UA82058C2 - Замещенные производные хиназолина как ингибиторы ауроракиназы, способ их получения, фармацевтическая композиция на их основе - Google Patents
Замещенные производные хиназолина как ингибиторы ауроракиназы, способ их получения, фармацевтическая композиция на их основе Download PDFInfo
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- UA82058C2 UA82058C2 UA20040706026A UA20040706026A UA82058C2 UA 82058 C2 UA82058 C2 UA 82058C2 UA 20040706026 A UA20040706026 A UA 20040706026A UA 20040706026 A UA20040706026 A UA 20040706026A UA 82058 C2 UA82058 C2 UA 82058C2
- Authority
- UA
- Ukraine
- Prior art keywords
- amino
- methoxyquinazolin
- pyrazol
- acetamide
- hydroxyethyl
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Изобретение обеспечивает производные хиназолина формулы (І):для получения медикамента для применения при ингибировании ауроракиназы, а также новые производные хиназолина, способы их получения, фармацевтические композиции, которые их содержат, и их применение в терапии.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01403357 | 2001-12-24 | ||
| PCT/GB2002/005845 WO2003055491A1 (en) | 2001-12-24 | 2002-12-20 | Substituted quinazoline derivatives as inhibitors of aurora kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA82058C2 true UA82058C2 (ru) | 2008-03-11 |
Family
ID=8183051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20040706026A UA82058C2 (ru) | 2001-12-24 | 2002-12-20 | Замещенные производные хиназолина как ингибиторы ауроракиназы, способ их получения, фармацевтическая композиция на их основе |
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| CN (1) | CN100491372C (ru) |
| AR (1) | AR038052A1 (ru) |
| AT (1) | ATE446093T1 (ru) |
| AU (1) | AU2002353196B2 (ru) |
| BR (1) | BRPI0215312B8 (ru) |
| CA (1) | CA2471577C (ru) |
| CY (1) | CY1109681T1 (ru) |
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| ES (1) | ES2333702T3 (ru) |
| HK (1) | HK1076598A1 (ru) |
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| MX (1) | MXPA04006260A (ru) |
| MY (1) | MY141739A (ru) |
| NO (1) | NO328159B1 (ru) |
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| UA (1) | UA82058C2 (ru) |
| UY (1) | UY27604A1 (ru) |
| WO (1) | WO2003055491A1 (ru) |
| ZA (1) | ZA200404923B (ru) |
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| CN100491372C (zh) * | 2001-12-24 | 2009-05-27 | 阿斯特拉曾尼卡有限公司 | 作为欧若拉激酶抑制剂的取代喹唑啉衍生物 |
| JP4703183B2 (ja) | 2002-07-15 | 2011-06-15 | シンフォニー エボルーション， インク． | 受容体型キナーゼモジュレーターおよびその使用方法 |
| BRPI0317717B8 (pt) | 2002-12-24 | 2021-05-25 | Astrazeneca Ab | composto, composição farmacêutica, e uso de um composto |
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| TW321649B (ru) | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
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