UA73787C2 - Cyclopentanoindoles, composition containing them and methods for the treatment of prostaglandin mediated diseases - Google Patents

Cyclopentanoindoles, composition containing them and methods for the treatment of prostaglandin mediated diseases Download PDF

Info

Publication number: UA73787C2
Authority: UA; Ukraine
Prior art keywords: optionally substituted; alkyl; halogen; groups; formula
Prior art date: 2000-07-25

Application number

UA2003021565A

Other languages

English (en)

Ukrainian (uk)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-25

Filing date

2001-07-23

Publication date

2005-09-15

2001-07-23 Application filed filed Critical

2005-09-15 Publication of UA73787C2 publication Critical patent/UA73787C2/uk

Links

208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 36
150000003180 prostaglandins Chemical class 0.000 title claims abstract description 31
201000010099 disease Diseases 0.000 title claims abstract description 29
230000001404 mediated effect Effects 0.000 title claims abstract description 23
238000000034 method Methods 0.000 title claims description 49
239000000203 mixture Substances 0.000 title description 39
229940094443 oxytocics prostaglandins Drugs 0.000 claims abstract description 5
150000001875 compounds Chemical class 0.000 claims description 134
150000002367 halogens Chemical class 0.000 claims description 53
229910052736 halogen Inorganic materials 0.000 claims description 51
125000000217 alkyl group Chemical group 0.000 claims description 42
-1 (2) CM Chemical class 0.000 claims description 34
125000003118 aryl group Chemical group 0.000 claims description 24
125000001072 heteroaryl group Chemical group 0.000 claims description 21
229910052739 hydrogen Inorganic materials 0.000 claims description 21
150000003839 salts Chemical class 0.000 claims description 21
150000002148 esters Chemical class 0.000 claims description 17
239000001257 hydrogen Substances 0.000 claims description 17
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208000006673 asthma Diseases 0.000 claims description 13
125000005842 heteroatom Chemical group 0.000 claims description 13
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 12
229910052799 carbon Inorganic materials 0.000 claims description 12
125000000623 heterocyclic group Chemical group 0.000 claims description 11
206010028748 Nasal obstruction Diseases 0.000 claims description 10
125000004432 carbon atom Chemical group C* 0.000 claims description 10
125000005843 halogen group Chemical group 0.000 claims description 10
125000000896 monocarboxylic acid group Chemical group 0.000 claims description 9
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125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000005247 tetrazinyl group Chemical group N1=NN=NC(=C1)* 0.000 description 1
229960004559 theobromine Drugs 0.000 description 1
238000011287 therapeutic dose Methods 0.000 description 1
125000000335 thiazolyl group Chemical group 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
DBDCNCCRPKTRSD-UHFFFAOYSA-N thieno[3,2-b]pyridine Chemical compound C1=CC=C2SC=CC2=N1 DBDCNCCRPKTRSD-UHFFFAOYSA-N 0.000 description 1
229940125670 thienopyridine Drugs 0.000 description 1
239000002175 thienopyridine Substances 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
229960001312 tiaprofenic acid Drugs 0.000 description 1
229960000257 tiotropium bromide Drugs 0.000 description 1
229960002905 tolfenamic acid Drugs 0.000 description 1
YEZNLOUZAIOMLT-UHFFFAOYSA-N tolfenamic acid Chemical compound CC1=C(Cl)C=CC=C1NC1=CC=CC=C1C(O)=O YEZNLOUZAIOMLT-UHFFFAOYSA-N 0.000 description 1
229960001017 tolmetin Drugs 0.000 description 1
UPSPUYADGBWSHF-UHFFFAOYSA-N tolmetin Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC=C(CC(O)=O)N1C UPSPUYADGBWSHF-UHFFFAOYSA-N 0.000 description 1
239000012049 topical pharmaceutical composition Substances 0.000 description 1
210000003437 trachea Anatomy 0.000 description 1
LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 description 1
229960002117 triamcinolone acetonide Drugs 0.000 description 1
125000004306 triazinyl group Chemical group 0.000 description 1
125000001425 triazolyl group Chemical group 0.000 description 1
QIWRFOJWQSSRJZ-UHFFFAOYSA-N tributyl(ethenyl)stannane Chemical compound CCCC[Sn](CCCC)(CCCC)C=C QIWRFOJWQSSRJZ-UHFFFAOYSA-N 0.000 description 1
125000002889 tridecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
YOIAWAIKYVEKMF-UHFFFAOYSA-N trifluoromethanesulfonic acid Chemical compound OS(=O)(=O)C(F)(F)F.OS(=O)(=O)C(F)(F)F YOIAWAIKYVEKMF-UHFFFAOYSA-N 0.000 description 1
229960003223 tripelennamine Drugs 0.000 description 1
229960001128 triprolidine Drugs 0.000 description 1
CBEQULMOCCWAQT-WOJGMQOQSA-N triprolidine Chemical compound C1=CC(C)=CC=C1C(\C=1N=CC=CC=1)=C/CN1CCCC1 CBEQULMOCCWAQT-WOJGMQOQSA-N 0.000 description 1
YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
238000001665 trituration Methods 0.000 description 1
229960001641 troglitazone Drugs 0.000 description 1
GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 1
GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 description 1
229960000281 trometamol Drugs 0.000 description 1
230000005747 tumor angiogenesis Effects 0.000 description 1
230000004614 tumor growth Effects 0.000 description 1
125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
229960002004 valdecoxib Drugs 0.000 description 1
208000021331 vascular occlusion disease Diseases 0.000 description 1
230000036642 wellbeing Effects 0.000 description 1
229960000833 xylometazoline Drugs 0.000 description 1
229960004764 zafirlukast Drugs 0.000 description 1
229960003414 zomepirac Drugs 0.000 description 1
ZXVNMYWKKDOREA-UHFFFAOYSA-N zomepirac Chemical compound C1=C(CC(O)=O)N(C)C(C(=O)C=2C=CC(Cl)=CC=2)=C1C ZXVNMYWKKDOREA-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04W—WIRELESS COMMUNICATION NETWORKS
- H04W52/00—Power management, e.g. TPC [Transmission Power Control], power saving or power classes
- H04W52/04—TPC
- H04W52/38—TPC being performed in particular situations
- H04W52/46—TPC being performed in particular situations in multi hop networks, e.g. wireless relay networks
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04B—TRANSMISSION
- H04B17/00—Monitoring; Testing
- H04B17/30—Monitoring; Testing of propagation channels
- H04B17/309—Measuring or estimating channel quality parameters
- H04B17/318—Received signal strength
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04W—WIRELESS COMMUNICATION NETWORKS
- H04W48/00—Access restriction; Network selection; Access point selection
- H04W48/02—Access restriction performed under specific conditions
- H04W48/04—Access restriction performed under specific conditions based on user or terminal location or mobility data, e.g. moving direction, speed
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04W—WIRELESS COMMUNICATION NETWORKS
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- H04W52/04—TPC
- H04W52/06—TPC algorithms
- H04W52/14—Separate analysis of uplink or downlink
- H04W52/146—Uplink power control
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04W—WIRELESS COMMUNICATION NETWORKS
- H04W52/00—Power management, e.g. TPC [Transmission Power Control], power saving or power classes
- H04W52/04—TPC
- H04W52/18—TPC being performed according to specific parameters
- H04W52/24—TPC being performed according to specific parameters using SIR [Signal to Interference Ratio] or other wireless path parameters
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04W—WIRELESS COMMUNICATION NETWORKS
- H04W52/00—Power management, e.g. TPC [Transmission Power Control], power saving or power classes
- H04W52/04—TPC
- H04W52/18—TPC being performed according to specific parameters
- H04W52/28—TPC being performed according to specific parameters using user profile, e.g. mobile speed, priority or network state, e.g. standby, idle or non transmission
- H04W52/288—TPC being performed according to specific parameters using user profile, e.g. mobile speed, priority or network state, e.g. standby, idle or non transmission taking into account the usage mode, e.g. hands-free, data transmission, telephone
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04W—WIRELESS COMMUNICATION NETWORKS
- H04W48/00—Access restriction; Network selection; Access point selection
- H04W48/20—Selecting an access point
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04W—WIRELESS COMMUNICATION NETWORKS
- H04W52/00—Power management, e.g. TPC [Transmission Power Control], power saving or power classes
- H04W52/04—TPC
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04W—WIRELESS COMMUNICATION NETWORKS
- H04W52/00—Power management, e.g. TPC [Transmission Power Control], power saving or power classes
- H04W52/04—TPC
- H04W52/18—TPC being performed according to specific parameters
- H04W52/24—TPC being performed according to specific parameters using SIR [Signal to Interference Ratio] or other wireless path parameters
- H04W52/245—TPC being performed according to specific parameters using SIR [Signal to Interference Ratio] or other wireless path parameters taking into account received signal strength
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04W—WIRELESS COMMUNICATION NETWORKS
- H04W52/00—Power management, e.g. TPC [Transmission Power Control], power saving or power classes
- H04W52/04—TPC
- H04W52/18—TPC being performed according to specific parameters
- H04W52/24—TPC being performed according to specific parameters using SIR [Signal to Interference Ratio] or other wireless path parameters
- H04W52/247—TPC being performed according to specific parameters using SIR [Signal to Interference Ratio] or other wireless path parameters where the output power of a terminal is based on a path parameter sent by another terminal

Landscapes

Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Signal Processing (AREA)
Computer Networks & Wireless Communication (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pulmonology (AREA)
Quality & Reliability (AREA)
Physics & Mathematics (AREA)
Electromagnetism (AREA)
Computer Security & Cryptography (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Steroid Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Materials For Photolithography (AREA)

UA2003021565A 2000-07-25 2001-07-23 Cyclopentanoindoles, composition containing them and methods for the treatment of prostaglandin mediated diseases UA73787C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US22068300P	2000-07-25	2000-07-25
PCT/CA2001/001069 WO2002008186A2 (fr)	2000-07-25	2001-07-23	Cyclopentanoindoles, compositions contenant de tels composes et procedes de traitement

Publications (1)

Publication Number	Publication Date
UA73787C2 true UA73787C2 (en)	2005-09-15

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UA2003021565A UA73787C2 (en)	2000-07-25	2001-07-23	Cyclopentanoindoles, composition containing them and methods for the treatment of prostaglandin mediated diseases

Country Status (34)

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US (1)	US6410583B1 (fr)
EP (1)	EP1305286B1 (fr)
JP (1)	JP4119745B2 (fr)
KR (1)	KR100746814B1 (fr)
CN (1)	CN1214007C (fr)
AT (1)	ATE284388T1 (fr)
AU (2)	AU2001277430B2 (fr)
BG (1)	BG66084B1 (fr)
BR (1)	BR0112756A (fr)
CA (1)	CA2416867C (fr)
CZ (1)	CZ2003236A3 (fr)
DE (1)	DE60107687T2 (fr)
DK (1)	DK1305286T3 (fr)
DZ (1)	DZ3402A1 (fr)
EA (1)	EA006765B1 (fr)
EC (1)	ECSP034428A (fr)
EE (1)	EE05287B1 (fr)
ES (1)	ES2231526T3 (fr)
GE (1)	GEP20053595B (fr)
HK (1)	HK1058934A1 (fr)
HR (1)	HRP20021039B1 (fr)
HU (1)	HUP0301745A3 (fr)
IL (2)	IL153406A0 (fr)
IS (1)	IS2170B (fr)
MX (1)	MXPA03000710A (fr)
NO (1)	NO325011B1 (fr)
NZ (1)	NZ523106A (fr)
PL (1)	PL207342B1 (fr)
PT (1)	PT1305286E (fr)
RS (1)	RS50491B (fr)
SK (1)	SK287507B6 (fr)
UA (1)	UA73787C2 (fr)
WO (1)	WO2002008186A2 (fr)
ZA (1)	ZA200300554B (fr)

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Also Published As

Publication number	Publication date
NO20030374D0 (no)	2003-01-24
IL153406A (en)	2008-03-20
ZA200300554B (en)	2004-04-23
PT1305286E (pt)	2005-04-29
HUP0301745A3 (en)	2010-03-29
DE60107687T2 (de)	2005-12-01
YU97902A (sh)	2006-05-25
PL207342B1 (pl)	2010-12-31
BG66084B1 (bg)	2011-03-31
AU2001277430B2 (en)	2006-05-25
CA2416867A1 (fr)	2002-01-31
HRP20021039A2 (en)	2004-10-31
DK1305286T3 (da)	2005-03-14
HRP20021039B1 (en)	2011-03-31
CN1443165A (zh)	2003-09-17
JP4119745B2 (ja)	2008-07-16
BG107438A (bg)	2003-09-30
US6410583B1 (en)	2002-06-25
AU7743001A (en)	2002-02-05
NO20030374L (no)	2003-01-24
DE60107687D1 (de)	2005-01-13
EA200300171A1 (ru)	2003-06-26
SK932003A3 (en)	2003-06-03
NZ523106A (en)	2005-01-28
BR0112756A (pt)	2003-06-24
CA2416867C (fr)	2008-03-25
ECSP034428A (es)	2003-03-10
WO2002008186A2 (fr)	2002-01-31
GEP20053595B (en)	2005-08-10
RS50491B (sr)	2010-03-02
PL363168A1 (en)	2004-11-15
DZ3402A1 (fr)	2002-01-31
EP1305286A2 (fr)	2003-05-02
IL153406A0 (en)	2003-07-06
IS2170B (is)	2006-11-15
CZ2003236A3 (cs)	2003-05-14
KR20030024810A (ko)	2003-03-26
EE200300033A (et)	2004-10-15
HUP0301745A2 (hu)	2003-09-29
SK287507B6 (sk)	2010-12-07
EP1305286B1 (fr)	2004-12-08
NO325011B1 (no)	2008-01-14
HK1058934A1 (en)	2004-06-11
JP2004504380A (ja)	2004-02-12
EA006765B1 (ru)	2006-04-28
ATE284388T1 (de)	2004-12-15
KR100746814B1 (ko)	2007-08-06
EE05287B1 (et)	2010-04-15
WO2002008186A3 (fr)	2002-03-21
MXPA03000710A (es)	2003-06-04
IS6655A (is)	2002-12-12
CN1214007C (zh)	2005-08-10
ES2231526T3 (es)	2005-05-16

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