TWI508664B - ２５-羥基維他命ｄ３於改善雄性動物繁殖力之用途 - Google Patents
２５-羥基維他命ｄ３於改善雄性動物繁殖力之用途 Download PDFInfo
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Description
本發明係關於25－羥基維他命D3
於改善動物繁殖力之用途。
在本發明之框架中，動物意謂包括哺乳動物(其實例包括人)之動物。除人類外之外哺乳動物的較佳實例為：反芻動物及非反芻動物，例如牛cow(cattle)，如狗及貓之寵物、馬、駱駝、綿羊、山羊及豬。
更特定言之，本發明係關於25－羥基維他命D3
用於改善雄性動物(包括男性)精液品質之用途。在一較佳實施例中，本發明係關於25－羥基維他命D3
用於改善例如牛、狗、貓及馬，較佳豬之動物的精液品質及/或受孕率之用途。
對於高價的遺傳優良的諸如公豬、公馬或公牛之雄性動物，不僅給予特別管理及照料，而亦盡可能長久地飼養以使其於畜群中或人工授精中心之作用最大化。某些農場或人工授精中心現向其雄性育種動物提供最佳條件以保持其高水平效能，例如置於隧道型通風豬舍或空調豬舍中的公豬。實踐人工授精以使該等雄性動物之作用最大化，且最終將其優良遺傳學傳遞給更多數目的子代。然而，隨著雄性動物年齡增長，精液量、精子活力及精子數趨向於逐漸下降。同樣地，雌性動物之受精率及受孕率亦逐漸下降。
根據本發明已發現將25－羥基維他命D3
投予公豬改善公豬之精液品質，且進一步增加經投予25－羥基維他命D3
之公豬授精之豬的受孕率。
因此，本發明之一態樣係關於25－羥基維他命D3
用於改善動物之精液(例如公豬精液)品質及改善動物(例如豬)之受孕率之用途。本發明之另一態樣係關於一種改善動物之精液品質及受孕率之方法，其包含向雄性動物投予有效量之25－羥基維他命D3
。
如本文所使用之術語，食品(food product)係指任何適用於人類或動物消耗之食物或飼料。食品可為預製人類食品及包裝人類食物(例如蛋黃醬、沙拉醬、麵包或乳酪食物)或動物飼料(例如擠製及粒狀動物飼料、粗混飼料或寵物食物組合物)。術語食物(food)亦包含固體食物及液體食物以及諸如飲用水之飲用流體。如本文所使用之術語，食料(foodstuff)係指任何適於人類或動物消耗的物質。術語膳食補充劑係指以單一或多劑量單位封裝之用於補充人類或動物飲食之少量化合物。膳食補充劑一般不提供大量熱量而可含有其他微量營養素(例如維他命或礦物質)。術語營養補充劑係指包含與熱量源組合之膳食補充劑的組合物。在一些實施例中，營養補充劑為膳食替代品或補充品(例如營養或能量條或營養飲料或濃縮物)。
出於本發明之目的，25－羥基維他命D3
適於作為食品補充劑投用。可藉由將(例如)作為諸如以商標ROVIMIX Hy－D獲得的市售調配物之25－羥基維他命D3
與常規食物摻合或藉由首先製備食物組份與25－羥基維他命D3
之預混物，且隨後將該預混物與其他食物組份混合來補充動物食物。關於豬，該食物可為任何習知豬食。25－羥基維他命D3
尤其可作為調配粉劑添加至含其他礦物質、維他命、胺基酸及微量元素之預混物中，將該預混物添加至常規動物食物中並徹底混合以實現在其中均勻分佈。
在製造根據本發明之豬食期間，將約10 mcg/kg至約100 mcg/kg之25－羥基維他命D3
添加至常規豬食中。或者，可基於常規食物組份藉由向該等食物組份添加較高濃度之活性成份(例如濃度為約10 mg/kg至約100 mg/kg之25－羥基維他命D3
)來製備食物預混物。若每1000 kg常規食物添加1千克此預混物，則此通常將滿足個別動物正常食物消耗之需要。對於公豬而言，較佳劑量在每千克食物約50至約80 mcg 25－羥基維他命D3
之範圍內，且自每千克食物約50至約80 mcg 25－羥基維他命D3
。
出於本發明之目的，每公斤個體動物體重每天適於投用25－羥基維他命D3
之量為約0.112 mcg至約1.120 mcg，尤其約0.560 mcg至約0.784 mcg。因此，25－羥基維他命D3
適於以滿足此劑量要求之量添加至食物。通常公豬食物之每千克食物可含有約10 mcg至約100 mcg、尤其約50 mcg至約80 mcg 25－羥基維他命D3
。
25－羥基維他命D3
投予公豬對於其精液品質之功效可藉由確定公豬之總精液量及稠度、精子活力及精子數以及與以不含有25－羥基維他命D3
之食物所得之數據相比經投予25－羥基維他命D3
後之公豬的精液授精之豬的受孕率來判定。
對於狗25－羥基維他命D3
通常適於以每公斤個體動物體重每天約0.125 mcg至約1 mcg之量投用；且對於馬25－羥基維他命D3
通常適於以每公斤個體動物體重每天約0.112 mcg至約1.120 mcg之量技用。
對於人類消耗，根據本發明之食物補充劑可以單位劑量之形式投用，該等單位劑量例如錠劑、膠囊、經量測之粉劑或經量測之液體部分，若需要該液體部分可經充以碳酸氣(carbonated)。此外，本發明之食物補充劑可另外含有習知惰性且生理可接受之載體、芳香劑、著色劑及鈣。例如錠劑可經滿足每公斤體重約5至15 mcg之25－羥基維他命D3
的日劑量之量的25－羥基維生素D3
來補充，其中常用日劑量為1或2個錠劑。
藉由以下實例進一步說明本發明。
實例1：包含下表1中所示之組份的習知豬食之每kg食物經50至80 mcg 25－羥基維他命D3
增補。
藉由將50至80 mg之25－羥基維他命D3
(4至6.4 g由DSM Nutritional Products,Kaiseraugst,Switzerland所供應之ROVIMIXHy．D1.25%)與剩餘食品項目混合來以25－羥基維他命D3
補充以上所說明之食物。若需要，則所得粉碎食品可為粒狀的。
實例2：除每千克維他命與礦物質預混物添加約50至80 mg之25－羥基維他命D3
外，如實例1所指示來製備公豬食物。
實例3：含25－羥基維他命D3
之公豬食物預混物可製備如下：
將所有成份仔細混合在一起且將0.5%(5 kg/1000 kg食物)之此預混物添加至最終食物。
或者，亦可將25－羥基維他命D3
添加至含有適當載體之1%之稀釋預混物中。此載體可僅為麵粉、粗麥粉、玉米芯、稻殼、杏仁殼或碳酸鈣或為若干該等載體之不同混合物。典型配方為：
將所有成份仔細混合在一起且將0.05%(0.5 kg/1000 kg食物)之此預混物添加至最終食物。
實例4：包含下表2及3中所示之組份的習知狗食(基本飲食)之每千克食物經10至80 mcg 25－羥基維他命D3
(ROVIMIXHy．D,1.25%)補充。
實例5：包含下表4及5中所示之組份的習知馬食(基本飲食)經滿足每公斤體重約0.112 mcg至約1.120 mcg之25－羥基維他命D3
的日劑量之量的25－羥基維他命D3
(ROVIMIXHy．D1.25%)補充。
實例6：以錠劑形式之人類消耗膳食補充劑可在維他命調配物之標準化基質組份中包含25－羥基維他命D3
。該標準基質組份可包括具有乳化能力之天然多醣膠或具有乳化能力之不同天然多醣膠之混合物而無任何蛋白質摻合物。
可藉由熟習此項技術者所熟知之習知制錠方法來製備及調配錠劑。因此(例如)錠劑可藉由將食物補充劑之所有組份混合、粉碎及制粒且在制錠加工機上壓縮該粒狀物來製備。
Claims (18)
- 一種25-羥基維他命D3 之用途，其係用以改善動物之精液品質及/或受孕率，其中25-羥基維他命D3 係加至包含含有維他命D3 之維他命之食物或飼料中。
- 如請求項1之用途，其係用以改善寵物之精液的品質，該寵物較佳為狗及貓。
- 如請求項1之用途，其係用以改善馬之公馬精液的品質。
- 如請求項1之用途，其係用以改善牛之公牛精液的品質。
- 如請求項1之用途，其係用以改善公豬精液的品質及母豬之受孕率。
- 如請求項1之用途，其係用以改善人類之精液品質。
- 如請求項1至6之用途，其中25-羥基維他命D3 係作為食物補充劑來投用。
- 如請求項7之用途，其中25-羥基維他命D3 係以每公斤個體動物體重每天要求投予約0.1mcg至約1.2mcg之25-羥基維他命D3 之量添加至該食物。
- 如請求項8之用途，其中25-羥基維他命D3 係以每公斤個體動物體重每天要求投予約0.5mcg至約0.8mcg之25-羥基維他命D3 之量添加至該食物。
- 如請求項8之用途，其中25-羥基維他命D3 係以每公斤食物約10mcg至約100mcg之量添加至公豬食物。
- 如請求項10之用途，其中25-羥基維他命D3 係以每公斤食 物約50mcg至約80mcg之量添加至公豬食物。
- 一種改善非人類雄性精液品質之方法，其包含將有效量之25-羥基維他命D3 投予雄性動物，其中25-羥基維他命D3 係加至包含含有維他命D3 之維他命之食物或飼料中。
- 如請求項12之方法，其中25-羥基維他命D3 以每公斤體重每天約0.1mcg至約1.2mcg之量投予。
- 如請求項13之方法，其中25-羥基維他命D3 以每公斤體重每天約0.5mcg至約0.8mcg之量投予。
- 如請求項12之方法，其中25-羥基維他命D3 係作為食物補充劑來投用。
- 一種用於改善公豬精液品質及增加母豬受孕率之方法，其包含向公豬投予有效量之25-羥基維他命D3 ，其中25-羥基維他命D3 係加至包含含有維他命D3 之維他命之食物或飼料中。
- 如請求項16之方法，其中25-羥基維他命D3 以每公斤個體動物體重每天約10mcg至約100mcg之量投予。
- 如請求項17之方法，其中25-羥基維他命D3 以每公斤個體動物體重每天約50mcg至約80mcg之量投予。
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| EP05017949 | 2005-08-18 |
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| TWI508664B true TWI508664B (zh) | 2015-11-21 |
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|---|---|
| US (1) | US20100227840A1 (zh) |
| EP (1) | EP1917071B1 (zh) |
| JP (1) | JP5566026B2 (zh) |
| KR (4) | KR20140105873A (zh) |
| CN (1) | CN101242874A (zh) |
| TW (1) | TWI508664B (zh) |
| WO (1) | WO2007020042A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008043857A2 (en) * | 2006-10-13 | 2008-04-17 | Bioxell Spa | Novel method of treatment of male sub-fertility |
| ES2477877T5 (es) * | 2007-08-07 | 2018-09-21 | Dsm Ip Assets B.V. | Uso de 25-hidroxi vitamina D3 para incrementar la masa muscular en mamíferos |
| KR20150139629A (ko) * | 2008-02-13 | 2015-12-11 | 디에스엠 아이피 어셋츠 비.브이. | 비타민 ｄ와 25-하이드록시비타민 ｄ3의 조합물 |
| BRPI0907951A2 (pt) * | 2008-02-13 | 2015-08-04 | Dsm Ip Assets Bv | Uso combinado de 25-hidroxivitamina d3 e vitamina d3 para melhorar a densidade mineral do osso e para tratar a osteoporose |
| CN101623051B (zh) * | 2009-08-11 | 2012-05-30 | 四川农业大学 | 一种提高猪对繁殖与呼吸综合症抵抗力的饲料添加剂 |
| KR20120109566A (ko) * | 2009-12-22 | 2012-10-08 | 디에스엠 아이피 어셋츠 비.브이. | 수탉의 향상된 번식력 및 성능을 위한 칸타잔틴 및/또는 25-ｏｈ ｄ3의 용도 |
| EP2681311B1 (en) * | 2011-02-28 | 2018-03-28 | Rigshospitalet, Copenhagen University Hospital | Active vitamin d or analogs thereof for use in in vitro fertilization |
| CN102613407B (zh) * | 2012-03-29 | 2013-11-20 | 张淑二 | 一种改善肉用种公牛精液品质的添加剂预混合饲料 |
| CN105208878A (zh) * | 2013-03-27 | 2015-12-30 | 帝斯曼知识产权资产管理有限公司 | 25-羟基维生素d3用于增强执行功能的用途 |
| WO2015018421A1 (en) * | 2013-08-07 | 2015-02-12 | Rigshospitalet Copenhagen University Hospital | Antibodies, compounds and derivatives thereof for use in the treatment of male infertility |
| CN103392670B (zh) * | 2013-08-10 | 2015-06-10 | 内蒙古赛科星繁育生物技术（集团）股份有限公司 | 由种公牛体外受精率对种公牛精子体内受胎率的评价方法 |
| CN104431482A (zh) * | 2014-11-28 | 2015-03-25 | 新津邦得科技有限公司 | 妊娠母猪维生素预混合饲料 |
| DK3244911T3 (da) * | 2015-01-12 | 2019-12-16 | Rigshospitalet Copenhagen Univ Hospital | Fremgangsmåde til bestemmelse af en sandsynlig virkning af en behandling til forbedring af mandlig ufrugtbarhed |
| CN107319150A (zh) * | 2016-04-29 | 2017-11-07 | 广州领鲜生物科技有限公司 | 一种提高种公猪精液品质的配合饲料 |
| CN107183378A (zh) * | 2017-05-19 | 2017-09-22 | 赣州八维生物科技有限公司 | 羟基蛋氨酸钙和25‑羟基维生素d3在提高猪生长性能和繁殖性能的应用 |
| CN108720025A (zh) * | 2018-06-08 | 2018-11-02 | 唐飞 | 25-羟基维生素d3在食品中的应用 |
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| US4970203A (en) * | 1988-12-09 | 1990-11-13 | Deluca Hector F | Method for improving reproductive functions in mammals |
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| US7632518B2 (en) * | 2002-01-15 | 2009-12-15 | Dsm Ip Assets B.V. | 25-hydroxy vitamin D3 compositions |
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- 2006-08-15 KR KR1020157034382A patent/KR20150143872A/ko active Search and Examination
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- 2006-08-15 KR KR1020167034067A patent/KR20160143887A/ko not_active Application Discontinuation
- 2006-08-15 WO PCT/EP2006/008032 patent/WO2007020042A1/en active Application Filing
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- 2006-08-15 JP JP2008526422A patent/JP5566026B2/ja active Active
- 2006-08-15 CN CNA2006800300917A patent/CN101242874A/zh active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4970203A (en) * | 1988-12-09 | 1990-11-13 | Deluca Hector F | Method for improving reproductive functions in mammals |
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| Biochemical and Biophysical Research Communication 324(2004) pp451-457. * |
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| Publication number | Publication date |
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| EP1917071B1 (en) | 2014-01-08 |
| KR20160143887A (ko) | 2016-12-14 |
| KR20080039420A (ko) | 2008-05-07 |
| TW200800037A (en) | 2008-01-01 |
| JP5566026B2 (ja) | 2014-08-06 |
| KR20140105873A (ko) | 2014-09-02 |
| EP1917071A1 (en) | 2008-05-07 |
| WO2007020042A1 (en) | 2007-02-22 |
| US20100227840A1 (en) | 2010-09-09 |
| CN101242874A (zh) | 2008-08-13 |
| JP2009504699A (ja) | 2009-02-05 |
| KR20150143872A (ko) | 2015-12-23 |
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