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CN111973471A - Cosmetic composition - Google Patents

Cosmetic composition Download PDF

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Publication number
CN111973471A
CN111973471A CN201910440904.9A CN201910440904A CN111973471A CN 111973471 A CN111973471 A CN 111973471A CN 201910440904 A CN201910440904 A CN 201910440904A CN 111973471 A CN111973471 A CN 111973471A
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Prior art keywords
parts
peg
cosmetic composition
composition
skin
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CN201910440904.9A
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Chinese (zh)
Inventor
郭笑笑
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Xi'an Bohong Biotechnology Co ltd
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Xi'an Bohong Biotechnology Co ltd
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Priority to CN201910440904.9A priority Critical patent/CN111973471A/en
Publication of CN111973471A publication Critical patent/CN111973471A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/005—Preparations for sensitive skin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Cosmetics (AREA)

Abstract

The present invention provides a cosmetic composition comprising: glycerin, sodium hyaluronate, allantoin, dipotassium glycyrrhizinate, trehalose, bisabolol, panthenol, arginine and disodium ethylenediaminetetraacetate. The cosmetic composition disclosed by the invention is anti-allergic, better in repairing effect, better in moisture retention, milder, capable of relieving the skin sensitivity problem, and also has the effect of repairing skin injury and a better skin repairing effect.

Description

Cosmetic composition
Technical Field
The invention relates to the field of cosmetics, and particularly relates to a cosmetic composition and application thereof.
Background
Modern people have fast pace of life, poor sleep, lack of skin care, increasingly serious environmental pollution, ultraviolet rays, radioactive rays, computer electric appliance radiation, smoking and drinking, excessive exercise, stress, excessive intake of processed food and grease which are too much eaten, and the like, which cause a plurality of skin problems.
The skin is an important component for maintaining the life and health of human body, is the first barrier of the body, is directly contacted with the outside, and is easily damaged by the influence of environmental factors. In recent years, people in a highly sensitive skin state have increased year by year due to air pollution, abuse of various industrial additives, change of life habits of people and the like, and skin allergy phenomena such as redness, swelling, heat, pain, itching, desquamation and the like are frequently generated and become a great factor influencing the appearance and health of people.
Sensitive skin is a high-response state of skin under physiological or pathological conditions, mainly occurs on the face, and is clinically characterized in that when the skin is stimulated by physical, chemical, mental and other factors, the skin is easy to have subjective symptoms such as burning, stabbing pain, pruritus, tightness and the like, and is accompanied or not accompanied by objective signs such as erythema, scale, telangiectasia and the like, and the sensitive skin cannot tolerate common cosmetics.
Sensitive skin is classified into primary and secondary, the former is caused by hereditary, age, spirit and other factors, and the latter is secondary to abused cosmetics, external irritant drugs, improper cosmetic treatment, certain skin diseases and the like. Sensitive skin is mainly associated with impaired skin barrier and abnormal nerve function, which can lead to the phenomena of damaged skin structure, dryness, tightness, redness, etc. Due to the characteristics of barrier function damage or nerve function abnormality of sensitive skin, the sensitive skin is more difficult to resist the invasion of external irritants and allergens compared with normal skin, a series of irritation or skin inflammatory reactions caused by allergy are easy to occur, and then the barrier structure and nerve endings of the skin are further damaged, so that the vicious circle is caused.
Sensitive skin is not actually a disease, it refers to a state of physiological hyperresponsiveness of the skin to environmental or internal factors (Italy). This condition can occur when exposed to cosmetics, soaps, sunscreen products, detergents, and can exacerbate common skin discomfort symptoms in dry and cold environments. Most of the existing anti-allergy products are added with some irritant raw materials, the components are complex, and the skin tolerance is weakened due to some anaphylactic reaction caused by the inadaptability of the skin. Meanwhile, most anti-allergy products neglect the reconstruction capability of the skin self-repair system, and increase the dosage of the reagent can increase the skin pressure, so that the skin is more sensitive.
Patent CN102988199A discloses a skin-tendering and anti-allergy essence, which is prepared from 1, 3-dihydroxybutane, propylene glycol, sodium pyrrolidone carboxylate, dimethyl glycyrrhizinate, algal polysaccharides, water-soluble vitamin E and other raw materials through the processes of heating, emulsifying, stirring, cooling and the like. Compared with the prior art, the patent has the following advantages: 1. the skin care effect is good: the facial skin of people can be tender; 2. and (3) antiallergic: the formulation contains dipotassium glycyrrhizinate and antiallergic agent, so that the composition can be used by people with sensitive skin; 3. simple production process and low cost. However, the components of the patent are complex, and the small molecular emulsifier such as sodium hydroxide solution which is possibly permeated into the horny layer can cause excessive skin irritation, and the banana is adopted to increase the irritation.
Therefore, in the cosmetic field, there is a strong demand for cosmetic compositions that are more resistant to allergy, better in the repair effect, better in the moisturizing type, and milder.
Disclosure of Invention
In view of the above, the invention aims to provide a cosmetic composition which is anti-allergic, better in repairing effect, better in moisturizing type and milder, can relieve the skin sensitivity problem, has the effect of repairing skin injury, and has a better skin repairing effect.
Therefore, the invention provides the following technical scheme.
In a first aspect, the present invention provides a cosmetic composition, wherein the composition comprises: glycerin, sodium hyaluronate, allantoin, dipotassium glycyrrhizinate, trehalose, bisabolol, panthenol, arginine and disodium ethylenediaminetetraacetate.
In a preferred embodiment, the composition further comprises: polyhydric alcohol, grease, macromolecular emulsifier, thickener and preservative.
In a preferred embodiment, the composition may further comprise water.
In a more preferred embodiment of the present invention,
the polyalcohol is one or more selected from pentanediol, butanediol, propanediol and hexanediol;
the oil is selected from one or more of squalene, squalane, hydrogenated polydecene, hydrogenated polyisobutene and jojoba oil;
the macromolecular emulsifier is one or more selected from PEG-20 methyl glucose sesquistearate, PEG-150 distearate, PEG-100 distearate, PEG-40 hydrogenated castor oil, sorbitan olivate, cetearyl glucoside, PEG-11 methyl ether polydimethylsiloxane and PEG-20 sorbitan cocoate;
the thickening agent is one or more of carbomer, xanthan gum, sodium carrageenan, Arabic gum, polyethylene glycol-14M, polyethylene glycol-90M, succinoglycan, hydroxyethyl cellulose, hydroxypropyl cellulose and hydroxypropyl methyl cellulose;
The preservative is selected from one or more of methyl hydroxybenzoate, propyl hydroxybenzoate, phenoxyethanol, glyceryl caprylate, ethylhexyl glycerol, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, caprylyl hydroximic acid and glyceryl caprylate.
In a preferred embodiment, wherein, in parts by weight, the composition comprises:
2-4 parts glycerol, for example, the parts by weight of glycerol may be 2, 2.2, 2.5, 2.7, 3, 3.2, 3.5 or 4;
0.1 to 0.5 parts sodium hyaluronate, for example, the parts by weight of sodium hyaluronate may be 0.1, 0.2, 0.3, 0.4 or 0.5;
0.01-0.2 parts allantoin, for example the weight parts of allantoin may be 0.01, 0.03, 0.05, 0.07, 0.09, 0.1, 0.15 or 0.2;
0.2-0.5 parts of dipotassium glycyrrhizinate, for example, the weight parts of dipotassium glycyrrhizinate can be 0.2, 0.25, 0.3, 0.35, 0.4, 0.45 or 0.5;
0.2-2 parts trehalose, for example, the trehalose may be in a weight part of 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9 or 2;
0.1-1 parts of bisabolol, for example, the parts by weight of the bisabolol may be 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9 or 1;
0.5 to 3 parts by weight of panthenol, which may be, for example, 0.5, 0.7, 1, 1.5, 1.7, 2, 2.5, 2.7 or 3;
0.1-0.7 parts arginine, e.g., the parts by weight of arginine may be 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, or 0.7;
and 0.01 to 0.1 parts of disodium ethylenediaminetetraacetate, which may be, for example, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, or 0.1 parts by weight.
In a preferred embodiment, wherein, according to parts by weight, the composition further comprises:
1-4 parts polyol, for example, the parts by weight of the polyol can be 1, 1.5, 2, 2.5, 3, 3.5, or 4;
0.2 to 1.2 parts of an oil, for example, the parts by weight of the oil may be 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1 or 1.2;
0.2 to 1 part of macromolecular emulsifier, for example, the parts by weight of macromolecular emulsifier may be 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9 or 1;
0.1 to 0.6 parts of thickener, for example, the parts by weight of the thickener may be 0.1, 0.2, 0.3, 0.4, 0.5 or 0.6;
and 0.3 to 0.7 parts preservative, for example, the preservative may be present in an amount of 0.3, 0.4, 0.5, 0.6 or 0.7 parts by weight.
In a more preferred embodiment of the present invention,
the polyalcohol is one or more selected from pentanediol, butanediol, propanediol and hexanediol;
the oil is selected from one or more of squalene, squalane, hydrogenated polydecene, hydrogenated polyisobutene and jojoba oil;
the macromolecular emulsifier is one or more selected from PEG-20 methyl glucose sesquistearate, PEG-150 distearate, PEG-100 distearate, PEG-40 hydrogenated castor oil, sorbitan olivate, cetearyl glucoside, PEG-11 methyl ether polydimethylsiloxane and PEG-20 sorbitan cocoate;
the thickening agent is one or more of carbomer, xanthan gum, sodium carrageenan, Arabic gum, polyethylene glycol-14M, polyethylene glycol-90M, succinoglycan, hydroxyethyl cellulose, hydroxypropyl cellulose and hydroxypropyl methyl cellulose;
the preservative is selected from one or more of methyl hydroxybenzoate, propyl hydroxybenzoate, phenoxyethanol, glyceryl caprylate, ethylhexyl glycerol, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, caprylyl hydroximic acid and glyceryl caprylate.
In a second aspect, the present invention provides a cosmetic composition, wherein, in parts by weight:
The composition comprises: 2-4 parts of glycerol, 1-4 parts of polyalcohol, 0.1-0.5 part of sodium hyaluronate, 0.2-1.2 parts of grease, 0.2-1 part of macromolecular emulsifier, 0.01-0.2 part of allantoin, 0.2-0.5 part of dipotassium glycyrrhizinate, 0.2-2 parts of trehalose, 0.1-1 part of bisabolol, 0.5-3 parts of panthenol, 0.1-0.6 part of thickener, 0.1-0.7 part of arginine, 0.3-0.7 part of preservative and 0.01-0.1 part of disodium ethylenediamine tetraacetate.
In a preferred embodiment of the present invention,
the polyalcohol is one or more selected from pentanediol, butanediol, propanediol and hexanediol;
the oil is selected from one or more of squalene, squalane, hydrogenated polydecene, hydrogenated polyisobutene and jojoba oil;
the macromolecular emulsifier is one or more selected from PEG-20 methyl glucose sesquistearate, PEG-150 distearate, PEG-100 distearate, PEG-40 hydrogenated castor oil, sorbitan olivate, cetearyl glucoside, PEG-11 methyl ether polydimethylsiloxane and PEG-20 sorbitan cocoate;
the thickening agent is one or more of carbomer, xanthan gum, sodium carrageenan, Arabic gum, polyethylene glycol-14M, polyethylene glycol-90M, succinoglycan, hydroxyethyl cellulose, hydroxypropyl cellulose and hydroxypropyl methyl cellulose;
The preservative is selected from one or more of methyl hydroxybenzoate, propyl hydroxybenzoate, phenoxyethanol, glyceryl caprylate, ethylhexyl glycerol, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, caprylyl hydroximic acid and glyceryl caprylate.
In a third aspect, the present invention provides a cosmetic composition, wherein, in parts by weight:
the composition comprises: 3 parts of glycerol, 2 parts of polyhydric alcohol, 0.3 part of sodium hyaluronate, 1 part of grease, 0.5 part of macromolecular emulsifier, 0.1 part of allantoin, 0.3 part of dipotassium glycyrrhizinate, 1.5 parts of trehalose, 0.5 part of bisabolol, 2.5 parts of panthenol, 0.5 part of thickener, 0.2 part of arginine, 0.6 part of preservative and 0.03 part of disodium ethylenediamine tetraacetate.
In a preferred embodiment of the present invention,
the polyalcohol is one or more selected from pentanediol, butanediol, propanediol and hexanediol;
the oil is selected from one or more of squalene, squalane, hydrogenated polydecene, hydrogenated polyisobutene and jojoba oil;
the macromolecular emulsifier is one or more selected from PEG-20 methyl glucose sesquistearate, PEG-150 distearate, PEG-100 distearate, PEG-40 hydrogenated castor oil, sorbitan olivate, cetearyl glucoside, PEG-11 methyl ether polydimethylsiloxane and PEG-20 sorbitan cocoate;
The thickening agent is one or more of carbomer, xanthan gum, sodium carrageenan, Arabic gum, polyethylene glycol-14M, polyethylene glycol-90M, succinoglycan, hydroxyethyl cellulose, hydroxypropyl cellulose and hydroxypropyl methyl cellulose;
the preservative is selected from one or more of methyl hydroxybenzoate, propyl hydroxybenzoate, phenoxyethanol, glyceryl caprylate, ethylhexyl glycerol, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, caprylyl hydroximic acid and glyceryl caprylate.
In a fourth aspect, the present invention provides a method for preparing a cosmetic composition, the method comprising the steps of:
the method comprises the following steps: mixing polyalcohol, glycerol, sodium hyaluronate, trehalose, thickener and macromolecular emulsifier, heating to 75-85 deg.C, stirring to dissolve;
step two: dissolving oil and fat, bisabolol and dipotassium glycyrrhizinate in the material obtained in the first step, mixing and heating to 75-85 ℃, and stirring to dissolve;
step three: mixing the materials obtained in step two in a container, adding arginine to adjust pH when the temperature is reduced to 40-50 ℃, adding allantoin, panthenol, antiseptic and disodium ethylene diamine tetraacetate, and stirring uniformly.
In a preferred embodiment, the cosmetic composition is the cosmetic composition described in the present specification.
In a preferred embodiment of the present invention,
the polyalcohol is one or more selected from pentanediol, butanediol, propanediol and hexanediol;
the oil is selected from one or more of squalene, squalane, hydrogenated polydecene, hydrogenated polyisobutene and jojoba oil;
the macromolecular emulsifier is one or more selected from PEG-20 methyl glucose sesquistearate, PEG-150 distearate, PEG-100 distearate, PEG-40 hydrogenated castor oil, sorbitan olivate, cetearyl glucoside, PEG-11 methyl ether polydimethylsiloxane and PEG-20 sorbitan cocoate;
the thickening agent is one or more of carbomer, xanthan gum, sodium carrageenan, Arabic gum, polyethylene glycol-14M, polyethylene glycol-90M, succinoglycan, hydroxyethyl cellulose, hydroxypropyl cellulose and hydroxypropyl methyl cellulose;
the preservative is selected from one or more of methyl hydroxybenzoate, propyl hydroxybenzoate, phenoxyethanol, glyceryl caprylate, ethylhexyl glycerol, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, caprylyl hydroximic acid and glyceryl caprylate.
In a fifth aspect, a cosmetic product is provided, the cosmetic product comprising the cosmetic composition of the present invention.
In a sixth aspect, a pharmaceutical composition is provided comprising a safe and effective amount of a cosmetic composition according to the present invention.
In addition, the invention also provides the application of the cosmetic composition in preparing cosmetic products.
And the use of the cosmetic composition of the present invention in the preparation of a pharmaceutical composition is provided.
In the present invention, polyols are a class of water-soluble substances that can moisturize the skin or reduce the transdermal water loss from the skin.
In the present invention, the oil component can form a hydrophobic film on the skin surface, which imparts softness, smoothness, gloss and elasticity to the skin, while preventing the invasion of external harmful substances and protecting against the erosion from natural factors; inhibiting skin dryness and water evaporation from the skin surface in cold; the massage cream has the function of lubricating and reducing friction when massaging skin.
The emulsifier can improve the surface tension between various constituent phases in the emulsion, so that a uniform and stable dispersion system or an emulsion substance is formed; emulsifiers are surface-active substances which have both hydrophilic and lipophilic groups in the molecule and which accumulate at the oil/water interface and reduce the interfacial tension and the energy required to form an emulsion, thereby increasing the energy of the emulsion. In the invention, the used macromolecular emulsifier can not permeate below the stratum corneum of the skin and can not cause irritation to the skin; while the general emulsifier may penetrate into the dermis layer, causing excessive irritation to the skin.
In the present invention, the thickener has an important influence on the appearance and shape of the product. The thickener enables the system to achieve the thickening purpose through a rod-shaped micelle formed by the thickener and a surfactant, a three-dimensional hydration network structure formed by the action of the thickener and water, a self macromolecular long-chain structure and the like.
In the present invention, a preservative means a substance added to an agent composition for skin care for the purpose of inhibiting the growth and proliferation of microorganisms in the agent composition for skin care, to prolong the shelf life of the agent composition for skin care.
In the present invention, the cosmetic product may include, as desired, a container, instructions for use, use aids, and/or other structures and/or agents necessary for performing the performance test; adjuvants used in the cosmetic products of the present invention include, but are not limited to, oils, emulsifiers, moisturizers, thickeners, skin conditioners, and/or preservatives; other structures required for performing performance tests in the cosmetic products of the present invention include, but are not limited to, structures for sampling, structures for performing control, and/or structures for observing the course or result of the assay; the other agents required for performing performance tests in the skin care products of the present invention include, but are not limited to, culture media, detergents, developers, and/or terminators.
In the present invention, the pharmaceutical composition comprises the cosmetic composition of the present invention and a pharmaceutically acceptable excipient.
In the present invention, a safe and effective amount refers to an amount of a compound or composition sufficient to significantly induce a positive benefit, preferably a positive skin tissue appearance or feel benefit, including the benefits disclosed herein, either individually or in combination, but low enough to avoid serious side effects, i.e., to provide a reasonable benefit to risk ratio, within the scope of sound judgment of the skilled artisan.
Compared with the prior art, the invention has the beneficial effects that:
the sodium hyaluronate used in the cosmetic composition disclosed by the invention is used as a natural macromolecular humectant, has very strong water retention capacity, and can keep skin moist, smooth, fine, tender and elastic within a certain time; the used oil can strengthen the oil barrier, supplement skin lipid and repair keratinocytes; the used macromolecular emulsifier can not permeate below the stratum corneum of the skin, so that a stimulus is avoided; the allantoin used can promote tissue growth and cell metabolism, soften stratum corneum protein, accelerate wound healing and increase skin brightness; the dipotassium glycyrrhizinate used can reduce the expression of proinflammatory hormones TNF-alpha, IL-6, IL-1 beta and IL-8; the trehalose used as a natural saccharide has good affinity with membrane protein, can increase the hydration function of cells, has good moisture retention, can form a layer of special protective film on the cell surface under a dry condition, can bind water molecules under the hydration function, and can also play a role in replacing water in the cells when water is lost, thereby protecting skin cells from being damaged; the used bisabolol can reduce the expression of proinflammatory hormones TNF-alpha, IL-6, IL-1 alpha, IL-1 beta and PEG 2; the used panthenol can stimulate the growth of epithelial cells, promote wound healing and has an anti-inflammatory effect; the used arginine has high safety, has skin moisturizing effect, and can be used for wound healing.
By screening the types of the components in the cosmetic composition and adjusting the content of the components in the cosmetic composition, the cosmetic composition has better anti-allergy and repairing effects, better moisturizing type and milder property.
Detailed Description
The present invention will be described in detail below with reference to specific embodiments and examples, and the advantages and various effects of the present invention will be more clearly apparent therefrom. It will be understood by those skilled in the art that these specific embodiments and examples are for the purpose of illustrating the invention and are not to be construed as limiting the invention.
Example 1
The present example provides a cosmetic composition, comprising, in parts by weight:
2 parts of glycerol, 1 part of propylene glycol, 0.1 part of sodium hyaluronate, 0.2 part of squalane, 0.2 part of cetearyl glucoside, 0.01 part of allantoin, 0.2 part of dipotassium glycyrrhizinate, 0.2 part of trehalose, 0.1 part of bisabolol, 0.5 part of panthenol, 0.1 part of xanthan gum, 0.1 part of arginine, 0.3 part of methylparaben, 0.01 part of disodium edetate and a proper amount of water.
The cosmetic composition of this example was prepared by a process comprising:
the method comprises the following steps: mixing 1 part of propylene glycol, 2 parts of glycerol, 0.1 part of sodium hyaluronate, 0.2 part of trehalose, 0.1 part of xanthan gum, 0.2 part of cetearyl glucoside and a proper amount of water, heating to 80 ℃, and stirring to dissolve the mixture;
Step two: dissolving 0.2 part of squalane, 0.1 part of bisabolol and 0.2 part of dipotassium glycyrrhizinate in the material obtained in the step one, mixing and heating to 80 ℃, and stirring to dissolve;
step three: and (3) mixing the materials obtained in the step two in a container, adding 0.1 part of arginine to adjust the pH when the temperature is reduced to 45 ℃, adding 0.01 part of allantoin, 0.5 part of panthenol, 0.3 part of methylparaben and 0.01 part of disodium ethylene diamine tetraacetate, and uniformly stirring.
Example 2
The present example provides a cosmetic composition, wherein the composition comprises, in parts by weight:
4 parts of glycerol, 4 parts of propylene glycol, 0.5 part of sodium hyaluronate, 1.2 parts of squalane, 1 part of cetearyl glucoside, 0.2 part of allantoin, 0.5 part of dipotassium glycyrrhizinate, 2 parts of trehalose, 1 part of bisabolol, 3 parts of panthenol, 0.6 part of xanthan gum, 0.7 part of arginine, 0.7 part of methylparaben, 0.1 part of disodium edetate and a proper amount of water.
The cosmetic composition of this example was prepared by a process comprising:
the method comprises the following steps: mixing 4 parts of propylene glycol, 4 parts of glycerol, 0.5 part of sodium hyaluronate, 2 parts of trehalose, 0.6 part of xanthan gum, 1 part of cetearyl glucoside and a proper amount of water, heating to 80 ℃, and stirring to dissolve;
Step two: dissolving 1.2 parts of squalane, 1 part of bisabolol and 0.5 part of dipotassium glycyrrhizinate in the material obtained in the step one, mixing and heating to 80 ℃, and stirring to dissolve;
step three: and (3) mixing the materials obtained in the step two in a container, adding 0.7 part of arginine to adjust the pH when the temperature is reduced to 45 ℃, adding 0.2 part of allantoin, 3 parts of panthenol, 0.7 part of methylparaben and 0.1 part of disodium ethylene diamine tetraacetate, and uniformly stirring.
Example 3
The present example provides a cosmetic composition, comprising, in parts by weight:
3 parts of glycerol, 2 parts of propylene glycol, 0.3 part of sodium hyaluronate, 1 part of squalane, 0.5 part of cetearyl glucoside, 0.1 part of allantoin, 0.3 part of dipotassium glycyrrhizinate, 1.5 parts of trehalose, 0.5 part of bisabolol, 2.5 parts of panthenol, 0.5 part of xanthan gum, 0.2 part of arginine, 0.6 part of methylparaben, 0.03 part of disodium edetate and a proper amount of water.
The cosmetic composition of this example was prepared by a process comprising:
the method comprises the following steps: mixing 2 parts of propylene glycol, 3 parts of glycerol, 0.3 part of sodium hyaluronate, 1.5 parts of trehalose, 0.5 part of xanthan gum, 0.5 part of cetearyl glucoside and a proper amount of water, heating to 80 ℃, and stirring to dissolve;
Step two: dissolving 1 part of squalane, 0.5 part of bisabolol and 0.3 part of dipotassium glycyrrhizinate in the material obtained in the step one, mixing and heating to 80 ℃, and stirring to dissolve;
step three: and (3) mixing the materials obtained in the step two in a container, adding 0.2 part of arginine to adjust the pH when the temperature is reduced to 45 ℃, adding 0.1 part of allantoin, 2.5 parts of panthenol, 0.6 part of methylparaben and 0.03 part of disodium ethylene diamine tetraacetate, and uniformly stirring.
Example 4
The present embodiment provides a cosmetic product, comprising, in parts by weight:
2 parts of glycerol, 1 part of propylene glycol, 0.1 part of sodium hyaluronate, 0.2 part of squalane, 0.2 part of cetearyl glucoside, 0.01 part of allantoin, 0.2 part of dipotassium glycyrrhizinate, 0.2 part of trehalose, 0.1 part of bisabolol, 0.5 part of panthenol, 0.1 part of xanthan gum, 0.1 part of arginine, 0.3 part of methylparaben, 0.01 part of disodium edetate and a proper amount of water.
The cosmetic product of this example was prepared by a method comprising:
the method comprises the following steps: mixing 1 part of propylene glycol, 2 parts of glycerol, 0.1 part of sodium hyaluronate, 0.2 part of trehalose, 0.1 part of xanthan gum, 0.2 part of cetearyl glucoside and a proper amount of water, heating to 80 ℃, and stirring to dissolve;
Step two: dissolving 0.2 part of squalane, 0.1 part of bisabolol and 0.2 part of dipotassium glycyrrhizinate in the material obtained in the step one, mixing and heating to 80 ℃, and stirring to dissolve;
step three: and (3) mixing the materials obtained in the step two in a container, adding 0.1 part of arginine to adjust the pH when the temperature is reduced to 45 ℃, adding 0.01 part of allantoin, 0.5 part of panthenol, 0.3 part of methylparaben and 0.01 part of disodium ethylene diamine tetraacetate, and uniformly stirring.
Example 5
The present embodiment provides a cosmetic product, wherein the cosmetic product comprises, in parts by weight:
4 parts of glycerol, 4 parts of propylene glycol, 0.5 part of sodium hyaluronate, 1.2 parts of squalane, 1 part of cetearyl glucoside, 0.2 part of allantoin, 0.5 part of dipotassium glycyrrhizinate, 2 parts of trehalose, 1 part of bisabolol, 3 parts of panthenol, 0.6 part of xanthan gum, 0.7 part of arginine, 0.7 part of methylparaben, 0.1 part of disodium edetate and a proper amount of water.
The cosmetic product of this example was prepared by a method comprising:
the method comprises the following steps: mixing 4 parts of propylene glycol, 4 parts of glycerol, 0.5 part of sodium hyaluronate, 2 parts of trehalose, 0.6 part of xanthan gum and 1 part of cetearyl glucoside with a proper amount of water, heating to 80 ℃, and stirring to dissolve;
Step two: dissolving 1.2 parts of squalane, 1 part of bisabolol and 0.5 part of dipotassium glycyrrhizinate in the material obtained in the step one, mixing and heating to 80 ℃, and stirring to dissolve;
step three: and (3) mixing the materials obtained in the step two in a container, adding 0.7 part of arginine to adjust the pH when the temperature is reduced to 45 ℃, adding 0.2 part of allantoin, 3 parts of panthenol, 0.7 part of methylparaben and 0.1 part of disodium ethylene diamine tetraacetate, and uniformly stirring.
Example 6
The present embodiment provides a cosmetic product, comprising, in parts by weight:
3 parts of glycerol, 2 parts of propylene glycol, 0.3 part of sodium hyaluronate, 1 part of squalane, 0.5 part of cetearyl glucoside, 0.1 part of allantoin, 0.3 part of dipotassium glycyrrhizinate, 1.5 parts of trehalose, 0.5 part of bisabolol, 2.5 parts of panthenol, 0.5 part of xanthan gum, 0.2 part of arginine, 0.6 part of methylparaben, 0.03 part of disodium edetate and a proper amount of water.
The cosmetic product of this example was prepared by a method comprising:
the method comprises the following steps: mixing 2 parts of propylene glycol, 3 parts of glycerol, 0.3 part of sodium hyaluronate, 1.5 parts of trehalose, 0.5 part of xanthan gum, 0.5 part of cetearyl glucoside and a proper amount of water, heating to 80 ℃, and stirring to dissolve;
Step two: dissolving 1 part of squalane, 0.5 part of bisabolol and 0.3 part of dipotassium glycyrrhizinate in the material obtained in the step one, mixing and heating to 80 ℃, and stirring to dissolve;
step three: and (3) mixing the materials obtained in the step two in a container, adding 0.2 part of arginine to adjust the pH when the temperature is reduced to 45 ℃, adding 0.1 part of allantoin, 2.5 parts of panthenol, 0.6 part of methylparaben and 0.03 part of disodium ethylene diamine tetraacetate, and uniformly stirring.
Comparative example 1
In order to further illustrate the beneficial effects of the invention, the skin-tendering and anti-allergy essence is provided, and the essence is prepared by adopting the method in patent CN 102988199A.
Comparative example 2
To further illustrate the beneficial effects of the present invention, comparative example 2 is provided, which comparative example 2 differs from example 3 in that: cetearyl glucoside of the present invention was replaced with PEG-9 dimethiconoethyl dimethicone.
Comparative example 2 provides a cosmetic composition prepared by a method comprising:
the method comprises the following steps: mixing 2 parts of propylene glycol, 3 parts of glycerol, 0.3 part of sodium hyaluronate, 1.5 parts of trehalose, 0.5 part of xanthan gum, 0.5 part of PEG-9 polydimethylsiloxyethyl polydimethylsiloxane and a proper amount of water, heating to 80 ℃, and stirring to dissolve the materials;
Step two: dissolving 1 part of squalane, 0.5 part of bisabolol and 0.3 part of dipotassium glycyrrhizinate in the material obtained in the step one, mixing and heating to 80 ℃, and stirring to dissolve;
step three: and (3) mixing the materials obtained in the step two in a container, adding 0.2 part of arginine to adjust the pH when the temperature is reduced to 45 ℃, adding 0.1 part of allantoin, 2.5 parts of panthenol, 0.6 part of methylparaben and 0.03 part of disodium ethylene diamine tetraacetate, and uniformly stirring.
Comparative example 3
To further illustrate the beneficial effects of the present invention, comparative example 3 is provided, which is different from example 6 in that: cetearyl glucoside of the present invention was replaced with PEG-9 dimethiconoethyl dimethicone.
Comparative example 3 provides a cosmetic product prepared by a method comprising:
the method comprises the following steps: mixing 2 parts of propylene glycol, 3 parts of glycerol, 0.3 part of sodium hyaluronate, 1.5 parts of trehalose, 0.5 part of xanthan gum, 0.5 part of PEG-9 polydimethylsiloxyethyl polydimethylsiloxane and a proper amount of water, heating to 80 ℃, and stirring to dissolve the materials;
step two: dissolving 1 part of squalane, 0.5 part of bisabolol and 0.3 part of dipotassium glycyrrhizinate in the material obtained in the step one, mixing and heating to 80 ℃, and stirring to dissolve;
Step three: and (3) mixing the materials obtained in the step two in a container, adding 0.2 part of arginine to adjust the pH when the temperature is reduced to 45 ℃, adding 0.1 part of allantoin, 2.5 parts of panthenol, 0.6 part of methylparaben and 0.03 part of disodium ethylene diamine tetraacetate, and uniformly stirring.
Experiment 1: effect verification
And (3) testing a sample: the present specification shows the samples prepared in examples 1 to 6 and comparative examples 1 to 3.
The experimental method comprises the following steps: 90 facial allergy-prone volunteers were selected, with an age distribution of 15-40 years, and randomized into A, B, C, D, E, F, G, H, I nine groups of 10 people each. Wherein,
group a applied the cosmetic composition prepared by the above example 1 of the present invention,
group B applied the cosmetic composition prepared by the above example 2 of the present invention,
group C the cosmetic composition prepared by the above example 3 of the present invention was applied,
group D applied the cosmetic product prepared by the above-mentioned example 4 of the present invention,
group E applied the cosmetic product prepared by the above example 5 of the present invention,
group F applied the cosmetic product prepared by the above-described example 6 of the present invention,
group G applied the essence prepared in comparative example 1,
group H applied the cosmetic composition prepared in comparative example 2,
group I application of the cosmetic product prepared in comparative example 3,
The preparation is administered once a day, and 10 days later. The evaluation score was 10 points, and the test evaluation results are shown in table 1 below.
TABLE 1
Evaluation item Anti-allergic effect Repairing effects Mildness property Moisture retention
Example 1 8.4 8.5 8.2 8.2
Example 2 8.6 8.2 8.3 8.6
Example 3 9.6 9.4 9.7 9.5
Example 4 8.7 8.3 8.2 8.6
Example 5 8.1 8.6 8.9 8.3
Example 6 9.2 9.5 9.3 9.7
Comparative example 1 5.8 6.2 5.9 6.1
Comparative example 2 5.6 5.5 5.6 5.8
Comparative example 3 5.6 5.7 5.7 5.1
Likewise, to further illustrate the beneficial effects of the present invention, the following comparative examples are provided:
comparative example 2.1 is provided, which is distinguished from example 3 by the following: the methylparaben of the present invention is replaced with salicylic acid.
The cosmetic composition prepared in conjunction with the preparation method of the present invention was tested according to the test method of experiment 1. The skin care results of the cosmetic composition prepared in comparative example 2.1 were observed. The results were similar to those in group H above.
From the above results, it can be seen that:
the cosmetic composition provided by the invention can achieve good anti-allergy effect and repair effect, has better moisture retention and milder property, has no irritation to skin, and has the effect of more than 8 minutes. By screening the types of the components in the cosmetic composition or adjusting the weight parts of the components in the cosmetic composition, the anti-allergy effect and the repair effect are remarkable, the moisturizing effect is mild, the skin is not irritated, the result is more than 9 minutes, and the cosmetic composition has the effects of relieving the skin allergy problem, repairing skin injury, having a good skin repair effect and being mild and non-irritant. The cosmetic composition has certain moisture retention, but has obviously poor anti-allergy effect, and the facial sensitivity of the volunteers is not improved basically.
Similarly, the cosmetic product provided by the invention can achieve good anti-allergy effect and repair effect, has better moisture retention and milder property, has no irritation to skin, and has the effect of more than 8 minutes. By screening the types of the components in the cosmetic composition or adjusting the weight parts of the components in the cosmetic composition, the anti-allergy effect and the repair effect are remarkable, the moisturizing effect is mild, the skin is not irritated, the result is more than 9 minutes, and the cosmetic composition has the effects of relieving the skin allergy problem, repairing skin injury, having a good skin repair effect and being mild and non-irritant.
Moreover, the cosmetic composition and the cosmetic product have fewer components, simpler production operation and lower production cost.
It is to be understood that the invention disclosed is not limited to the particular methodology, protocols, and materials described, as these may vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention which will be limited only by the appended claims.
Those skilled in the art will also recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. Such equivalents are intended to be encompassed by the following claims.

Claims (10)

1. A cosmetic composition, wherein the composition comprises: glycerin, sodium hyaluronate, allantoin, dipotassium glycyrrhizinate, trehalose, bisabolol, panthenol, arginine and disodium ethylenediaminetetraacetate.
2. The composition of claim 1, further comprising: polyhydric alcohol, grease, macromolecular emulsifier, thickener and preservative; wherein,
the polyalcohol is one or more selected from pentanediol, butanediol, propanediol and hexanediol;
the oil is selected from one or more of squalene, squalane, hydrogenated polydecene, hydrogenated polyisobutene and jojoba oil;
the macromolecular emulsifier is one or more selected from PEG-20 methyl glucose sesquistearate, PEG-150 distearate, PEG-100 distearate, PEG-40 hydrogenated castor oil, sorbitan olivate, cetearyl glucoside, PEG-11 methyl ether polydimethylsiloxane and PEG-20 sorbitan cocoate;
The thickening agent is one or more of carbomer, xanthan gum, sodium carrageenan, Arabic gum, polyethylene glycol-14M, polyethylene glycol-90M, succinoglycan, hydroxyethyl cellulose, hydroxypropyl cellulose and hydroxypropyl methyl cellulose;
the preservative is selected from one or more of methyl hydroxybenzoate, propyl hydroxybenzoate, phenoxyethanol, glyceryl caprylate, ethylhexyl glycerol, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, caprylyl hydroximic acid and glyceryl caprylate.
3. The composition of claim 1, wherein the weight parts of:
the composition comprises: 2-4 parts of glycerin, 0.1-0.5 part of sodium hyaluronate, 0.01-0.2 part of allantoin, 0.2-0.5 part of dipotassium glycyrrhizinate, 0.2-2 parts of trehalose, 0.1-1 part of bisabolol, 0.5-3 parts of panthenol, 0.1-0.7 part of arginine and 0.01-0.1 part of disodium ethylenediamine tetraacetate.
4. The composition according to claim 2, wherein the weight parts of the composition are as follows:
the composition further comprises: 1-4 parts of polyhydric alcohol, 0.2-1.2 parts of grease, 0.2-1 part of macromolecular emulsifier, 0.1-0.6 part of thickening agent and 0.3-0.7 part of preservative.
5. A cosmetic composition comprises the following components in parts by weight:
the composition comprises: 2-4 parts of glycerol, 1-4 parts of polyhydric alcohol, 0.1-0.5 part of sodium hyaluronate, 0.2-1.2 parts of grease, 0.2-1 part of macromolecular emulsifier, 0.01-0.2 part of allantoin, 0.2-0.5 part of dipotassium glycyrrhizinate, 0.2-2 parts of trehalose, 0.1-1 part of bisabolol, 0.5-3 parts of panthenol, 0.1-0.6 part of thickener, 0.1-0.7 part of arginine, 0.3-0.7 part of preservative and 0.01-0.1 part of disodium ethylenediamine tetraacetate; wherein,
The polyalcohol is one or more selected from pentanediol, butanediol, propanediol and hexanediol;
the oil is selected from one or more of squalene, squalane, hydrogenated polydecene, hydrogenated polyisobutene and jojoba oil;
the macromolecular emulsifier is one or more selected from PEG-20 methyl glucose sesquistearate, PEG-150 distearate, PEG-100 distearate, PEG-40 hydrogenated castor oil, sorbitan olivate, cetearyl glucoside, PEG-11 methyl ether polydimethylsiloxane and PEG-20 sorbitan cocoate;
the thickening agent is one or more of carbomer, xanthan gum, sodium carrageenan, Arabic gum, polyethylene glycol-14M, polyethylene glycol-90M, succinoglycan, hydroxyethyl cellulose, hydroxypropyl cellulose and hydroxypropyl methyl cellulose;
the preservative is selected from one or more of methyl hydroxybenzoate, propyl hydroxybenzoate, phenoxyethanol, glyceryl caprylate, ethylhexyl glycerol, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, caprylyl hydroximic acid and glyceryl caprylate.
6. A method of preparing a cosmetic composition, the method comprising the steps of:
the method comprises the following steps: mixing polyalcohol, glycerol, sodium hyaluronate, trehalose, thickener and macromolecular emulsifier, heating to 75-85 deg.C, stirring to dissolve;
Step two: dissolving oil and fat, bisabolol and dipotassium glycyrrhizinate in the material obtained in the first step, mixing and heating to 75-85 ℃, and stirring to dissolve;
step three: mixing the materials obtained in the step two in a container, adding arginine to adjust the pH when the temperature is reduced to 40-50 ℃, adding allantoin, panthenol, a preservative and disodium ethylene diamine tetraacetate, and uniformly stirring; wherein,
the polyalcohol is one or more selected from pentanediol, butanediol, propanediol and hexanediol;
the oil is selected from one or more of squalene, squalane, hydrogenated polydecene, hydrogenated polyisobutene and jojoba oil;
the macromolecular emulsifier is one or more selected from PEG-20 methyl glucose sesquistearate, PEG-150 distearate, PEG-100 distearate, PEG-40 hydrogenated castor oil, sorbitan olivate, cetearyl glucoside, PEG-11 methyl ether polydimethylsiloxane and PEG-20 sorbitan cocoate;
the thickening agent is one or more of carbomer, xanthan gum, sodium carrageenan, Arabic gum, polyethylene glycol-14M, polyethylene glycol-90M, succinoglycan, hydroxyethyl cellulose, hydroxypropyl cellulose and hydroxypropyl methyl cellulose;
The preservative is selected from one or more of methyl hydroxybenzoate, propyl hydroxybenzoate, phenoxyethanol, glyceryl caprylate, ethylhexyl glycerol, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, caprylyl hydroximic acid and glyceryl caprylate.
7. The method of claim 6, wherein the cosmetic composition is the cosmetic composition of any one of claims 1-5.
8. A cosmetic product, wherein the cosmetic product comprises the cosmetic composition of any one of claims 1 to 5.
9. A pharmaceutical composition comprising a safe and effective amount of the cosmetic composition of any one of claims 1 to 5.
10. Use of a cosmetic composition according to any one of claims 1 to 5 for the preparation of a cosmetic or pharmaceutical product.
CN201910440904.9A 2019-05-24 2019-05-24 Cosmetic composition Withdrawn CN111973471A (en)

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