UA81121C2 - Microcapsules for the delayed, controlled release of perindopril, use thereof for the preparation of pharmaceutical composition and pharmaceutical composition containing microcapsules - Google Patents

Microcapsules for the delayed, controlled release of perindopril, use thereof for the preparation of pharmaceutical composition and pharmaceutical composition containing microcapsules Download PDF

Info

Publication number: UA81121C2
Authority: UA; Ukraine
Prior art keywords: microcapsules; perindopril; release; differ; microcapsules according
Prior art date: 2002-06-24

Application number

UAA200500568A

Other languages

English (en)

Ukrainian (uk)

Inventor

Patrick Wuthrich

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-06-24

Filing date

2003-06-24

Publication date

2007-12-10

2003-06-24 Application filed by Servier Lab filed Critical Servier Lab

2007-12-10 Publication of UA81121C2 publication Critical patent/UA81121C2/uk

Links

239000003094 microcapsule Substances 0.000 title claims abstract description 79
IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title claims abstract description 74
229960002582 perindopril Drugs 0.000 title claims abstract description 74
230000003111 delayed effect Effects 0.000 title claims abstract description 40
238000013270 controlled release Methods 0.000 title claims abstract description 23
239000008194 pharmaceutical composition Substances 0.000 title claims description 11
238000002360 preparation method Methods 0.000 title claims description 5
238000000576 coating method Methods 0.000 claims abstract description 14
239000011248 coating agent Substances 0.000 claims abstract description 13
150000001875 compounds Chemical class 0.000 claims abstract description 13
150000003839 salts Chemical class 0.000 claims abstract description 11
229920001477 hydrophilic polymer Polymers 0.000 claims abstract description 10
230000002209 hydrophobic effect Effects 0.000 claims abstract description 10
239000011859 microparticle Substances 0.000 claims abstract description 8
239000002131 composite material Substances 0.000 claims abstract description 4
239000000203 mixture Substances 0.000 claims description 25
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 12
229920003145 methacrylic acid copolymer Polymers 0.000 claims description 11
239000007903 gelatin capsule Substances 0.000 claims description 10
230000007935 neutral effect Effects 0.000 claims description 10
208000037849 arterial hypertension Diseases 0.000 claims description 6
229920002678 cellulose Polymers 0.000 claims description 5
239000001913 cellulose Substances 0.000 claims description 5
YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical class CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 claims description 5
206010019280 Heart failures Diseases 0.000 claims description 4
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 4
239000008172 hydrogenated vegetable oil Substances 0.000 claims description 4
239000000843 powder Substances 0.000 claims description 4
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 3
239000008121 dextrose Substances 0.000 claims description 3
230000007704 transition Effects 0.000 claims description 3
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 2
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims description 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
229930006000 Sucrose Natural products 0.000 claims description 2
238000004090 dissolution Methods 0.000 claims description 2
NDDAHWYSQHTHNT-UHFFFAOYSA-N indapamide Chemical compound CC1CC2=CC=CC=C2N1NC(=O)C1=CC=C(Cl)C(S(N)(=O)=O)=C1 NDDAHWYSQHTHNT-UHFFFAOYSA-N 0.000 claims description 2
229960004569 indapamide Drugs 0.000 claims description 2
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ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 4
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102100026678 Carboxypeptidase N catalytic chain Human genes 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
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FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 2
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150000002634 lipophilic molecules Chemical class 0.000 description 2
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HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
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BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
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239000008188 pellet Substances 0.000 description 2
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238000013268 sustained release Methods 0.000 description 2
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UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 description 1
DOUBAFNWVFAWEC-UHFFFAOYSA-N 3-hydroxypropyl acetate Chemical compound CC(=O)OCCCO DOUBAFNWVFAWEC-UHFFFAOYSA-N 0.000 description 1
FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
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PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical compound CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 description 1
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DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Indole Compounds (AREA)

UAA200500568A 2002-06-24 2003-06-24 Microcapsules for the delayed, controlled release of perindopril, use thereof for the preparation of pharmaceutical composition and pharmaceutical composition containing microcapsules UA81121C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0207778A FR2841140B1 (fr)	2002-06-24	2002-06-24	Microcapsules pour la liberation retardee et controlee du perindopril
PCT/FR2003/001931 WO2004000286A1 (fr)	2002-06-24	2003-06-24	Microcapsules pour la liberation retardee et controlee du perindopril

Publications (1)

Publication Number	Publication Date
UA81121C2 true UA81121C2 (en)	2007-12-10

Family

ID=29719985

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UAA200500568A UA81121C2 (en)	2002-06-24	2003-06-24	Microcapsules for the delayed, controlled release of perindopril, use thereof for the preparation of pharmaceutical composition and pharmaceutical composition containing microcapsules

Country Status (37)

Country	Link
US (1)	US20060165808A1 (ko)
EP (1)	EP1515704B1 (ko)
JP (1)	JP4723243B2 (ko)
KR (1)	KR100722082B1 (ko)
CN (1)	CN100345541C (ko)
AP (1)	AP2029A (ko)
AR (1)	AR040461A1 (ko)
AT (1)	ATE429214T1 (ko)
AU (1)	AU2003260620B2 (ko)
BR (1)	BR0312026A (ko)
CA (1)	CA2491172C (ko)
CR (1)	CR7648A (ko)
CY (1)	CY1109154T1 (ko)
DE (1)	DE60327318D1 (ko)
DK (1)	DK1515704T3 (ko)
EA (1)	EA007571B1 (ko)
EC (1)	ECSP055570A (ko)
ES (1)	ES2326218T3 (ko)
FR (1)	FR2841140B1 (ko)
GE (1)	GEP20074212B (ko)
HR (1)	HRP20050055B1 (ko)
IL (1)	IL165896A0 (ko)
IS (1)	IS2679B (ko)
MA (1)	MA27262A1 (ko)
ME (1)	ME00452B (ko)
MX (1)	MXPA05000086A (ko)
NO (1)	NO20050163L (ko)
NZ (1)	NZ537408A (ko)
OA (1)	OA12875A (ko)
PL (1)	PL374377A1 (ko)
PT (1)	PT1515704E (ko)
RS (1)	RS50914B (ko)
SI (1)	SI1515704T1 (ko)
TN (1)	TNSN04259A1 (ko)
UA (1)	UA81121C2 (ko)
WO (1)	WO2004000286A1 (ko)
ZA (1)	ZA200410333B (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8101209B2 (en) *	2001-10-09	2012-01-24	Flamel Technologies	Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
BRPI0615607A2 (pt) *	2005-08-30	2011-05-24	Lek Pharmaceuticals	composição farmacêutica compreendendo perindopril ou seus sais
FR2891459B1 (fr) *	2005-09-30	2007-12-28	Flamel Technologies Sa	Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant
FR2897865B1 (fr) *	2006-02-28	2008-04-18	Servier Lab	Forme cristalline beta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FI125776B2 (fi)	2008-06-27	2023-07-28	Metsaeliitto Osuuskunta	Menetelmä puulevyn käsittelemiseksi
CN106983731A (zh) *	2017-04-20	2017-07-28	上药东英（江苏）药业有限公司	一种培哚普利控释片及其制备方法
DE102018123500A1 (de)	2018-09-25	2020-03-26	Man Energy Solutions Se	Vorrichtung und Verfahren zur Einstellung der Länge einer Pleuelstange eines Zylinders einer Brennkraftmaschine

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Publication number	Priority date	Publication date	Assignee	Title
DE2247186A1 (de) *	1972-09-26	1974-03-28	Bayer Ag	Antimykotisches mittel
JPS55129219A (en) *	1979-03-29	1980-10-06	Asahi Chem Ind Co Ltd	Slow-releasing preparation
EP2036558A3 (en) *	1993-10-07	2010-04-28	Euro-Celtique S.A.	Orally administrable opioid formulations having extended duration of effect
DE19724696A1 (de) *	1997-06-12	1998-12-24	Hexal Ag	Pharmazeutische Zubereitung mit drei Pelletarten
FR2771010B1 (fr) *	1997-11-19	2003-08-15	Adir	Utilisation d'une combinaison d'un inhibiteur de l'enzyme de conversion de l'angiotensine et d'un diuretique pour le traitement des desordres microcirculatoires
JPH11171769A (ja) *	1997-12-05	1999-06-29	Nichiko Pharmaceutical Co Ltd	３−イソブチリル−２−イソプロピルピラゾロ〔１，５−ａ〕ピリジンの徐放性製剤及びその製法
GB9910773D0 (en) *	1999-05-11	1999-07-07	West Pharm Serv Drug Res Ltd	Novel single unit coated dosage forms that can be used to minimise the effect of food on the absorption of drugs from the gastrointestinal tract
AU2001261434A1 (en) *	2000-05-11	2001-11-26	Pharmacia Corporation	Aldosterone antagonist composition for release during aldosterone acrophase
ATE419840T1 (de) *	2002-04-09	2009-01-15	Flamel Tech Sa	Orale wässrige suspension, mikrokapseln enthaltend, zur kontrollierten freisetzung von wirkstoffen
CN1189150C (zh) *	2002-11-07	2005-02-16	张凤英	祛斑美白面膜
CN100389300C (zh) *	2004-01-17	2008-05-21	湖北清江水布垭工程建设公司	大坝面板挠度或坝体内部变形监测方法及装置

2002
- 2002-06-24 FR FR0207778A patent/FR2841140B1/fr not_active Expired - Fee Related
2003
- 2003-06-23 AR AR20030102233A patent/AR040461A1/es not_active Application Discontinuation
- 2003-06-24 KR KR1020047021127A patent/KR100722082B1/ko not_active IP Right Cessation
- 2003-06-24 WO PCT/FR2003/001931 patent/WO2004000286A1/fr active Application Filing
- 2003-06-24 AU AU2003260620A patent/AU2003260620B2/en not_active Ceased
- 2003-06-24 AP AP2004003193A patent/AP2029A/xx active
- 2003-06-24 MX MXPA05000086A patent/MXPA05000086A/es active IP Right Grant
- 2003-06-24 DE DE60327318T patent/DE60327318D1/de not_active Expired - Lifetime
- 2003-06-24 PT PT03760778T patent/PT1515704E/pt unknown
- 2003-06-24 JP JP2004514980A patent/JP4723243B2/ja not_active Expired - Fee Related
- 2003-06-24 AT AT03760778T patent/ATE429214T1/de active
- 2003-06-24 SI SI200331594T patent/SI1515704T1/sl unknown
- 2003-06-24 CN CNB03816048XA patent/CN100345541C/zh not_active Expired - Fee Related
- 2003-06-24 CA CA2491172A patent/CA2491172C/fr not_active Expired - Fee Related
- 2003-06-24 BR BR0312026-0A patent/BR0312026A/pt not_active Application Discontinuation
- 2003-06-24 US US10/519,641 patent/US20060165808A1/en not_active Abandoned
- 2003-06-24 DK DK03760778T patent/DK1515704T3/da active
- 2003-06-24 EA EA200500030A patent/EA007571B1/ru not_active IP Right Cessation
- 2003-06-24 OA OA1200400340A patent/OA12875A/fr unknown
- 2003-06-24 NZ NZ537408A patent/NZ537408A/en not_active IP Right Cessation
- 2003-06-24 GE GEAP8594A patent/GEP20074212B/en unknown
- 2003-06-24 RS YUP-1129/04A patent/RS50914B/sr unknown
- 2003-06-24 EP EP03760778A patent/EP1515704B1/fr not_active Expired - Lifetime
- 2003-06-24 PL PL03374377A patent/PL374377A1/xx not_active Application Discontinuation
- 2003-06-24 ES ES03760778T patent/ES2326218T3/es not_active Expired - Lifetime
- 2003-06-24 UA UAA200500568A patent/UA81121C2/uk unknown
- 2003-06-24 ME MEP-2008-686A patent/ME00452B/me unknown
2004
- 2004-12-21 TN TNP2004000259A patent/TNSN04259A1/fr unknown
- 2004-12-21 IL IL16589604A patent/IL165896A0/xx unknown
- 2004-12-22 ZA ZA200410333A patent/ZA200410333B/en unknown
2005
- 2005-01-07 IS IS7634A patent/IS2679B/is unknown
- 2005-01-11 CR CR7648A patent/CR7648A/es unknown
- 2005-01-12 NO NO20050163A patent/NO20050163L/no not_active Application Discontinuation
- 2005-01-19 MA MA28056A patent/MA27262A1/fr unknown
- 2005-01-19 HR HRP20050055AA patent/HRP20050055B1/hr not_active IP Right Cessation
- 2005-01-24 EC EC2005005570A patent/ECSP055570A/es unknown
2009
- 2009-06-15 CY CY20091100632T patent/CY1109154T1/el unknown

Also Published As

Publication number	Publication date
DK1515704T3 (da)	2009-07-20
ECSP055570A (es)	2006-04-19
RS112904A (en)	2007-02-05
ZA200410333B (en)	2006-07-26
KR100722082B1 (ko)	2007-05-25
IS2679B (is)	2010-09-15
DE60327318D1 (de)	2009-06-04
RS50914B (sr)	2010-08-31
MA27262A1 (fr)	2005-03-01
HRP20050055A2 (en)	2005-02-28
CN1665491A (zh)	2005-09-07
JP2005533079A (ja)	2005-11-04
FR2841140A1 (fr)	2003-12-26
CR7648A (es)	2005-07-18
IS7634A (is)	2005-01-07
WO2004000286A1 (fr)	2003-12-31
CA2491172C (fr)	2011-02-15
OA12875A (en)	2006-09-15
PT1515704E (pt)	2009-05-20
MXPA05000086A (es)	2005-04-08
AP2004003193A0 (en)	2004-12-31
FR2841140B1 (fr)	2004-10-01
IL165896A0 (en)	2006-01-15
AR040461A1 (es)	2005-04-06
AU2003260620A1 (en)	2004-01-06
AU2003260620B2 (en)	2008-07-31
JP4723243B2 (ja)	2011-07-13
ATE429214T1 (de)	2009-05-15
CN100345541C (zh)	2007-10-31
HRP20050055B1 (hr)	2013-11-08
NZ537408A (en)	2006-07-28
EP1515704B1 (fr)	2009-04-22
SI1515704T1 (sl)	2009-08-31
EA007571B1 (ru)	2006-12-29
CA2491172A1 (fr)	2003-12-31
TNSN04259A1 (fr)	2007-03-12
ME00452B (me)	2011-10-10
NO20050163L (no)	2005-01-12
US20060165808A1 (en)	2006-07-27
CY1109154T1 (el)	2014-07-02
PL374377A1 (en)	2005-10-17
BR0312026A (pt)	2005-03-22
ES2326218T3 (es)	2009-10-05
GEP20074212B (en)	2007-10-10
KR20050023337A (ko)	2005-03-09
EP1515704A1 (fr)	2005-03-23
AP2029A (en)	2009-08-24
EA200500030A1 (ru)	2005-06-30

Publication	Publication Date	Title
USRE47084E1 (en)	2018-10-16	Oral medicinal product with modified release of at least one active principle in multimicrocapsular form
JP5619342B2 (ja)	2014-11-05	少なくとも１つの有効成分の放出を改変するためのマルチマイクロカプセル形態の経口医薬
EP1123087B1 (en)	2009-04-01	Oral pulsed dose drug delivery system
US20120128764A1 (en)	2012-05-24	Controlled-release compositions comprising a proton pump inhibitor
MXPA04003367A (es)	2005-01-25	Formulacion oral microparticulada galenica para la liberacion retrasada y controlada de principios activos farmaceuticos.
JP5687185B2 (ja)	2015-03-18	多粒子系を含む二段階の放出プロフィールを有する固形経口剤
US7108866B1 (en)	2006-09-19	Chronotherapeutic diltiazem formulations and the administration thereof
UA81121C2 (en)	2007-12-10	Microcapsules for the delayed, controlled release of perindopril, use thereof for the preparation of pharmaceutical composition and pharmaceutical composition containing microcapsules
JPH05139964A (ja)	1993-06-08	塩酸メキシレチン腸溶性製剤
CA2307547C (en)	2007-08-14	Chronotherapeutic diltiazem formulations and the administration thereof
AU2004200325B2 (en)	2006-09-28	Oral Pulsed Dose Drug Delivery System
US20060153914A1 (en)	2006-07-13	Chronotherapeutic diltiazem formulations and the administration thereof
CA2292247A1 (en)	2001-06-10	Chronotherapeutic formulations of diltiazem and the administration thereof
KR20070017585A (ko)	2007-02-12	페린도프릴의 지연 조절 방출을 위한 마이크로캡슐