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TR201910592T4 - Spesifik olarak dll4 ve vegf ye bağlanan yeni çift-hedefli protein ve bunun kullanımı. - Google Patents

Spesifik olarak dll4 ve vegf ye bağlanan yeni çift-hedefli protein ve bunun kullanımı. Download PDF

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Publication number
TR201910592T4
TR201910592T4 TR2019/10592T TR201910592T TR201910592T4 TR 201910592 T4 TR201910592 T4 TR 201910592T4 TR 2019/10592 T TR2019/10592 T TR 2019/10592T TR 201910592 T TR201910592 T TR 201910592T TR 201910592 T4 TR201910592 T4 TR 201910592T4
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TR
Turkey
Prior art keywords
specifically binds
dll4
vegf
targeted protein
new double
Prior art date
Application number
TR2019/10592T
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English (en)
Inventor
Heon Lee Dong
Duk Moon Kyung
Bin Choi Yu
Jae Kang Kyung
In Kim Dong
Hyung Ahn Jin
Kyoo You Weon
Jung Jinwon
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Ablbio
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Publication of TR201910592T4 publication Critical patent/TR201910592T4/tr

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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
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    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • C07K16/286—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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Abstract

Mevcut buluş, şunları içeren bir yeni çift-hedefli protein ile ilgilidir: spesifik olarak delta-benzeri ligand 4'e (DLL4) bağlanan bir yeni protein ve spesifik olarak vasküler endoteliyal hücre büyüme faktörüne (VEGF) bağlanan bir antikor.
TR2019/10592T 2013-07-09 2014-07-08 Spesifik olarak dll4 ve vegf ye bağlanan yeni çift-hedefli protein ve bunun kullanımı. TR201910592T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20130080523 2013-07-09

Publications (1)

Publication Number Publication Date
TR201910592T4 true TR201910592T4 (tr) 2019-08-21

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ID=52280248

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Application Number Title Priority Date Filing Date
TR2019/10592T TR201910592T4 (tr) 2013-07-09 2014-07-08 Spesifik olarak dll4 ve vegf ye bağlanan yeni çift-hedefli protein ve bunun kullanımı.

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Country Link
US (1) US10184010B2 (tr)
EP (1) EP3020731B1 (tr)
JP (1) JP6283411B2 (tr)
KR (1) KR101673389B1 (tr)
CN (1) CN105518028B (tr)
AU (1) AU2014287984B2 (tr)
CA (1) CA2917402C (tr)
ES (1) ES2742855T3 (tr)
PL (1) PL3020731T3 (tr)
RU (1) RU2648154C2 (tr)
TR (1) TR201910592T4 (tr)
WO (1) WO2015005632A1 (tr)

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PE20141537A1 (es) 2011-09-23 2014-11-17 Oncomed Pharm Inc Agentes de ligacion al factor de crecimiento endotelial vascular/ligando 4 similar a delta (vegf/dll4) y usos de los mismos
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
AU2016326609B2 (en) 2015-09-23 2023-03-09 Mereo Biopharma 5, Inc. Methods and compositions for treatment of cancer
IL290457B1 (en) 2015-12-30 2024-10-01 Kodiak Sciences Inc Antibodies and their conjugates
CN109311949B (zh) 2016-05-11 2022-09-16 思拓凡生物工艺研发有限公司 储存分离基质的方法
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
US10654887B2 (en) 2016-05-11 2020-05-19 Ge Healthcare Bio-Process R&D Ab Separation matrix
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
ES2874974T3 (es) 2016-05-11 2021-11-05 Cytiva Bioprocess R & D Ab Matriz de separación
CN109311948B (zh) 2016-05-11 2022-09-16 思拓凡生物工艺研发有限公司 清洁和/或消毒分离基质的方法
US10730908B2 (en) 2016-05-11 2020-08-04 Ge Healthcare Bioprocess R&D Ab Separation method
JP7031934B2 (ja) 2016-05-11 2022-03-08 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ 分離マトリックス
EP3610888A4 (en) * 2017-03-27 2021-01-20 BioconTAC Co., Ltd. ANTIBODIES BINDING SPECIFICALLY TO THE N-TERMINAL REGION OF LYSYL-ARNT SYNTHETASE EXPOSED ON A CELLULAR MEMBRANE
KR20200140817A (ko) 2018-03-02 2020-12-16 코디악 사이언시스 인코포레이티드 Il-6 항체 그리고 이의 융합 작제물 및 접합체
EP3880697A2 (en) * 2018-11-15 2021-09-22 OncoMed Pharmaceuticals, Inc. Methods and monitoring of treatment with vegf/dll4 binding agent
CN109666073B (zh) * 2018-12-28 2022-02-01 中国药科大学 一种抗人dll4和抗人vegf双特异性抗体及其制备与应用
CA3157509A1 (en) 2019-10-10 2021-04-15 Kodiak Sciences Inc. Methods of treating an eye disorder
JP2023500054A (ja) 2019-11-07 2023-01-04 オンクセルナ セラピューティクス，インコーポレイテッド 腫瘍微小環境の分類
KR20220124008A (ko) 2021-03-02 2022-09-13 서상로 자동 연마장치
IL306090A (en) 2021-03-25 2023-11-01 Oncxerna Therapeutics Inc Targeted cancer treatments

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US7906116B2 (en) 2005-09-01 2011-03-15 Parkash Gill Methods for using and identifying modulators of Delta-like 4
RU2448979C2 (ru) 2006-12-14 2012-04-27 Ридженерон Фармасьютикалз, Инк. Антитела человека к дельта-подобному лиганду-4 человека
US9266967B2 (en) * 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
SG190572A1 (en) 2008-04-29 2013-06-28 Abbott Lab Dual variable domain immunoglobulins and uses thereof
US8192738B2 (en) * 2008-09-19 2012-06-05 Medimmune, Llc Targeted antibodies directed to DLL4
US8268314B2 (en) * 2008-10-08 2012-09-18 Hoffmann-La Roche Inc. Bispecific anti-VEGF/anti-ANG-2 antibodies
CN102459346B (zh) * 2009-04-27 2016-10-26 昂考梅德药品有限公司 制造异源多聚体分子的方法
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JO3183B1 (ar) 2010-01-29 2018-03-08 Regeneron Pharma طرق لمعالجة أمراض المناعة الذاتية مضادات dll4
CA2816803A1 (en) * 2010-11-02 2012-05-10 Abbott Laboratories Dual variable domain immunoglobulins and uses thereof
PE20141537A1 (es) * 2011-09-23 2014-11-17 Oncomed Pharm Inc Agentes de ligacion al factor de crecimiento endotelial vascular/ligando 4 similar a delta (vegf/dll4) y usos de los mismos
KR101535341B1 (ko) * 2012-07-02 2015-07-13 한화케미칼 주식회사 Dll4에 특이적으로 결합하는 신규한 단일클론항체 및 이의 용도
MX2015005593A (es) * 2012-11-01 2016-02-05 Abbvie Inc Inmunoglobulinas de dominio variable dual anti-vegf/dll4 y usos de las mismas.

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Publication number Publication date
AU2014287984A1 (en) 2016-02-04
CN105518028A (zh) 2016-04-20
ES2742855T3 (es) 2020-02-17
WO2015005632A1 (ko) 2015-01-15
CA2917402C (en) 2019-10-22
AU2014287984B2 (en) 2016-09-22
JP6283411B2 (ja) 2018-02-21
KR20150007241A (ko) 2015-01-20
EP3020731A4 (en) 2017-02-22
EP3020731B1 (en) 2019-06-12
US10184010B2 (en) 2019-01-22
US20160159929A1 (en) 2016-06-09
CA2917402A1 (en) 2015-01-15
CN105518028B (zh) 2019-08-13
RU2016104057A (ru) 2017-08-15
PL3020731T3 (pl) 2019-11-29
RU2648154C2 (ru) 2018-03-22
KR101673389B1 (ko) 2016-11-08
EP3020731A1 (en) 2016-05-18
JP2016531097A (ja) 2016-10-06

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