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TR201904906T4 - Bir mikroreaktörde sürekli virüs inaktivasyonuna yönelik yöntem. - Google Patents

Bir mikroreaktörde sürekli virüs inaktivasyonuna yönelik yöntem. Download PDF

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Publication number
TR201904906T4
TR201904906T4 TR2019/04906T TR201904906T TR201904906T4 TR 201904906 T4 TR201904906 T4 TR 201904906T4 TR 2019/04906 T TR2019/04906 T TR 2019/04906T TR 201904906 T TR201904906 T TR 201904906T TR 201904906 T4 TR201904906 T4 TR 201904906T4
Authority
TR
Turkey
Prior art keywords
virus inactivation
microreactor
product stream
continuous virus
continuous
Prior art date
Application number
TR2019/04906T
Other languages
English (en)
Inventor
Schwan Peter
VESTER Andrea
Lobedann Martin
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of TR201904906T4 publication Critical patent/TR201904906T4/tr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/0035—Gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0023—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0094—Gaseous substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/10—Ultraviolet radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/21—Pharmaceuticals, e.g. medicaments, artificial body parts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Buluş, sürekli virüs inaktivasyonuna yönelik bir yöntem sağlar. Ürün akışı, ürün akışı ile karışmayan bir ayırma ortamının eklenmesi yoluyla bölünür ve bölünen ürün akışı, gerekli retansiyon süresi boyunca virüsleri inaktive eden koşullar altında retansiyon alanı olarak bir reaktöre (1) aktarılır.
TR2019/04906T 2015-04-28 2016-04-25 Bir mikroreaktörde sürekli virüs inaktivasyonuna yönelik yöntem. TR201904906T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15165505.7A EP3088006A1 (de) 2015-04-28 2015-04-28 Verfahren zur kontinuierlichen virusinaktivierung in einem mikroreaktor

Publications (1)

Publication Number Publication Date
TR201904906T4 true TR201904906T4 (tr) 2019-05-21

Family

ID=53016520

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/04906T TR201904906T4 (tr) 2015-04-28 2016-04-25 Bir mikroreaktörde sürekli virüs inaktivasyonuna yönelik yöntem.

Country Status (21)

Country Link
US (1) US10434201B2 (tr)
EP (2) EP3088006A1 (tr)
JP (1) JP6851981B2 (tr)
KR (1) KR20170140219A (tr)
CN (1) CN107624073B (tr)
AR (1) AR104440A1 (tr)
AU (1) AU2016254582C1 (tr)
BR (1) BR112017023246B1 (tr)
CA (1) CA2983884A1 (tr)
DK (1) DK3288596T3 (tr)
ES (1) ES2720034T3 (tr)
HK (1) HK1249867A1 (tr)
IL (1) IL255137B (tr)
MX (1) MX2017013893A (tr)
RU (1) RU2719363C2 (tr)
SA (1) SA517390240B1 (tr)
SG (1) SG11201708749WA (tr)
TR (1) TR201904906T4 (tr)
TW (1) TWI695070B (tr)
WO (1) WO2016173982A1 (tr)
ZA (1) ZA201708043B (tr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7117329B2 (ja) * 2017-05-11 2022-08-12 イー・エム・デイー・ミリポア・コーポレイシヨン 連続流動システムにおける狭い滞留時間分布を維持する機械的方法
EP3621714A4 (en) * 2017-05-11 2021-01-20 EMD Millipore Corporation METHOD OF MAINTAINING NARROW RESIDENTIAL TIME DISTRIBUTIONS IN CONTINUOUS FLOW SYSTEMS
MX2020000353A (es) 2017-07-10 2020-08-17 Takeda Pharmaceuticals Co Metodos para incubar liquidos e inactivar virus.
SG11202103443XA (en) * 2018-10-08 2021-05-28 Boehringer Ingelheim Int A novel continuous flow reactor for low ph viral inactivation
DE102018009597A1 (de) 2018-12-07 2020-06-10 Sartorius Stedim Biotech Gmbh Vorrichtung und Verfahren zur mehrfachen Änderung der Zusammensetzung eines Fluids
CN114247395B (zh) * 2020-09-23 2023-04-25 中国科学院大连化学物理研究所 一种中空纤维膜式微通道反应器及应用

Family Cites Families (18)

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ATE194921T1 (de) * 1992-03-02 2000-08-15 Bioeng Inc Verfahren zur inaktivierung von viren
DE69707288T2 (de) 1996-07-15 2002-07-18 Calcitech Ltd., Hamilton Herstellung von pulvern
GB2359765B (en) * 2000-03-02 2003-03-05 Univ Newcastle Capillary reactor distribution device and method
DE10056096A1 (de) 2000-11-13 2002-06-13 Bayer Ag Vorrichtung zur Bestrahlung von Flüssigkeiten
DK1337280T3 (da) 2000-11-13 2013-12-02 Bayer Ip Gmbh Fremgangsmåde til inaktivering af mikroorganismer i en fluid ved anvendelse af ultraviolet stråling
DE10312765A1 (de) 2003-03-21 2004-09-30 Bayer Technology Services Gmbh Vorrichtung und Verfahren zur Sterilisation flüssiger Medien mittels UV-Bestrahlung und Kurzzeiterhitzung
JP4611989B2 (ja) * 2003-05-16 2011-01-12 ヴェロシス，インク． マイクロチャネルプロセス技術を用いてエマルジョンを作製するプロセス
US7485671B2 (en) * 2003-05-16 2009-02-03 Velocys, Inc. Process for forming an emulsion using microchannel process technology
US7993580B2 (en) * 2004-08-24 2011-08-09 Baxter International Inc. Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors
WO2006027757A2 (en) * 2004-09-09 2006-03-16 Institut Curie Microfluidic device using a collinear electric field
EP1804964A1 (en) * 2004-10-01 2007-07-11 Velocys Inc. Multiphase mixing process using microchannel process technology
CN1786018B (zh) * 2005-12-12 2011-06-22 天津协和生物科技发展有限公司 高纯度血红蛋白的分离纯化与病毒灭活工艺
DE102006019242A1 (de) 2006-04-21 2007-10-25 Bayer Technology Services Gmbh Prozessanalysensystem mit steriler Probenahme von mechanisch empfindlichem Material aus einem Bioreaktor
CN101772821A (zh) * 2007-08-10 2010-07-07 株式会社日本光电科技 短波长紫外线放电灯和紫外线照射处理装置
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EP2918294A1 (de) * 2014-03-11 2015-09-16 Bayer Technology Services GmbH Vorrichtung und Verfahren zur kontinuierlichen Virusinaktivierung

Also Published As

Publication number Publication date
RU2017141168A (ru) 2019-05-28
RU2719363C2 (ru) 2020-04-17
WO2016173982A1 (de) 2016-11-03
IL255137B (en) 2020-10-29
CA2983884A1 (en) 2016-11-03
BR112017023246B1 (pt) 2021-09-08
EP3088006A1 (de) 2016-11-02
RU2017141168A3 (tr) 2019-11-14
MX2017013893A (es) 2018-03-15
CN107624073A (zh) 2018-01-23
DK3288596T3 (da) 2019-05-06
ZA201708043B (en) 2020-01-29
KR20170140219A (ko) 2017-12-20
AU2016254582A1 (en) 2017-11-09
TWI695070B (zh) 2020-06-01
SG11201708749WA (en) 2017-11-29
SA517390240B1 (ar) 2021-03-01
JP6851981B2 (ja) 2021-03-31
EP3288596B1 (de) 2019-03-20
AU2016254582C1 (en) 2020-04-30
TW201702377A (zh) 2017-01-16
JP2018517455A (ja) 2018-07-05
AR104440A1 (es) 2017-07-19
US20190117803A1 (en) 2019-04-25
AU2016254582B2 (en) 2020-01-30
CN107624073B (zh) 2020-05-22
BR112017023246A2 (pt) 2020-05-19
ES2720034T3 (es) 2019-07-17
IL255137A0 (en) 2017-12-31
US10434201B2 (en) 2019-10-08
HK1249867A1 (zh) 2018-11-16
EP3288596A1 (de) 2018-03-07

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