JP6628197B2 - Skin preparation kit - Google Patents

Description

  The present invention is a kit for obtaining an effervescent skin external preparation, wherein the first agent is a composition containing an acidic substance and water, and the second agent reacts with the acidic substance to generate carbon dioxide gas. The present invention relates to a kit comprising a composition containing a carbon dioxide generating substance and a thickener.

  Since the effect of carbon dioxide on the skin has the effect of promoting blood circulation in the skin, various skin external preparations utilizing carbon dioxide have been proposed. Most of them generate carbon dioxide by the reaction between an acidic substance and a carbon dioxide generating substance. For example, in order to maintain the effect of generated carbon dioxide, a method of mixing and using a water-containing viscous composition containing an acidic substance, water and a thickener, and a solid carbon dioxide generation substance immediately before use has been proposed. (Patent Document 1). In addition, a substance that is hydrolyzed to generate an acid, a carbonate, a thickener, a gelling agent that gels with calcium ions, and a granular material containing a water-insoluble or poorly water-soluble calcium salt, mixed with water immediately before use. A method has been proposed for use (Patent Document 2)

WO99 / 24043 WO2006 / 80398

  However, when carbon dioxide is generated by the method described in Patent Document 1, it is difficult to uniformly mix the water-containing viscous composition and the solid carbon dioxide-generating substance, and foaming due to carbon dioxide is likely to cause unevenness. It takes time to start. In addition, the method described in Patent Document 2 is troublesome for the user because it takes time to measure water, and the viscosity and the amount of carbon dioxide generated during use do not become constant depending on the quality of the water used. However, the effect differs for each use.

  The present invention has been made in view of the above circumstances, and it is an object of the present invention to provide a kit for obtaining a foamable skin external preparation of uniform quality, which is easily mixed uniformly at the time of mixing, generates even carbon dioxide gas, and has a constant quality.

The present invention provides a kit for obtaining the following effervescent skin preparation (hereinafter, also referred to as a kit of the present invention).
<1> A kit for obtaining an effervescent skin external preparation, wherein the first agent is a composition containing an acidic substance and water, and the second agent reacts with the acidic substance to generate carbon dioxide. A kit comprising a gas generating substance and a thickener.
<2> The kit according to <1>, wherein the first agent further contains at least one of a thickener and a humectant.
<3> The kit according to <1> or <2>, wherein the first agent is a composition having a viscosity of 10,000 mPa · s or less.
<4> The kit according to any one of <1> to <3>, wherein the second agent is a solid composition.
<5> The method according to any one of <1> to <4>, wherein the first agent and the second agent are mixed at a weight ratio of 0.1: 1 to 30: 1 and used. kit.

  ADVANTAGE OF THE INVENTION According to this invention, a user can mix easily at the time of mixing, a carbon dioxide gas is immediately generated evenly, and the kit for obtaining foaming skin external preparation of constant quality can be provided. Further, by mixing an acidic substance with the first agent and a carbon dioxide generating substance with the second agent, the quality can be kept stable. In particular, it is not necessary to mix a storage stabilizer or an antioxidant in order to prevent quality deterioration, or to limit the storage container to a specific storage container. Furthermore, by using the foamable skin external preparation obtained using the kit of the present invention as a pack, a skin condition improving effect, in particular, a whitening effect in a short time can be obtained.

3 shows the water content of the stratum corneum after using the foamable external preparation for skin obtained by using the kits of Examples 1 and 2 and Comparative Example 1. 5 shows the rate of increase in volume due to carbon dioxide of the effervescent skin external preparation obtained using the kit of Example 3.

  The present invention is a kit for obtaining an effervescent skin external preparation, wherein the first agent is a composition containing an acidic substance and water, and the second agent reacts with the acidic substance to generate carbon dioxide gas. A kit containing a carbon dioxide generating substance and a thickener.

  Then, in the kit of the present invention, the user can appropriately mix the first agent and the second agent at the time of use to cause foaming due to the generation of carbon dioxide gas, and can be used by applying to the skin. The kit of the present invention has a feature that storage stability is good by dividing into a first agent and a second agent, and that a user can easily handle it during use. Hereinafter, each component contained in the kit of the present invention and the effervescent external preparation obtained by using the kit of the present invention and a method for producing the same will be described.

<First agent>
The first agent (hereinafter, also referred to as the first agent) in the kit of the present invention contains an acidic substance and water. Preferably, it contains at least one of an acidic substance, water, and a thickener or humectant.

<< acidic substances >>
The acidic substance used in the first agent of the present invention may be any of an organic acid and an inorganic acid, and one or more of these may be used.

  Examples of the organic acid include linear fatty acids such as formic acid, acetic acid, propionic acid, butyric acid, and valeric acid or salts thereof, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, and phthalic acid. Acid, isophthalic acid, dicarboxylic acids such as terephthalic acid or salts thereof, glutamic acid, acidic amino acids such as aspartic acid or salts thereof, glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, α-oxybutyric acid, glycerin Acids, tartronic acid, salicylic acid, gallic acid, tropic acid, ascorbic acid, oxyacids such as gluconic acid and salts thereof, and the like.As the inorganic acid, phosphoric acid, inorganic acids such as sulfurous acid and salts thereof, One or more of these can be used. Among them, citric acid or a salt thereof, ascorbic acid or a salt thereof, malic acid or a salt thereof, succinic acid or a salt thereof are preferable, and citric acid or a salt thereof, ascorbin, from the viewpoint of safety and solubility in the second agent. Acids or salts thereof are more preferred. In the present invention, the acidic substance may be 0.01% by mass or more in the first agent, preferably 0.05% by mass or more, more preferably 0.1% by mass or more, and particularly preferably 0.5% by mass or more. . Moreover, 30 mass% or less is preferable, 20 mass% or less is more preferable, and 10 mass% or less is especially preferable. When the amount of the acidic substance is less than 0.01% by mass, the reaction with the carbon dioxide-generating substance hardly occurs, and the foamable skin external preparation after mixing with the second agent becomes basic. It causes skin troubles such as rough skin after use and weakened skin protection. On the other hand, if it is more than 30% by mass, the skin is strongly irritated when only the first agent is used by mistake, which is not preferable from the viewpoint of safety.

≪water≫
As the water that can be used in the present invention, water that can be used in cosmetics, external medicines, quasi-drugs, and the like can be used, but purified water, distilled water, membrane filtration water, and ion-exchanged water are preferable. The compounding amount may be 5% by mass or more in the first agent, preferably 10% by mass or more, and more preferably 15% by mass or more. If the content is less than 5% by mass, problems such as a difficulty in generating carbon dioxide gas and a decrease in the amount of carbon dioxide gas generated when the first agent and the second agent are mixed are caused, and as a result, However, a sufficient blood circulation promoting effect cannot be obtained.

粘 Thickener≫
The first agent of the present invention preferably contains a thickener. When the first agent contains the thickener, the first agent can have an appropriate viscosity in advance. As a result, an excellent foaming amount can be obtained, and as is clear from Example 2 described later, an effect of improving the skin condition such as an increase in the water content of the stratum corneum, a moist feeling of the skin, brightness, redness, and warmth after use. In addition, the usability, such as ease of mixing during use, resistance to sagging, and ease of removal, is improved. The content of the thickener contained in the first agent may be 0.001% by mass or more in the first agent, preferably 0.005% by mass or more, more preferably 0.01% by mass, and 0% by mass. 0.05% by mass or more is particularly preferred. It is sufficient that the content be 3% by mass or less, preferably 1% by mass or less, and more preferably 0.8% by mass or less. When the content of the thickener in the first agent is 0.001% by mass or less, the viscosity of the first agent is too low, so that it is difficult to obtain a blood circulation promoting effect by carbon dioxide gas. On the other hand, if it is more than 3% by mass, the viscosity of the first agent becomes high, so that it is difficult to mix, and it is difficult to remove the first agent after use. Problems such as a decrease in the amount of foaming due to carbon dioxide gas occur, and as a result, a sufficient blood circulation promoting action by carbon dioxide gas cannot be obtained.

  The first agent of the present invention preferably has a low viscosity from the viewpoint of miscibility with the second agent. Specifically, the viscosity at 25 ° C. is preferably 50,000 mPa · s or less, more preferably 30,000 mPa · s or less, particularly preferably 10,000 mPa · s or less, and further preferably 5,000 mPa · s or less. -It is s or less. In the present invention, when the viscosity of the first agent exceeds 50,000 mPa · s, it becomes difficult for the first agent to be uniformly dispersed in the second agent which is a viscous composition at the time of mixing with the second agent, and foaming due to carbon dioxide gas Unevenness tends to occur. In addition, since it takes a long time before foaming starts, it takes a long time to use, for example, a pack agent and obtain a blood circulation promoting effect by carbon dioxide gas. The use of the liquid composition having a low viscosity as the first agent has the effect of brightening the skin and improving the moist feeling of the skin, redness, and warmth after use, as is apparent from Example 2 described below. In addition, it is preferable because the feeling of use such as ease of mixing and application during use is improved.

  As the thickener used in the first agent, for example, a synthetic polymer, a semi-synthetic polymer, a natural polymer, a viscous mineral and the like can be used. Specifically, as the synthetic polymer, carboxyvinyl polymer, polyvinyl Hydrophilic synthesis including alcohol, acrylic acid / alkyl methacrylate copolymer, acrylates / alkyl acrylate crosspolymer, polyacrylic acid, polyacrylamide, polyalkylacrylamide / polyacrylamide copolymer, carboxymethylcellulose, cationized cellulose, pluronic Examples of the polymer or semi-synthetic polymer include cellulose derivatives such as carboxymethylcellulose or salts thereof, methylcellulose, ethylcellulose, propylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, and B hydroxypropyl cellulose, sulfonated cellulose derivatives. Semi-synthetic polymers include propylene glycol alginate, ethylene glycol alginate, dextrin fatty acid esters, gelatin fatty acid esters, and gelatin fatty acid amides. Examples of natural polymers include polysaccharides and derivatives thereof, for example, xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, celluloses, galactan, arabic gum, tragacanth gum, tamarind gum, agar, agarose, mannan, curdlan, Alginic acid or its salts, gum arabic, pectin, quinseed, starch, alge colloid, chondroitin sulfate or its salts, chitosan and its derivatives, nucleic acids or its salts, ribonucleic acids or its salts, casein, collagen, gelatin, albumin, fibroin, Examples include water-soluble proteins such as elastin, keratin, and sericin, hyaluronic acid or salts thereof, and mucopolysaccharides such as chondroitin sulfate. Examples of the clay mineral include laponite, bentonite, smectite kaolinite, and montmorillonite.

  In the present invention, one or more of the above thickeners can be used, and among the above thickeners, those having high solubility or dispersibility in water are used at the time of use. This is preferable because roughness of the skin due to undissolved components and undispersed components can be reduced. Here, whether the solubility in water is good or bad is that, when water at about room temperature is added and stirred, the external preparation for skin is instantaneously dissolved in water or dispersed and uniformly dissolved to have sufficient viscosity. It can be judged from the fact that no lump is generated at the time of dissolution or dispersion or the like.

  Such thickeners include, for example, carboxyvinyl polymer, carboxymethylcellulose or salts thereof, polyvinyl alcohol, sodium polyacrylate, acrylic acid / alkyl methacrylate copolymer, xanthan gum, succinoglycan, carrageenan, guar gum, locust Bean gum, celluloses, galactan, gum arabic, gum tragacanth, tamarind gum, agar, mannan, curdlan, alginic acid or its salts, collagen, gelatin, albumin, and the like, and carboxymethyl cellulose or its salts, xanthan gum, carrageenan, It is preferable to use tamarind gum and albumin.

湿 Moisturizer≫
The first agent of the present invention also preferably contains a humectant. Examples of the humectant used in the present invention include polyhydric alcohols, saccharides, amino acids, organic acids, sterols, urea, proteins, plant extracts, and the like, which are usually used in cosmetics, external medicines, quasi-drugs, and the like. Usable humectants can be used. Specific examples include, for example, glycerin, diglycerin, triglycerin, polyglycerin such as tetraglycerin, ethylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, 1, Polyhydric alcohols such as 3-propanediol, 1,2-pentanediol, sorbitol, and polyglycerin derivatives, polyoxyalkylene alkyl glucosides, sodium lactate, sodium pyrrolidonecarboxylate, almonds, avocados, altea, aloe, usbnia oi, ononis, oats , Licorice, quince seed, clara (kudjin), gardenia, grapefruit, watercress, gentian, gennoshoko, burdock, wheat, saishin, cactus, cactus Saw, hawthorn, geome, spider lily, ginger, mallow, mulberry, falcon, caterpillar, dokudami, peppermint, pearl barley, hamamelis, rose, hinoki, coltsfoot, poppy, grape, prunes, loofah, bodaiju, hop, pine, quince, maroni, melissa And plant extracts such as cornflower, lily, lime, lavender, apple, rice and rice bran, blackcurrant, ibukitorano, neubara, eleuthero, seaweed and the like, and one or more of these can be used. . In the present invention, it is preferable to use one or more polyhydric alcohols. By using a humectant as the first agent, as is apparent from Example 3 described below, the effect of keeping the freshness of the skin after use longer while maintaining a high amount of carbon dioxide gas generated during use is exerted. . Also, by using it together with an acidic substance and water, it becomes possible to use only the first agent as a peeling agent.

<Second agent>
The second agent in the kit of the present invention contains a carbon dioxide-generating substance that reacts with an acidic substance to generate carbon dioxide, and a thickener. The second agent may be in any form such as solid, liquid, and gel.However, the ease of mixing at the time of mixing with the first agent, the solid state is preferred from the viewpoint of the cost during production, and the solid state is preferred. Among them, it is particularly preferable to be in the form of granules, fine granules or powder.

≪Carbon dioxide generating substance≫
As the carbon dioxide generating substance used in the second agent of the present invention, various substances can be used without particular limitation. Further, the carbon dioxide gas generating substance used is preferably solid, and from the viewpoint of ease of mixing with other components contained in the second agent and ease of mixing at the time of mixing with the first agent, granules are preferably used. Shape, fine grain, and powder are more preferable.

  As the carbon dioxide generating substance, carbonates such as sodium carbonate, calcium carbonate, potassium carbonate, magnesium carbonate, sodium sesquicarbonate, ammonium hydrogen carbonate, potassium hydrogen carbonate, sodium hydrogen carbonate, lithium hydrogen carbonate, cesium hydrogen carbonate, magnesium hydrogen carbonate , Calcium bicarbonate and the like, and one or more of these are used. Of these, sodium bicarbonate is more preferable, since bicarbonate can be preferably used and moderate foaming power can be realized.

  The content of the carbon dioxide generating substance in the second agent is preferably 1% or more, more preferably 3% or more, and particularly preferably 5% or more. Further, it is preferably at most 90 mass%, more preferably at most 80 mass%, particularly preferably at most 70 mass%. Beyond the above range, the stability of the second agent becomes worse, the foaming property at the time of use becomes worse, or the pH when used as a foaming skin external preparation becomes strong carbon dioxide gas generation or strong basicity It may cause irritation to the skin.

  The carbon dioxide-generating substance can be used as a second agent as a mixture with other components. Here, when granules of the carbon dioxide-generating substance are obtained by granulating the carbon dioxide-generating substance and other components, the content of the other components is not particularly limited, but is 95% by mass in the granules. It is preferred to be less than. If the other components are present in a content of more than 95% by mass, the foaming property is undesirably reduced.

  The method for producing the powder or granules is not limited to this example, but includes dry crushing granulation, wet crushing granulation, fluidized bed granulation, high-speed stirring granulation, extrusion granulation, and the like. It can be manufactured according to a conventional method.

  For example, in the production of granules, a matrix substrate having functions such as granulation may be used. When a low melting point compound is used as the matrix base, the carbon dioxide generating substance is added to the low melting point compound melted by heating in a vessel such as a beaker, and sufficiently stirred and mixed. If necessary, an appropriate additive may be added thereto. This is further stirred while gradually cooling it at room temperature, and allowed to stand until it hardens. When it has hardened to some extent, it may be cooled rapidly in a refrigerator or the like.

  Alternatively, for example, the above-mentioned materials may be charged into a fluidized bed granulator, mixed for several minutes by an air current, and granulated by spraying water.

  When a low melting point compound is not used as the matrix base, the granulating agent is dissolved or dispersed in a suitable solvent such as water or ethanol in a container such as a beaker, and the carbon dioxide-generating substance is dissolved or dispersed therein. After sufficient mixing, the mixture is heated in an oven or the like to remove the solvent and dried. After it is completely hardened, it is pulverized and sieved to make the size of the particles uniform, and then granulated.

  As the shape of the carbon dioxide generating substance, for example, an irregular shape, a planar shape, a polyhedral shape, a spherical shape, a drop shape, a fibrous shape, a columnar shape, a fine powder shape and the like can be adopted without any particular limitation. Further, as the particle size, those having a wide range can be used without particular limitation. In particular, those having a particle size distribution of about 1,000 μm or less are more preferable from the viewpoint of easy handling and mixing with the viscous composition. The particle size distribution in the present invention can be determined by a usual laser diffraction / scattering method.

  The carbon dioxide-generating substance may be blended as it is with the component contained in the second agent, or may be blended so as not to physically contact other components in the same agent and may coexist. In this case, for example, one or both of the carbon dioxide-generating substance and the other component may be provided with a coat layer enclosing the same, or one or both of the carbon dioxide-generating substance and the other component may be provided. It may be encapsulated. Further, a layer not containing the carbon dioxide-generating substance and other components may be interposed between the carbon dioxide-generating substance and the component so that they do not come into direct contact with each other, and compression-molded.

  Hereinafter, means for coexisting the carbon dioxide-generating substance and other components in the same agent will be specifically described, but the present invention is not limited thereto.

[Formation of coat layer]
As a method of forming a coat layer, for example, a method of forming a coat layer using at least one of a carbon dioxide gas generating substance and other components may be used. Providing a coat layer is preferable in terms of stability and durability of the carbon dioxide-generating substance, the other components, and other components in the same agent.

  As a preferable coating agent for forming the above-mentioned coat layer, any one having low reactivity with the carbon dioxide-generating substance or the other components can be used without particular limitation. For example, fats and oils, fatty acids, fatty acid salts, acetylcellulose, hydroxyethylcellulose, sodium carboxymethylcellulose, polyvinylpyrrolidone, polyvinylalcohol, sodium polyacrylate, hydroxypropylmethylcellulose, methyl methacrylate-methacrylic acid copolymer, ethyl acrylate-methacrylic acid Copolymers, gum arabic, sodium alginate, soluble starch, hydroxypropylcellulose, wheat starch, polysaccharides (eg, sucrose, lactose, etc.), and organic acid salts such as citrate are exemplified. The coating layer may be formed by using a solid hydrocarbon wax, a solid fat or the like, which is dissolved at a certain temperature or more by heating. When the coat layer is formed on the carbon dioxide-generating substance, it is preferable that the coating agent constituting the coat layer does not hinder the reaction between the acidic substance in the first agent and the carbon dioxide-generating substance in the second agent. For example, in the case of a pack using polyethylene glycol as a coating layer, it takes a long time to react with an acidic substance in the first part, so that it takes a long time to generate carbon dioxide, and is excellent in an extremely short time of 10 seconds. A foaming agent cannot be obtained.

  The amount of the coating agent used for the carbon dioxide generating substance and / or other components is preferably 1 to 20% (w / w), more preferably 1 to 10% (w / w) based on the carbon dioxide generating substance or other components. w).

  The coating method of the coat layer may be performed by any method that is generally used for coating particles. For example, by spray granulation or tumbling granulation, etc., it may be coated at the same time as granulation, oil or fat coating on the powder or granulation, granulation coating, transport layer method, pan coating, tumbling coating, fluid coating or You may coat | cover using methods, such as dry coating. During coating, if excessive heat or physical force is applied, the carbon dioxide-generating substance or the other components are destroyed, and the formed film is broken, and the surface of the carbon dioxide-generating substance or the other components is damaged. Not only is it difficult to uniformly coat the lipid powder as a whole, but also the carbon dioxide-generating substance or the other components leaks to the surface and solidifies due to moisture absorption, or causes a bad influence on other components at the time of blending. The coating conditions must be such that the coat layer and the object to be coated are not destroyed.

[Encapsulation]
When encapsulating the carbon dioxide-generating substance and / or other components, a known method may be employed without any particular limitation.

  As a method of encapsulation, a known method can be applied without particular limitation, and as a material for encapsulation, gelatin, starch, gum arabic, methylcellulose, acrylate, methacrylate, vinyl acetate, Examples include polyvinyl alcohol, silicone resin, solid wax, polyethylene, fatty acids, higher alcohols, and the like, and those in which multiple layers of surfactants such as liposomes are formed, but can be widely used without limitation. For example, the basic structure of the capsule is composed of a homopolymer or a copolymer formed from one or more monomers selected from acrylates, methacrylates, vinyl acetate, and styrene, or the monomers and acrylic acid, methacrylic acid, divinyl It is also preferable to use a resin capsule made of a copolymer formed from a monomer selected from benzene and ethylene glycol dimethacrylate. Such microcapsules are prepared by emulsifying the contents and a monomer constituting the polymer constituting the outer shell of the capsule in a reaction solvent such as water, and then starting polymerization of azobisisobutyronitrile and benzoyl peroxide. An emulsion polymerization may be performed by adding an agent. As the surfactant component used for such emulsification, for example, hexlite sold under the name of "Laponite XLG" can be preferably exemplified. The microcapsules of the present invention can be produced by separating the resulting microcapsules by means such as centrifugation and washing if necessary.

[Compression molding]
As a method of compression molding, a substance other than the carbon dioxide gas generating substance and the other component (so that the first layer containing the carbon dioxide gas generating substance and the second layer containing the other component do not come into direct contact with each other ( For example, a method of sandwiching a third layer composed of an excipient, a thickener, etc.) and compression molding may be adopted. The compression-molded dosage form may be any dosage form as long as it is solid, such as a tablet, a sphere, a plate, and the like. Here, the carbon dioxide-generating substance and the other components used may be used as they are, or the carbon dioxide-generating substance provided with a coat layer by at least one of the first layer and the second layer. Alternatively, the other component, the encapsulated carbon dioxide-generating substance or the other component may be used. The compression molding method is not particularly limited, and a known method can be applied.

  The carbon dioxide-generating substance and the other components contained in the first layer and the second layer may be used as they are, or may be used by mixing an excipient, a thickener, and the like. . As the excipients, thickeners and the like used for the first layer, the second layer and the third layer, those described in the description of the above granules can be used without any particular limitation.

粘 Thickener≫
The thickener used in the second agent of the present invention is not particularly limited as long as it is a water-soluble component that can be used in cosmetics, external medicines, quasi-drugs, and the like. Molecules, natural polymers, viscous minerals and the like can be used.

  Synthetic polymers include carboxyvinyl polymer, polyvinyl alcohol, acrylic acid / alkyl methacrylate copolymer, acrylates / alkyl acrylate crosspolymer, polyacrylic acid, polyacrylamide, polyalkylacrylamide / polyacrylamide copolymer, carboxymethylcellulose, and cation And hydrophilic synthetic polymers such as cellulose and pluronic.

  Examples of the semi-synthetic polymer include cellulose derivatives such as carboxymethylcellulose or salts thereof, methylcellulose, ethylcellulose, propylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, and sulfonated cellulose derivatives. Other semi-synthetic polymers include propylene glycol alginate, ethylene glycol alginate, dextrin fatty acid esters, gelatin fatty acid esters, and gelatin fatty acid amides.

  Examples of natural polymers include polysaccharides and derivatives thereof, for example, xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, celluloses, galactan, arabic gum, tragacanth gum, tamarind gum, agar, agarose, mannan, curdlan, Alginic acid or its salts, gum arabic, pectin, quinseed, starch, alge colloid, chondroitin sulfate or its salts, chitosan and its derivatives, nucleic acids or its salts, ribonucleic acids or its salts, casein, collagen, gelatin, albumin, fibroin, Examples include water-soluble proteins such as elastin, keratin, and sericin, hyaluronic acid or salts thereof, and mucopolysaccharides such as chondroitin sulfate.

  Examples of the clay mineral include laponite, bentonite, smectite kaolinite, and montmorillonite.

  In the present invention, one or more of the above thickeners can be used, but among the above thickeners, those having high solubility or dispersibility in the first agent may be used. This is preferable because the second agent can be uniformly dissolved or dispersed without producing lumps, and the roughness of the skin caused by undissolved components and undispersed components can be reduced. Here, the solubility of the first agent is determined by the fact that the external agent for skin is instantaneously dissolved or dispersed and uniformly dissolved when the first agent at about room temperature is added and stirred. Judgment can be made based on the fact that it has a sufficient viscosity to retain carbon dioxide gas and that no lumps occur during dissolution or dispersion.

  Such thickeners include, for example, carboxyvinyl polymer, carboxymethylcellulose or salts thereof, polyvinyl alcohol, sodium polyacrylate, acrylic acid / alkyl methacrylate copolymer, xanthan gum, succinoglycan, carrageenan, guar gum, locust Bean gum, celluloses, galactan, gum arabic, gum tragacanth, tamarind gum, agar, mannan, curdlan, alginic acid or its salts, collagen, gelatin, albumin, and the like, and carboxymethyl cellulose or its salts, xanthan gum, carrageenan, It is preferable to use tamarind gum and albumin. One or more of the above thickeners can be used. When two or more types are used, it is preferable to use a water-soluble protein from the viewpoint of retaining generated carbon dioxide gas and foaming properties of the carbon dioxide gas, and it is preferable to use a combination of the water-soluble protein and another thickener. More preferred. As the water-soluble protein, collagen, gelatin and albumin are preferred.

  The amount of the thickener can be appropriately adjusted according to the mixing ratio with the first agent, but is preferably 1% or more, more preferably 3% or more, and particularly preferably 5% or more in the second agent. preferable. Further, it is preferably at most 90 mass%, more preferably at most 80 mass%, particularly preferably at most 70 mass%. When the content is small, a rough feeling due to an undissolved component or an undispersed component is apt to occur at the time of mixing the first agent and the second agent, so that the feeling of use is impaired. In addition, dripping easily occurs during use and lack of adhesion to the skin, and the ability to retain generated carbon dioxide gas is poor, so that a sufficient blood circulation promoting action cannot be obtained. On the other hand, when the content of the thickener is more than the above range, the solubility and dispersibility in the second agent are inferior. Since the viscosity after mixing is too high, it is difficult to apply the composition to the skin or to wash off the skin. Further, since the generation of carbon dioxide is uneven and the ability to retain the generated carbon dioxide is not so high, a sufficient blood circulation promoting action cannot be obtained.

  An excipient can be used as needed for the second agent. Excipients that can be used include excipients that can be used in cosmetics, external medicines, quasi-drugs, and the like. Specific examples include glucose, maltitol, lactose, dextrin, starch, talc, silica and the like, and glucose, dextrin and starch are preferred.

<Kit for external preparation for skin>
As described above, the kit for external preparation for skin of the present invention contains a first agent containing an acidic substance and water and a second agent containing a carbon dioxide-generating substance and a thickener. Preferably, it comprises a first agent containing at least one of an acidic substance, water, a thickener and a humectant, and a second agent containing a carbon dioxide-generating substance and a thickener. The kit of the present invention can enhance the storage stability by using an acidic substance and a carbon dioxide-generating substance as separate agents. In addition, by using a thickener or a humectant in combination with the first agent, it is possible to simultaneously improve the effect and feeling when used as an external preparation for skin. In particular, since the first agent and the second agent each contain a thickening agent, it is possible to increase the strength of the bubbles, and therefore, use of a foaming auxiliary agent having a function of keeping the foam stable for a long time. As is clear from Example 2 described below, not only the effects of improving skin condition such as moist feeling, brightness, and redness, but also ease of mixing during use, ease of application, and resistance to dripping are clear. This has the effect of improving the usability. In particular, when the thickener is contained only in the first agent, as is apparent from Comparative Example 1, not only the amount of foaming of the carbon dioxide gas is reduced, but also the usability such as ease of mixing, application and removal. Also gets worse. When a thickener is used for both the first agent and the second agent in the present invention, the thickener used may be the same or different.

<Skin external preparation>
Foamable skin external preparations obtained using the kit of the present invention, depending on the application and purpose, in addition to the components contained in the first agent, the second agent, other active ingredients, preservatives, pH adjusters, fats and oils, Fragrances, coloring agents, antioxidants, antibacterial and fungicides, alcohols, nonionic surfactants, anionic surfactants, cationic surfactants, surfactants such as amphoteric surfactants, inorganic salts, lubricants, One or more components commonly used in external preparations for skin, such as solvents, can be used. In this case, the component to be added can be used for either one of the first agent and the second agent, or may be used for either agent.

  Hereinafter, typical components other than the acidic substance, the carbon dioxide-generating substance, the thickener, and the humectant, which are contained in the effervescent skin external preparation obtained by using the kit of the present invention, will be further described.

  The active ingredient used in the present invention is not particularly limited, and drugs and plants used in cosmetics, external medicines, quasi-drugs and the like can be used according to the purpose. Representative examples include, for example, glycyrrhizic acid and derivatives thereof and their salts, glycyrrhetinic acid and their derivatives and their salts, mefenamic acid, phenylbutazone, indomethacin, ibuprofen, ketoprofen, allantoin, guaiazulene, panthenol, Anti-inflammatory agents such as allantoin, ascorbic acid and its derivatives and salts thereof, cysteine and its derivatives and salts thereof, glabridine, glabrin, liquiritin, isoliquiritin, placenta, hydroquinone and its derivatives, resorcinol and its derivatives, and whitening agents such as glutathione , Sulfur, thiantrol, etc., antiseborrheic agents, salicylic acid, fungicides such as oak extract, tocopherol and its derivatives, plant components such as licorice, aloe, tea leaves, estradiol Hormones, etc. and the like. When plant components are used, whole plants, leaves (leaves, petiole, etc.), fruits (mature, immature, etc.), seeds, flowers (petals, ovary, etc.), stems, rhizomes, roots, tubers, etc. Can be used as it is, by cutting, crushing, pulverizing, squeezing, extracting, or drying or pulverizing the treated product. The active ingredient used in the present invention can be used for both the first agent and the second agent.

  When the extract is used in the present invention, examples of the solvent used for the extraction include water; methanol, ethanol, propanol, butanol, ethylene glycol, propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, and hexylene glycol. Organic solvents such as glycerin, methyl acetate, ethyl acetate, isopropyl acetate, ethyl ether and acetone. These can be used alone or in combination of two or more. From the viewpoint of safety and the like, it is preferable to use water, ethanol, 1,3-butylene glycol, or a mixed solvent thereof that is harmless to the human body as the extraction solvent. The extraction may be performed at any temperature below the boiling point of the extraction solvent, and the extraction time can be appropriately changed depending on the extraction temperature. When the extract is used in the second agent of the present invention, the extract may contain water used as an extraction solvent, but when used as a component of the second agent, it contains substantially no water. preferable. Here, "substantially free of water" means that the second agent does not contain an amount of water necessary to deteriorate the quality during storage.

  Examples of the surfactant used in the present invention include a nonionic surfactant, an anionic surfactant, a cationic surfactant, and an amphoteric surfactant. As the surfactant, any of a synthetic surfactant and a natural surfactant can be used, but from the viewpoint of safety on the skin, a natural surfactant is preferable. The term "natural surfactant" used herein refers to a substance having a surfactant effect mainly derived from animals or plants. Specific examples thereof include phospholipids such as lecithin, glycolipids, lanolin, cholesterol, saponin, and ceramide. Sphingolipids, glycyrrhizinate, bile acids, plant-extracted amino acid-based surfactants, and the like. Among them, it is preferable to contain an extract containing a phospholipid, a saponin, a sphingolipid, pectin, and glycyrrhizinate, and particularly preferable to contain an extract containing a saponin. It is preferable to use a plant-derived extract as the extract containing saponin. Examples of plants containing saponins include soybeans, adzuki beans, kidney beans, spinach, sugar beet, grapes, fennel, licorice, senega, quilla, mukuroji, sabonso, panax ginseng, loofah, tea seeds, enju, lily family, and yam family Plants, chimo (Chimo), Bakumondou (Bakumon winter) and the like can be mentioned. In the present invention, as an extract containing saponin, among these plants, it is preferable to contain an extract of one or more plants selected from soybean, adzuki bean, licorice, mukuroji, and loofah, and in particular, mukuroji extract Is preferable.

  When the surfactant is used in combination with a thickener, bubbles can be kept longer. Thickeners that can be used in combination are the same as those used for the first agent or the second agent.

<Form of use of effervescent skin external preparation>
When the kit of the present invention is used to obtain an effervescent skin external preparation, the first agent and the second agent are mixed in an appropriate amount in a container to cause foaming by carbon dioxide gas. The first agent and the second agent are preferably mixed at a ratio of 0.1: 1 to 30: 1, more preferably at a ratio of 0.5: 1 to 20: 1, and more preferably 1: 1 to 10: 1. : 1 is particularly preferred.

  As a method for storing the kit of the present invention, a method for storing cosmetics, external medicines, quasi-drugs, and the like can be used, and there is no particular limitation. Good to be. The shape of the storage container used can be appropriately selected depending on the purpose, and examples thereof include a cup shape, a tube shape, a bag shape, a bottle shape, a stick shape, a pump shape, a jar shape, a canned shape, and the like. In addition, as a material constituting the storage container, for example, plastic, glass, aluminum, paper, various polymers, and the like can be used alone or in a combination of two or more, but are not limited thereto.

  Specific examples of the container include a storage container such as an aluminum stick or an aluminum bag whose inner surface is laminated with polyethylene terephthalate, a stand pouch with a chuck, and a polyethylene terephthalate inner surface in terms of hermeticity, storage stability of contents, production cost, and the like. A storage container made of polyethylene terephthalate, whose lid is heat-sealed with an aluminum film or the like laminated with, for example, is preferable.

<Use of foaming skin external preparation>
The effervescent skin external preparation obtained using the kit of the present invention promotes increase in skin blood flow, whitening, skin quality improvement, freckle improvement, skin rejuvenation, skin tightening, partial skin thinning, Cleanse, prepare skin, prepare skin texture, keep skin healthy, prevent rough skin, tighten skin, give skin moisture, keep skin moisture and oil content, keep skin soft, Protects the skin, prevents the skin from drying out, softens the skin, gives the skin a shine, gives the skin a luster, smoothes the skin, prevents sunburn spots and freckles, and highlights wrinkles due to drying Not only cosmetics for the purpose of elimination, but also skin roughness, irritability, prevention of heat, rash, cracks, irritations, acne, oily skin, prevention of razor breaks, prevention of spots and freckles due to sunburn, sunburn・ Snow burn Cosmetics and pharmaceuticals for the purpose of preventing hot flashes, tightening the skin, purifying the skin, preparing the skin, keeping the skin healthy, giving the skin moisture, protecting the skin, preventing the skin from drying out, etc. It can be suitably used for any of quasi-drugs and medicines such as medicines. The external preparation for skin of the present invention is preferably used as cosmetics and quasi-drugs, more preferably as cosmetics such as emulsions, creams, packs, and peeling agents, and more preferably as cosmeceuticals. In particular, it is preferable to use the composition as a pack, since the feeling of use is good and a high skin condition improving effect can be easily obtained in a short time as compared with a type using a composition having high viscosity.

  When the effervescent skin external preparation obtained by using the kit of the present invention is used as a pack, it may be applied to a thickness of 0.2 mm or more, preferably 0.5 mm or more so as to cover a desired site. By applying to a thickness of 0.2 mm or more, the skin condition improving effect by carbon dioxide gas can be obtained. The use time may be 1 minute or more, preferably 3 minutes or more, more preferably 5 minutes or more. After the application is completed, wiping, rinsing with water, or both may be performed.

  Hereinafter, the present invention will be described more specifically with reference to Examples, but the scope of the present invention is not limited to these Examples. In each of the following Examples and Comparative Examples, commercial materials were used as raw materials to be used unless otherwise specified.

<Production of effervescent skin external preparation>
According to the composition shown in Table 1, the kit of the present invention was produced.

Examples 1 and 2, Comparative Example 1
[First agent]
Purified water was added to the beaker, then the raw materials described in the first agent were added and stirred to obtain a first agent of a liquid or viscous composition.
[Second agent]
The raw materials described in the second agent were mixed to obtain a powdered first agent.

<Characteristic evaluation of effervescent skin external preparation>
According to the following procedures, the characteristics of the foamable skin external preparations obtained in Examples 1 and 2 and Comparative Example 1 were evaluated.
[Evaluation Example 1. Evaluation of viscosity of second agent]
In the second agent shown in Table 1, the viscosities of Examples 1 and 2 and Comparative Example 1 were measured using a viscometer (RVT type manufactured by Brookfield). Table 2 shows the results.

[Evaluation Example 2. Evaluation of foaming amount]
The first agent was placed in a bottle having a diameter of about 4.8 cm and a height of about 10.5 cm, and the second agent was added thereto, followed by stirring 20 times for 10 seconds. The amounts used were the masses described in Table 1. The volume immediately after stirring was measured, and the rate of increase of the volume with respect to the volume before stirring was measured. Table 2 shows the results.

[Evaluation Example 3. Measurement of skin condition before and after use]
Using the kits of the present invention obtained in the above Examples 1 and 2 and Comparative Example 1, an effervescent skin external preparation was prepared, and the horny layer water content before and after using the obtained effervescent skin external preparation (measuring device: SKICON-200EX).
The inside of the forearm of each of the test subjects (three women in their twenties to thirties) was washed with a face wash, and was left in the measurement room for 15 minutes. Next, the measurement was performed before using the foaming skin external preparation. Next, the foamable skin external preparation was applied to the measurement site and allowed to stand for 10 minutes. Next, the foaming skin external preparation was removed and washed with water. After the elapse of 15 minutes from the washing, the measurement after the use of the effervescent skin external preparation was performed. The subject spent a rest in the measurement room during the measurement.
FIG. 1 shows the results of skin condition measurement after use. The values are relative values when the value before use is set to 1.

[Evaluation Example 4. Evaluation of feeling of use of effervescent skin external preparation]
Using the kits of the present invention obtained in Examples 1 and 2 and Comparative Example 1, an effervescent skin external preparation was prepared. Table 4 shows when and after use of the effervescent skin external preparation obtained. The items shown were evaluated.
First, the inside of the forearm of each of the test subjects (three women in their twenties to thirties) was washed with a facial cleanser, and was rested for 15 minutes. Next, the foamable skin external preparation was applied to the measurement site and allowed to stand for 10 minutes. Next, the foaming skin external preparation was removed and washed with water. Thereafter, a questionnaire was conducted for eight items of (1) to (8) in Table 4. The evaluation of the questionnaire is based on the example 1 for the following items (1) to (8), and 4 (neither) is equivalent to the example 1, and 1 (bad) to 7 (good). Evaluation was made on a seven-point scale, and the average score of three persons was calculated. The subject spent a rest in the measurement room during the measurement.

From Table 2, it can be seen that Examples 1 and 2 are liquid compositions having no viscosity in the second agent and exhibiting excellent fluidity. Further, the amount of generated carbon dioxide was twice or more in Examples 1 and 2 as compared with Comparative Example 1. From this, it can be seen that Examples 1 and 2 have a larger foaming amount in an extremely short time of 10 seconds than Comparative Example 1.
In FIG. 1, the skin condition after use showed good results in the order of Example 2> Example 1> Comparative Example 1 with respect to the water content of the stratum corneum. That is, Examples 1 and 2 were found to be more effective in improving the condition after use than Comparative Example 1, and the effect was particularly enhanced in Example 2 in which a thickener was used in combination with the first agent. It can be seen that the skin is kept fresh.
In addition, Table 3 shows that the effervescent external preparation for skin obtained using the kit of the present invention has a higher evaluation in use than Comparative Example 1. In particular, it is easy to mix when mixing the first agent and the second agent, it is hard to sag, it is easy to remove after use, you can feel moderate irritation when foaming, and the moist feeling of the skin after use, the skin becomes bright Since the effect of confirming the redness and warmth of the skin is obtained, it is understood that the user can easily use it and has a high effect on the skin.
From the above results, it was found that the effervescent external preparation obtained by using the kit of the present invention was easy to use for the user, and had a high effect on the skin. It can be seen that the effect is remarkably exhibited when a tackifier is used in combination.

<Production of effervescent skin external preparation>
According to the composition shown in Table 4, the kit of the present invention was produced.

  Example 3

<Characteristic evaluation of effervescent skin external preparation>
The properties of the foamable skin external preparation obtained in Example 3 were evaluated according to the following procedures.
[Evaluation Example 1. Evaluation of first agent viscosity]
For the second agent shown in Table 1, the viscosity of Example 3 was measured using a viscometer (RVT type manufactured by Brookfield). Table 5 shows the results.

[Evaluation Example 2. Evaluation of foaming amount]
27 g of the second agent was placed in a bottle having a diameter of about 4.8 cm and a height of about 10.5 cm, and 9 g of the first agent was added thereto, followed by stirring 20 times for 10 seconds. The volume after 1 minute, 10 minutes, and 20 minutes was measured, and the rate of increase in volume with respect to the volume before stirring was measured. The result is shown in FIG.

[Evaluation Example 3. Measurement of skin condition before and after use]
Using the kit of the present invention obtained in Example 3 above, an effervescent skin external preparation was prepared, and the water content of the stratum corneum (measuring device: SKICON-200EX) was measured before and after using the effervescent skin external preparation obtained. did.
The inside of the forearm of each of the test subjects (three women in their twenties to thirties) was washed with a face wash, and was left in the measurement room for 15 minutes. Next, the measurement was performed before using the foaming skin external preparation. Next, the foamable skin external preparation was applied to the measurement site and allowed to stand for 10 minutes. Next, the foaming skin external preparation was removed and washed with water. After the elapse of 15 minutes from the washing, the measurement after the use of the effervescent skin external preparation was performed. The subject spent a rest in the measurement room during the measurement.
Table 5 shows the skin condition measurement results after use. In Table 5, the water content of the stratum corneum is a comparative value with 1 before using the foamable skin external preparation. The higher the numerical value of the water content of the stratum corneum, the better.

From Table 5, it can be seen that Example 3 is a liquid composition having no viscosity in the second agent and exhibiting excellent fluidity. From FIG. 2, the volume increase rate of the effervescent skin external preparation obtained using the kit of Example 3 was maintained at 400% or more even after 10 minutes after mixing, and the generated carbon dioxide gas was efficiently removed. It can be seen that it can be held.
Table 5 shows that the skin condition after use of the effervescent skin external preparation obtained using the kit of Example 3 showed that the stratum corneum had a good water content. That is, it is found that Example 3 is effective in improving the condition after use, and that the skin is kept fresh by using water and a humectant in combination.
From the above, it can be seen that the kit of the present invention containing an acidic substance, water, and a humectant in the first agent can both maintain carbon dioxide and improve skin condition.

  Hereinafter, specific formulation examples of the kit of the present invention will be described. Both the first agent and the second agent can be manufactured by the same manufacturing method as the manufacturing method of Example 1 or a general cosmetic manufacturing method.

  According to the formulation shown in Table 6, a kit for effervescent skin external preparation was prepared in the same manner as in Example 1. When the first agent and the second agent of the obtained kit are mixed at a ratio of 3: 1, an effervescent skin external preparation can be obtained.

  Example 4

  According to the formulation shown in Table 7, a kit for effervescent skin external preparation was prepared in the same manner as in Example 1. When the first agent and the second agent of the obtained kit are mixed at a ratio of 5: 1, an effervescent skin external preparation can be obtained.

  Example 5

  According to the formulation shown in Table 8, a kit for effervescent skin external preparation was prepared in the same manner as in Example 1. When the first agent and the second agent of the obtained kit are mixed at a ratio of 2: 1, an effervescent skin external preparation can be obtained.

  Example 6

  According to the formulation shown in Table 9, a kit for effervescent skin external preparation was prepared in the same manner as in Example 1. When the first agent and the second agent of the obtained kit are mixed at a ratio of 2: 1, an effervescent skin external preparation can be obtained.

  Example 7

  According to the formulation shown in Table 10, a kit for an effervescent skin external preparation was prepared in the same manner as in Example 1. When the first agent and the second agent of the obtained kit are mixed at a ratio of 2: 1, an effervescent skin external preparation can be obtained.

  Example 8

  According to the formulation shown in Table 11, a kit for effervescent skin external preparation was prepared in the same manner as in Example 1. When the first agent and the second agent of the obtained kit are mixed at a ratio of 5: 2, an effervescent skin external preparation can be obtained.

  Example 9

  According to the formulation shown in Table 12, a kit for effervescent skin external preparation was prepared in the same manner as in Example 1. When the first agent and the second agent of the obtained kit are mixed at a ratio of 3: 1, an effervescent skin external preparation can be obtained.

  Example 10

  According to the formulation shown in Table 13, a kit for an effervescent skin external preparation was prepared in the same manner as in Example 1. When the first agent and the second agent of the obtained kit are mixed at a ratio of 3: 1, an effervescent skin external preparation can be obtained.

  Example 11

  According to the formulation shown in Table 14, a kit for an effervescent skin external preparation was prepared in the same manner as in Example 1. When the first agent and the second agent of the obtained kit are mixed at 4: 1, an effervescent skin external preparation can be obtained.

  Example 12

  According to the formulation shown in Table 15, a kit for effervescent skin external preparation was prepared in the same manner as in Example 1. When the first agent and the second agent of the obtained kit are mixed at a ratio of 9: 1, an effervescent skin external preparation can be obtained.

  Example 13

  As is clear from the above examination, the kit of the present invention is easy to mix uniformly, and has an effect that carbon dioxide gas is generated evenly when used. Furthermore, it can be seen that the use of the effervescent skin external preparation obtained using the kit of the present invention has an effect of keeping the skin white and fresh.

Claims (3)

A kit for obtaining an effervescent skin external preparation for use as a pack, wherein the first agent is an acidic substance , water and a thickener of 0.001% or more and 1% or less (provided that a hydrophobized modified alkylcellulose is used). And a viscosity of 10,000 mPa · s or less , wherein the second agent reacts with the acidic substance to generate carbon dioxide gas, and a carbon dioxide-generating substance and a cellulose derivative (provided that the substance is hydrophobically modified). (Excluding alkylcellulose) .   The kit according to claim 1, wherein the second agent is a solid composition. The kit according to claim 1, which is for increasing the water content of the stratum corneum.

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