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TN2014000415A1 - Novel thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof - Google Patents

Novel thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof

Info

Publication number
TN2014000415A1
TN2014000415A1 TNP2014000415A TN2014000415A TN2014000415A1 TN 2014000415 A1 TN2014000415 A1 TN 2014000415A1 TN P2014000415 A TNP2014000415 A TN P2014000415A TN 2014000415 A TN2014000415 A TN 2014000415A TN 2014000415 A1 TN2014000415 A1 TN 2014000415A1
Authority
TN
Tunisia
Prior art keywords
preparation
processes
therapeutic uses
thienopyrimidine derivatives
novel thienopyrimidine
Prior art date
Application number
TNP2014000415A
Other languages
English (en)
Inventor
Jean-Christophe Carry
Fabienne Chatreaux
Stephanie Deprets
Olivier Duclos
Vincent Leroy
Sergio Mallart
Dominique Melon-Manguer
Maria Mendez-Perez
Fabrice Vergne
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48095815&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2014000415(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of TN2014000415A1 publication Critical patent/TN2014000415A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Professional, Industrial, Or Sporting Protective Garments (AREA)
TNP2014000415A 2012-04-03 2014-09-30 Novel thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof TN2014000415A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1253044A FR2988722B1 (fr) 2012-04-03 2012-04-03 Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques
PCT/EP2013/056958 WO2013150036A1 (fr) 2012-04-03 2013-04-02 Nouveaux dérivés de thiénopyrimidine, leurs procédés de préparation et leurs utilisations thérapeutiques

Publications (1)

Publication Number Publication Date
TN2014000415A1 true TN2014000415A1 (en) 2015-12-21

Family

ID=48095815

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2014000415A TN2014000415A1 (en) 2012-04-03 2014-09-30 Novel thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof

Country Status (38)

Country Link
US (6) US9115140B2 (fr)
EP (1) EP2834248B1 (fr)
JP (1) JP6096278B2 (fr)
KR (1) KR102039764B1 (fr)
CN (2) CN104540834B (fr)
AR (1) AR090572A1 (fr)
AU (1) AU2013244992B2 (fr)
BR (1) BR112014024489B1 (fr)
CA (1) CA2868685C (fr)
CL (1) CL2014002661A1 (fr)
CO (1) CO7091179A2 (fr)
CR (1) CR20140435A (fr)
CY (1) CY1117843T1 (fr)
DK (1) DK2834248T3 (fr)
DO (1) DOP2014000216A (fr)
EA (1) EA025558B1 (fr)
ES (1) ES2577382T3 (fr)
FR (1) FR2988722B1 (fr)
HK (2) HK1201263A1 (fr)
HR (1) HRP20160649T1 (fr)
HU (1) HUE027895T2 (fr)
IL (1) IL234960A (fr)
MA (1) MA37384B1 (fr)
MX (1) MX355104B (fr)
MY (1) MY166151A (fr)
PE (1) PE20150289A1 (fr)
PH (1) PH12014502180B1 (fr)
PL (1) PL2834248T3 (fr)
PT (1) PT2834248E (fr)
RS (1) RS54850B1 (fr)
SG (1) SG11201406091RA (fr)
SI (1) SI2834248T1 (fr)
TN (1) TN2014000415A1 (fr)
TW (1) TWI579288B (fr)
UA (1) UA112685C2 (fr)
UY (1) UY34725A (fr)
WO (1) WO2013150036A1 (fr)
ZA (1) ZA201407021B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2988722B1 (fr) * 2012-04-03 2014-05-09 Sanofi Sa Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques
CN110372720B (zh) * 2014-05-28 2021-03-05 锦州奥鸿药业有限责任公司 一类激酶抑制剂
CN111440189B (zh) * 2015-04-24 2022-08-09 广州再极医药科技有限公司 稠环嘧啶氨基衍生物、其制备方法、中间体、药物组合物及应用
WO2017114351A1 (fr) * 2015-12-27 2017-07-06 Chongqing Fochon Pharmaceutical Co., Ltd. Inhibiteurs de certaines protéines kinases
MX2018013573A (es) * 2016-05-07 2019-08-01 Shanghai Fochon Pharmaceutical Co Ltd Ciertos inhibidores de la proteína cinasa.
WO2019054427A1 (fr) 2017-09-14 2019-03-21 第一三共株式会社 Composé à structure cyclique
CN118290402A (zh) 2018-03-08 2024-07-05 因赛特公司 作为PI3K-γ抑制剂的氨基吡嗪二醇化合物
CN110551142B (zh) 2018-05-31 2023-05-12 上海再极医药科技有限公司 一种稠环嘧啶类化合物的盐、晶型及其制备方法和应用
WO2020010003A1 (fr) 2018-07-02 2020-01-09 Incyte Corporation DÉRIVÉS D'AMINOPYRAZINE UTILISÉS EN TANT QU'INHIBITEURS DE PI3K-γ
EP3886854A4 (fr) 2018-11-30 2022-07-06 Nuvation Bio Inc. Composés pyrrole et pyrazole et leurs procédés d'utilisation
CN110922421B (zh) * 2019-12-17 2023-05-05 安徽英特美科技有限公司 一种n-甲基-1,2,5,6-四氢吡啶-4-硼酸频哪醇酯的合成方法
CN113384582A (zh) * 2020-03-13 2021-09-14 广州再极医药科技有限公司 稠环嘧啶化合物在制备治疗癌症的药物中的应用
CN116731035A (zh) * 2022-03-08 2023-09-12 广州再极医药科技有限公司 一种噻吩并嘧啶类化合物、中间体、其制备方法、组合物和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1470356A1 (de) * 1964-01-15 1970-04-30 Thomae Gmbh Dr K Neue Thieno[3,2-d]pyrimidine und Verfahren zu ihrer Herstellung
AU9454198A (en) 1997-11-11 1999-05-31 Pfizer Products Inc. Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
WO2000075145A1 (fr) 1999-06-03 2000-12-14 Abbott Laboratories Composes anti-inflammatoires inhibant l'adhesion cellulaire
DE10042997A1 (de) 2000-09-01 2002-03-14 Merck Patent Gmbh Thienopyrimidine
US20080108611A1 (en) 2006-01-19 2008-05-08 Battista Kathleen A Substituted thienopyrimidine kinase inhibitors
MX2008013583A (es) 2006-04-26 2008-10-31 Genentech Inc Compuestos del inhibidor de fosfoinositido 3-cinasa y composiciones farmaceuticas que los contienen.
CN103641816A (zh) 2006-12-08 2014-03-19 Irm责任有限公司 作为蛋白激酶抑制剂的化合物和组合物
CA2703600C (fr) 2007-11-15 2017-04-25 Ym Biosciences Australia Pty Ltd Composes heterocycliques de thieno ou pyrrolo pyrimidine fusionnes et leur utilisation comme inhibiteurs de jak1, jak2 ou jak3
DE102008017853A1 (de) 2008-04-09 2009-10-15 Merck Patent Gmbh Thienopyrimidine
KR101147550B1 (ko) * 2009-10-22 2012-05-17 한국과학기술연구원 단백질 키나아제 저해활성을 가지는 2,7-치환된 티에노［3,2-ｄ］피리미딘 화합물
KR101094446B1 (ko) * 2009-11-19 2011-12-15 한국과학기술연구원 단백질 키나아제 저해활성을 가지는 2,4,7-치환된 티에노［3,2-ｄ］피리미딘 화합물
WO2012004900A1 (fr) 2010-07-09 2012-01-12 Aska Pharmaceutical Co., Ltd. Composés thiénopyrimidines
FR2988722B1 (fr) 2012-04-03 2014-05-09 Sanofi Sa Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques

Also Published As

Publication number Publication date
MX2014011921A (es) 2015-02-24
US20200323874A1 (en) 2020-10-15
ZA201407021B (en) 2015-11-25
MX355104B (es) 2018-04-05
DK2834248T3 (en) 2016-07-04
EA025558B1 (ru) 2017-01-30
FR2988722A1 (fr) 2013-10-04
PL2834248T3 (pl) 2016-09-30
US10220044B2 (en) 2019-03-05
PT2834248E (pt) 2016-06-24
AU2013244992A1 (en) 2014-10-23
CY1117843T1 (el) 2017-05-17
US20150352124A1 (en) 2015-12-10
US20200078370A1 (en) 2020-03-12
US9115140B2 (en) 2015-08-25
EA201491820A1 (ru) 2015-02-27
MA37384A1 (fr) 2016-06-30
PH12014502180A1 (en) 2014-12-10
RS54850B1 (sr) 2016-10-31
PH12014502180B1 (en) 2014-12-10
CL2014002661A1 (es) 2014-12-26
AU2013244992B2 (en) 2017-04-20
UA112685C2 (uk) 2016-10-10
HK1248214A1 (zh) 2018-10-12
IL234960A (en) 2017-06-29
CN104540834A (zh) 2015-04-22
CN104540834B (zh) 2017-11-14
CA2868685C (fr) 2021-01-12
SI2834248T1 (sl) 2016-07-29
US20170319594A1 (en) 2017-11-09
EP2834248B1 (fr) 2016-03-16
CN107652303B (zh) 2020-08-04
US20190151330A1 (en) 2019-05-23
CR20140435A (es) 2015-03-13
MY166151A (en) 2018-06-06
PE20150289A1 (es) 2015-03-05
WO2013150036A1 (fr) 2013-10-10
AR090572A1 (es) 2014-11-19
JP6096278B2 (ja) 2017-03-15
KR102039764B1 (ko) 2019-11-01
TW201345914A (zh) 2013-11-16
CN107652303A (zh) 2018-02-02
US10980816B2 (en) 2021-04-20
UY34725A (es) 2013-09-30
FR2988722B1 (fr) 2014-05-09
HRP20160649T1 (hr) 2016-07-15
KR20150001781A (ko) 2015-01-06
ES2577382T3 (es) 2016-07-14
DOP2014000216A (es) 2017-09-15
US20130261106A1 (en) 2013-10-03
US10736904B2 (en) 2020-08-11
HUE027895T2 (en) 2016-10-28
US10500212B2 (en) 2019-12-10
SG11201406091RA (en) 2014-10-30
MA37384B1 (fr) 2017-03-31
CA2868685A1 (fr) 2013-10-10
CO7091179A2 (es) 2014-10-21
US9744176B2 (en) 2017-08-29
HK1201263A1 (zh) 2015-08-28
JP2015512434A (ja) 2015-04-27
EP2834248A1 (fr) 2015-02-11
TWI579288B (zh) 2017-04-21
BR112014024489B1 (pt) 2020-11-10

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