) 2005-08-05 2007-02-08 I-Sioun Lin Modified hydrophilic polyurethane memory foam, application and manufacturing method thereof
US20070055173A1 (en) 2005-08-23 2007-03-08 Sanarus Medical, Inc. Rotational core biopsy device with liquid cryogen adhesion probe
CN2850585Y (zh) 2005-09-05 2006-12-27 李钟俊 一种有磁场的新型冷冻嫩肤美容仪
CN2850584Y (zh) 2005-09-05 2006-12-27 李钟俊 一种新型冷冻嫩肤美容仪
GB2431108A (en) 2005-09-07 2007-04-18 Mohammed Firoz Hussein Applicator for dispensing cryogenic fluid
US7967763B2 (en) 2005-09-07 2011-06-28 Cabochon Aesthetics, Inc. Method for treating subcutaneous tissues
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
EP1928549B1 (en) 2005-09-28 2014-06-11 Candela Corporation Apparatus for treating cellulite
US20070078502A1 (en) 2005-10-05 2007-04-05 Thermage, Inc. Method and apparatus for estimating a local impedance factor
US7572268B2 (en) 2005-10-13 2009-08-11 Bacoustics, Llc Apparatus and methods for the selective removal of tissue using combinations of ultrasonic energy and cryogenic energy
US7729773B2 (en) 2005-10-19 2010-06-01 Advanced Neuromodualation Systems, Inc. Neural stimulation and optical monitoring systems and methods
US8702691B2 (en) 2005-10-19 2014-04-22 Thermage, Inc. Treatment apparatus and methods for delivering energy at multiple selectable depths in tissue
WO2007056493A1 (en) 2005-11-08 2007-05-18 Schumann Daniel H Device and method for the treatment of pain with electrical energy
US9248317B2 (en) 2005-12-02 2016-02-02 Ulthera, Inc. Devices and methods for selectively lysing cells
US20080195036A1 (en) 2005-12-02 2008-08-14 Cabochon Aesthetics, Inc. Devices and methods for selectively lysing cells
US20080014627A1 (en) 2005-12-02 2008-01-17 Cabochon Aesthetics, Inc. Devices and methods for selectively lysing cells
US20070135876A1 (en) 2005-12-08 2007-06-14 Weber Paul J Acne and skin defect treatment via non-radiofrequency electrical current controlled power delivery device and methods
US7799018B2 (en) 2006-01-06 2010-09-21 Olga Goulko Cryogenic applicator for rejuvenating human skin and related method
WO2007088547A2 (en) 2006-02-02 2007-08-09 Tylerton International Inc. Metabolic sink
CN100362067C (zh) 2006-02-08 2008-01-16 舒宏纪 一种高疏水性、高导热性和高粘附性界面涂料
US7824437B1 (en) 2006-02-13 2010-11-02 Gina Saunders Multi-functional abdominal cramp reducing device and associated method
US8133191B2 (en) 2006-02-16 2012-03-13 Syneron Medical Ltd. Method and apparatus for treatment of adipose tissue
CA2642886A1 (en) 2006-02-16 2007-08-30 Denise C. Polacek Cooling device and method
US7854754B2 (en) 2006-02-22 2010-12-21 Zeltiq Aesthetics, Inc. Cooling device for removing heat from subcutaneous lipid-rich cells
GB0605107D0 (en) 2006-03-14 2006-04-26 Bioforskning As Use
JP4903471B2 (ja) 2006-03-30 2012-03-28 東急建設株式会社 建物用壁材及び無線伝送システム
US20070249519A1 (en) 2006-04-20 2007-10-25 Kalypsys, Inc. Methods for the upregulation of glut4 via modulation of ppar delta in adipose tissue and for the treatment of disease
US20070255187A1 (en) 2006-04-26 2007-11-01 Branch Alan P Vibrating therapy device
ZA200801930B (en) 2006-04-28 2009-09-30 Zeltiq Aesthetics Inc Cryoprotecant for use with a treatment device for improved cooling of subcuteneous lipid-rich cells
US20070255362A1 (en) 2006-04-28 2007-11-01 Juniper Medical, Inc. Cryoprotectant for use with a cooling device for improved cooling of subcutaneous lipid-rich cells
US7615036B2 (en) 2006-05-11 2009-11-10 Kalypto Medical, Inc. Device and method for wound therapy
US20070282318A1 (en) 2006-05-16 2007-12-06 Spooner Gregory J Subcutaneous thermolipolysis using radiofrequency energy
US20070270925A1 (en) 2006-05-17 2007-11-22 Juniper Medical, Inc. Method and apparatus for non-invasively removing heat from subcutaneous lipid-rich cells including a coolant having a phase transition temperature
KR100746323B1 (ko) 2006-06-12 2007-08-06 주식회사 바이오스마트 냉동 치료 및 관리를 위한 롤러형 피부관리기
KR100746322B1 (ko) 2006-06-12 2007-08-06 주식회사 바이오스마트 냉동 치료 및 관리를 위한 로드형 피부관리기
US8246611B2 (en) 2006-06-14 2012-08-21 Candela Corporation Treatment of skin by spatial modulation of thermal heating
FR2902645B1 (fr) 2006-06-22 2008-10-03 Louisin Researhc Dev Ltd Dispositif de traitement, notamment de massage, du tissu conjonctif de la peau
US8460352B2 (en) 2006-07-05 2013-06-11 Kaz Usa, Inc. Site-specific pad with notch
USD550362S1 (en) 2006-07-26 2007-09-04 Alcon, Inc. Surgical console
US20080046047A1 (en) 2006-08-21 2008-02-21 Daniel Jacobs Hot and cold therapy device
US8758786B2 (en) 2006-08-28 2014-06-24 Gerard Hassler Preparation for reducing and/or preventing body fat and respective uses, in particular together with a dressing material
US20090171253A1 (en) 2006-09-06 2009-07-02 Cutera, Inc. System and method for dermatological treatment using ultrasound
DE602007010807D1 (de) 2006-09-08 2011-01-05 Arbel Medical Ltd Vorrichtung für kombinierte behandlung
US20080097207A1 (en) 2006-09-12 2008-04-24 Siemens Medical Solutions Usa, Inc. Ultrasound therapy monitoring with diagnostic ultrasound
US20080077201A1 (en) 2006-09-26 2008-03-27 Juniper Medical, Inc. Cooling devices with flexible sensors
US9132031B2 (en) 2006-09-26 2015-09-15 Zeltiq Aesthetics, Inc. Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile
CN200970265Y (zh) 2006-11-09 2007-11-07 韩秀玲 冷冻治疗装置
US20080140371A1 (en) 2006-11-15 2008-06-12 General Electric Company System and method for treating a patient
CN101573156A (zh) 2006-12-18 2009-11-04 皇家飞利浦电子股份有限公司 包含至少一种热电材料的细胞裂解或电穿孔设备
US20080161892A1 (en) 2006-12-28 2008-07-03 John Anthony Mercuro Facial Cold -Pack Holder
US8128401B2 (en) 2006-12-29 2012-03-06 Clifford J. Ruddle Cannula for a combined dental irrigator and vacuum device
US8267983B2 (en) 2007-01-11 2012-09-18 Scion Neurostim, Llc. Medical devices incorporating thermoelectric transducer and controller
US8414631B2 (en) 2007-02-13 2013-04-09 Thermotek, Inc. System and method for cooled airflow for dermatological applications
EP2104462A4 (en) 2007-02-16 2009-11-04 Paul K Perl NONINVASIVE ULTRASOUND-BASED BODY CONTOURING WITH SKIN CONTACT COOLING
CN101259329A (zh) 2007-03-08 2008-09-10 德切勒·克里斯托夫·迪亚特曼 一种绒毛玩具温热装置
US20090016980A1 (en) 2007-03-26 2009-01-15 Irina Tsivkin Method of Pre-Treating Hair Prior to Coloring
USD568258S1 (en) 2007-04-06 2008-05-06 Zeltiq Aesthetics, Inc. Control unit
RU2523620C2 (ru) 2007-04-19 2014-07-20 Мирамар Лэбс,Инк. Системы и способы создания воздействия на заданную ткань с использованием микроволновой энергии
WO2008131302A2 (en) 2007-04-19 2008-10-30 The Foundry, Inc. Methods and apparatus for reducing sweat production
WO2009075879A1 (en) 2007-12-12 2009-06-18 Miramar Labs, Inc. Systems, apparatus, methods and procedures for the noninvasive treatment of tissue using microwave energy
US20080287839A1 (en) 2007-05-18 2008-11-20 Juniper Medical, Inc. Method of enhanced removal of heat from subcutaneous lipid-rich cells and treatment apparatus having an actuator
US20080300529A1 (en) 2007-06-04 2008-12-04 Farr Laboratories, Llc Skin Care Method and Kit Using Peltier Thermoelectric Device
WO2008154000A1 (en) 2007-06-08 2008-12-18 Cynosure, Inc. Thermal surgery safety suite
US20080312651A1 (en) 2007-06-15 2008-12-18 Karl Pope Apparatus and methods for selective heating of tissue
US20090012434A1 (en) 2007-07-03 2009-01-08 Anderson Robert S Apparatus, method, and system to treat a volume of skin
KR20090000258U (ko) 2007-07-06 2009-01-09 주식회사 바이오스마트 냉동 치료 및 관리를 위한 롤러형 피부관리기
US20090018625A1 (en) 2007-07-13 2009-01-15 Juniper Medical, Inc. Managing system temperature to remove heat from lipid-rich regions
US20090018626A1 (en) 2007-07-13 2009-01-15 Juniper Medical, Inc. User interfaces for a system that removes heat from lipid-rich regions
US8523927B2 (en) 2007-07-13 2013-09-03 Zeltiq Aesthetics, Inc. System for treating lipid-rich regions
US20090018627A1 (en) 2007-07-13 2009-01-15 Juniper Medical, Inc. Secure systems for removing heat from lipid-rich regions
EP2182872A1 (en) 2007-07-13 2010-05-12 Zeltiq Aesthetics, Inc. System for treating lipid-rich regions
US20090018624A1 (en) 2007-07-13 2009-01-15 Juniper Medical, Inc. Limiting use of disposable system patient protection devices
WO2009026471A1 (en) 2007-08-21 2009-02-26 Zeltiq Aesthetics, Inc. Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue
WO2009055581A2 (en) 2007-10-24 2009-04-30 Skintreet, Llc Method and portable device for treating skin disorders
US20090149930A1 (en) 2007-12-07 2009-06-11 Thermage, Inc. Apparatus and methods for cooling a treatment apparatus configured to non-invasively deliver electromagnetic energy to a patient's tissue
BRPI0820706B8 (pt) 2007-12-12 2021-06-22 Miramar Labs Inc aparelho médico descartável para uso com um aplicador
CA2713939C (en) 2008-02-01 2017-12-05 Alma Lasers Ltd. Apparatus and method for selective ultrasonic damage of adipocytes
JP2009189757A (ja) 2008-02-15 2009-08-27 Akira Hirai 熱冷まし機
US8461108B2 (en) 2008-03-07 2013-06-11 Myoscience, Inc. Subdermal tissue remodeling using myostatin, methods and related systems
EP2271276A4 (en) 2008-04-17 2013-01-23 Miramar Labs Inc SYSTEMS, APPARATUS, METHODS AND PROCEDURES FOR NON-INVASIVE TREATMENT OF TISSUE USING MICROWAVE ENERGY
EP2280675B1 (en) 2008-04-30 2014-04-23 Eric William Brader Apparatus for preventing brain damage during cardiac arrest, cpr, or severe shock
WO2009137699A2 (en) 2008-05-07 2009-11-12 Sanuwave, Inc. Medical treatment system including an ancillary medical treatment apparatus with an associated data storage medium
US20180104094A9 (en) 2008-05-16 2018-04-19 Seth A. Biser Thermal eye compress systems and methods of use
US20090299234A1 (en) 2008-05-28 2009-12-03 Nuga Medical Co., Ltd Fat remover
ES2927873T3 (es) 2008-06-06 2022-11-11 Ulthera Inc Sistema y procedimiento para tratamiento cosmético y formación de imágenes
US20090306749A1 (en) 2008-06-07 2009-12-10 Damalie Mulindwa Therapeutic hot and cold water belt
US20090312693A1 (en) 2008-06-13 2009-12-17 Vytronus, Inc. System and method for delivering energy to tissue
EP3811912A1 (en) 2008-08-07 2021-04-28 The General Hospital Corporation Method and apparatus for dermatological hypopigmentation
US20100036295A1 (en) 2008-08-08 2010-02-11 Palomar Medical Technologies, Inc. Method and apparatus for fractional deformation and treatment of cutaneous and subcutaneous tissue
US8672931B2 (en) 2008-08-18 2014-03-18 3JT Enterprises, LLC Cryosurgical device with metered dose
US9149386B2 (en) 2008-08-19 2015-10-06 Niveus Medical, Inc. Devices and systems for stimulation of tissues
CA2736221C (en) 2008-09-03 2016-01-05 John M. Baust A cryogenic system and method of use
US8409184B2 (en) 2009-09-09 2013-04-02 Cpsi Holdings Llc Cryo-medical injection device and method of use
US20100087806A1 (en) 2008-10-07 2010-04-08 Vandolay, Inc. Automated Cryogenic Skin Treatment
US8603073B2 (en) 2008-12-17 2013-12-10 Zeltiq Aesthetics, Inc. Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells
WO2010075448A1 (en) 2008-12-22 2010-07-01 Myoscience, Inc. Skin protection for subdermal cryogenic remodeling for cosmetic and other treatments
KR20110101204A (ko) 2008-12-24 2011-09-15 가이디드 테라피 시스템스, 엘.엘.씨. 지방 감소 및/또는 셀룰라이트 치료 방법 및 시스템
US20100168726A1 (en) 2008-12-31 2010-07-01 Marc Arthur Brookman Cryogenic Dispensing System and Method for Treatment of Dermatological Conditions
US7981080B2 (en) 2009-01-07 2011-07-19 Halaka Folim G Skin cooling apparatus and method
US8882758B2 (en) 2009-01-09 2014-11-11 Solta Medical, Inc. Tissue treatment apparatus and systems with pain mitigation and methods for mitigating pain during tissue treatments
US8372130B2 (en) 2009-01-23 2013-02-12 Forever Young International, Inc. Temperature controlled facial mask with area-specific treatments
JP5650137B2 (ja) 2009-02-20 2015-01-07 ニヴェウス メディカル， インコーポレーテッド エネルギー誘導域を用いた電動筋肉刺激システム及び方法
WO2010096840A2 (en) 2009-02-23 2010-08-26 Miramar Labs, Inc. Tissue interface system and method
US8939914B2 (en) 2009-02-27 2015-01-27 Thermimage, Inc. Radiometers and related devices and methods
US8298225B2 (en) 2009-03-19 2012-10-30 Tyco Healthcare Group Lp System and method for return electrode monitoring
DE102009014976B3 (de) 2009-03-30 2010-06-02 Jutta Munz Applikatoreinrichtung zur kosmetischen und/oder medizinischen Anwendung
WO2010125531A1 (en) 2009-04-30 2010-11-04 Alma Lasers Limited Devices and methods for dermatological treatment
CA3156737A1 (en) 2009-04-30 2010-11-04 Zeltiq Aesthetics, Inc. Vacuum applicator for removing heat from subcutaneous lipid-rich cells
FR2946845B1 (fr) 2009-06-18 2011-08-19 Oreal Dispositif de traitement des matieres keratiniques humaines
US9919168B2 (en) 2009-07-23 2018-03-20 Palomar Medical Technologies, Inc. Method for improvement of cellulite appearance
US8523791B2 (en) 2009-08-11 2013-09-03 Laboratoire Naturel Paris, Llc Multi-modal drug delivery system
US8932238B2 (en) 2009-09-29 2015-01-13 Liposonix, Inc. Medical ultrasound device with liquid dispensing device coupled to a therapy head
US20110112520A1 (en) 2009-11-11 2011-05-12 Invasix Corporation Method and device for fat treatment
WO2011091293A1 (en) 2010-01-21 2011-07-28 Zeltiq Aesthetics, Inc. Compositions for use with a system for improved cooling of subcutaneous lipid-rich tissue
CA2787309A1 (en) 2010-01-25 2011-07-28 Enanta Pharmaceuticals, Inc. Hepatitis c virus inhibitors
AU2011207506A1 (en) 2010-01-25 2012-08-09 Zeltiq Aesthetics, Inc. Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants, and associated devices, systems and methods
DE102010007177B4 (de) 2010-02-08 2017-06-22 Siemens Healthcare Gmbh Anzeigeverfahren für ein vor einer Aufweitungseinrichtung liegendes Bild des Inneren eines Gefäßes und hiermit korrespondierende Anzeigeeinrichtung
US20110196438A1 (en) 2010-02-10 2011-08-11 Lukas Mnozil Therapy device and method for treating underlying tissue using electrical and acoustic energies
US20110202048A1 (en) 2010-02-12 2011-08-18 Solta Medical, Inc. Methods for pain reduction with functional thermal stimulation and tissue treatment systems
US9980765B2 (en) 2010-02-15 2018-05-29 The General Hospital Corporation Methods and devices for selective disruption of visceral fat by controlled cooling
US20110257642A1 (en) 2010-04-16 2011-10-20 Griggs Iii Charles Sherman Method for producing a permanent or nearly permanent skin image, design or tattoo by freezing the skin
US20120158100A1 (en) 2010-06-21 2012-06-21 Kevin Schomacker Driving Microneedle Arrays into Skin and Delivering RF Energy
US8676338B2 (en) 2010-07-20 2014-03-18 Zeltiq Aesthetics, Inc. Combined modality treatment systems, methods and apparatus for body contouring applications
FR2967893B1 (fr) 2010-11-25 2013-10-18 Zadeh David Khorassani Appareil de massage comportant un systeme d'aspiration
NZ596830A (en) 2010-12-01 2013-06-28 Gold Rythmn Pty Ltd Cryogenic freezing of skin folds or wrinkles on merino sheep to tighten or contract the skin to reduce flystrike and infestation
WO2012094426A2 (en) 2011-01-04 2012-07-12 Schwartz Alan N Gel-based seals and fixation devices and associated systems and methods
WO2012103242A1 (en) 2011-01-25 2012-08-02 Zeltiq Aesthetics, Inc. Devices, application systems and methods with localized heat flux zones for removing heat from subcutaneous lipid-rich cells
US20120209363A1 (en) 2011-02-10 2012-08-16 R2T2 Solutions Llc Hot and cold therapy device
US9021614B2 (en) 2011-02-18 2015-05-05 Medical Techology, Inc. Leg protector for sports activities
US9038640B2 (en) 2011-03-31 2015-05-26 Viora Ltd. System and method for fractional treatment of skin
US20120310232A1 (en) 2011-06-06 2012-12-06 Danny Erez System and method for treating a tissue using multiple energy types
BR112014000666A2 (pt) 2011-07-20 2019-06-04 Scr Inc almofada de aquecimento e/ou resfriamento e sistema de fornecimento de resfiamento a uma ou mais partes do corpo de um indivíduo e respectivo método para fornecer terapia de quente e frio
US9314301B2 (en) 2011-08-01 2016-04-19 Miramar Labs, Inc. Applicator and tissue interface module for dermatological device
ES2562990T3 (es) 2011-09-05 2016-03-09 Venus Concept Ltd Dispositivo estético mejorado para embellecer la piel
US20130073017A1 (en) 2011-09-15 2013-03-21 Fong Yu Liu Thermal vacuum therapy and apparatus thereof
KR20130043299A (ko) 2011-10-20 2013-04-30 김기태 초음파 진동자와 온냉웨이퍼를 결합하여 피부를 자극하는 피부 미용기기
CN109602489A (zh) 2011-11-16 2019-04-12 通用医疗公司 用于低温处理皮肤组织的方法和装置
CN116236339A (zh) 2011-11-16 2023-06-09 通用医疗公司 用于低温处理皮肤组织的方法和装置
US8397518B1 (en) 2012-02-20 2013-03-19 Dhama Innovations PVT. Ltd. Apparel with integral heating and cooling device
US20130331914A1 (en) 2012-06-11 2013-12-12 Martin Lee Thermal therapy system and method of use
EP2863850B1 (en) 2012-06-22 2017-11-01 Physiolab Technologies Limited Thermal and/or pressure regulation control system
KR20140038165A (ko) 2012-09-20 2014-03-28 (주)휴톤 다기능 미용기
KR20140092121A (ko) 2013-01-15 2014-07-23 삼성전자주식회사 초음파 치료 장치를 냉각하는 방법 및 이를 이용한 초음파 치료 장치
US9710607B2 (en) 2013-01-15 2017-07-18 Itrace Biomedical Inc. Portable electronic therapy device and the method thereof
KR101451891B1 (ko) 2013-01-22 2014-10-16 유니스파테크주식회사 금속 냉온 감압 피부 관리 장치
US9844460B2 (en) 2013-03-14 2017-12-19 Zeltiq Aesthetics, Inc. Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same
US9545523B2 (en) 2013-03-14 2017-01-17 Zeltiq Aesthetics, Inc. Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue
BR112015029466A2 (pt) 2013-05-30 2017-07-25 Koninklijke Philips Nv dispositivo não-invasivo para rejuvenescimento de tecido cutâneo, e, método de tratamento de pele para rejuvenescer o tecido cutâneo
US8764693B1 (en) 2013-11-20 2014-07-01 Richard A. Graham Systems and methods for decompression and elliptical traction of the cervical and thoracic spine
JP2017505657A (ja) 2014-01-10 2017-02-23 マーシオ マーク アブリュー Ａｂｒｅｕ脳トンネルでモニタして治療を提供するデバイス
EP3099261A2 (en) 2014-01-31 2016-12-07 Zeltiq Aesthetics, Inc. Treating systems for treating cellulite by cooling
EP3099262B1 (en) 2014-01-31 2022-02-23 The General Hospital Corporation Cooling device to disrupt function sebaceous glands
WO2015123420A1 (en) 2014-02-12 2015-08-20 The General Hospital Corporation Method and apparatus for affecting pigmentation of tissue
US10935174B2 (en) 2014-08-19 2021-03-02 Zeltiq Aesthetics, Inc. Stress relief couplings for cryotherapy apparatuses
US10568759B2 (en) 2014-08-19 2020-02-25 Zeltiq Aesthetics, Inc. Treatment systems, small volume applicators, and methods for treating submental tissue
US20160089550A1 (en) 2014-09-25 2016-03-31 Zeltiq Aesthetics, Inc. Treatment systems, methods, and apparatuses for altering the appearance of skin
WO2017041022A1 (en) 2015-09-04 2017-03-09 R2 Dermatology, Inc. Medical systems, methods, and devices for hypopigmentation cooling treatments
US20170079833A1 (en) 2015-09-21 2017-03-23 Zeltiq Aesthestics, Inc. Transcutaneous treatment systems, cooling devices, and methods for cooling nerves
ES2892598T3 (es) 2015-10-19 2022-02-04 Zeltiq Aesthetics Inc Métodos de tratamiento vascular para enfriar estructuras vasculares
CN108472151B (zh) 2016-01-07 2020-10-27 斯尔替克美学股份有限公司 在组织冷却期间施用器与皮肤之间的温度依赖性粘附
US10765552B2 (en) 2016-02-18 2020-09-08 Zeltiq Aesthetics, Inc. Cooling cup applicators with contoured heads and liner assemblies
US20170326346A1 (en) 2016-05-10 2017-11-16 Zeltiq Aesthetics, Inc. Permeation enhancers and methods of cryotherapy
US10555831B2 (en) 2016-05-10 2020-02-11 Zeltiq Aesthetics, Inc. Hydrogel substances and methods of cryotherapy
US10682297B2 (en) 2016-05-10 2020-06-16 Zeltiq Aesthetics, Inc. Liposomes, emulsions, and methods for cryotherapy
US11382790B2 (en) 2016-05-10 2022-07-12 Zeltiq Aesthetics, Inc. Skin freezing systems for treating acne and skin conditions
US20180263677A1 (en) 2017-03-16 2018-09-20 Zeltiq Aesthetics, Inc. Adhesive liners for cryotherapy
WO2018175111A1 (en) 2017-03-21 2018-09-27 Zeltiq Aesthetics, Inc. Use of saccharides for cryoprotection and related technology
US11076879B2 (en) 2017-04-26 2021-08-03 Zeltiq Aesthetics, Inc. Shallow surface cryotherapy applicators and related technology

Patent Citations (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US681806A (en) * 1901-05-25 1901-09-03 Armand Mignault Lung-protector.
US889810A (en) * 1908-01-04 1908-06-02 Henry Robinson Medicating and massaging appliance.
US3132688A (en) * 1963-04-08 1964-05-12 Welville B Nowak Electronic cold and/or hot compress device
US3502080A (en) * 1965-06-28 1970-03-24 Max L Hirschhorn Thermoelectrically cooled surgical instrument
US3786814A (en) * 1972-12-15 1974-01-22 T Armao Method of preventing cryoadhesion of cryosurgical instruments and cryosurgical instruments
US3942519A (en) * 1972-12-26 1976-03-09 Ultrasonic Systems, Inc. Method of ultrasonic cryogenic cataract removal
US3948269A (en) * 1973-08-31 1976-04-06 Dragerwerk Aktiengesellschaft Cryomedical device
US4266043A (en) * 1974-08-15 1981-05-05 Toyo Rubber Chemical Industrial Corporation Resilient hydrophobic foamed polymer
US4202336A (en) * 1976-05-14 1980-05-13 Erbe Elektromedizin Kg Cauterizing probes for cryosurgery
US4140130A (en) * 1977-05-31 1979-02-20 Storm Iii Frederick K Electrode structure for radio frequency localized heating of tumor bearing tissue
US4381009A (en) * 1980-01-28 1983-04-26 Bon F Del Hand-held device for the local heat-treatment of the skin
US4644955A (en) * 1982-12-27 1987-02-24 Rdm International, Inc. Circuit apparatus and method for electrothermal treatment of cancer eye
US5197466A (en) * 1983-01-21 1993-03-30 Med Institute Inc. Method and apparatus for volumetric interstitial conductive hyperthermia
US4718429A (en) * 1983-03-10 1988-01-12 Udo Smidt Method of reducing fatty deposits in the human body
US4664110A (en) * 1985-03-18 1987-05-12 University Of Southern California Controlled rate freezing for cryorefractive surgery
US4585002A (en) * 1985-04-22 1986-04-29 Igor Kissin Method and apparatus for treatment of pain by frequently alternating temperature stimulation
US4832022A (en) * 1986-05-26 1989-05-23 Tomsky Gosudarstvenny Universitet Im. Kuibysheva Cryogenic ultrasonic scalpel
US4990144A (en) * 1986-08-20 1991-02-05 Smith And Nephew Associated Companies Plc Medicating impressed film wound dressing
US4741338A (en) * 1986-10-06 1988-05-03 Toshiaki Miyamae Thermoelectric physical remedy apparatus
US4906463A (en) * 1986-12-22 1990-03-06 Cygnus Research Corporation Transdermal drug-delivery composition
US4802475A (en) * 1987-06-22 1989-02-07 Weshahy Ahmed H A G Methods and apparatus of applying intra-lesional cryotherapy
US5084671A (en) * 1987-09-02 1992-01-28 Tokyo Electron Limited Electric probing-test machine having a cooling system
US5007433A (en) * 1988-06-23 1991-04-16 Phywe Systeme Gmbh Stimulation device
US5108390A (en) * 1988-11-14 1992-04-28 Frigitronics, Inc. Flexible cryoprobe
US5207674A (en) * 1991-05-13 1993-05-04 Hamilton Archie C Electronic cryogenic surgical probe apparatus and method
US5514105A (en) * 1992-01-03 1996-05-07 The Procter & Gamble Company Resilient plastic web exhibiting reduced skin contact area and enhanced fluid transfer properties
US5314423A (en) * 1992-11-03 1994-05-24 Seney John S Cold electrode pain alleviating tissue treatment assembly
US5277030A (en) * 1993-01-22 1994-01-11 Welch Allyn, Inc. Preconditioning stand for cooling probe
US5871526A (en) * 1993-10-13 1999-02-16 Gibbs; Roselle Portable temperature control system
US5497596A (en) * 1994-01-27 1996-03-12 E. I. Du Pont De Nemours And Company Method for reducing penetration of liquid through nonwoven film-fibril sheets pierced by fastening elements
US5505726A (en) * 1994-03-21 1996-04-09 Dusa Pharmaceuticals, Inc. Article of manufacture for the photodynamic therapy of dermal lesion
US5507790A (en) * 1994-03-21 1996-04-16 Weiss; William V. Method of non-invasive reduction of human site-specific subcutaneous fat tissue deposits by accelerated lipolysis metabolism
US5603221A (en) * 1994-06-30 1997-02-18 State Of Israel, Ministry Of Defense, Rafael-Armaments Development Authority Multiprobe surgical cryogenic apparatus
US5755663A (en) * 1994-08-19 1998-05-26 Novoste Corporation Apparatus for procedures related to the electrophysiology of the heart
US5514170A (en) * 1994-08-25 1996-05-07 Mauch; Rose M. Cold pack device
US5628769A (en) * 1994-09-30 1997-05-13 Saringer Research, Inc. Method and devices for producing somatosensory stimulation using temperature
US5895418A (en) * 1994-09-30 1999-04-20 Saringer Research Inc. Device for producing cold therapy
US6548297B1 (en) * 1994-11-09 2003-04-15 Celadon Science, Inc. Sheets of cultured epithelial cells used for wound repair and their cryopreservation
US6381498B1 (en) * 1995-05-05 2002-04-30 Thermage, Inc. Method and apparatus for controlled contraction of collagen tissue
US5871524A (en) * 1995-05-05 1999-02-16 Thermage, Inc. Apparatus for controlled contraction of collagen tissue
US20020062142A1 (en) * 1995-05-05 2002-05-23 Edward W. Knowlton Method and apparatus for tissue remodeling
US6387380B1 (en) * 1995-05-05 2002-05-14 Thermage, Inc. Apparatus for controlled contraction of collagen tissue
US6381497B1 (en) * 1995-05-05 2002-04-30 Thermage, Inc. Method for smoothing contour irregularity of skin surface by controlled contraction of collagen tissue
US5755753A (en) * 1995-05-05 1998-05-26 Thermage, Inc. Method for controlled contraction of collagen tissue
US6377855B1 (en) * 1995-05-05 2002-04-23 Thermage, Inc. Method and apparatus for controlled contraction of collagen tissue
US6377854B1 (en) * 1995-05-05 2002-04-23 Thermage, Inc. Method for controlled contraction of collagen in fibrous septae in subcutaneous fat layers
US5901707A (en) * 1995-05-19 1999-05-11 Hpl Biomedical, Inc. Silicone mask for cryosurgery and method
US5741248A (en) * 1995-06-07 1998-04-21 Temple University-Of The Commonwealth System Of Higher Education Fluorochemical liquid augmented cryosurgery
US5746736A (en) * 1995-08-09 1998-05-05 Lumedics, Ltd. Cryogenic laser lithotripsy with enhanced light absorption
US5733280A (en) * 1995-11-15 1998-03-31 Avitall; Boaz Cryogenic epicardial mapping and ablation
US6051159A (en) * 1995-12-19 2000-04-18 Hao; Jie Soft ice
US6350276B1 (en) * 1996-01-05 2002-02-26 Thermage, Inc. Tissue remodeling apparatus containing cooling fluid
US20020049483A1 (en) * 1996-01-05 2002-04-25 Knowlton Edward W. Fluid delivery apparatus
US20040030332A1 (en) * 1996-01-05 2004-02-12 Knowlton Edward W. Handpiece with electrode and non-volatile memory
US7005558B1 (en) * 1996-05-02 2006-02-28 Sca Hygiene Products Ab Apertured covering sheet for an absorbent article and a method of producing the covering sheet
US6544248B1 (en) * 1996-08-08 2003-04-08 Starion Instruments Corporation Device for suction-assisted lipectomy and method of using same
US6017337A (en) * 1996-11-04 2000-01-25 Pira; Luc Cryoprobe based on a peltier module
US7204832B2 (en) * 1996-12-02 2007-04-17 Pálomar Medical Technologies, Inc. Cooling system for a photo cosmetic device
US6878144B2 (en) * 1996-12-02 2005-04-12 Palomar Medical Technologies, Inc. System for electromagnetic radiation dermatology and head for use therewith
US6032675A (en) * 1997-03-17 2000-03-07 Rubinsky; Boris Freezing method for controlled removal of fatty tissue by liposuction
US6041787A (en) * 1997-03-17 2000-03-28 Rubinsky; Boris Use of cryoprotective agent compounds during cryosurgery
US20060030778A1 (en) * 1997-08-19 2006-02-09 Mendlein John D Ultrasonic transmission films and devices for hygienic transducer surfaces
US6023932A (en) * 1997-08-25 2000-02-15 Johnston; Robert Topical cooling device
US6551349B2 (en) * 1998-03-24 2003-04-22 Innercool Therapies, Inc. Selective organ cooling apparatus
US6569189B1 (en) * 1998-04-06 2003-05-27 Augustine Medical, Inc. Tissue treatment apparatus including a bandpass filter transparent to selected wavelengths of IR electromagnetic spectrum
US6354297B1 (en) * 1998-04-16 2002-03-12 The Uniformed Services University Of The Health Sciences Method and device for destroying fat cells by induction of programmed cell death
US6039694A (en) * 1998-06-25 2000-03-21 Sonotech, Inc. Coupling sheath for ultrasound transducers
US20040006328A1 (en) * 1999-01-04 2004-01-08 Anderson Richard Rox Targeting of sebaceous follicles as a treatment of sebaceous gland disorders
US20040049178A1 (en) * 1999-01-25 2004-03-11 Marwan Abboud Cooling system
US7022121B2 (en) * 1999-03-09 2006-04-04 Thermage, Inc. Handpiece for treatment of tissue
US20040009936A1 (en) * 1999-05-03 2004-01-15 Tang De-Chu C. Vaccine and drug delivery by topical application of vectors and vector extracts
US20020058975A1 (en) * 1999-12-14 2002-05-16 Bieberich Mark Thomas High-efficiency cooling pads, mattresses, and sleeves
US6840955B2 (en) * 2000-01-27 2005-01-11 Robert J. Ein Therapeutic apparatus
US6718785B2 (en) * 2000-04-11 2004-04-13 Arizant Healthcare Inc. Cooling devices with high-efficiency cooling features
US20030079488A1 (en) * 2000-04-11 2003-05-01 Bieberich Mark Thomas Cooling devices with high-efficiency cooling features
US6519964B2 (en) * 2000-04-11 2003-02-18 Augustine Medical, Inc. Cooling devices with high-efficiency cooling features
US6527765B2 (en) * 2000-10-06 2003-03-04 Charles D. Kelman Cryogenic surgical system and method of use in removal of tissue
US20030069618A1 (en) * 2001-04-26 2003-04-10 Smith Edward Dewey Method, kit and device for the treatment of cosmetic skin conditions
US7192426B2 (en) * 2001-05-31 2007-03-20 Endocare, Inc. Cryogenic system
US7183360B2 (en) * 2001-10-05 2007-02-27 Basf Aktiengesellschaft Method for crosslinking hydrogels with morpholine-2,3-diones
US20030077329A1 (en) * 2001-10-19 2003-04-24 Kipp James E Composition of and method for preparing stable particles in a frozen aqueous matrix
US20030100936A1 (en) * 2001-11-29 2003-05-29 Gregory Altshuler Method and apparatus for controlling the temperature of a surface
US6699266B2 (en) * 2001-12-08 2004-03-02 Charles A. Lachenbruch Support surface with phase change material or heat tubes
US20040039312A1 (en) * 2002-02-20 2004-02-26 Liposonix, Inc. Ultrasonic treatment and imaging of adipose tissue
US6523354B1 (en) * 2002-03-08 2003-02-25 Deborah Ann Tolbert Cooling blanket
US20070010861A1 (en) * 2002-03-15 2007-01-11 Anderson Richard R Methods and devices for selective disruption of fatty tissue by controlled cooling
US20040093042A1 (en) * 2002-06-19 2004-05-13 Palomar Medical Technologies, Inc. Method and apparatus for photothermal treatment of tissue at depth
US20040073079A1 (en) * 2002-06-19 2004-04-15 Palomar Medical Technologies, Inc. Method and apparatus for treatment of cutaneous and subcutaneous conditions
US20040074629A1 (en) * 2002-10-18 2004-04-22 Noel Thomas P. Method and thermally active convection apparatus and method for abstracting heat with circulation intermediate three dimensional--parity heat transfer elements in bi-phase heat exchanging composition
US20060079852A1 (en) * 2002-12-31 2006-04-13 Bubb Stephen K Externally-applied patient interface system and method
US7037326B2 (en) * 2003-03-14 2006-05-02 Hee-Young Lee Skin cooling device using thermoelectric element
US7189252B2 (en) * 2003-03-25 2007-03-13 Krueger & Gothe Gmbh Warming/chilling apparatus
US7220778B2 (en) * 2003-04-15 2007-05-22 The General Hospital Corporation Methods and devices for epithelial protection during photodynamic therapy
US20050049661A1 (en) * 2003-09-03 2005-03-03 Koffroth Shirley B. Ice belt to reduce body temperature
US20060036300A1 (en) * 2004-08-16 2006-02-16 Syneron Medical Ltd. Method for lypolisis
US20060074313A1 (en) * 2004-10-06 2006-04-06 Guided Therapy Systems, L.L.C. Method and system for treating cellulite
US20070032661A1 (en) * 2005-08-03 2007-02-08 Glenmark Pharmaceuticals Limited Process for the preparation of intermediates of perindopril
US20080077202A1 (en) * 2006-09-26 2008-03-27 Juniper Medical, Inc. Tissue Treatment Methods
US20090118722A1 (en) * 2006-10-31 2009-05-07 Ebbers Edward A Method and apparatus for cooling subcutaneous lipid-rich cells or tissue
US20100081971A1 (en) * 2008-09-25 2010-04-01 Allison John W Treatment planning systems and methods for body contouring applications

Cited By (282)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8073550B1 (en) 1997-07-31 2011-12-06 Miramar Labs, Inc. Method and apparatus for treating subcutaneous histological features
US8853600B2 (en) 1997-07-31 2014-10-07 Miramar Labs, Inc. Method and apparatus for treating subcutaneous histological features
US20190000663A1 (en) * 2002-03-15 2019-01-03 The General Hospital Corporation Treatment systems for removing heat from subcutaneous lipid-rich cells
US11590020B2 (en) 2002-03-15 2023-02-28 The General Hospital Corporation Methods and devices for selective disruption of fatty tissue by controlled cooling
US20170319378A1 (en) * 2002-03-15 2017-11-09 The General Hospital Corporation Treatment systems for removing heat from subcutaneous lipid-rich cells and treatment systems for affecting subcutaneous lipid-rich cells
US11243494B2 (en) 2002-07-31 2022-02-08 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US11415936B2 (en) 2002-07-31 2022-08-16 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US11422504B2 (en) 2002-07-31 2022-08-23 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US7850683B2 (en) 2005-05-20 2010-12-14 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US7998137B2 (en) 2005-05-20 2011-08-16 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US10363080B2 (en) 2005-05-20 2019-07-30 Pacira Cryotech, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US9345526B2 (en) 2005-05-20 2016-05-24 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US7862558B2 (en) 2005-05-20 2011-01-04 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US20070129714A1 (en) * 2005-05-20 2007-06-07 Echo Healthcare Llc Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (FAT)
US9072498B2 (en) 2005-05-20 2015-07-07 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US7713266B2 (en) 2005-05-20 2010-05-11 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US11350979B2 (en) 2005-05-20 2022-06-07 Pacira Cryotech, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US11963706B2 (en) 2005-05-20 2024-04-23 Pacira Cryotech, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US8337539B2 (en) 2006-02-22 2012-12-25 Zeltiq Aesthetics, Inc. Cooling device for removing heat from subcutaneous lipid-rich cells
US12070411B2 (en) 2006-04-28 2024-08-27 Zeltiq Aesthetics, Inc. Cryoprotectant for use with a treatment device for improved cooling of subcutaneous lipid-rich cells
US11179269B2 (en) 2006-09-26 2021-11-23 Zeltiq Aesthetics, Inc. Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile
US11986421B2 (en) 2006-09-26 2024-05-21 Zeltiq Aesthetics, Inc. Cooling devices with flexible sensors
US9132031B2 (en) * 2006-09-26 2015-09-15 Zeltiq Aesthetics, Inc. Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile
US11395760B2 (en) 2006-09-26 2022-07-26 Zeltiq Aesthetics, Inc. Tissue treatment methods
US20080077211A1 (en) * 2006-09-26 2008-03-27 Juniper Medical, Inc. Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile
US10292859B2 (en) 2006-09-26 2019-05-21 Zeltiq Aesthetics, Inc. Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile
US9375345B2 (en) 2006-09-26 2016-06-28 Zeltiq Aesthetics, Inc. Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile
US11219549B2 (en) 2006-09-26 2022-01-11 Zeltiq Aesthetics, Inc. Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile
US10939947B2 (en) 2006-12-21 2021-03-09 Pacira Cryotech, Inc. Dermal and transdermal cryogenic microprobe systems
US9254162B2 (en) 2006-12-21 2016-02-09 Myoscience, Inc. Dermal and transdermal cryogenic microprobe systems
US8409185B2 (en) 2007-02-16 2013-04-02 Myoscience, Inc. Replaceable and/or easily removable needle systems for dermal and transdermal cryogenic remodeling
US9113855B2 (en) 2007-02-16 2015-08-25 Myoscience, Inc. Replaceable and/or easily removable needle systems for dermal and transdermal cryogenic remodeling
US20080200910A1 (en) * 2007-02-16 2008-08-21 Myoscience, Inc. Replaceable and/or Easily Removable Needle Systems for Dermal and Transdermal Cryogenic Remodeling
US9427285B2 (en) 2007-04-19 2016-08-30 Miramar Labs, Inc. Systems and methods for creating an effect using microwave energy to specified tissue
US9149331B2 (en) 2007-04-19 2015-10-06 Miramar Labs, Inc. Methods and apparatus for reducing sweat production
US8688228B2 (en) 2007-04-19 2014-04-01 Miramar Labs, Inc. Systems, apparatus, methods and procedures for the noninvasive treatment of tissue using microwave energy
US11419678B2 (en) 2007-04-19 2022-08-23 Miradry, Inc. Methods, devices, and systems for non-invasive delivery of microwave therapy
US9241763B2 (en) 2007-04-19 2016-01-26 Miramar Labs, Inc. Systems, apparatus, methods and procedures for the noninvasive treatment of tissue using microwave energy
US10463429B2 (en) 2007-04-19 2019-11-05 Miradry, Inc. Methods, devices, and systems for non-invasive delivery of microwave therapy
US10166072B2 (en) 2007-04-19 2019-01-01 Miradry, Inc. Systems and methods for creating an effect using microwave energy to specified tissue
US10624696B2 (en) 2007-04-19 2020-04-21 Miradry, Inc. Systems and methods for creating an effect using microwave energy to specified tissue
US8401668B2 (en) 2007-04-19 2013-03-19 Miramar Labs, Inc. Systems and methods for creating an effect using microwave energy to specified tissue
US10779887B2 (en) 2007-04-19 2020-09-22 Miradry, Inc. Systems and methods for creating an effect using microwave energy to specified tissue
US11291606B2 (en) 2007-05-18 2022-04-05 Zeltiq Aesthetics, Inc. Treatment apparatus for removing heat from subcutaneous lipid-rich cells and massaging tissue
US10383787B2 (en) 2007-05-18 2019-08-20 Zeltiq Aesthetics, Inc. Treatment apparatus for removing heat from subcutaneous lipid-rich cells and massaging tissue
US9655770B2 (en) 2007-07-13 2017-05-23 Zeltiq Aesthetics, Inc. System for treating lipid-rich regions
US8523927B2 (en) 2007-07-13 2013-09-03 Zeltiq Aesthetics, Inc. System for treating lipid-rich regions
US9408745B2 (en) 2007-08-21 2016-08-09 Zeltiq Aesthetics, Inc. Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue
EP3488833A1 (en) 2007-08-21 2019-05-29 Zeltiq Aesthetics, Inc. Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue
US8285390B2 (en) 2007-08-21 2012-10-09 Zeltiq Aesthetics, Inc. Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue
EP2182898B1 (en) 2007-08-21 2018-10-03 Zeltiq Aesthetics, Inc. Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue
US10675178B2 (en) 2007-08-21 2020-06-09 Zeltiq Aesthetics, Inc. Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue
US11583438B1 (en) 2007-08-21 2023-02-21 Zeltiq Aesthetics, Inc. Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue
US8298216B2 (en) 2007-11-14 2012-10-30 Myoscience, Inc. Pain management using cryogenic remodeling
US9907693B2 (en) 2007-11-14 2018-03-06 Myoscience, Inc. Pain management using cryogenic remodeling
US10864112B2 (en) 2007-11-14 2020-12-15 Pacira Cryotech, Inc. Pain management using cryogenic remodeling
US11672694B2 (en) 2007-11-14 2023-06-13 Pacira Cryotech, Inc. Pain management using cryogenic remodeling
US10869779B2 (en) 2007-11-14 2020-12-22 Pacira Cryotech, Inc. Pain management using cryogenic remodeling
US9101346B2 (en) 2007-11-14 2015-08-11 Myoscience, Inc. Pain management using cryogenic remodeling
US8715275B2 (en) 2007-11-14 2014-05-06 Myoscience, Inc. Pain management using cryogenic remodeling
US8406894B2 (en) 2007-12-12 2013-03-26 Miramar Labs, Inc. Systems, apparatus, methods and procedures for the noninvasive treatment of tissue using microwave energy
US8825176B2 (en) 2007-12-12 2014-09-02 Miramar Labs, Inc. Apparatus for the noninvasive treatment of tissue using microwave energy
US8275442B2 (en) 2008-09-25 2012-09-25 Zeltiq Aesthetics, Inc. Treatment planning systems and methods for body contouring applications
US9737434B2 (en) 2008-12-17 2017-08-22 Zeltiq Aestehtics, Inc. Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells
US8603073B2 (en) 2008-12-17 2013-12-10 Zeltiq Aesthetics, Inc. Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells
US9066712B2 (en) 2008-12-22 2015-06-30 Myoscience, Inc. Integrated cryosurgical system with refrigerant and electrical power source
US11452634B2 (en) * 2009-04-30 2022-09-27 Zeltiq Aesthetics, Inc. Device, system and method of removing heat from subcutaneous lipid-rich cells
US20140257443A1 (en) * 2009-04-30 2014-09-11 Zeltiq Aesthetics, Inc. Device, system and method of removing heat from subcutaneous lipid-rich cells
US11224536B2 (en) 2009-04-30 2022-01-18 Zeltiq Aesthetics, Inc. Device, system and method of removing heat from subcutaneous lipid-rich cells
US9861520B2 (en) * 2009-04-30 2018-01-09 Zeltiq Aesthetics, Inc. Device, system and method of removing heat from subcutaneous lipid-rich cells
EP4066797A1 (en) 2009-04-30 2022-10-05 Zeltiq Aesthetics, Inc. Device for removing heat from subcutaneous lipid-rich cells
KR20130139382A (ko) 2009-04-30 2013-12-20 젤티크 애스세틱스, 인코포레이티드. 피하 지질 과다 세포로부터 열을 제거하는 디바이스, 시스템 및 방법
WO2010127315A3 (en) * 2009-04-30 2011-04-21 Zeltiq Aesthetics, Inc. Device, system and method of removing heat from subcutaneous lipid-rich cells
US20230122866A1 (en) * 2009-04-30 2023-04-20 Zeltiq Aesthetics, Inc. Device, system and method of removing heat from subcutaneous lipid-rich cells
EP2424475A4 (en) * 2009-04-30 2012-10-03 Zeltiq Aesthetics Inc DEVICE, SYSTEM AND METHOD FOR REMOVING HEAT FROM SUBCUTANEOUS LIPID RICH CELLS
EP2424475A2 (en) * 2009-04-30 2012-03-07 Zeltiq Aesthetics, Inc. Device, system and method of removing heat from subcutaneous lipid-rich cells
EP2769703A3 (en) * 2009-04-30 2014-09-24 Zeltiq Aesthetics, Inc. Device and system for removing heat from subcutaneous lipid-rich cells
US20240115418A1 (en) * 2009-04-30 2024-04-11 Zeltiq Aesthetics, Inc. Device, system and method of removing heat from subcutaneous lipid-rich cells
JP2016165543A (ja) * 2009-04-30 2016-09-15 ゼルティック エステティックス インコーポレイテッド 脂肪が豊富な皮下細胞から熱を除去するためのデバイス、システム、及び方法
EP2769703A2 (en) 2009-04-30 2014-08-27 Zeltiq Aesthetics, Inc. Device and system for removing heat from subcutaneous lipid-rich cells
AU2010242785B2 (en) * 2009-04-30 2014-03-06 Zeltiq Aesthetics, Inc. Device, system and method of removing heat from subcutaneous lipid-rich cells
US8702774B2 (en) 2009-04-30 2014-04-22 Zeltiq Aesthetics, Inc. Device, system and method of removing heat from subcutaneous lipid-rich cells
WO2011091293A1 (en) * 2010-01-21 2011-07-28 Zeltiq Aesthetics, Inc. Compositions for use with a system for improved cooling of subcutaneous lipid-rich tissue
US20110300079A1 (en) * 2010-01-21 2011-12-08 Zeltiq Aesthetics, Inc. Compositions for use with a system for improved cooling of subcutaneous lipid-rich tissue
US9314368B2 (en) 2010-01-25 2016-04-19 Zeltiq Aesthetics, Inc. Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants, and associates devices, systems and methods
US9844461B2 (en) 2010-01-25 2017-12-19 Zeltiq Aesthetics, Inc. Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants
US20110190856A1 (en) * 2010-02-04 2011-08-04 FreezeAwayFat LLC Garment and Method for Treating Fatty Deposits on a Human Body
US8676338B2 (en) * 2010-07-20 2014-03-18 Zeltiq Aesthetics, Inc. Combined modality treatment systems, methods and apparatus for body contouring applications
US10092346B2 (en) 2010-07-20 2018-10-09 Zeltiq Aesthetics, Inc. Combined modality treatment systems, methods and apparatus for body contouring applications
US20120022518A1 (en) * 2010-07-20 2012-01-26 Zeltiq Aesthetics, Inc. Combined modality treatement systems, methods and apparatus for body contouring applications
US11965816B2 (en) 2010-11-16 2024-04-23 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
US11193879B2 (en) 2010-11-16 2021-12-07 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
US20120239123A1 (en) * 2011-01-25 2012-09-20 Zeltiq Aesthetics, Inc. Devices, application systems and methods with localized heat flux zones for removing heat from subcutaneous lipid-rich cells
WO2012103242A1 (en) 2011-01-25 2012-08-02 Zeltiq Aesthetics, Inc. Devices, application systems and methods with localized heat flux zones for removing heat from subcutaneous lipid-rich cells
US10722395B2 (en) * 2011-01-25 2020-07-28 Zeltiq Aesthetics, Inc. Devices, application systems and methods with localized heat flux zones for removing heat from subcutaneous lipid-rich cells
US9439805B2 (en) 2011-01-27 2016-09-13 Cryosa, Llc Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
US11419757B2 (en) 2011-01-27 2022-08-23 Cryosa, Inc. Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
US9078634B2 (en) 2011-01-27 2015-07-14 Cryosa, Llc Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
US10111774B2 (en) 2011-01-27 2018-10-30 Cryosa, Inc. Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
US20120221083A1 (en) * 2011-02-27 2012-08-30 Meliza Cruzada Treatment System by Heat Extraction and Methods of Use Thereof
US8535302B2 (en) 2011-08-01 2013-09-17 Miramar Labs, Inc. Applicator and tissue interface module for dermatological device
US9314301B2 (en) 2011-08-01 2016-04-19 Miramar Labs, Inc. Applicator and tissue interface module for dermatological device
US10321954B2 (en) 2011-08-01 2019-06-18 Miradry, Inc. Applicator and tissue interface module for dermatological device
US11123136B2 (en) 2011-08-01 2021-09-21 Miradry, Inc. Applicator and tissue interface module for dermatological device
US8469951B2 (en) 2011-08-01 2013-06-25 Miramar Labs, Inc. Applicator and tissue interface module for dermatological device
US9028477B2 (en) 2011-08-01 2015-05-12 Miramar Labs, Inc. Applicator and tissue interface module for dermatological device
US9314290B2 (en) 2012-01-13 2016-04-19 Myoscience, Inc. Cryogenic needle with freeze zone regulation
US9155584B2 (en) 2012-01-13 2015-10-13 Myoscience, Inc. Cryogenic probe filtration system
US9241753B2 (en) 2012-01-13 2016-01-26 Myoscience, Inc. Skin protection for subdermal cryogenic remodeling for cosmetic and other treatments
US10213244B2 (en) 2012-01-13 2019-02-26 Myoscience, Inc. Cryogenic needle with freeze zone regulation
US11857239B2 (en) 2012-01-13 2024-01-02 Pacira Cryotech, Inc. Cryogenic needle with freeze zone regulation
US10188444B2 (en) 2012-01-13 2019-01-29 Myoscience, Inc. Skin protection for subdermal cryogenic remodeling for cosmetic and other treatments
US9017318B2 (en) 2012-01-20 2015-04-28 Myoscience, Inc. Cryogenic probe system and method
US11382789B2 (en) 2012-06-11 2022-07-12 Rhmd Pty. Ltd. Thermal therapy system and method of use
US20130331914A1 (en) * 2012-06-11 2013-12-12 Martin Lee Thermal therapy system and method of use
WO2013191699A1 (en) * 2012-06-21 2013-12-27 Liliana Paez Cooling device for lipid-rich cell disruption
US11612758B2 (en) 2012-07-05 2023-03-28 Btl Medical Solutions A.S. Device for repetitive nerve stimulation in order to break down fat tissue means of inductive magnetic fields
EP2687174A1 (en) * 2012-07-19 2014-01-22 Jose Antonio Sanchez Jaime Head end for device for cool therapy and method for applying locally a cool therapy with the use of the head end
US20150216718A1 (en) * 2012-08-03 2015-08-06 Board Of Regents, The University Of Texas System Devices, systems and methods for thermoelectric heating and cooling of mammalian tissue
US9052129B2 (en) * 2012-11-29 2015-06-09 Luciano Faccin Charging device for cooling system
US20140144170A1 (en) * 2012-11-29 2014-05-29 Luciano Faccin Charging device for cooling system
US9545523B2 (en) 2013-03-14 2017-01-17 Zeltiq Aesthetics, Inc. Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue
US9844460B2 (en) 2013-03-14 2017-12-19 Zeltiq Aesthetics, Inc. Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same
WO2014151850A2 (en) 2013-03-14 2014-09-25 Zeltiq Aesthetics, Inc. Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue
US9668800B2 (en) 2013-03-15 2017-06-06 Myoscience, Inc. Methods and systems for treatment of spasticity
US10085881B2 (en) 2013-03-15 2018-10-02 Myoscience, Inc. Methods, systems, and devices for treating neuromas, fibromas, nerve entrapment, and/or pain associated therewith
US11865038B2 (en) 2013-03-15 2024-01-09 Pacira Cryotech, Inc. Methods, systems, and devices for treating nerve spasticity
US11253393B2 (en) 2013-03-15 2022-02-22 Pacira Cryotech, Inc. Methods, systems, and devices for treating neuromas, fibromas, nerve entrapment, and/or pain associated therewith
US9295512B2 (en) 2013-03-15 2016-03-29 Myoscience, Inc. Methods and devices for pain management
US10888366B2 (en) 2013-03-15 2021-01-12 Pacira Cryotech, Inc. Cryogenic blunt dissection methods and devices
US11134999B2 (en) 2013-03-15 2021-10-05 Pacira Cryotech, Inc. Methods and systems for treatment of occipital neuralgia
US10016229B2 (en) 2013-03-15 2018-07-10 Myoscience, Inc. Methods and systems for treatment of occipital neuralgia
US11642241B2 (en) 2013-03-15 2023-05-09 Pacira Cryotech, Inc. Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis
US10314739B2 (en) 2013-03-15 2019-06-11 Myoscience, Inc. Methods and devices for pain management
US9610112B2 (en) 2013-03-15 2017-04-04 Myoscience, Inc. Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis
US10596030B2 (en) 2013-03-15 2020-03-24 Pacira Cryotech, Inc. Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis
US10085789B2 (en) 2013-03-15 2018-10-02 Myoscience, Inc. Methods and systems for treatment of occipital neuralgia
US11512691B2 (en) 2013-07-16 2022-11-29 Abs Global, Inc. Microfluidic chip
US11187224B2 (en) 2013-07-16 2021-11-30 Abs Global, Inc. Microfluidic chip
US10779885B2 (en) 2013-07-24 2020-09-22 Miradry. Inc. Apparatus and methods for the treatment of tissue using microwave energy
US20160175193A1 (en) * 2013-08-08 2016-06-23 Classys Inc. Device for curing obesity using cooling
US10292903B2 (en) * 2013-08-08 2019-05-21 Classys Inc. Device for curing obesity using cooling
EP3031418A4 (en) * 2013-08-08 2016-09-28 Classys Inc DEVICE FOR TREATING ADIPOSITAS BY COOLING
US11415503B2 (en) 2013-10-30 2022-08-16 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
US11639888B2 (en) 2013-10-30 2023-05-02 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
US11690661B2 (en) 2013-11-05 2023-07-04 Pacira Cryotech, Inc. Secure cryosurgical treatment system
US10864033B2 (en) 2013-11-05 2020-12-15 Pacira Cryotech, Inc. Secure cryosurgical treatment system
US10130409B2 (en) 2013-11-05 2018-11-20 Myoscience, Inc. Secure cryosurgical treatment system
WO2015117036A2 (en) 2014-01-30 2015-08-06 Zeltiq Aesthetics, Inc. Treatment systems, methods, and apparatuses for improving the appearance of skin and providing for other treatments
WO2015117001A1 (en) * 2014-01-31 2015-08-06 Zeltiq Aesthetics, Inc. Compositions, treatment systems and methods for improved cooling of lipid-rich tissue
US20210282829A1 (en) * 2014-01-31 2021-09-16 Zeltiq Aesthetics, Inc. Compositions, treatment systems and methods for improved cooling of lipid-rich tissue
US10806500B2 (en) 2014-01-31 2020-10-20 Zeltiq Aesthetics, Inc. Treatment systems, methods, and apparatuses for improving the appearance of skin and providing other treatments
WO2015117005A1 (en) * 2014-01-31 2015-08-06 The General Hospital Corporation Cooling device to disrupt function sebaceous glands
US20150216816A1 (en) * 2014-01-31 2015-08-06 Zeltiq Aesthetics, Inc. Compositions, treatment systems and methods for improved cooling of lipid-rich tissue
US9861421B2 (en) * 2014-01-31 2018-01-09 Zeltiq Aesthetics, Inc. Compositions, treatment systems and methods for improved cooling of lipid-rich tissue
US10575890B2 (en) 2014-01-31 2020-03-03 Zeltiq Aesthetics, Inc. Treatment systems and methods for affecting glands and other targeted structures
US20170165105A1 (en) * 2014-01-31 2017-06-15 The General Hospital Corporation Methods, kits, and cooling devices for disrupting function of one or more sebaceous glands
US20220387091A1 (en) * 2014-01-31 2022-12-08 Zeltiq Aesthetics, Inc. Treatment systems and methods for treating cellulite and for providing other treatments
US10912599B2 (en) * 2014-01-31 2021-02-09 Zeltiq Aesthetics, Inc. Compositions, treatment systems and methods for improved cooling of lipid-rich tissue
EP4279041A3 (en) * 2014-01-31 2024-01-24 Zeltiq Aesthetics, Inc. Compositions and treatment systems for improved cooling of lipid-rich tissue
WO2015117032A1 (en) 2014-01-31 2015-08-06 Zeltiq Aesthestic, Inc. Treatment systems for treating glands by cooling
US20150216719A1 (en) * 2014-01-31 2015-08-06 Zeltiq Aesthetics, Inc Treatment systems and methods for treating cellulite and for providing other treatments
US11819257B2 (en) * 2014-01-31 2023-11-21 Zeltiq Aesthetics, Inc. Compositions, treatment systems and methods for improved cooling of lipid-rich tissue
US10201380B2 (en) 2014-01-31 2019-02-12 Zeltiq Aesthetics, Inc. Treatment systems, methods, and apparatuses for improving the appearance of skin and providing other treatments
EP4279041A2 (en) 2014-01-31 2023-11-22 Zeltiq Aesthetics, Inc. Compositions and treatment systems for improved cooling of lipid-rich tissue
US10675176B1 (en) 2014-03-19 2020-06-09 Zeltiq Aesthetics, Inc. Treatment systems, devices, and methods for cooling targeted tissue
USD777338S1 (en) 2014-03-20 2017-01-24 Zeltiq Aesthetics, Inc. Cryotherapy applicator for cooling tissue
US20200261137A1 (en) * 2014-05-12 2020-08-20 Gary Kalser Cryotherapy device with cryoprotection and methods for performing cryotherapy with cryoprotection
US10952891B1 (en) 2014-05-13 2021-03-23 Zeltiq Aesthetics, Inc. Treatment systems with adjustable gap applicators and methods for cooling tissue
US10935174B2 (en) 2014-08-19 2021-03-02 Zeltiq Aesthetics, Inc. Stress relief couplings for cryotherapy apparatuses
US10568759B2 (en) 2014-08-19 2020-02-25 Zeltiq Aesthetics, Inc. Treatment systems, small volume applicators, and methods for treating submental tissue
EP4324441A2 (en) 2014-08-19 2024-02-21 Zeltiq Aesthetics, Inc. Treatment systems and small volume applicators for treating tissue
WO2016048721A1 (en) 2014-09-25 2016-03-31 Zeltiq Aesthetics, Inc. Treatment systems, methods, and apparatuses for altering the appearance of skin
US20160089550A1 (en) * 2014-09-25 2016-03-31 Zeltiq Aesthetics, Inc. Treatment systems, methods, and apparatuses for altering the appearance of skin
US11534335B2 (en) 2014-10-01 2022-12-27 Cryosa, Inc. Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
US20170224529A1 (en) * 2014-10-15 2017-08-10 Braincool Ab Device and method for reducing the body core temperature of a patient for hypothermia treatment by cooling at least two body parts of the patient
US10959877B2 (en) * 2014-10-15 2021-03-30 Braincool Ab Device and method for reducing the body core temperature of a patient for hypothermia treatment by cooling at least two body parts of the patient
US11320361B2 (en) 2015-02-19 2022-05-03 1087 Systems, Inc. Scanning infrared measurement system
US11674882B2 (en) 2015-02-19 2023-06-13 1087 Systems, Inc. Scanning infrared measurement system
US11559421B2 (en) 2015-06-25 2023-01-24 Hill-Rom Services, Inc. Protective dressing with reusable phase-change material cooling insert
US11491342B2 (en) 2015-07-01 2022-11-08 Btl Medical Solutions A.S. Magnetic stimulation methods and devices for therapeutic treatments
US10695576B2 (en) 2015-07-01 2020-06-30 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US10821295B1 (en) 2015-07-01 2020-11-03 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US10478633B2 (en) 2015-07-01 2019-11-19 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US10709894B2 (en) 2015-07-01 2020-07-14 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US10471269B1 (en) 2015-07-01 2019-11-12 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US11253718B2 (en) 2015-07-01 2022-02-22 Btl Healthcare Technologies A.S. High power time varying magnetic field therapy
WO2017070112A1 (en) 2015-10-19 2017-04-27 Zeltiq Aesthetics, Inc. Vascular treatment systems, cooling devices, and methods for cooling vascular structures
US11154418B2 (en) * 2015-10-19 2021-10-26 Zeltiq Aesthetics, Inc. Vascular treatment systems, cooling devices, and methods for cooling vascular structures
US20170105869A1 (en) * 2015-10-19 2017-04-20 Zeltiq Aesthestics, Inc. Vascular treatment systems, cooling devices, and methods for cooling vascular structures
US11253717B2 (en) 2015-10-29 2022-02-22 Btl Healthcare Technologies A.S. Aesthetic method of biological structure treatment by magnetic field
US10524956B2 (en) * 2016-01-07 2020-01-07 Zeltiq Aesthetics, Inc. Temperature-dependent adhesion between applicator and skin during cooling of tissue
US20170239079A1 (en) * 2016-02-18 2017-08-24 Zeltiq Aesthetics, Inc. Cooling cup applicators with contoured heads and liner assemblies
US10765552B2 (en) * 2016-02-18 2020-09-08 Zeltiq Aesthetics, Inc. Cooling cup applicators with contoured heads and liner assemblies
US20210045912A1 (en) * 2016-02-18 2021-02-18 Zeltiq Aesthetics, Inc. Cooling cup applicators with contoured heads and liner assemblies
US11602629B2 (en) 2016-05-03 2023-03-14 Btl Healthcare Technologies A.S. Systems and methods for treatment of a patient including rf and electrical energy
US11247039B2 (en) 2016-05-03 2022-02-15 Btl Healthcare Technologies A.S. Device including RF source of energy and vacuum system
US11883643B2 (en) 2016-05-03 2024-01-30 Btl Healthcare Technologies A.S. Systems and methods for treatment of a patient including RF and electrical energy
US11464993B2 (en) 2016-05-03 2022-10-11 Btl Healthcare Technologies A.S. Device including RF source of energy and vacuum system
WO2017196548A1 (en) 2016-05-10 2017-11-16 Zeltiq Aesthetics, Inc. Skin freezing systems for treating acne and skin conditions
US11382790B2 (en) 2016-05-10 2022-07-12 Zeltiq Aesthetics, Inc. Skin freezing systems for treating acne and skin conditions
US11691024B2 (en) 2016-05-10 2023-07-04 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US10695575B1 (en) 2016-05-10 2020-06-30 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US10682297B2 (en) * 2016-05-10 2020-06-16 Zeltiq Aesthetics, Inc. Liposomes, emulsions, and methods for cryotherapy
US20170326042A1 (en) * 2016-05-10 2017-11-16 Zeltiq Aesthetics, Inc. Liposomes, emulsions, and methods for cryotherapy
CN109310516A (zh) * 2016-05-10 2019-02-05 斯尔替克美学股份有限公司 用于处理痤疮和皮肤状况的皮肤冷冻系统
US12109426B2 (en) 2016-05-10 2024-10-08 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US11590356B2 (en) 2016-05-10 2023-02-28 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US20240122822A1 (en) * 2016-05-10 2024-04-18 Zeltiq Aesthetics, Inc. Liposomes, emulsions, and methods for cryotherapy
US20230021151A1 (en) * 2016-05-10 2023-01-19 Zeltiq Aesthetics, Inc. Liposomes, emulsions, and methods for cryotherapy
US10555831B2 (en) * 2016-05-10 2020-02-11 Zeltiq Aesthetics, Inc. Hydrogel substances and methods of cryotherapy
US20170326346A1 (en) * 2016-05-10 2017-11-16 Zeltiq Aesthetics, Inc. Permeation enhancers and methods of cryotherapy
US10709895B2 (en) 2016-05-10 2020-07-14 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US11534619B2 (en) 2016-05-10 2022-12-27 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US11464994B2 (en) 2016-05-10 2022-10-11 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US12076069B2 (en) 2016-05-13 2024-09-03 Pacira Cryotech, Inc. Methods and systems for locating and treating nerves with cold therapy
US11311327B2 (en) 2016-05-13 2022-04-26 Pacira Cryotech, Inc. Methods and systems for locating and treating nerves with cold therapy
US11458307B2 (en) 2016-05-23 2022-10-04 Btl Healthcare Technologies A.S. Systems and methods for tissue treatment
US11185690B2 (en) 2016-05-23 2021-11-30 BTL Healthcare Technologies, a.s. Systems and methods for tissue treatment
US11878162B2 (en) 2016-05-23 2024-01-23 Btl Healthcare Technologies A.S. Systems and methods for tissue treatment
US11896821B2 (en) 2016-05-23 2024-02-13 Btl Healthcare Technologies A.S. Systems and methods for tissue treatment
US11623083B2 (en) 2016-05-23 2023-04-11 Btl Healthcare Technologies A.S. Systems and methods for tissue treatment
US11524171B2 (en) 2016-07-01 2022-12-13 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US10632321B2 (en) 2016-07-01 2020-04-28 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US12109427B2 (en) 2016-07-01 2024-10-08 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US10596386B2 (en) 2016-07-01 2020-03-24 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US11679270B2 (en) 2016-07-01 2023-06-20 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US11484727B2 (en) 2016-07-01 2022-11-01 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US11628308B2 (en) 2016-07-01 2023-04-18 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US11794029B2 (en) 2016-07-01 2023-10-24 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US11266852B2 (en) 2016-07-01 2022-03-08 Btl Healthcare Technologies A.S. Aesthetic method of biological structure treatment by magnetic field
US11607556B2 (en) 2016-07-01 2023-03-21 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US11497925B2 (en) 2016-07-01 2022-11-15 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
KR20190064609A (ko) * 2016-09-28 2019-06-10 하이 테크놀로지 프로덕츠, 에스.엘.유. 냉각 미용 치료를 위해 피부 및 조직을 보호하기 위한 장치
AU2017334051B2 (en) * 2016-09-28 2022-06-16 High Technology Products, S.l.u. Device for protecting skin and tissues for aesthetic cold treatments
WO2018060533A1 (es) * 2016-09-28 2018-04-05 High Technology Products, S.L. Dispositivo protector de la piel y tejidos para tratamientos estéticos con frío
KR102714352B1 (ko) 2016-09-28 2024-10-10 하이 테크놀로지 프로덕츠, 에스.엘.유. 냉각 미용 치료를 위해 피부 및 조직을 보호하기 위한 장치
US11890225B2 (en) 2016-11-02 2024-02-06 Miraki Innovation Think Tank Llc Devices and methods for slurry generation
US11000409B2 (en) 2016-11-02 2021-05-11 Miraki Innovation Think Tank Llc Devices and methods for slurry generation
US11324673B2 (en) 2016-11-18 2022-05-10 Miraki Innovation Think Tank Llc Cosmetic appearance of skin
FR3061012A1 (fr) * 2016-12-27 2018-06-29 Deleo Procede de reduction d'un volume graisseux sous-cutane par le froid utilisant un actif anticellulite
WO2018122535A1 (fr) * 2016-12-27 2018-07-05 Deleo Procédé de réduction d'un volume graisseux sous-cutané par le froid utilisant un actif anticellulite
WO2018175111A1 (en) 2017-03-21 2018-09-27 Zeltiq Aesthetics, Inc. Use of saccharides for cryoprotection and related technology
US20180271767A1 (en) * 2017-03-21 2018-09-27 Zeltiq Aesthetics, Inc. Use of saccharides for cryoprotection and related technology
US11439532B2 (en) 2017-04-05 2022-09-13 Miraki Innovation Think Tank Llc Point of delivery cold slurry generation
US11446178B2 (en) 2017-04-05 2022-09-20 Miraki Innovation Think Tank Llc Cold slurry containment
US11076879B2 (en) 2017-04-26 2021-08-03 Zeltiq Aesthetics, Inc. Shallow surface cryotherapy applicators and related technology
US10500342B2 (en) 2017-08-21 2019-12-10 Miraki Innovation Think Tank Llc Cold slurry syringe
US11241541B2 (en) 2017-08-21 2022-02-08 Miraki Innovation Think Tank Llc Cold slurry syringe
US11134998B2 (en) 2017-11-15 2021-10-05 Pacira Cryotech, Inc. Integrated cold therapy and electrical stimulation systems for locating and treating nerves and associated methods
US12102840B2 (en) 2017-11-21 2024-10-01 Cutera, Inc. Dermatological laser treatment systems and methods using optical parametric oscillator
US10729496B2 (en) 2017-11-21 2020-08-04 Cutera, Inc. Dermatological picosecond laser treatment systems and methods using optical parametric oscillator
US11400308B2 (en) 2017-11-21 2022-08-02 Cutera, Inc. Dermatological picosecond laser treatment systems and methods using optical parametric oscillator
US11389237B2 (en) 2017-11-21 2022-07-19 Cutera, Inc. Dermatological picosecond laser treatment systems and methods using optical parametric oscillator
US11583437B2 (en) 2018-02-06 2023-02-21 Aspen Surgical Products, Inc. Reusable warming blanket with phase change material
WO2019162539A1 (es) 2018-02-26 2019-08-29 High Technology Products, Sl Dispositivo protector de la piel y tejidos para tratamientos estéticos con frío
US11331670B2 (en) 2018-05-23 2022-05-17 Abs Global, Inc. Systems and methods for particle focusing in microchannels
US12102557B2 (en) 2018-07-31 2024-10-01 Zeltiq Aesthetics, Inc. Methods, devices, and systems for improving skin characteristics
US11446175B2 (en) 2018-07-31 2022-09-20 Zeltiq Aesthetics, Inc. Methods, devices, and systems for improving skin characteristics
US11653763B2 (en) 2019-02-14 2023-05-23 Deer Solutions LLC Athletic chair with adjustable heating and height
US11140987B2 (en) * 2019-02-14 2021-10-12 Deer Solutions LLC Athletic chair with adjustable heating and height
US11484725B2 (en) 2019-04-11 2022-11-01 Btl Medical Solutions A.S. Methods and devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy
US11247063B2 (en) 2019-04-11 2022-02-15 Btl Healthcare Technologies A.S. Methods and devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy
US12076576B2 (en) 2019-04-11 2024-09-03 Btl Medical Solutions A.S. Methods and devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy
US11889830B2 (en) 2019-04-18 2024-02-06 Abs Global, Inc. System and process for continuous addition of cryoprotectant
WO2020215011A1 (en) * 2019-04-18 2020-10-22 Abs Global, Inc. System and process for continuous addition of cryoprotectant
WO2021105929A3 (en) * 2019-11-26 2021-07-08 Amir Katz Cryotherapy skin growth removal device
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
US11826565B2 (en) 2020-05-04 2023-11-28 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
US12029905B2 (en) 2020-05-04 2024-07-09 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
US11878167B2 (en) 2020-05-04 2024-01-23 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
US11813451B2 (en) 2020-05-04 2023-11-14 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
US11806528B2 (en) 2020-05-04 2023-11-07 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
CN113827545A (zh) * 2020-06-23 2021-12-24 微创医美科技(嘉兴)有限公司 辅助冷冻溶脂的防冻液注射制剂、导液器、试剂盒及冷冻溶脂系统
US11819451B2 (en) 2020-07-10 2023-11-21 C° Change Surgical Llc Injectable slush feed supply
WO2022036271A1 (en) 2020-08-14 2022-02-17 Zeltiq Aesthetics, Inc. Multi-applicator system and method for body contouring
US12135270B2 (en) 2020-11-23 2024-11-05 Abs Global, Inc. Modular flow cytometry systems and methods of processing samples
US12064163B2 (en) 2021-10-13 2024-08-20 Btl Medical Solutions A.S. Methods and devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy
US11896816B2 (en) 2021-11-03 2024-02-13 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
US12115365B2 (en) 2021-11-03 2024-10-15 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
CN114857792A (zh) * 2022-04-21 2022-08-05 山前（珠海）医疗科技有限公司 冷冻减脂装置及其控制方法

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