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TW336222B - Novel depeptide p-amidinobenzylamides with N-terminal sulfonyl or aminosulfonyl radicals - Google Patents

Novel depeptide p-amidinobenzylamides with N-terminal sulfonyl or aminosulfonyl radicals

Info

Publication number
TW336222B
TW336222B TW084113131A TW84113131A TW336222B TW 336222 B TW336222 B TW 336222B TW 084113131 A TW084113131 A TW 084113131A TW 84113131 A TW84113131 A TW 84113131A TW 336222 B TW336222 B TW 336222B
Authority
TW
Taiwan
Prior art keywords
alkyl
cycloalkyl
substituted
amidinobenzylamides
depeptide
Prior art date
Application number
TW084113131A
Other languages
English (en)
Inventor
Bohm Hans-Joachim
Koser Stefan
Mack Helmut
Pfeiffer Thomas
Seitz Werner
Wolfgang Hoffken Hans
Hornberger Wilfried
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Application granted granted Critical
Publication of TW336222B publication Critical patent/TW336222B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Enzymes And Modification Thereof (AREA)
TW084113131A 1994-12-06 1995-12-09 Novel depeptide p-amidinobenzylamides with N-terminal sulfonyl or aminosulfonyl radicals TW336222B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4443390A DE4443390A1 (de) 1994-12-06 1994-12-06 Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten

Publications (1)

Publication Number Publication Date
TW336222B true TW336222B (en) 1998-07-11

Family

ID=6535046

Family Applications (1)

Application Number Title Priority Date Filing Date
TW084113131A TW336222B (en) 1994-12-06 1995-12-09 Novel depeptide p-amidinobenzylamides with N-terminal sulfonyl or aminosulfonyl radicals

Country Status (20)

Country Link
US (1) US5852051A (zh)
EP (1) EP0796271B1 (zh)
JP (1) JPH10509727A (zh)
CN (1) CN1168673A (zh)
AT (1) ATE189458T1 (zh)
AU (1) AU699579B2 (zh)
BR (1) BR9509970A (zh)
CA (1) CA2207874A1 (zh)
CZ (1) CZ153797A3 (zh)
DE (2) DE4443390A1 (zh)
ES (1) ES2143666T3 (zh)
FI (1) FI972384A (zh)
HU (1) HU222353B1 (zh)
IL (1) IL116231A (zh)
MX (1) MX9704050A (zh)
NO (1) NO972559L (zh)
RU (1) RU2152953C1 (zh)
TW (1) TW336222B (zh)
WO (1) WO1996017860A1 (zh)
ZA (1) ZA9510295B (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9900043D0 (sv) * 1999-01-11 1999-01-11 Astra Ab New use
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
US6200967B1 (en) 1996-06-25 2001-03-13 Eli Lilly And Company Anticoagulant agents
CA2258915A1 (en) * 1996-06-25 1997-12-31 Michael Robert Wiley Anticoagulant agents
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
PL351441A1 (en) * 1999-04-09 2003-04-22 Basf Ag Low-molecular inhibitors of complement proteases
AU785260B2 (en) * 2000-08-11 2006-12-07 Wilex Ag Non-covalent inhibitors of urokinase and blood vessel formation
EP1808440B1 (en) * 2000-08-11 2011-07-27 Wilex AG Non-covalent inhibitors of urokinase and blood vessel formation
DE10049937A1 (de) * 2000-10-06 2002-04-11 Knoll Ag Niedermolekulare Inhibitoren von Serinproteasen mit Polyhydroxyalkyl- und Polyhydroxycycloalkylresten
CH695999A5 (de) 2002-02-28 2006-11-15 Wilex Ag Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten.
DE102004029812A1 (de) * 2004-06-19 2006-05-24 Clariant Gmbh Verfahren zur Herstellung von Nitrilen aus Aldehydoximen durch Umsetzung mit Alkylphosphonsäureanhydriden

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9103612D0 (sv) * 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
AU675981B2 (en) * 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
AU1025795A (en) * 1994-01-27 1995-08-03 Mitsubishi Chemical Corporation Prolineamide derivatives
ZA951617B (en) * 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.

Also Published As

Publication number Publication date
HUT77289A (hu) 1998-03-30
RU2152953C1 (ru) 2000-07-20
CZ153797A3 (cs) 1998-02-18
DE4443390A1 (de) 1996-06-13
EP0796271A1 (de) 1997-09-24
DE59507755D1 (de) 2000-03-09
US5852051A (en) 1998-12-22
ES2143666T3 (es) 2000-05-16
FI972384A0 (fi) 1997-06-05
ATE189458T1 (de) 2000-02-15
JPH10509727A (ja) 1998-09-22
IL116231A (en) 2001-01-28
ZA9510295B (en) 1997-06-05
NO972559L (no) 1997-08-05
CA2207874A1 (en) 1996-06-13
FI972384A (fi) 1997-06-05
MX9704050A (es) 1997-08-30
WO1996017860A1 (de) 1996-06-13
EP0796271B1 (de) 2000-02-02
AU699579B2 (en) 1998-12-10
IL116231A0 (en) 1996-03-31
AU4255996A (en) 1996-06-26
NO972559D0 (no) 1997-06-05
HU222353B1 (hu) 2003-06-28
BR9509970A (pt) 1997-11-25
CN1168673A (zh) 1997-12-24

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Legal Events

Date Code Title Description
GD4A Issue of patent certificate for granted invention patent