TWI801711B - Composition for restoring the skin barrier and use thereof - Google Patents

Abstract

A composition for restoring the skin barrier is provided. The composition includes a Ganoderma extract and an ion regulator, wherein the ion regulator comprises calcium ion, magnesium ion, sodium, potassium ion and chloride ion. A use of the composition is also provided. The composition is for the manufacture of a medicament for the treatment of skin disease, or skin discomfort or abnormal symptoms caused by disease.

Description

Composition for repairing skin barrier and use thereof

The present invention relates to a composition for repairing skin barrier and its use, and in particular to a composition for repairing skin barrier with Ganoderma lucidum extract and ion regulator and its use.

The skin is the largest known organ in the human body. The importance of the skin is to isolate the moisture-rich internal organs from the external dry environment. The skin has a barrier function, and the barrier function is provided by the stratum corneum (approximately 10 microns to 20 microns for humans) located on the uppermost layer of the skin. The normal skin barrier function can prevent external stimuli from invading the skin and the skin moisture is not easy to lose.

The stratum corneum is the outermost layer of the skin epidermis and consists mainly of 15 to 20 layers of dead cells without nuclei. When these cells are shed, the underlying cells in the basal layer are pushed up to form a new stratum corneum. The stratum corneum is composed of two components: protein-rich inactive keratinocytes and an intercellular matrix composed of lipids. Keratinocytes and lipids The combination of them forms a specific "brick and mud" structure, which makes the cuticle highly impermeable.

The ion concentration in the skin plays an important role in the function of the barrier. Calcium ions are important messengers in the cell's message transmission system, and most cells have special receptors that accept calcium ions. In the skin, calcium ions can provide intracellular or extracellular signals to cells. It has been found that the concentration of intracellular calcium ions increases with the increase of the concentration of extracellular calcium ions, and the increase of intracellular calcium ions is a signal to stimulate keratinocyte differentiation. In keratinocytes, the extracellular content is normally in balance with the intracellular concentration. In addition, calcium ions participate in the differentiation of keratinocytes and also help keratinocytes secrete lipids.

In normal skin, calcium ions are localized at high concentrations in the granular layer of the epidermis below the stratum corneum, and there is a concentration gradient of calcium ions in the epidermis. The calcium ion content of the upper epidermis is higher than that of the lower epidermis, that is, it increases steadily from the basal layer to the stratum corneum, forming an inverted trapezoidal concentration distribution, while other ions do not. However, when the skin is under pathological conditions, the concentration distribution of calcium ions in the epidermis will change, that is, the concentration gradient of calcium ions is no longer distributed in an inverted trapezoid as in healthy skin.

Ganoderma Extract can promote cell regeneration and help wound healing. Ganoderma lucidum extract restores wounds through the following four mechanisms: (1) Ganoderma lucidum extract can significantly promote the proliferation of fibroblast cells and keratinocytes, and at the same time increase the ability of fibroblast cell migration to accelerate wound healing Efficacy; (2) Ganoderma lucidum extract can effectively reduce the activity of Matrix metalloproteinase MMP-9, reduce the excessive decomposition of cell matrix in the tissue around the wound, and then achieve the effect of helping tissue reconstruction and shortening the wound inflammation period; (3) Ganoderma lucidum extract can effectively inhibit the activity of proteases, causing bacteria to die due to lack of nutrients; by inhibiting the growth of bacteria on the skin surface, it can naturally inhibit inflammation; (4) Ganoderma lucidum cell wall extract is mainly composed of 50-60 % polysaccharides (polysaccharides) and 40-50% chitin (chitin), these two ingredients are known to have excellent moisturizing activity, which can provide the moisturizing environment required for wound healing, thereby accelerating wound repair.

However, although Ganoderma lucidum extract alone can promote skin keratinocyte proliferation and restore wound healing, it cannot restore the inverted trapezoidal distribution of calcium ion concentration gradient in healthy skin, resulting in the failure of the skin barrier to function normally. If the external stimulus invades the skin cells, the water will be easily lost, and the cells will be prone to inflammation after being stimulated.

In view of this, how to develop a composition that promotes the proliferation of skin keratinocytes and restores the inverted trapezoidal distribution of the calcium ion concentration gradient in the skin to repair the skin barrier, the prior art needs to be improved.

The object of the present invention is to provide a composition for repairing the skin barrier, which can not only promote the proliferation of skin keratinocytes, but also provide an appropriate ion environment in the skin, so as to restore the inverted trapezoidal distribution of the calcium ion concentration gradient in the skin and restore the skin. The efficacy of the barrier.

The present invention provides a composition for repairing the skin barrier, comprising: Ganoderma lucidum extract; and an ion regulator, comprising calcium ions, magnesium ions, sodium ions, potassium ions and chloride ions, wherein the total weight of the composition is based on 100%, the weight percentage of Ganoderma lucidum extract is 0.0000072% to 0.11%, the weight percentage of calcium ions is 0.0001244% to 0.04998%, and the weight percentage of magnesium ions is 0.0000412% to 0.03157%, the weight percentage of sodium ions is 0.0002133% to 0.09114%, the weight percentage of potassium ions is 0.0000875% to 0.03301%, and the weight percentage of chloride ions is 0.0004754% to 0.16639%.

In some embodiments, the Ganoderma lucidum extract comprises a copolymer of dextran comprising α-glucan, β-glucan or a combination thereof and glucosamine comprising N-acetylglucosamine ( N -Acetylglucosamine, GlcNAc), N-acetylmuramic acid (N-Acetylmuramic acid, MurNAc) or a combination thereof.

In some embodiments, the Ganoderma lucidum extract comprises micron-scale Ganoderma lucidum extract or nano-scale Ganoderma lucidum extract, wherein the weight percentage of the micron-scale Ganoderma lucidum extract is 0.0000072% to 0.088%, and the weight percentage of the nano-scale Ganoderma lucidum extract is The weight percentage is 0.00018% to 0.11%.

In some embodiments, the composition further comprises lipid, and the weight percentage of lipid is 0.001% to 40%.

In some embodiments, the composition further comprises lipid, and the weight percentage of lipid is 0.001% to 15%.

In some embodiments, the lipid comprises ceramides, glycerides, cholesterol, free fatty acids, or combinations thereof.

In some embodiments, the ceramide comprises ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide 7, ceramide 8, Ceramide 9, or a combination thereof.

In some embodiments, the composition is used for treating skin diseases or improving skin discomfort or abnormal symptoms caused by diseases. Skin diseases include atopic dermatitis, seborrhoeic dermatitis, Contact dermatitis, lupus erythematosus, lichen planus, urticaria, keratosis, acne, psoriasis, or ichthyosis Disease (ichthyosis).

In some embodiments, the composition is in the form of a lotion, serum, lotion, makeup remover, mask, wipe, lotion, cream, ointment, or gel. Wherein, the liquid formulation may be, for example, lotion.

In some embodiments, the composition further comprises a cosmetically acceptable carrier.

In some embodiments, the cosmetically acceptable carrier comprises solvents, emollients, humectants, emulsifiers, thickeners, antioxidants, preservatives, or combinations thereof.

In some embodiments, the weight percentage of emollient is 7% to 22%; the weight percentage of humectant is 4% to 12%; the weight percentage of emulsifier is 2% to 6.5%; the weight percentage of thickener is 0.3% to 1%; antioxidants 0.2% to 0.8% by weight; and preservatives 0.0004% to 0.002% by weight.

In some embodiments, the weight percentage of emollient is 2% to 30%; the weight percentage of humectant is 0.1% to 20%; the weight percentage of emulsifier is 0.1% to 10%; the weight percentage of thickener is 0.1% to 5%; antioxidants 0.01% to 5% by weight; and preservatives 0.0004% to 5% by weight.

In some embodiments, the composition further comprises a pharmaceutically acceptable carrier.

The present invention also provides the use of a composition for preparing preparations for treating skin diseases or improving skin discomfort or abnormal symptoms caused by diseases, wherein the composition is as described above.

In some embodiments, the skin disease comprises atopic dermatitis, seborrheic dermatitis, contact dermatitis, lupus erythematosus, lichen planus, urticaria, keratosis, acne, psoriasis, or ichthyosis.

The present invention also provides the use of a composition, which is used to prepare preparations for treating skin diseases or improving skin discomfort or abnormal symptoms caused by diseases, wherein the composition is as described above, wherein the composition is administered daily at least once.

In some embodiments, the recovery rate of the skin disease or skin discomfort or abnormal symptoms caused by the disease is increased by 10% or more compared with the control group when the composition is administered for two days.

As mentioned above, in the composition of the present invention, the Ganoderma lucidum extract in the composition promotes cell regeneration and accelerates the proliferation of skin keratinocytes. Then use the ion combination in a specific ratio in the ion regulator to restore the inverted trapezoidal distribution of the calcium ion concentration gradient in the epidermal layer of the skin to provide a suitable environment for the growth of keratinocytes. environment. Finally, the combination of ions in a specific ratio can sustainably maintain the inverted trapezoidal distribution of the calcium ion concentration gradient of the skin barrier layer and maintain the function of the new skin barrier. Repairing the skin barrier by the composition of the present invention can prevent external stimuli from invading the skin and losing water in the skin, and prevent the skin from being irritated by external stimuli and causing discomfort such as redness, swelling, and heat. Secondly, the composition of the present invention can also be used on the skin under pathological conditions to treat or improve skin discomfort or abnormal symptoms by repairing the skin barrier, including skin itching symptoms of kidney dialysis patients.

In order to make the above and other objects, features, advantages and embodiments of the present invention more clearly understood, the accompanying drawings are described as follows:

Figure 1 shows a histogram of the transdermal water loss of each group on day 2 according to an embodiment of the present disclosure.

Figure 2 depicts a histogram of Day 2 recovery rates for each group according to one embodiment of the present disclosure.

In order to make the description of the present invention more detailed and complete, the implementation modes and specific examples of the present invention are described in detail below; but this is not the only form for implementing or using the specific embodiments of the present invention. The various embodiments disclosed below can be combined or replaced with each other when beneficial, and other embodiments can also be added to one embodiment, without further description or illustration.

As used herein, "comprises", "comprises", "has" and similar words indicate the features, regions, integers, steps, operations, elements and/or components described therein, but do not exclude other features and regions , integers, steps, operations, elements, components, and/or groups thereof.

The invention provides a composition for repairing the skin barrier, comprising: ganoderma lucidum extract and an ion regulator; the ion regulator includes calcium ions, magnesium ions, sodium ions, potassium ions and chloride ions.

In some embodiments, the Ganoderma lucidum extract comprises a copolymer of dextran comprising α-glucan, β-glucan or a combination thereof and glucosamine comprising N-acetylglucosamine , N-acetylmuramic acid, or a combination thereof. In some embodiments, the alpha-glucan comprises alpha-1,4-glucan, alpha-1,6-glucan or a combination thereof, the beta-glucan comprises beta-1,3-D-glucan Glycans, beta-1,4-D-glucans, beta-1,6-D-glucans, or combinations thereof.

In some embodiments, the total weight of the composition is based on 100%, the weight percentage of Ganoderma lucidum extract is 0.0000072% to 0.11%, the weight percentage of calcium ion is 0.0001244% to 0.04998%, and the weight percentage of magnesium ion is 0.0000412% to 0.03157%, the weight percentage of sodium ions is 0.0002133% to 0.09114%, the weight percentage of potassium ions is 0.0000875% to 0.03301%, and the weight percentage of chloride ions is 0.0004754% to 0.16639%.

In one embodiment, the Ganoderma lucidum extract is Ganoderma lucidum cell wall extract. Ganoderma lucidum includes fungi under the genus Ganoderma ( Ganoderma ), such as Ganoderma lucidum or Ganoderma Tsugae . According to the size of the fiber, Ganoderma lucidum extract can be micron scale Ganoderma lucidum extract, or nano scale Ganoderma lucidum extract. In some embodiments, based on 100% of the total weight of the composition, the weight percentage of the micron-sized Ganoderma lucidum extract may be 0.0000072% to 0.088%. In some embodiments, the total weight of the composition is based on 100%, and the weight percentage of the nanoscale Ganoderma lucidum extract is 0.00018% to 0.11%.

In one embodiment, the weight percentage of Ganoderma lucidum extract is 0.02%, the weight percentage of calcium ions is 0.0469%, the weight percentage of magnesium ions is 0.02296%, the weight percentage of sodium ions is 0.08225%, and the weight percentage of potassium ions is 0.0315% %, and the percentage by weight of chloride ions is 0.16639%.

In some embodiments, the composition for repairing the skin barrier is in the form of a liquid, serum, lotion, makeup remover, mask, wipe, lotion, cream, ointment, or gel.

In some embodiments, the composition for repairing the skin barrier further comprises a cosmetically acceptable carrier, and the carrier includes solvents, emollients, moisturizers, emulsifiers, thickeners, antioxidants, preservatives or combinations thereof .

In one embodiment, the solvent includes, but is not limited to water.

In some embodiments, the total weight of the composition is 100%, and the emollient is present in an amount of 7% to 22% by weight.

In some embodiments, the total weight of the composition is 100%, and the emollient is present in an amount of 2% to 30% by weight. In one embodiment, emollients include, but are not limited to, Caprylic Triglyceride, Capric Triglyceride, Isononyl Isononanoate Isononanoate), Polybutene, Cyclopentasiloxane, Dodecene, or a combination thereof.

In some embodiments, based on 100% of the total weight of the composition, the weight percentage of the moisturizer is 4% to 12%.

In some embodiments, based on 100% of the total weight of the composition, the weight percentage of the moisturizing agent is 0.1% to 20%. In one embodiment, humectants include, but are not limited to, glycerin (Glycerin), 1,2-hexanediol (1,2-Hexanediol), mannitol (Mannitol), 1,3-propanediol (Propanediol), ethanol Ethylhexylglycerin or combinations thereof.

In some embodiments, based on 100% of the total weight of the composition, the weight percentage of the emulsifier is 2% to 6.5%.

In some embodiments, based on 100% of the total weight of the composition, the weight percentage of the emulsifier is 0.1% to 10%. In one embodiment, emulsifiers include, but are not limited to, lauryl methicone (e.g., lauryl PEG/PPG-18/18 methicone, Lauryl PEG/PPG-18/18 Methicone), Isostearyl Alcohol, Sodium Lauroyl Lactylate, or a combination thereof.

In some embodiments, based on 100% of the total weight of the composition, the weight percentage of the thickener is 0.3% to 1%.

In some embodiments, based on 100% of the total weight of the composition, the weight percentage of the thickener is 0.1% to 5%. In one embodiment, increasing Thickeners include, but are not limited to, Hydroxyethylcellulose, Dimethicone Crosspolymer, Xanthan Gum, Carbomer, or combinations thereof .

In some embodiments, based on 100% of the total weight of the composition, the weight percentage of the antioxidant is 0.2% to 0.8%.

In some embodiments, based on 100% of the total weight of the composition, the weight percentage of the antioxidant is 0.01% to 5%. In one embodiment, antioxidants include, but are not limited to, Hydroxyacetophenone or Tocopheryl Acetate.

In some embodiments, based on 100% of the total weight of the composition, the weight percentage of the preservative is 0.0004% to 0.002%.

In some embodiments, based on 100% of the total weight of the composition, the weight percentage of the preservative is 0.0004% to 5%. In one embodiment, preservatives include, but are not limited to, phenoxyethanol (Phenoxyethanol).

In some embodiments, the composition for repairing the skin barrier further includes a pharmaceutically acceptable carrier.

The present invention also provides the use of a composition for repairing the skin barrier, which is used for preparing preparations for treating skin diseases or improving skin discomfort or abnormal symptoms caused by diseases.

In some embodiments, the skin disease comprises atopic dermatitis, seborrheic dermatitis, contact dermatitis, lupus erythematosus, lichen planus, urticaria, keratosis, acne, psoriasis, or ichthyosis.

The present invention also provides the use of a composition for repairing the skin barrier, which is used to prepare preparations for treating skin diseases or improving skin discomfort or abnormal symptoms caused by diseases, wherein the composition is administered at least once a day. In some embodiments, the composition is administered once, twice, three times, or four times daily.

In some embodiments, when the skin disease or the skin discomfort or abnormal symptoms caused by the disease is administered for two days, the recovery rate is increased by 10% or more compared with the control group. In one embodiment, the recovery rate is increased by 10-50%, for example, 11%, 12%, 13%, 15%, 20%, 25%, 30% or 40% compared with the control group.

In a specific embodiment, the composition for repairing the skin barrier is prepared according to the ratio of ingredients listed in Table 1:

In some embodiments, the composition for repairing the skin barrier further comprises lipid, the total weight of the composition is based on 100%, and the weight percentage of lipid is 0.001% to 40%, and in other embodiments, the weight percentage of lipid is 0.001% to 15%. In one embodiment, the lipid comprises ceramides, glycerides, cholesterol, free fatty acids, or combinations thereof. In some embodiments, the ceramide comprises ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide 7, ceramide 8, Ceramide 9, or a combination thereof. In one embodiment, the ceramide comprises ceramide 1, ceramide 3, and ceramide 6II.

Ceramide is the main component of the intercellular matrix of the stratum corneum of human skin. The intercellular matrix of the stratum corneum is mainly composed of lipids, that is, the mud in the "brick and mud" structure. Lipids are composed of about 50% ceramide, about 25% cholesterol and about 15% free fatty acids. Ceramide, Cholesterol and free fatty acids together create an impermeable protective structure that prevents excess water from evaporating and also prevents the entry of microorganisms and external irritants.

In another specific embodiment, the composition for repairing the skin barrier is prepared according to the ratio of ingredients listed in Table 2:

The composition for repairing the skin barrier of the present invention can be used to treat skin diseases or improve skin discomfort or abnormal symptoms caused by diseases. The skin disease can be, for example, atopic dermatitis, seborrheic dermatitis, contact dermatitis, lupus erythematosus, lichen planus, urticaria, keratosis, acne, psoriasis, or ichthyosis. Skin discomfort or abnormal symptoms caused by diseases can be, for example, skin dryness, itching, peeling, redness, swelling and tingling caused by skin diseases or other diseases.

Kidney dialysis patients often experience itching all over the body, which is called "uremic pruritus". Symptoms of uremic pruritus are usually generalized, most often in the back (50%), face (30%), ductal upper extremities (10%), and lower extremities (5%). The possible causes of uremic pruritus are: (1) hyperparathyroidism; (2) changes in the metabolism of divalent ions, such as high blood calcium or blood magnesium, and a large amount of divalent cations may be deposited in the dermis as a source of stimulation; (3) CNS-derived itching, which may be from the nervous system of opioids; (4) Peripheral neuropathy, the phenomenon of increased nerve fibers observed in epidermal sections of patients with uremia, which may be related to skin itching; ( 5) Abnormal secretion of sebaceous glands or decreased sweat secretion, resulting in dry skin; (6) hypervitaminosis A, which makes the skin drier and easier to peel; (7) mast cells proliferate or are easily stimulated to release histamine. In some embodiments, the composition for repairing the skin barrier of the present invention can be used to improve skin discomfort or abnormal symptoms caused by uremic pruritus.

The following experimental example will illustrate the effect of the composition for repairing the skin barrier of the embodiment of the present invention on repairing the skin barrier.

Repair skin barrier experiment

Take a few nude mice (Nude mice) about 7 weeks old, with a body weight of 20±2 grams, and eat and drink freely. The experiment was divided into 1 control group and 3 experimental groups, a total of 4 groups. After the nude mice were anesthetized, the spine was centered, and the left and right thighs were wiped back and forth with 2 sterile cotton swabs dipped in saline. Each cotton swab was wiped back and forth 5 times, and then a dry sterile cotton swab was wiped back and forth 3 times and waited. dry. Then, draw a square of 1.5 cm * 1.5 cm on both sides of the thigh, measure the transepidermal water loss (TEWL), and record it as the basic value. Then, in the four corners of the thighs on both sides, peel off the tape with a size of about 3 cm * 2.5 cm 10-15 times, and stay for 10 seconds each time. Then measure the transdermal water loss. Finally, administer medicines according to each group, and apply the hydrogel prepared according to the formula in Table 3 back and forth on a fixed area of 4.5 cm * 2.5 cm for 3 minutes until it becomes dry and can no longer be applied. Afterwards, the process of cleaning, drying, measuring and dosing was repeated every day. Therefore, the transdermal water loss on day 0 (basic value before tearing), day 0 (after tearing), day 1, day 2, and day 3 was recorded.

The formulations of the control group and the experimental groups A-C are shown in Table 3, and the contents of calcium ions, magnesium ions, sodium ions, potassium ions and chloride ions in the ion regulator are shown in Table 1.

Please refer to Figure 1 for the experimental results. On the second day, the average transdermal water loss of each group after deducting the base value was 23.70g/h/m ² for the control group and 21.09g/h/m ² for the experimental group A 18.80g/h/m ² for experimental group B and 14.26g/h/m ² for experimental group C. It can be seen that compared with the use of ion regulators alone (experimental group A) and the use of ganoderma lucidum extract alone (experimental group B), the experimental group C that uses ion regulators and ganoderma lucidum extracts at the same time has less transdermal water loss. The reduction in volume is more pronounced. In other words, the repair effect of the skin barrier is better. It is worth noting that, compared with the control group, the reduction in skin transdermal water loss (9.44) using the composition of the present invention is greater than the sum of the reductions in transdermal water loss of using Ganoderma lucidum extract and ion regulator alone (2.61+4.90), it can be seen that Ganoderma lucidum extract and ion regulator have a synergistic effect.

Furthermore, calculate the recovery rate of each group on the second day, and the calculation method of the recovery rate is {1-[(the average TEWL on the second day-the average value of the base value)/(the tear after tearing on the 0th day TEWL average - base value average)]} * 100. As shown in Figure 2, the recovery rate of the control group was 54.3%, the recovery rate of the experimental group A was 50%, the recovery rate of the experimental group B was 55.1%, and the recovery rate of the experimental group C was 66.7%. In other words, the recovery rate of C in the experimental group increased by 12.4% compared with that in the control group. This may be due to the fact that Ganoderma lucidum extract alone can promote keratinocyte proliferation, but the specific ion combination and ratio in the ion regulator can adjust the calcium ion concentration gradient in the epidermis to present an inverted trapezoidal distribution, accelerating skin keratinocyte proliferation, in order to achieve The effect of repairing the skin barrier. Secondly, calcium ions can also help keratinocytes differentiate.

In the composition of the present invention, the ganoderma lucidum extract in the composition promotes cell regeneration and accelerates skin keratinocyte proliferation. Then use the ion combination in a specific ratio in the ion regulator to restore the inverted trapezoidal distribution of the calcium ion concentration gradient in the epidermal layer of the skin to provide an environment suitable for the growth of keratinocytes. Finally, the combination of ions in a specific ratio can sustainably maintain the inverted trapezoidal distribution of the calcium ion concentration gradient of the skin barrier layer and maintain the function of the new skin barrier. Repairing the skin barrier by the composition of the present invention can prevent external stimuli from invading the skin and losing water in the skin, and prevent the skin from being irritated by external stimuli and causing discomfort such as redness, swelling, and heat. Secondly, the composition of the present invention can also be used on skin under pathological conditions to treat or improve skin discomfort or abnormal symptoms by repairing the skin barrier, including skin itching symptoms of kidney dialysis patients.

Although the present invention has been disclosed above in terms of implementation, it is not intended to limit the present invention. Anyone skilled in this art can make various changes and modifications without departing from the spirit and scope of the present invention. Therefore, the protection of the present invention The scope shall be defined by the appended patent application scope.

Claims (10)

A composition for repairing the skin barrier, comprising: a Ganoderma lucidum extract, comprising a copolymer of dextran and glucosamine, wherein the glucan comprises α-glucan, β-glucan or a combination thereof, and the amine The base glucose comprises N-acetylglucosamine, N-acetylmuramic acid or a combination thereof; and an ion regulator comprising calcium ions, magnesium ions, sodium ions, potassium ions and chloride ions, wherein the total weight of the composition Based on 100%, the weight percentage of the ganoderma lucidum extract is 0.02%, the weight percentage of the calcium ion is 0.0469, the weight percentage of the magnesium ion is 0.02296%, the weight percentage of the sodium ion is 0.08225%, and the weight percentage of the potassium ion The percentage is 0.0315%, and the weight percentage of the chloride ion is 0.16639%. The composition according to claim 1 further comprises a lipid, and the weight percentage of the lipid is 0.001% to 15%. The composition according to claim 2, wherein the lipid comprises ceramide, glyceride, cholesterol, free fatty acid or a combination thereof. The composition as described in claim 3, wherein the ceramide comprises ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, and ceramide 7 , Ceramide 8, God Amide 9, or a combination thereof. The composition as described in Claim 1, wherein the composition is used to treat skin diseases or improve skin discomfort or abnormal symptoms caused by diseases, and the skin diseases include atopic dermatitis, seborrheic dermatitis, contact Dermatitis, lupus erythematosus, lichen planus, urticaria, keratosis, acne, psoriasis, or ichthyosis. The composition according to claim 1, wherein the composition is in the form of liquid, essence, lotion, makeup remover, facial mask, wiping product, lotion, cream, ointment, or gel. The composition according to any one of claims 1 to 5, further comprising a cosmetically acceptable carrier. The composition according to claim 7, wherein the cosmetically acceptable carrier comprises solvents, emollients, moisturizers, emulsifiers, thickeners, antioxidants, preservatives or combinations thereof. The composition as described in Claim 8, wherein the weight percentage of the emollient is 2% to 30%; the weight percentage of the moisturizing agent is 0.1% to 20%; the weight percentage of the emulsifier is 0.1% to 10% ; The weight percentage of the thickener is 0.1% to 5%; The weight percentage of the antioxidant is 0.01% to 5%; and the weight percentage of the preservative is 0.0004% to 5%. The composition according to any one of claims 1 to 5, further comprising a pharmaceutically acceptable carrier.

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