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UA92761C2 - Кристаллы лаквинимода натрия и способ их изготовления - Google Patents

Кристаллы лаквинимода натрия и способ их изготовления

Info

Publication number
UA92761C2
UA92761C2 UAA200806003A UAA200806003A UA92761C2 UA 92761 C2 UA92761 C2 UA 92761C2 UA A200806003 A UAA200806003 A UA A200806003A UA A200806003 A UAA200806003 A UA A200806003A UA 92761 C2 UA92761 C2 UA 92761C2
Authority
UA
Ukraine
Prior art keywords
smarttagscrystalsof
schemas
urn
microsoft
com
Prior art date
Application number
UAA200806003A
Other languages
English (en)
Ukrainian (uk)
Inventor
Антон Френкель
Эдуард Гуревич
Авитал Лаксер
Original Assignee
Тева Фармасьютикл Индастриз, Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тева Фармасьютикл Индастриз, Лтд. filed Critical Тева Фармасьютикл Индастриз, Лтд.
Publication of UA92761C2 publication Critical patent/UA92761C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Раскрыт способ изготовления лаквинимода натрия, который удаляет примеси после этапа образования соли, что приводит к появлению кристаллов более высокой чистоты, а также к появлению кристаллов, имеющих улучшенные кристаллические характеристики.
UAA200806003A 2005-10-19 2006-10-18 Кристаллы лаквинимода натрия и способ их изготовления UA92761C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72865705P 2005-10-19 2005-10-19

Publications (1)

Publication Number Publication Date
UA92761C2 true UA92761C2 (ru) 2010-12-10

Family

ID=37963287

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200806003A UA92761C2 (ru) 2005-10-19 2006-10-18 Кристаллы лаквинимода натрия и способ их изготовления

Country Status (24)

Country Link
US (4) US7884208B2 (ru)
EP (2) EP1937642B1 (ru)
JP (3) JP5832716B2 (ru)
KR (1) KR101440982B1 (ru)
CN (3) CN107176923A (ru)
AR (1) AR056708A1 (ru)
AU (1) AU2006304672B2 (ru)
BR (1) BRPI0617477A2 (ru)
CA (1) CA2625287C (ru)
DK (1) DK1937642T3 (ru)
ES (1) ES2523762T3 (ru)
HK (1) HK1117160A1 (ru)
HR (1) HRP20141160T1 (ru)
IL (1) IL190137A (ru)
NZ (2) NZ592897A (ru)
PL (1) PL1937642T3 (ru)
PT (1) PT1937642E (ru)
RS (1) RS53666B1 (ru)
RU (1) RU2415841C2 (ru)
SG (1) SG10201508623RA (ru)
SI (1) SI1937642T1 (ru)
UA (1) UA92761C2 (ru)
WO (1) WO2007047863A2 (ru)
ZA (1) ZA200803527B (ru)

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BR112012021905A2 (pt) 2010-03-03 2015-09-29 Teva Pharma tratamento de nefrite lúpica usando laquinimod
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CN103626701A (zh) * 2012-08-28 2014-03-12 天津药物研究院 一种制备喹啉衍生物的方法
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Also Published As

Publication number Publication date
RU2415841C2 (ru) 2011-04-10
CN101291911A (zh) 2008-10-22
IL190137A0 (en) 2008-08-07
US8673322B2 (en) 2014-03-18
CN107176923A (zh) 2017-09-19
SG10201508623RA (en) 2015-11-27
CN101291911B (zh) 2014-08-13
EP1937642A2 (en) 2008-07-02
CA2625287C (en) 2016-07-26
AR056708A1 (es) 2007-10-17
ES2523762T3 (es) 2014-12-01
JP2009512708A (ja) 2009-03-26
NZ567088A (en) 2012-06-29
RS53666B1 (en) 2015-04-30
BRPI0617477A2 (pt) 2011-07-26
US20070088050A1 (en) 2007-04-19
NZ592897A (en) 2012-12-21
WO2007047863A2 (en) 2007-04-26
WO2007047863A3 (en) 2007-06-28
US20140171647A1 (en) 2014-06-19
HK1117160A1 (en) 2009-01-09
JP5832716B2 (ja) 2015-12-16
JP2016020353A (ja) 2016-02-04
US8647646B2 (en) 2014-02-11
DK1937642T3 (en) 2014-12-15
IL190137A (en) 2015-06-30
KR20080064978A (ko) 2008-07-10
PT1937642E (pt) 2014-11-25
US7884208B2 (en) 2011-02-08
ZA200803527B (en) 2009-09-30
SI1937642T1 (sl) 2015-01-30
JP2013100299A (ja) 2013-05-23
US20110112141A1 (en) 2011-05-12
AU2006304672A1 (en) 2007-04-26
AU2006304672B2 (en) 2013-01-10
EP1937642B1 (en) 2014-09-10
CA2625287A1 (en) 2007-04-26
EP1937642A4 (en) 2009-03-18
KR101440982B1 (ko) 2014-09-17
PL1937642T3 (pl) 2015-02-27
EP2687512A1 (en) 2014-01-22
CN103333107A (zh) 2013-10-02
RU2008119456A (ru) 2009-11-27
HRP20141160T1 (hr) 2015-01-16
US20110118308A1 (en) 2011-05-19

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