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TWI787186B - Tablet type freeze-dried cosmetic - Google Patents

Tablet type freeze-dried cosmetic Download PDF

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Publication number
TWI787186B
TWI787186B TW106120653A TW106120653A TWI787186B TW I787186 B TWI787186 B TW I787186B TW 106120653 A TW106120653 A TW 106120653A TW 106120653 A TW106120653 A TW 106120653A TW I787186 B TWI787186 B TW I787186B
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tablet
freeze
mass
dried
type freeze
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TW106120653A
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TW201904552A (en
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菊田雅之
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日商資生堂股份有限公司
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Abstract

The present invention provides a tablet type cosmetic excellent in ease of handling.
The tablet type cosmetic composition of the present invention comprises (A) 30 to 91% by mass of trehalose, (B) 4.0 to 16% by mass of polyethylene glycol having a molecular weight of 11000 to 25000, and a bulk specific gravity of 0.1 to 0.5 g/ ml.

Description

錠型凍結乾燥化妝料 Tablet freeze-dried cosmetics

本發明是關於一種錠型凍結乾燥化妝料,特別是關於提升其作為錠劑的操作容易性。 The present invention relates to a lozenge-type freeze-dried cosmetic, in particular to improving its ease of handling as a lozenge.

通常,調配有有效成分的高功能的護膚化妝品,主要以化妝水、美容液等液體的狀態供應,藉由每日習慣性的使用,來發揮其效果。 Usually, high-performance skin care cosmetics formulated with active ingredients are mainly supplied in the form of liquids such as lotion and beauty essence, and their effects can be exerted through daily habitual use.

另一方面,近年來,在旅遊地、出差地、或競賽場等進行護膚的機會增加,因此有要求攜帶時負擔較少的製品。再者,由於近年的美容意識的提高,針對在外出地使用的護膚化妝品,有要求可獲得與日常的保養有同等以上滿足感的高品質的製品。 On the other hand, in recent years, opportunities to perform skin care in tourist destinations, business trip destinations, competition venues, etc. have increased, and therefore there are products that are less burdensome to carry. Furthermore, due to the improvement of beauty awareness in recent years, there is a demand for high-quality products that can provide the same or higher satisfaction as daily maintenance for skin care cosmetics used outside.

又,不限於如上述的攜帶用,在日常、或視皮膚的狀態而使用的護膚化妝品,亦高度要求製品為輕便且可個人化使用的形態。 In addition, it is not limited to the above-mentioned skin care cosmetics for carrying, but also for daily use or depending on the state of the skin. It is also highly required that the product be in a form that is portable and can be used individually.

作為因應上述要求的手段之一,可考慮將化妝水等液狀組成物製成乾燥製劑,在使用時將其以水再溶解來使用的形態。 As one of the means to meet the above-mentioned requirements, it is conceivable to use a liquid composition such as lotion as a dry preparation, which is redissolved in water at the time of use.

作為與液狀組成物的乾燥製劑化相關的技術而言,例 如,在專利文獻1,記載有藉由將與水共存下為不安定的L-抗壞血酸-2-磷酸鹽,與糖醇及低吸濕性的寡糖以及水溶性高分子進行混合製成水溶液,並且實施凍結乾燥,而可安定地維持到使用時為止。 As a technology related to the dry preparation of liquid compositions, for example, in Patent Document 1, it is described that L-ascorbic acid-2-phosphate, which is unstable in the presence of water, and sugar alcohol and low Hygroscopic oligosaccharides and water-soluble polymers are mixed to form an aqueous solution, and freeze-dried to maintain stability until use.

又,在專利文獻2,記載有藉由使調配有玻尿酸鈉、膠原蛋白及抗壞血酸衍生物的水溶液進行凍結乾燥而得的凍結乾燥化妝品,即使在長期間保存後也沒有因吸濕引起的收縮及龜裂、由細菌類或氧化引起的變質等,且在使用時以水或化妝水再溶解時可在極短時間內溶解。 In addition, in Patent Document 2, it is described that a freeze-dried cosmetic obtained by freeze-drying an aqueous solution containing sodium hyaluronate, collagen, and an ascorbic acid derivative has no shrinkage and no shrinkage due to moisture absorption even after long-term storage. Cracks, deterioration caused by bacteria or oxidation, etc., and can be dissolved in a very short time when redissolved with water or lotion during use.

又,在專利文獻3,記載有藉由將含有玻尿酸鈉及糖類的水性溶液凍結乾燥,而得到在室溫安定的玻尿酸固形組成物。 Also, Patent Document 3 describes obtaining a hyaluronic acid solid composition stable at room temperature by freeze-drying an aqueous solution containing sodium hyaluronate and sugars.

又,在專利文獻4,亦記載有使用有含有玻尿酸或玻尿酸鈉及磷酸-L-抗壞血酸鎂的水溶液的凍結乾燥品的粉末或顆粒狀化妝料,可改善兩成分對水的溶解性。 In addition, Patent Document 4 also describes the use of powder or granular cosmetics of freeze-dried products containing hyaluronic acid or sodium hyaluronate and an aqueous solution of magnesium-L-ascorbate phosphate, which can improve the solubility of the two components in water.

[先前技術文獻] [Prior Art Literature] [專利文獻] [Patent Document]

[專利文獻1]日本特開2004-149468號公報 [Patent Document 1] Japanese Unexamined Patent Publication No. 2004-149468

[專利文獻2]日本特開2006-182750號公報 [Patent Document 2] Japanese Patent Laid-Open No. 2006-182750

[專利文獻3]日本特開2003-95955號公報 [Patent Document 3] Japanese Unexamined Patent Publication No. 2003-95955

[專利文獻4]日本特開平2-215707號公報 [Patent Document 4] Japanese Patent Application Laid-Open No. 2-215707

但是,專利文獻1至4教示的凍結乾燥組成物是,作為經成形為錠型之凍結乾燥物,在從容器等的剝離性或再溶解性、再溶解液的使用感等之點而言並不充分,亦難以製造為攜帶性高、可容易使用的錠型化妝料。特別是,從保存時的吸濕性較低的另一方面而言,目前尚未知有關於使錠劑具有添加水時能瞬間溶解的溶解性的技術。 However, the freeze-dried compositions taught in Patent Documents 1 to 4 are not suitable in terms of releasability from containers, etc., or redissolution properties, and the use feeling of redissolved liquids as freeze-dried products formed into tablet shapes. It is not sufficient, and it is difficult to manufacture a tablet-shaped cosmetic material that is highly portable and easy to use. In particular, since the hygroscopicity during storage is low, there is currently no known technique for imparting solubility to tablets that can be dissolved instantaneously when water is added.

本發明是有鑑於上述情況,而以提供操作容易性優異的錠型凍結乾燥化妝料為目的。 In view of the above circumstances, the present invention aims to provide a tablet-type freeze-dried cosmetic that is excellent in ease of handling.

本發明者等為了解決上述課題進行精心檢討,結果發現一種錠型組成物,係以含有特定分子量的聚乙二醇及海藻糖(trehalose),且具有特定的容積比重的方式經由凍結乾燥形成者,該錠型組成物為吸濕性雖低但添加水時會瞬間溶解、離型性高、操作容易性優異者,進而完成本發明。 In order to solve the above problems, the inventors of the present invention conducted careful examination and found that a tablet-shaped composition is formed by freeze-drying in a manner that contains polyethylene glycol and trehalose of a specific molecular weight and has a specific volume specific gravity. , the tablet-shaped composition is low in hygroscopicity but dissolves instantaneously when water is added, has high release properties, and is excellent in ease of handling, and further completed the present invention.

亦即,本發明的錠型凍結乾燥化妝料含有:(A)海藻糖30至91質量%,及(B)分子量11000至25000的聚乙二醇4.0至16質量%,並且,容積比重為0.1至0.5g/mL。 That is, the tablet-type freeze-dried cosmetic of the present invention contains: (A) 30 to 91% by mass of trehalose, and (B) 4.0 to 16% by mass of polyethylene glycol with a molecular weight of 11,000 to 25,000, and has a volume specific gravity of 0.1 to 0.5g/mL.

在前述化妝料中,較佳為含有(B)數量平均分子量15000至20000的聚乙二醇。 Among the aforementioned cosmetics, it is preferable to contain (B) polyethylene glycol having a number average molecular weight of 15,000 to 20,000.

在前述化妝料中,較佳為含有(C)玻尿酸及(D)增黏劑。 Among the aforementioned cosmetics, it is preferable to contain (C) hyaluronic acid and (D) a thickener.

在前述化妝料中,較佳為(C)玻尿酸的調配量為0.01 至2質量%。 In the aforementioned cosmetics, it is preferable that the blending amount of (C) hyaluronic acid is 0.01 to 2% by mass.

在前述化妝料中,較佳為(D)增黏劑的調配量為0.01至1.0質量%。 In the aforementioned cosmetics, it is preferable that the blending amount of the (D) thickener is 0.01 to 1.0% by mass.

在前述化妝料中,較佳為(D)增黏劑是選自三仙膠、羅望子膠、海藻酸鈉(sodium alginate)、結蘭膠(gellan gum)、瓊脂、聚乙烯醇、羧基乙烯聚合物、榅桲籽(quince seed)。 In the aforementioned cosmetics, it is preferred that (D) the tackifier is selected from Sanxian gum, tamarind gum, sodium alginate (sodium alginate), gellan gum (gellan gum), agar, polyvinyl alcohol, carboxyethylene Polymers, quince seed.

依照本發明,藉由調配海藻糖及特定數量平均分子量的聚乙二醇,而可得到一種適用於皮膚等之添加少量的水即可瞬間溶解的錠型凍結乾燥化妝料。又,前述錠型化妝料的吸濕性極小,可提供為具備攜帶性及輕便性的化妝料。 According to the present invention, by formulating trehalose and polyethylene glycol with a specific number and average molecular weight, a tablet-shaped freeze-dried cosmetic that is suitable for skin and the like and can be instantly dissolved by adding a small amount of water can be obtained. In addition, the aforementioned tablet-shaped cosmetics have extremely low hygroscopicity, and can be provided as cosmetics having portability and portability.

又,在更調配有玻尿酸及增黏劑時,可得到使用性優異的錠型凍結乾燥化妝料。 Also, when hyaluronic acid and a thickener are added, a tablet-type freeze-dried cosmetic with excellent usability can be obtained.

[實施發明的形態] [Mode of Carrying Out the Invention]

以下,詳細地說明本發明。 Hereinafter, the present invention will be described in detail.

本發明的錠型凍結乾燥化妝料含有海藻糖、及特定數量平均分子量的聚乙二醇,基本上,是從該成分呈均勻溶解/分散之液藉由使介質揮發而製造者。首先,說明本發明的構成成分。 The tablet-type freeze-dried cosmetic of the present invention contains trehalose and polyethylene glycol with a specific number average molecular weight, and is basically produced from a uniformly dissolved/dispersed liquid of the components by volatilizing the medium. First, the constituent components of the present invention will be described.

<賦形劑> <Excipient>

在本發明作為賦形劑調配的成分,係(A)海藻糖、(B)聚乙二醇。 The components formulated as excipients in the present invention are (A) trehalose and (B) polyethylene glycol.

(A)海藻糖 (A) Trehalose

本發明所使用的(A)海藻糖,係形態為兩個D-葡萄糖鍵結的2糖類,其鍵結模式有α,α-,α,β-,β,β-的3種類,一般而言觀察到在天然大多以α,α-的鍵結模式存在。 The (A) trehalose used in the present invention is a 2-saccharide in the form of two D-glucose bonds, and its bonding mode has three types: α, α-, α, β-, β, β-, generally It is observed that most of them exist in the α,α-bonding mode in nature.

屬於糖的一種之海藻糖,由於具有較強的保水力,相對於赤藻糖醇、木醣醇、山梨糖醇等糖,在作為凍結乾燥化妝料的安定性、再溶解性及離型性之點而言較優異。 Trehalose, which is a kind of sugar, has a strong water retention capacity. Compared with sugars such as erythritol, xylitol, and sorbitol, it has better stability, resolubility, and release properties as freeze-dried cosmetics. It is superior in point of view.

在化妝料中,海藻糖的調配量,較佳為30至91質量%。又,為65至91質量%時,在高溫安定性優異之點而言為更佳。未達30質量%時,在高溫安定性及再溶解時對水的溶解性有不充分的情況之點而言為不佳。又,超過91質量%時,在高溫耐性是優異,惟有不容易凍結且突沸的情況之點以及在使用感之點而言為不佳。 In cosmetics, the blending amount of trehalose is preferably 30 to 91% by mass. Moreover, when it is 65 to 91 mass %, it is more preferable at the point which is excellent in high-temperature stability. When it is less than 30% by mass, it is unfavorable in terms of high temperature stability and solubility in water at the time of redissolving may be insufficient. Also, when it exceeds 91% by mass, it is excellent in high temperature resistance, but it is not good in the point of being difficult to freeze and bumping, and in terms of usability.

海藻糖的市售品而言,可列舉例如,海藻糖(化妝品用)(林原社股份有限公司製)等。 As a commercial item of trehalose, Trehalose (for cosmetics) (manufactured by Hayashibara Co., Ltd.) etc. are mentioned, for example.

在不損害本發明效果的範圍內,除了海藻糖之外亦可添加其他糖類。 In addition to trehalose, other saccharides may be added within the range of not impairing the effect of the present invention.

可列舉例如,麥芽糖、麥芽四糖、麥芽糖基海藻糖 (maltosyl trehalose)等。 Examples thereof include maltose, maltotetraose, maltosyl trehalose and the like.

(B)聚乙二醇 (B) polyethylene glycol

作為本發明所使用的(B)聚乙二醇,由錠劑的賦形性之點而言,可舉數量平均分子量為11000至20000的聚乙二醇。較佳的是,若為15000至20000,從成型性及離型性之點而言為較佳。 Examples of (B) polyethylene glycol used in the present invention include those having a number average molecular weight of 11,000 to 20,000 from the point of view of lozenge excipient properties. Preferably, if it is 15,000 to 20,000, it is more preferable from the point of moldability and releasability.

數量平均分子量未達11000時,從離型性有變差的情況之點而言為不佳。又,數量平均分子量大於20000時,從再溶解性有不佳、使用感較差的情況之點而言為不佳。 When the number average molecular weight is less than 11,000, it is unfavorable from the point of view that the release property may deteriorate. Moreover, when the number average molecular weight exceeds 20,000, it is unfavorable from the viewpoint that resolubility may be poor and the usability may be poor.

在化妝料中,(B)聚乙二醇的調配量較佳為4至16質量%,更佳為12至16質量%。調配超過16質量%時,有錠劑的離型性及使用感降低的情況。 In cosmetics, the blending amount of (B) polyethylene glycol is preferably from 4 to 16% by mass, more preferably from 12 to 16% by mass. When more than 16% by mass is blended, the release property and usability of the tablet may decrease.

又,前述聚乙二醇,可使用以公知的合成方法合成者,亦可使用市售品。 In addition, the aforementioned polyethylene glycol may be synthesized by a known synthesis method, or a commercially available product may be used.

聚乙二醇的市售品而言,可列舉例如,PEG-20000(三洋化成工業股份有限公司製)等。 As a commercial item of polyethylene glycol, PEG-20000 (made by Sanyo Chemical Industry Co., Ltd.), etc. are mentioned, for example.

(C)玻尿酸 (C) Hyaluronic Acid

本發明所使用的(C)玻尿酸,係N-乙醯基-D-葡萄糖胺殘基與D-葡萄醣醛酸殘基交互鍵結的直鏈狀高分子,可使用將其加工成粉末狀者等。 The (C) hyaluronic acid used in the present invention is a straight-chain macromolecule in which N-acetyl-D-glucosamine residues and D-glucuronic acid residues are interactively bonded, and it can be processed into powder Wait.

前述玻尿酸,例如,可由雞冠或其他動物組織分離萃取、或使用有鏈球菌屬等微生物的發酵法而得。 又,在本發明中,例如,作為玻尿酸的衍生物,可使用玻尿酸鈉鹽、玻尿酸鉀鹽等玻尿酸金屬鹽,或使用將玻尿酸的羥基、羧基等進行醚化、酯化、醯胺化、乙醯化、縮醛化、縮酮化所得的玻尿酸衍生物等的粉末。 The aforementioned hyaluronic acid, for example, can be isolated and extracted from cockscombs or other animal tissues, or obtained by fermentation with microorganisms such as Streptococcus. In addition, in the present invention, for example, as hyaluronic acid derivatives, hyaluronic acid metal salts such as hyaluronic acid sodium salt and hyaluronic acid potassium salt can be used, or hyaluronic acid can be etherified, esterified, amidated, etc. Powder of hyaluronic acid derivatives obtained by acylation, acetalization, and ketalization.

又,亦可使用玻尿酸的市售品。作為市售的玻尿酸,可列舉例如,玻尿酸HA-LQ(QP Fine Chemicals社製)、玻尿酸FCH(Kikkoman Biochemifa股份有限公司製)等。 In addition, commercially available hyaluronic acid can also be used. Examples of commercially available hyaluronic acid include hyaluronic acid HA-LQ (manufactured by QP Fine Chemicals), hyaluronic acid FCH (manufactured by Kikkoman Biochemifa Co., Ltd.), and the like.

又,(C)玻尿酸的分子量,並沒有特別限定,較佳為分子量10萬以上,更佳為分子量為50萬至300萬左右。使用未達10萬的低分子化的玻尿酸時,對錠劑的賦形性及再溶解後的使用感有不充分的情況。又,分子量大於300萬時,從溶解性及再溶解後的使用感有不充分的情況之點而言為不佳。 Moreover, the molecular weight of (C) hyaluronic acid is not specifically limited, Preferably it is 100,000 or more, More preferably, it is about 500,000 to 3 million. When using hyaluronic acid with a low molecular weight of less than 100,000, the formability of tablets and the feeling of use after redissolving may not be sufficient. Moreover, when the molecular weight exceeds 3 million, it is unfavorable from the point that solubility and the usability after redissolving may be insufficient.

上述賦形劑中,特別是(C)玻尿酸,即使為低濃度的水溶液狀態亦顯示極高的黏性,故其調配量與凍結乾燥後的錠劑及其再溶解液的性質有高關連性。 Among the above-mentioned excipients, especially (C) hyaluronic acid exhibits extremely high viscosity even in a low-concentration aqueous solution state, so its compounding amount has a high correlation with the properties of the freeze-dried tablet and its reconstitution solution .

在化妝料中,(C)玻尿酸的調配量較佳為0.01至2質量%,更佳為0.05至0.2質量%。調配超過2質量%而時,由於錠劑的溶解性或離型性會降低,故不佳。 In cosmetics, the blending amount of (C) hyaluronic acid is preferably 0.01 to 2% by mass, more preferably 0.05 to 0.2% by mass. When blending exceeds 2% by mass, it is not preferable because the solubility or release property of the tablet decreases.

(D)增黏劑 (D) Tackifier

本發明所使用的(D)增黏劑,係為了提高錠劑化妝料的成型性及離型性而使用。 The (D) thickener used in the present invention is used to improve the moldability and release properties of tablet cosmetics.

作為(D)增黏劑,可使用三仙膠、羅望子膠、海藻酸鈉、 結蘭膠、瓊脂、聚乙烯醇、羧基乙烯聚合物、榅桲籽等水溶性高分子。其中,從使用錠劑化妝料,在乾燥時的黏性、伸張感少之點而言,較佳為使用三仙膠、羅望子膠、榅桲籽。 As the (D) thickener, water-soluble polymers such as sanxian gum, tamarind gum, sodium alginate, gellan gum, agar, polyvinyl alcohol, carboxyvinyl polymer, and quince seeds can be used. Among them, it is preferable to use sanxian gum, tamarind seed gum, and quince seed in terms of stickiness and less stretchy feeling during drying when using lozenge cosmetics.

在化妝料中,(D)增黏劑的調配量,較佳為0.01至1.0質量%,更佳為0.05至0.1質量%。調配超過1.0質量%時,錠劑的離型性及使用感有降低的情況,調配量未達0.01質量%時,成型性及離型性有降低的情況。 In cosmetics, the blending amount of the (D) thickener is preferably 0.01 to 1.0% by mass, more preferably 0.05 to 0.1% by mass. When the compounding amount exceeds 1.0% by mass, the release property and the feeling of use of the tablet may decrease, and when the compounding amount is less than 0.01 mass%, the moldability and the release property may decrease.

作為如此之增黏劑的市售品,可列舉例如,三仙膠(Keltrol,Kelco社製)、羅望子膠(Glyloid 6C,大日本製藥股份有限公司製)、海藻酸鈉(Duck Algin NSPH,Kikkoman Biochemifa股份有限公司製)、結蘭膠(Kelco Gel,DSP Gokyo Food & Chemical股份有限公司製)、瓊脂(伊那瓊脂CS-110,伊那食品工業股份有限公司製)等。 Commercially available products of such thickeners include, for example, sanxian gum (Keltrol, manufactured by Kelco), tamarind gum (Glyloid 6C, manufactured by Dainippon Pharmaceutical Co., Ltd.), sodium alginate (Duck Algin NSPH, Kikkoman Biochemifa Co., Ltd.), gellan gum (Kelco Gel, DSP Gokyo Food & Chemical Co., Ltd.), agar (Ina Agar CS-110, Ina Food Industry Co., Ltd.), and the like.

又,在本發明的錠型凍結乾燥化妝料中,除了上述成分之外,在不損害本發明效果的範圍內亦可含有通常可調配在化妝品或醫藥部外品的其他的成分。又,在乾燥化妝料,即使含有1至5質量%的水也無問題。 In addition, the tablet-type freeze-dried cosmetic of the present invention may contain other components that are usually formulated in cosmetics or quasi-drugs in addition to the above-mentioned components within the range that does not impair the effects of the present invention. Also, in dry cosmetics, there is no problem even if it contains 1 to 5% by mass of water.

本發明的製造上,就其他成分而言,特別是使用水性成分為較佳,但亦可使用界面活性劑等進行可溶化等,來調配油性成分。 In the production of the present invention, it is preferable to use water-based components as other components, but it is also possible to prepare an oil-based component by solubilizing with a surfactant or the like.

作為水性成分,可列舉例如,多元醇、(D)成分以外的水溶性高分子、螯合劑、pH調整劑、防腐劑等。 As an aqueous component, a polyhydric alcohol, the water-soluble polymer other than (D)component, a chelating agent, a pH adjuster, a preservative, etc. are mentioned, for example.

作為多元醇,可列舉例如,乙二醇、丙二醇、 1,3-丁二醇、甘油、上述分子量以外的聚乙二醇、聚甘油等。 Examples of the polyhydric alcohol include ethylene glycol, propylene glycol, 1,3-butanediol, glycerin, polyethylene glycol and polyglycerin having molecular weights other than those described above.

作為水溶性高分子,係上述以外的高分子,例如,作為親水性合成高分子,可列舉聚丙烯酸、聚乙二醇、聚丙烯醯胺、聚烷基丙烯醯胺/聚丙烯醯胺共聚物、羧甲基纖維素、陽離子化纖維素、普盧蘭尼克(Pluronic)、聚乙二醇(Macrogol)、聚維酮(Povidone)、聚乙烯甲基丙烯酸酯、聚乙烯亞胺等;作為親水性天然高分子,可列舉琥珀聚醣、瓜爾膠(Guar gum)、刺槐豆膠(Locust bean gum)、卡德蘭膠(Curdlan gum)、海藻酸、鹿角菜膠(carrageenan)、甘露聚醣、果膠、阿拉伯樹膠、刺蘋婆(Sterculia urens)膠、酪蛋白、α-環糊精、糊精、聚葡萄糖(dextran)、明膠、膠原蛋白、果膠、澱粉、幾丁質及其衍生物、幾丁聚醣及其衍生物、彈性蛋白、肝素、硫酸乙醯肝素(heparan sulfate)、甲基纖維素、羥乙基纖維素、羥丙基纖維素、羥丙基甲基纖維素等;作為親水性黏土礦物,可列舉合成鋰皂石(laponite)、皂土、膨潤石等。 Examples of water-soluble polymers include polymers other than those mentioned above. For example, examples of hydrophilic synthetic polymers include polyacrylic acid, polyethylene glycol, polyacrylamide, and polyalkylacrylamide/polyacrylamide copolymers. , carboxymethyl cellulose, cationized cellulose, Pluronic, macrogol, povidone, polyethylene methacrylate, polyethyleneimine, etc.; as hydrophilic Natural natural polymers, such as succinic acid, guar gum, locust bean gum, curdlan gum, alginic acid, carrageenan, and mannan , pectin, gum arabic, Sterculia urens gum, casein, alpha-cyclodextrin, dextrin, dextran, gelatin, collagen, pectin, starch, chitin and its derivatives Chitosan and its derivatives, elastin, heparin, heparan sulfate, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, etc. ; Examples of the hydrophilic clay minerals include laponite, bentonite, and bentonite.

作為螯合劑,可列舉例如,1-羥乙基-1,1-二磺酸、1-羥乙基-1,1-二磺酸四鈉鹽、乙二胺四乙酸二鈉、乙二胺四乙酸三鈉、乙二胺四乙酸四鈉、檸檬酸鈉、聚磷酸鈉、偏磷酸鈉、葡萄糖酸、磷酸、檸檬酸、抗壞血酸、琥珀酸、乙二胺四乙酸、乙烯二胺羥乙基三乙酸三鈉等。 Examples of the chelating agent include 1-hydroxyethyl-1,1-disulfonic acid, 1-hydroxyethyl-1,1-disulfonic acid tetrasodium salt, disodium edetate, ethylenediamine Trisodium Tetraacetate, Tetrasodium EDTA, Sodium Citrate, Sodium Polyphosphate, Sodium Metaphosphate, Gluconic Acid, Phosphoric Acid, Citric Acid, Ascorbic Acid, Succinic Acid, EDTA, Ethylenediamine Hydroxyethyl Trisodium triacetate, etc.

作為pH調整劑,可列舉例如,乳酸-乳酸鈉、檸檬酸-檸檬酸鈉、琥珀酸-琥珀酸鈉等緩衝劑等。 Examples of the pH adjuster include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, and succinic acid-sodium succinate.

作為防腐劑,可列舉對羥基苯甲酸(paraoxybenzoate)、苯氧基乙醇(Phenoxyethanol)等。 Examples of preservatives include paraoxybenzoate, phenoxyethanol and the like.

又,作為油性成分,可列舉例如,香料、油性藥劑(例如,維生素A等)。 Moreover, as an oily component, a fragrance|flavor, an oily drug (for example, vitamin A etc.) is mentioned, for example.

其他,作為可調配成分,可列舉例如,保濕劑(例如,2-甲基丙烯醯氧乙基磷酸膽鹼(2-Methacryloyloxyethyl phosphorylcholine,MPC)共聚物、PEG/PPG-14/7二甲基醚等PEG/PPG二甲基醚、水溶性膠原蛋白、過氧化氫處理酵母加水分解物、dl-吡咯烷酮羧酸鈉、L-羥基補胺酸、氯化鈣、氯化鎂);各種萃取物(例如,玫瑰、黃柏、黃蓮、紫根、芍藥、日本獐牙菜(Swertia japonica)、樺樹、鼠尾草(Salvia officinalis)、枇杷、紅蘿蔔、蘆薈、錦葵(Malva sylvestris)、花菖蒲、葡萄、薏仁、絲瓜、百合、番紅花(Saffron)、川芎、生薑、小連翹(Hypericum erectum)、芒柄花(Ononis spinose)、大蒜、辣椒、陳皮、當歸、海藻等);其他水溶性藥劑(例如,傳明酸(Tranexamic acid))等的有效成分,藉由此等的調配可對本發明的化妝料賦予期望的效果。 In addition, as ingredients that can be formulated, for example, humectants (for example, 2-methacryloyloxyethyl phosphorylcholine (2-Methacryloyloxyethyl phosphorylcholine, MPC) copolymer, PEG/PPG-14/7 dimethyl ether such as PEG/PPG dimethyl ether, water-soluble collagen, hydrogen peroxide-treated yeast hydrolyzate, sodium dl-pyrrolidone carboxylate, L-hydroxysupplementine, calcium chloride, magnesium chloride); various extracts (eg, Rose, Phellodendron, Cotton Lotus, Purple Root, Peony, Japanese Swertia (Swertia japonica), Birch, Sage (Salvia officinalis), Loquat, Carrot, Aloe Vera, Mallow (Malva sylvestris), Iris, Grapes, Barley , loofah, lily, saffron (Saffron), Chuanxiong, ginger, Hypericum erectum, Ononis spinose, garlic, pepper, tangerine peel, angelica, seaweed, etc.); other water-soluble agents (for example, Active ingredients such as tranexamic acid can impart desired effects to the cosmetic of the present invention by formulating such active ingredients.

又,屬於必須成分的增黏劑及海藻糖,亦可對本發明賦予保濕效果。 In addition, the thickener and trehalose which are essential components can also impart a moisturizing effect to the present invention.

本發明的錠型凍結乾燥化妝料,係將上述調配成分在水、低級醇等揮發性液狀介質中溶解或分散,調製乾燥前溶液後,進行凍結後減壓使其昇華而可得到殘留的乾燥物。 The tablet-type freeze-dried cosmetic of the present invention is obtained by dissolving or dispersing the above-mentioned compounded ingredients in volatile liquid media such as water and lower alcohols, preparing the solution before drying, freezing it, and sublimating it under reduced pressure to obtain a residual dry matter.

在本發明的錠型凍結乾燥化妝料的製造中,溶解在水等介質之上述賦形劑成分,係在介質中形成3維的網目狀結構。若從如此的狀態僅去除介質時,由於乾燥會使網目結構收縮,造成歪曲或崩潰,通常難以維持該結構。但是,在本發明中,由於與前述賦形劑一起調配的海藻糖在介質揮發後代替介質支持網目狀結構,故推測幾乎可維持由賦形劑形成的結構。 In the production of tablet-type freeze-dried cosmetics of the present invention, the above-mentioned excipient components dissolved in a medium such as water form a three-dimensional network structure in the medium. If only the medium is removed from such a state, the mesh structure shrinks due to drying, causing distortion or collapse, and it is generally difficult to maintain the structure. However, in the present invention, since the trehalose formulated together with the aforementioned excipient supports the network structure instead of the medium after volatilization of the medium, it is presumed that the structure formed by the excipient is almost maintained.

又,賦形劑的3維網目狀結構經維持的乾燥物,係從該結構抽除介質部分的多孔狀態,當加水進行再溶解時,水從各孔向網目狀構造內部滲透,進行錠劑製劑全體的溶解。此時,含有上述結構物的構成成分的密度越高,水向內部的滲透越困難,製劑的溶解變困難。另一方面,構成成分的密度過低時,製劑本身變脆弱,容易崩壞,又,在保存時容易吸收濕氣。 In addition, the dry product with the three-dimensional network structure of the excipient maintained is a porous state in which the medium part is removed from the structure, and when water is added for redissolution, water penetrates into the network structure from each hole to form a tablet. Dissolution of the entire preparation. In this case, the higher the density of the constituents containing the above-mentioned structure, the more difficult it is for water to permeate inside, and the dissolution of the preparation becomes difficult. On the other hand, when the density of the constituent components is too low, the preparation itself becomes fragile and easily collapses, and also absorbs moisture easily during storage.

因此,為了要製成一方面具有水會瞬間滲透,來崩壞製劑的溶解性,另一方面在保存時的吸濕性極低的製劑,必須進一步將構成成分的容積比重設定在一定的範圍。 Therefore, in order to make a preparation that has water that will permeate instantly to collapse the solubility of the preparation, and on the other hand, has extremely low hygroscopicity during storage, it is necessary to further set the volumetric specific gravity of the constituents within a certain range. .

因此,在本發明的錠型化妝料中,必須含有上述構成成分,並且,將其容積比重設定為0.1至0.5g/mL,較佳為0.15至0.3g/mL。 Therefore, in the tablet-type cosmetic of the present invention, the above-mentioned constituents must be contained, and the volume specific gravity thereof is set to 0.1 to 0.5 g/mL, preferably 0.15 to 0.3 g/mL.

容積比重未達0.1g/mL時有保存時的吸濕性變高之傾向,超過0.5g/mL時對水的溶解性有降低的傾向。另一方面,若容積比重在前述範圍內,則抽除介質的孔變得適中,且增黏劑的網目結構亦固定為適度擴散的狀態,在添加水 進行再溶解時,有極良好的溶解性。 When the volumetric specific gravity is less than 0.1 g/mL, the hygroscopicity during storage tends to increase, and when it exceeds 0.5 g/mL, the solubility to water tends to decrease. On the other hand, if the volume specific gravity is within the above range, the pores of the pumping medium become moderate, and the network structure of the thickener is also fixed in a moderately diffused state, and when water is added for redissolution, there is very good dissolution. sex.

作為容積比重的測定方法,由凍結乾燥後的錠劑的重量(g)÷凍結乾燥模的容積(mL)來算出。 As a measuring method of volume specific gravity, it calculated from the weight (g) of the tablet after freeze-drying÷the volume (mL) of the freeze-drying mold.

本發明的錠型化妝料,係例如藉由將在水或低級醇等揮發性液狀介質中溶解或分散有構成成分的溶液填充在錠劑模中後,使其凍結乾燥,並且視需要從前述模取出而製造。 The tablet-type cosmetic of the present invention is, for example, prepared by filling a tablet mold with a solution in which constituent components are dissolved or dispersed in a volatile liquid medium such as water or a lower alcohol, then freeze-drying it, and removing it from the The aforementioned mold is taken out and manufactured.

本發明係藉由將製劑的體積與構成成分及介質的量設定為滿足上述容積比重,而可成型為任何大小及形狀。 The present invention can be molded into any size and shape by setting the volume of the preparation and the amount of constituent components and media to satisfy the above-mentioned volume specific gravity.

但是,極端細的形狀或過於複雜的形狀是有成形性等問題而不佳。 However, an extremely thin shape or an overly complicated shape is not preferable because of problems such as formability.

又,本發明是製劑的吸濕性低,又,離型性高而容易由容器剝離,故不限於以填充在容器的狀態直接分裝成為每次使用量的包裝型態(例如,泡鼓包裝(blister pack)),亦可為只將由容器(模)剝離的製劑以任意的形態包裝。 In addition, the present invention has low hygroscopicity of the preparation, and high release property and is easy to be peeled off from the container, so it is not limited to the packaging form (for example, a blister pack) that is directly dispensed into the amount of each use in the state filled in the container. Blister pack) may be packaged in any form by simply peeling off the preparation from the container (mold).

本發明的錠型化妝料,通常,可藉由添加適量的水使製劑再溶解,將此溶液塗佈在皮膚等來使用。水的添加量,以製劑會完全溶解的程度作為下限,調製成為容易塗佈的黏度即可,但過多時,成分濃度過低而有不能得到充分效果的情況,過少時則塗佈時有黏稠的情況。因此,雖沒有特別的限定,但較佳為以製劑體積的1至10倍左右調整添加量。 The tablet-type cosmetic of the present invention can usually be used by adding an appropriate amount of water to redissolve the preparation, and applying the solution to the skin or the like. The amount of water to be added can be adjusted to a viscosity that is easy to apply based on the degree at which the preparation will completely dissolve as the lower limit. However, if it is too large, the concentration of the ingredients will be too low and sufficient effects may not be obtained. If it is too small, the coating will become sticky. Case. Therefore, although there is no particular limitation, it is preferable to adjust the addition amount to about 1 to 10 times the volume of the formulation.

又,對製劑添加水的場所,可為掌上或適用部位,亦可為適當的容器內等,惟作為本發明的使用方法,較佳為 將製劑的1次使用量置於掌上,在製劑添加水後,將掌上的溶解液直接以手塗佈在適用部位。 In addition, the place where water is added to the preparation can be on the palm or on the application site, or in an appropriate container, etc. However, as the method of use of the present invention, it is preferable to put the dosage of the preparation at one time on the palm and add it to the preparation. After watering, apply the solution on the palm of the hand directly to the affected area.

此外,若為可將製劑再溶解,亦可使用化妝水等代替水。 In addition, if the formulation can be redissolved, lotion or the like may be used instead of water.

本發明的錠型化妝料,依照調配的成分,可製成化妝水、美容液、面膜、卸妝品、潔面乳、護手霜、洗髮精、潤絲精、護髮乳、防曬劑等任意的製品形態,其中特別適合使用為保濕用的化妝水或美容液。 The ingot-shaped cosmetics of the present invention can be made into lotion, beauty lotion, facial mask, makeup remover, facial cleanser, hand cream, shampoo, conditioner, hair conditioner, sunscreen, etc. according to the formulated ingredients. In the form of products, it is especially suitable for use as lotion or beauty essence for moisturizing.

[實施例][Example]

以下,列舉實施例詳述本發明,但本發明不被該等所限定者。調配量如無特別記載時,以相對於調配該成分的系統的質量%表示。 Hereinafter, although an Example is given and this invention is described in detail, this invention is not limited to these. Unless otherwise specified, the compounded amount is expressed in mass % relative to the system in which the component is compounded.

首先,針對在下術試驗所使用的評估方法及評估基準進行說明。 First, the evaluation method and evaluation criteria used in the next surgery test will be described.

<溶解性> <Solubility>

將各試驗例的錠型凍結乾燥化妝料(約100mg)置於手掌上,滴下水500μl,針對以手指混合至使製劑完全溶解為止所需的時間,依照下述的基準進行評估。 The tablet-type freeze-dried cosmetic (about 100 mg) of each test example was placed on the palm of the hand, 500 μl of water was dripped, and the time required for mixing with fingers until the formulation was completely dissolved was evaluated according to the following criteria.

A:製劑瞬間完全溶解。 A: The preparation dissolves completely in an instant.

B:製劑需要些時間但完全溶解。 B: The preparation takes some time but dissolves completely.

C:製劑稍微難溶解且產生一部分殘留。 C: The preparation is slightly insoluble and a part remains.

D:製劑難溶解且產生殘留物。 D: The formulation is poorly soluble and produces residue.

E:製劑不溶解。 E: The formulation does not dissolve.

<使用性> <usability>

將各試驗例的錠型凍結乾燥化妝料(約100mg)置於手掌上,添加500μl的水使其溶解,針對在皮膚上塗佈時的使用感覺(濕潤度、無黏稠感度、皮膚的潤滑度),由10名的專門小組依照下述的基準進行評估。 Put the tablet-type freeze-dried cosmetic (about 100 mg) of each test example on the palm of your hand, add 500 μl of water to dissolve it, and evaluate the feeling of use (moisture, non-sticky feeling, smoothness of the skin) when applied to the skin. ), evaluated by a 10-member panel based on the following criteria.

A:10名中6名以上,回答使用感覺良好。 A: More than 6 out of 10 responded that the product feels good in use.

B:10名中3名以上未達6名,回答使用感覺良好。 B: 3 or more out of 10 and less than 6 answered that the feeling of use was good.

C:10名中未達3名,回答使用感覺良好。 C: Less than 3 out of 10 responded that the feeling of use was good.

<離型性> <Release>

在各試驗例的錠型凍結乾燥化妝料的製造方法的乾燥步驟後,針對將乾燥物由容器取出時的剝離容易性,依照下述的基準進行評估。 After the drying step of the method for producing tablet-type freeze-dried cosmetics in each test example, the ease of detachment when the dried product was taken out of the container was evaluated according to the following criteria.

A:製劑非常容易從容器剝離。 A: The preparation was very easily peeled off from the container.

B:製劑容易從容器剝離。 B: The formulation was easily peeled from the container.

C:製劑稍微難從容器剝離。 C: The preparation was slightly difficult to peel from the container.

D:製劑非常難從容器剝離。 D: The preparation was very difficult to peel from the container.

<成形性> <formability>

針對在各試驗例的錠型凍結乾燥化妝料的製造方法的乾燥步驟後的成形性,依照下述的基準進行評估。 The formability after the drying step of the manufacturing method of the tablet-type freeze-dried cosmetic of each test example was evaluated according to the following criteria.

A:製劑由容器依照成形模成形。 A: The preparation is shaped from the container according to the forming die.

B:製劑由容器大約依照成形模成形。 B: The formulation is shaped from the container approximately in accordance with the forming die.

C:製劑由容器產生小龜裂但可以成形。 C: The formulation produced small cracks from the container but could be molded.

D:製劑由容器縮小等且沒有依照成形模成形。 D: The preparation was shrunk from the container, etc. and was not shaped according to the forming die.

E:製劑由容器產生大龜裂、或脆弱而產生龜裂。 E: The preparation has large cracks in the container or cracks due to fragility.

依照下述製造方法調製出記載於下述各表的處方之試驗例組成物。 Compositions of test examples with formulations described in the following tables were prepared according to the following production methods.

<製造方法> <Manufacturing method>

將各種調配成分溶解或分散在水或低級醇等揮發性液狀介質,注入於成形模中,凍結後進行減壓使其昇華後作為乾燥物殘留而得錠型凍結乾燥化妝料。 Dissolve or disperse various formulated ingredients in volatile liquid media such as water or lower alcohols, inject them into forming molds, freeze, decompress and sublimate, and then remain as dry matter to obtain tablet-shaped freeze-dried cosmetics.

首先,本發明者針對作為賦形劑使用的糖對錠劑化妝料的成形性的影響進行檢討。 First, the present inventors examined the influence of sugar used as an excipient on the moldability of tablet cosmetics.

下述表1所示的試驗例的處方如下。 The formulations of the test examples shown in Table 1 below are as follows.

Figure 106120653-A0202-12-0015-1
Figure 106120653-A0202-12-0015-1

Figure 106120653-A0202-12-0015-2
Figure 106120653-A0202-12-0015-2

由此可知,作為賦形劑的基本骨架,各糖之中,從成形性之點而言,使用海藻糖為較佳。 From this, it can be seen that trehalose is preferably used as the basic skeleton of the excipient among various sugars from the viewpoint of formability.

因此,本發明者,在下述檢討相對於乾燥前溶液的海藻糖的調配量。表2中的調配量不是凍結乾燥化妝料中,而是表示乾燥前溶液中的各成分的調配量。 Therefore, the inventors of the present invention examined the preparation amount of trehalose relative to the solution before drying as follows. The compounded amounts in Table 2 are not in the freeze-dried cosmetics, but represent the compounded amounts of each component in the solution before drying.

Figure 106120653-A0202-12-0016-16
Figure 106120653-A0202-12-0016-16

由試驗例2-1至2-6可知,相對於乾燥前溶液海藻糖的調配量,超過20質量%時會突沸,故從成形性的觀點而言為不佳。又,就再溶解性而言,相對於乾燥前溶液海藻糖的調配量超過20質量%時,有不溶性殘留物而不佳。 From Test Examples 2-1 to 2-6, it can be seen that when the amount of trehalose formulated in the solution before drying exceeds 20% by mass, bumping occurs, which is unfavorable from the viewpoint of formability. Also, in terms of resolubility, when the prepared amount of trehalose exceeds 20% by mass relative to the solution before drying, insoluble residues are not preferable.

於是,本發明者,作為其他的成分,藉由在乾燥前溶液添加(B)聚乙二醇,檢討是否可改善凍結乾燥後的錠型化妝料的成型性及離型性。表3中的調配量,不是凍結乾燥化妝料中,而是表示乾燥前溶液中的各成分的調配量。 Then, the present inventors examined whether the moldability and release property of the tablet-shaped cosmetic after freeze-drying could be improved by adding (B) polyethylene glycol in solution as another component before drying. The compounded amounts in Table 3 are not freeze-dried cosmetics, but represent the compounded amounts of each component in the solution before drying.

Figure 106120653-A0202-12-0017-4
Figure 106120653-A0202-12-0017-4

(* 1)海藻糖;林原社股份有限公司製 (*1)Trehalose; made by Hayashibara Co., Ltd.

由試驗例3-1至3-2可知,在乾燥前溶液添加(B)聚乙二醇,則在維持再溶解性下,成為成形性及離型性優異的賦形劑。 From Test Examples 3-1 to 3-2, it can be seen that adding (B) polyethylene glycol to the solution before drying becomes an excipient with excellent formability and release property while maintaining resolubility.

本發明者進一步針對作為錠劑化妝料的使用性進行檢討。 The present inventors further examined usability as a lozenge cosmetic.

Figure 106120653-A0202-12-0018-5
Figure 106120653-A0202-12-0018-5

(* 3)BioHyalo 12;資生堂社製 (*3)BioHyalo 12; manufactured by Shiseido

(* 4)Glyloid 6C;大日本製藥社製 (*4) Glyloid 6C; manufactured by Dainippon Pharmaceutical Co., Ltd.

(* 5)Lipdure-PMB(Ph10);日油社製 (*5) Lipdure-PMB (Ph10); made by NOF

Figure 106120653-A0202-12-0019-6
Figure 106120653-A0202-12-0019-6

由表4及表5可知,為了提升錠劑化妝料的使用性,藉由一邊調配(B)聚乙二醇下,一邊更添加保濕劑及增黏劑,可在維持成形性、離型性、再溶解性下,提升使用性。 It can be seen from Table 4 and Table 5 that in order to improve the usability of tablet cosmetics, by adding (B) polyethylene glycol and adding humectants and thickeners, the formability and release properties can be maintained. , Re-solubility, improve usability.

其次,檢討調配的(B)聚乙二醇的數量平均分子量。 Secondly, the number average molecular weight of the formulated (B) polyethylene glycol was checked.

Figure 106120653-A0202-12-0020-7
Figure 106120653-A0202-12-0020-7

從試驗例6-1至6-7可知,從在成形性及使用性之點而言,(B)聚乙二醇之數量平均分子量較佳為4000 至20000。 From Test Examples 6-1 to 6-7, it can be seen that the number average molecular weight of (B) polyethylene glycol is preferably 4,000 to 20,000 in terms of formability and usability.

Figure 106120653-A0202-12-0021-8
Figure 106120653-A0202-12-0021-8

試驗例7-1至7-6,係再溶解性、使用性優異,進一步高溫安定性亦優異的錠劑化妝料。 Test Examples 7-1 to 7-6 are tablet cosmetics that are excellent in resolubility and usability, and also excellent in high temperature stability.

本發明的錠型凍結乾燥化妝料(清洗劑)的處方例如下。 The formulation example of the tablet type freeze-dried cosmetic (cleaning agent) of the present invention is as follows.

Figure 106120653-A0202-12-0022-9
Figure 106120653-A0202-12-0022-9

本發明的錠型凍結乾燥化妝料(護髮處理)的處方例如下。 The formulation example of the tablet type freeze-dried cosmetic (hair care treatment) of the present invention is as follows.

Figure 106120653-A0202-12-0023-10
Figure 106120653-A0202-12-0023-10

本發明的錠型凍結乾燥化妝料(洗髮精)的處方例如下。 The formulation of the tablet-type freeze-dried cosmetic (shampoo) of the present invention is as follows.

Figure 106120653-A0202-12-0024-11
Figure 106120653-A0202-12-0024-11

本發明的錠型凍結乾燥化妝料(皮膚塗佈用化妝料)的處方例4至7如下。 Formulation examples 4 to 7 of the tablet-type freeze-dried cosmetic (cosmetic for skin application) of the present invention are as follows.

Figure 106120653-A0202-12-0025-12
Figure 106120653-A0202-12-0025-12

Figure 106120653-A0202-12-0026-13
Figure 106120653-A0202-12-0026-13

Figure 106120653-A0202-12-0027-14
Figure 106120653-A0202-12-0027-14

Figure 106120653-A0202-12-0028-15
Figure 106120653-A0202-12-0028-15

Claims (6)

一種錠型凍結乾燥化妝料,其中,含有:(A)海藻糖30至91質量%,及(B)分子量11000至25000的聚乙二醇4.0至16質量%,並且,容積比重為0.1至0.5g/mL。 A tablet-type freeze-dried cosmetic, which contains: (A) 30 to 91% by mass of trehalose, and (B) 4.0 to 16% by mass of polyethylene glycol with a molecular weight of 11,000 to 25,000, and has a volume specific gravity of 0.1 to 0.5 g/mL. 如申請專利範圍第1項所述的錠型凍結乾燥化妝料,其含有(B)分子量15000至25000的聚乙二醇。 The tablet-type freeze-dried cosmetic according to item 1 of the patent application, which contains (B) polyethylene glycol with a molecular weight of 15,000 to 25,000. 如申請專利範圍第1項或第2項所述的錠型凍結乾燥化妝料,其含有(C)玻尿酸及(D)增黏劑。 The tablet-type freeze-dried cosmetic as described in item 1 or item 2 of the patent application, which contains (C) hyaluronic acid and (D) thickener. 如申請專利範圍第1項或第2項所述的錠型凍結乾燥化妝料,其中,(C)玻尿酸的調配量為0.01至2質量%。 The tablet-type freeze-dried cosmetic as described in item 1 or item 2 of the patent application, wherein the compounding amount of (C) hyaluronic acid is 0.01 to 2% by mass. 如申請專利範圍第4項所述的錠型凍結乾燥化妝料,其中,(D)增黏劑的調配量為0.01至1.0質量%。 The tablet-type freeze-dried cosmetic as described in item 4 of the patent application, wherein the blending amount of (D) thickener is 0.01 to 1.0% by mass. 如申請專利範圍第4項所述的錠型凍結乾燥化妝料,其中,(D)增黏劑選自三仙膠、羅望子膠、海藻酸鈉、結蘭膠、瓊脂、聚乙烯醇、羧基乙烯聚合物、榅桲籽。 The tablet-type freeze-dried cosmetic as described in item 4 of the scope of the patent application, wherein (D) the thickener is selected from Sanxian gum, tamarind gum, sodium alginate, gellan gum, agar, polyvinyl alcohol, carboxyl Ethylene polymer, quince seeds.
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61180800A (en) * 1985-02-06 1986-08-13 Kanebo Ltd Powdery silk fibroin peptide and production thereof
CA2022478C (en) * 1989-08-07 2000-10-17 Shinichiro Funatsu Solid cosmetic composition
CN1108823C (en) * 1993-02-23 2003-05-21 基因技术股份有限公司 Excipient stabilization of polypeptides treated with organic solvents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61180800A (en) * 1985-02-06 1986-08-13 Kanebo Ltd Powdery silk fibroin peptide and production thereof
CA2022478C (en) * 1989-08-07 2000-10-17 Shinichiro Funatsu Solid cosmetic composition
CN1108823C (en) * 1993-02-23 2003-05-21 基因技术股份有限公司 Excipient stabilization of polypeptides treated with organic solvents

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