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TR200001799T2 - Müstahzar olarak 5-(4-(2-(n-metil-n-(2-pirildil) mino)etoksi)benzil) tiyazolidin,-2,4-diyon, maleik asit tuzu, hidratı. - Google Patents

Müstahzar olarak 5-(4-(2-(n-metil-n-(2-pirildil) mino)etoksi)benzil) tiyazolidin,-2,4-diyon, maleik asit tuzu, hidratı.

Info

Publication number
TR200001799T2
TR200001799T2 TR2000/01799T TR200001799T TR200001799T2 TR 200001799 T2 TR200001799 T2 TR 200001799T2 TR 2000/01799 T TR2000/01799 T TR 2000/01799T TR 200001799 T TR200001799 T TR 200001799T TR 200001799 T2 TR200001799 T2 TR 200001799T2
Authority
TR
Turkey
Prior art keywords
thiazolidine
dione
pyridyl
ethoxy
benzyl
Prior art date
Application number
TR2000/01799T
Other languages
English (en)
Inventor
David James Blackler Paul
C. Lee David
John Sasse Michael
Original Assignee
Smithkline Beecham P.L.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham P.L.C. filed Critical Smithkline Beecham P.L.C.
Publication of TR200001799T2 publication Critical patent/TR200001799T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

(i) toplam agirligi içerisinde agirligi yüzde olarak0.4 ile 0.5 ararliginda su içermesi ve (ii) 1749,1703,1645,1623,1365 ve 736 cm-1 konumlarinda doruk noktalari içeren kizil ötesi bir spektrum vermesi ve/veya (iii) büyük ölçüde Sekil II'de gösterildigi gibi bir X-isini toz dagilim (XPRD) modeli saglamasi ve/veya 3106,3069,3002,2961,1750,1718,1684,1229,1078,917,428 ve 349 cm-1 konumlarinda doruk noktalari içeren bir Raman spektrumunu saglamasi ve/veya büyük ölçüde Tablo I'de açiklandigi gibi kimyasal degisimler içeren kati hal magnetik rezonans spektrumunu vermesi ile tanimlanan5-(4-(2-(N-metil-N- (2-piridil)amino)etoksi)benzil) tiyazolidin,-2,4-diyon, maleik asit tuzu hidrati;böyle bir birlesimin uygun bir birlestirme ve böylesine bir bilesim veya birlestirmenin tibda kullanilmasi.
TR2000/01799T 1997-12-16 1998-12-14 Müstahzar olarak 5-(4-(2-(n-metil-n-(2-pirildil) mino)etoksi)benzil) tiyazolidin,-2,4-diyon, maleik asit tuzu, hidratı. TR200001799T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9726566.4A GB9726566D0 (en) 1997-12-16 1997-12-16 Novel pharmaceutical

Publications (1)

Publication Number Publication Date
TR200001799T2 true TR200001799T2 (tr) 2001-01-22

Family

ID=10823692

Family Applications (2)

Application Number Title Priority Date Filing Date
TR2000/01799T TR200001799T2 (tr) 1997-12-16 1998-12-14 Müstahzar olarak 5-(4-(2-(n-metil-n-(2-pirildil) mino)etoksi)benzil) tiyazolidin,-2,4-diyon, maleik asit tuzu, hidratı.
TR1998/02625A TR199802625A2 (tr) 1997-12-16 1998-12-16 Yeni farmasötikler

Family Applications After (1)

Application Number Title Priority Date Filing Date
TR1998/02625A TR199802625A2 (tr) 1997-12-16 1998-12-16 Yeni farmasötikler

Country Status (35)

Country Link
EP (2) EP1661895A1 (tr)
JP (1) JP2002508373A (tr)
KR (1) KR100549142B1 (tr)
CN (3) CN101302215A (tr)
AP (1) AP1365A (tr)
AR (1) AR017214A1 (tr)
AU (1) AU1967999A (tr)
BG (1) BG64988B1 (tr)
BR (1) BR9813600A (tr)
CA (1) CA2314107A1 (tr)
CO (1) CO4980880A1 (tr)
CZ (1) CZ299965B6 (tr)
DZ (1) DZ2681A1 (tr)
EA (1) EA004260B1 (tr)
EG (1) EG22337A (tr)
GB (1) GB9726566D0 (tr)
HR (1) HRP20000408B1 (tr)
HU (1) HUP0100509A3 (tr)
IL (1) IL136424A (tr)
IN (1) IN192487B (tr)
MA (1) MA26580A1 (tr)
MY (1) MY135612A (tr)
NO (1) NO317254B1 (tr)
OA (1) OA11766A (tr)
PE (1) PE20000058A1 (tr)
PL (1) PL341146A1 (tr)
RS (1) RS50126B (tr)
SA (1) SA99191115B1 (tr)
SK (1) SK286618B6 (tr)
TR (2) TR200001799T2 (tr)
TW (1) TW509690B (tr)
UA (1) UA72198C2 (tr)
UY (2) UY25308A1 (tr)
WO (1) WO1999031095A1 (tr)
ZA (1) ZA9811506B (tr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6664278B2 (en) 1997-12-16 2003-12-16 Smithkline Beecham P.L.C. Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
GB9726568D0 (en) 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical
GB9909041D0 (en) * 1999-04-20 1999-06-16 Smithkline Beecham Plc Novel pharmaceutical
TR200103060T2 (tr) * 1999-04-23 2002-05-21 Smithkline Beecham P. L. C. Yeni farmasötik maddeler
US6815457B1 (en) * 1999-04-23 2004-11-09 Smithkline Beecham P.L.C. Thiazolidinedione derivative and its use as antidiabetic
AR023565A1 (es) * 1999-04-23 2002-09-04 Smithkline Beecham Cork Ltd Un procedimiento para preparar una forma polimorfica de sal del acido maleico de tizazolidin-2,4 diona
IL152224A0 (en) 2000-04-25 2003-05-29 Kyorin Seiyaku Kk Stable crystals of thiazolidinedione derivative and process for the preparation thereof
GB0014005D0 (en) * 2000-06-08 2000-08-02 Smithkline Beecham Plc Novel pharmaceutical
GB0021784D0 (en) * 2000-09-05 2000-10-18 Smithkline Beecham Plc Novel pharmaceutical
GB0021978D0 (en) * 2000-09-07 2000-10-25 Smithkline Beecham Plc Novel pharmaceutical
SK3752003A3 (sk) * 2000-09-26 2005-03-04 Dr. Reddy's Laboratories Limited Polymorfné formy 5-[4[2-[N-metyl-N-(2- pyridyl)aminol]etoxy]benzyl]tiazolidín-2,4-dión maleátu a spôsob ich prípravy
GB0129872D0 (en) * 2001-12-13 2002-02-06 Smithkline Beecham Plc Novel pharmaceutical
WO2003050112A1 (en) * 2001-12-13 2003-06-19 Smithkline Beecham Plc Toluenesulfonate hydrates of a thiazolidinedione derivative
GB0129876D0 (en) * 2001-12-13 2002-02-06 Smithkline Beecham Plc Novel pharmaceutical
GB2405403A (en) * 2003-08-29 2005-03-02 Cipla Ltd Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base
ITMI20041537A1 (it) * 2004-07-28 2004-10-28 Chemi Spa Nuova forma polimorfa del rosiglitazone maleato
CZ298424B6 (cs) * 2005-05-24 2007-09-26 Zentiva, A. S. Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel
EP2184055A1 (en) 2008-11-07 2010-05-12 LEK Pharmaceuticals d.d. Process for preparing solid dosage forms of rosiglitazone maleate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3856378T2 (de) * 1987-09-04 2000-05-11 Beecham Group P.L.C., Brentford Substituierte Thiazolidindionderivate
GB8820389D0 (en) * 1988-08-26 1988-09-28 Beecham Group Plc Novel compounds
GB9218830D0 (en) * 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds
EP0777469A1 (en) * 1994-02-10 1997-06-11 Smithkline Beecham Plc Use of insulin sensitisers for treating renal diseases

Also Published As

Publication number Publication date
AP1365A (en) 2005-01-26
UA72198C2 (en) 2005-02-15
KR20010033141A (ko) 2001-04-25
HRP20000408A2 (en) 2000-08-31
EG22337A (en) 2002-12-31
YU36300A (sh) 2004-03-12
BR9813600A (pt) 2000-10-10
GB9726566D0 (en) 1998-02-11
NO20003069L (no) 2000-06-15
AU1967999A (en) 1999-07-05
OA11766A (en) 2005-07-19
PL341146A1 (en) 2001-03-26
CO4980880A1 (es) 2000-11-27
BG104603A (en) 2001-03-30
UY25308A1 (es) 1999-07-19
MA26580A1 (fr) 2004-12-20
IL136424A0 (en) 2001-06-14
EA200000654A1 (ru) 2000-12-25
ZA9811506B (en) 2000-11-06
NO20003069D0 (no) 2000-06-15
SK286618B6 (sk) 2009-02-05
UY25304A1 (es) 2000-12-29
TW509690B (en) 2002-11-11
HUP0100509A2 (hu) 2002-05-29
MY135612A (en) 2008-05-30
BG64988B1 (bg) 2006-11-30
KR100549142B1 (ko) 2006-02-03
PE20000058A1 (es) 2000-02-26
WO1999031095A1 (en) 1999-06-24
CN101302215A (zh) 2008-11-12
CA2314107A1 (en) 1999-06-24
HRP20000408B1 (en) 2008-04-30
CZ20002204A3 (cs) 2000-11-15
EP1040110A1 (en) 2000-10-04
RS50126B (sr) 2009-03-25
SK9172000A3 (en) 2001-01-18
IN192487B (tr) 2004-04-24
NO317254B1 (no) 2004-09-27
AP2000001831A0 (en) 2000-06-30
AR017214A1 (es) 2001-08-22
HUP0100509A3 (en) 2002-06-28
CN101381367A (zh) 2009-03-11
IL136424A (en) 2003-12-10
TR199802625A3 (tr) 1999-10-21
EP1661895A1 (en) 2006-05-31
EA004260B1 (ru) 2004-02-26
CN1281453A (zh) 2001-01-24
SA99191115B1 (ar) 2006-10-11
DZ2681A1 (fr) 2004-06-20
TR199802625A2 (tr) 1999-10-21
JP2002508373A (ja) 2002-03-19
CZ299965B6 (cs) 2009-01-07

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