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TR200100780T2 - Cetp önleyicileri olarak 4-amino ikame edilmiş-2-ikame edilmiş-1-2,3,4- tetrahidrokinolinler - Google Patents

Cetp önleyicileri olarak 4-amino ikame edilmiş-2-ikame edilmiş-1-2,3,4- tetrahidrokinolinler

Info

Publication number
TR200100780T2
TR200100780T2 TR2001/00780T TR200100780T TR200100780T2 TR 200100780 T2 TR200100780 T2 TR 200100780T2 TR 2001/00780 T TR2001/00780 T TR 2001/00780T TR 200100780 T TR200100780 T TR 200100780T TR 200100780 T2 TR200100780 T2 TR 200100780T2
Authority
TR
Turkey
Prior art keywords
inhibitors
substituted
cholesterol
tetrahydroquinolines
levels
Prior art date
Application number
TR2001/00780T
Other languages
English (en)
Inventor
Paul Deninno Michael
Tetteh Magnus-Aryitey George
Benjamin Ruggeri Roger
Thure Wester Ronald
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of TR200100780T2 publication Critical patent/TR200100780T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Formül (I)'e ait kolesteril ester transfer proteini önleyicileri, bunun bir ön ilaci ya da adi geçen bilesigin ya da adi geçen ön ilacin farmasötik açidan kabul gören bir tuzu, bu önleyicileri ihtiva eden farmasötik kompozisyonlar ve bu önleyicilerin, yogunlugu yüksek lipoprotein-kolesterol gibi belirli plazma lipid seviyelerini yükseltmek ve LDL-kolesterol ve trigliseritler gibi diger belirli plazma lipid seviyelerini düsürmek ve böylece düsük düzeylerde HDL kolesterol ve/veya yüksek düzeylerde LDL-kolesterol ve trigliseritlerle karakterize edilen insan dahil bazi memelilerde ateroskleroz ve kardiyovasküler hastaliklar gibi hastaliklari tedavi etmek için kullanilmasi.
TR2001/00780T 1998-09-17 1999-09-10 Cetp önleyicileri olarak 4-amino ikame edilmiş-2-ikame edilmiş-1-2,3,4- tetrahidrokinolinler TR200100780T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10092798P 1998-09-17 1998-09-17

Publications (1)

Publication Number Publication Date
TR200100780T2 true TR200100780T2 (tr) 2001-07-23

Family

ID=22282246

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/00780T TR200100780T2 (tr) 1998-09-17 1999-09-10 Cetp önleyicileri olarak 4-amino ikame edilmiş-2-ikame edilmiş-1-2,3,4- tetrahidrokinolinler

Country Status (50)

Country Link
US (2) US6140343A (tr)
EP (1) EP1114032B1 (tr)
JP (1) JP3561474B2 (tr)
KR (1) KR100422286B1 (tr)
CN (2) CN1515259A (tr)
AP (1) AP1345A (tr)
AR (1) AR030523A1 (tr)
AT (1) ATE268324T1 (tr)
AU (1) AU747715B2 (tr)
BG (1) BG65101B1 (tr)
BR (1) BR9913855A (tr)
CA (1) CA2344248C (tr)
CO (1) CO5290250A1 (tr)
CR (1) CR6306A (tr)
CU (1) CU23053A3 (tr)
CZ (1) CZ2001954A3 (tr)
DE (1) DE69917790T2 (tr)
DK (1) DK1114032T3 (tr)
DZ (1) DZ2891A1 (tr)
EA (1) EA005761B1 (tr)
EE (1) EE200100167A (tr)
ES (1) ES2221420T3 (tr)
GC (1) GC0000108A (tr)
GE (1) GEP20032973B (tr)
GT (1) GT199900147A (tr)
HK (1) HK1039938A1 (tr)
HR (1) HRP20010200B1 (tr)
HU (1) HUP0103512A3 (tr)
ID (1) ID27838A (tr)
IL (1) IL141388A0 (tr)
IS (1) IS2278B (tr)
MA (1) MA26689A1 (tr)
MY (1) MY121405A (tr)
NO (1) NO319781B1 (tr)
NZ (1) NZ509837A (tr)
OA (1) OA11651A (tr)
PA (1) PA8481201A1 (tr)
PE (1) PE20001054A1 (tr)
PL (1) PL198124B1 (tr)
PT (1) PT1114032E (tr)
SI (1) SI1114032T1 (tr)
SK (1) SK3532001A3 (tr)
SV (1) SV1999000150A (tr)
TN (1) TNSN99170A1 (tr)
TR (1) TR200100780T2 (tr)
TW (1) TW502022B (tr)
UA (1) UA70960C2 (tr)
WO (1) WO2000017165A1 (tr)
YU (1) YU18101A (tr)
ZA (1) ZA200101745B (tr)

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