TR200401955T4 - Diazepan türevleri veya bunların tuzları. - Google Patents
Diazepan türevleri veya bunların tuzları.Info
- Publication number
- TR200401955T4 TR200401955T4 TR2004/01955T TR200401955T TR200401955T4 TR 200401955 T4 TR200401955 T4 TR 200401955T4 TR 2004/01955 T TR2004/01955 T TR 2004/01955T TR 200401955 T TR200401955 T TR 200401955T TR 200401955 T4 TR200401955 T4 TR 200401955T4
- Authority
- TR
- Turkey
- Prior art keywords
- diazepan
- methoxybenzoyl
- benzoyl
- hydroxy
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Bulus, özellikle kan pihtilasma faktörü X'in aktif inhibitörü olarak yararli yeni diazepan türevlerine, örnegin: 3-hidroksi-N1-(4-metoksibenzoil)-N2- [4-(4-metil-1,4-diazepan-1-il)benzoil]-1, 2-fenilen diamin, 3-hidroksi- N1-(4-metoksibenzoil)-N2- [6-(4-metil-1,4-diazepan-1-il)benzoil] -1,2-fenilen diamin, 3-hidroksi-N2-[4-(4-izopropil-1, 4-diazepan-1-il)benzoil]-N1-(4-metoksibenzoil)-1, 2-fenilendiamin, 3-hidroksi-N1-(4-metoksibenzoil)- N2-{4-[4-(4-piridil)-1, 4-diazepan-1-il]benzoil]-1, 2-fenilen diamin veya bunlarin tuzlarina ve bu tür farmasötik maddelere iliskindir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000096858 | 2000-03-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200401955T4 true TR200401955T4 (tr) | 2004-09-21 |
Family
ID=18611560
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2004/01955T TR200401955T4 (tr) | 2000-03-31 | 2001-03-29 | Diazepan türevleri veya bunların tuzları. |
Country Status (21)
Country | Link |
---|---|
US (3) | US6642224B1 (tr) |
EP (2) | EP1415990B1 (tr) |
JP (1) | JP3788349B2 (tr) |
KR (1) | KR100739359B1 (tr) |
CN (1) | CN1226292C (tr) |
AR (1) | AR027985A1 (tr) |
AT (2) | ATE267178T1 (tr) |
AU (2) | AU776053B2 (tr) |
BR (1) | BR0101264A (tr) |
CA (1) | CA2395846C (tr) |
DE (2) | DE60103390T2 (tr) |
DK (1) | DK1273575T3 (tr) |
ES (2) | ES2271464T3 (tr) |
HU (1) | HUP0101333A3 (tr) |
MX (1) | MXPA01003279A (tr) |
PL (1) | PL207651B1 (tr) |
PT (1) | PT1273575E (tr) |
RU (1) | RU2257381C2 (tr) |
TR (1) | TR200401955T4 (tr) |
TW (1) | TW575569B (tr) |
WO (1) | WO2001074791A1 (tr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6376515B2 (en) * | 2000-02-29 | 2002-04-23 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor Xa |
AU776053B2 (en) | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
ATE374765T1 (de) | 2000-07-27 | 2007-10-15 | Lilly Co Eli | Substituierte heterocyclische amide |
AU2406402A (en) * | 2000-11-22 | 2002-06-03 | Yamanouchi Pharma Co Ltd | Substituted benzene derivatives or salts thereof |
US7163938B2 (en) | 2000-11-28 | 2007-01-16 | Eli Lilly And Company | Substituted carboxamides |
SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
AU2002350172A1 (en) | 2001-12-07 | 2003-06-23 | Eli Lilly And Company | Substituted heterocyclic carboxamides with antithrombotic activity |
TWI319387B (en) * | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
AU2004246766B2 (en) * | 2003-06-18 | 2009-09-17 | Merck Patent Gmbh | Pyrrolidin-1, 2- dicarboxylic acid- 1- [(4- ethinyl- phenyl) - amid]- 2- [(phenyl)- amid] derivative as inhibitors of coagulation factor Xa and VIIa for the treatment of thrombosis |
WO2005049604A2 (en) | 2003-09-30 | 2005-06-02 | Eli Lilly And Company | Antithrombotic aromatic ethers |
US7700628B2 (en) | 2004-11-24 | 2010-04-20 | Eli Lilly And Company | Aromatic ether derivatives useful as thrombin inhibitors |
ES2330461T3 (es) | 2004-11-29 | 2009-12-10 | Eli Lilly And Company | Diamidas antitromboticas. |
WO2006083003A1 (ja) | 2005-02-02 | 2006-08-10 | Ajinomoto Co., Inc. | 新規ベンズアミジン化合物 |
GB0521244D0 (en) | 2005-10-19 | 2005-11-30 | Astrazeneca Ab | Benzamide compounds |
TW200734304A (en) | 2005-11-08 | 2007-09-16 | Astellas Pharma Inc | Benzene derivative or salt thereof |
WO2008057972A1 (en) | 2006-11-02 | 2008-05-15 | Millennium Pharmaceuticals, Inc. | Methods of synthesizing pharmaceutical salts of a factor xa inhibitor |
JP2010120852A (ja) * | 2007-03-09 | 2010-06-03 | Daiichi Sankyo Co Ltd | 新規なジアミド誘導体 |
EP2311810A4 (en) | 2008-07-11 | 2012-04-04 | Ajinomoto Kk | AMIDINE DERIVATIVE |
TW201021832A (en) * | 2008-09-30 | 2010-06-16 | Astellas Pharma Inc | Pharmaceutical composition for oral administration |
EP2590510B1 (en) | 2010-07-07 | 2016-09-28 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
EP2590656B1 (en) | 2010-07-07 | 2017-11-15 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
WO2012006475A1 (en) * | 2010-07-07 | 2012-01-12 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
EP2590655B1 (en) | 2010-07-07 | 2015-06-24 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
JP5827327B2 (ja) | 2010-07-07 | 2015-12-02 | アーデリクス,インコーポレーテッド | リン酸輸送を阻害する化合物及び方法 |
EP2635559A2 (en) * | 2010-11-01 | 2013-09-11 | Neurotune AG | Neurotrypsin inhibitors |
JPWO2013161871A1 (ja) * | 2012-04-25 | 2015-12-24 | 興和株式会社 | Tlr阻害作用を有するチオフェン誘導体 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5417200A (en) * | 1994-01-25 | 1995-05-23 | Wasielewski; John J. | Lantern cooker |
WO1996016940A1 (fr) | 1994-12-02 | 1996-06-06 | Yamanouchi Pharmaceutical Co., Ltd. | Nouveau derive d'amidinonaphtyle ou sel de celui-ci |
IL133621A0 (en) | 1997-06-26 | 2001-04-30 | Lilly Co Eli | Antithrombotic agents |
ATE306261T1 (de) | 1997-06-26 | 2005-10-15 | Lilly Co Eli | Antithrombosemittel |
JP2002510313A (ja) | 1997-06-26 | 2002-04-02 | イーライ・リリー・アンド・カンパニー | 抗血栓物質 |
WO1999000128A1 (en) | 1997-06-26 | 1999-01-07 | Eli Lilly And Company | Antithrombotic agents |
US6140351A (en) | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
JP3811006B2 (ja) | 1997-12-19 | 2006-08-16 | シエーリング アクチエンゲゼルシャフト | 抗凝血物質類としてのオルト−アントラニルアミド誘導体類 |
AU2074699A (en) * | 1998-01-26 | 1999-08-09 | Yamanouchi Pharmaceutical Co., Ltd. | Novel benzene-fused heterocyclic derivatives or salts thereof |
US6610704B1 (en) | 1998-12-23 | 2003-08-26 | Eli Lilly And Company | Antithrombotic amides |
CA2361149A1 (en) | 1998-12-23 | 2000-07-06 | Eli Lilly And Company | Aromatic amides |
WO2000039117A1 (en) | 1998-12-23 | 2000-07-06 | Eli Lilly And Company | HETEROROAROMATIC AMIDES AS INHIBITOR OF FACTOR Xa |
JP4390024B2 (ja) * | 1999-04-23 | 2009-12-24 | アステラス製薬株式会社 | 新規なジアゼパン誘導体又はその塩 |
WO2001019798A2 (en) | 1999-09-17 | 2001-03-22 | Cor Therapeutics Inc. | INHIBITORS OF FACTOR Xa |
CA2385592C (en) | 1999-09-17 | 2011-01-11 | Bing-Yan Zhu | Benzamides and related inhibitors of factor xa |
US6632815B2 (en) | 1999-09-17 | 2003-10-14 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
US6376515B2 (en) | 2000-02-29 | 2002-04-23 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor Xa |
AU776053B2 (en) | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
ATE374765T1 (de) * | 2000-07-27 | 2007-10-15 | Lilly Co Eli | Substituierte heterocyclische amide |
US7163938B2 (en) * | 2000-11-28 | 2007-01-16 | Eli Lilly And Company | Substituted carboxamides |
-
2001
- 2001-03-22 AU AU29827/01A patent/AU776053B2/en not_active Ceased
- 2001-03-28 PL PL346731A patent/PL207651B1/pl not_active IP Right Cessation
- 2001-03-29 AU AU2001244634A patent/AU2001244634A1/en not_active Abandoned
- 2001-03-29 ES ES03029061T patent/ES2271464T3/es not_active Expired - Lifetime
- 2001-03-29 ES ES01917634T patent/ES2217129T3/es not_active Expired - Lifetime
- 2001-03-29 EP EP03029061A patent/EP1415990B1/en not_active Expired - Lifetime
- 2001-03-29 TR TR2004/01955T patent/TR200401955T4/tr unknown
- 2001-03-29 PT PT01917634T patent/PT1273575E/pt unknown
- 2001-03-29 DE DE60103390T patent/DE60103390T2/de not_active Expired - Lifetime
- 2001-03-29 DK DK01917634T patent/DK1273575T3/da active
- 2001-03-29 WO PCT/JP2001/002673 patent/WO2001074791A1/ja active IP Right Grant
- 2001-03-29 RU RU2001108494/04A patent/RU2257381C2/ru not_active IP Right Cessation
- 2001-03-29 US US10/148,544 patent/US6642224B1/en not_active Expired - Fee Related
- 2001-03-29 CA CA002395846A patent/CA2395846C/en not_active Expired - Fee Related
- 2001-03-29 JP JP2001572486A patent/JP3788349B2/ja not_active Expired - Fee Related
- 2001-03-29 AR ARP010101497A patent/AR027985A1/es active IP Right Grant
- 2001-03-29 AT AT01917634T patent/ATE267178T1/de active
- 2001-03-29 DE DE60123294T patent/DE60123294T2/de not_active Expired - Lifetime
- 2001-03-29 EP EP01917634A patent/EP1273575B1/en not_active Expired - Lifetime
- 2001-03-29 MX MXPA01003279A patent/MXPA01003279A/es active IP Right Grant
- 2001-03-29 AT AT03029061T patent/ATE340166T1/de not_active IP Right Cessation
- 2001-03-30 BR BR0101264-9A patent/BR0101264A/pt not_active IP Right Cessation
- 2001-03-30 CN CNB011121904A patent/CN1226292C/zh not_active Expired - Fee Related
- 2001-03-30 TW TW90107761A patent/TW575569B/zh not_active IP Right Cessation
- 2001-03-30 KR KR1020010016952A patent/KR100739359B1/ko not_active IP Right Cessation
- 2001-03-30 HU HU0101333A patent/HUP0101333A3/hu unknown
-
2003
- 2003-09-08 US US10/656,129 patent/US7307074B2/en not_active Ceased
-
2008
- 2008-09-03 US US12/203,640 patent/USRE43481E1/en not_active Expired - Fee Related
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