TN2009000347A1 - Derives de pleuromutiline pour le traitement de maladies transmises par des microbes - Google Patents
Derives de pleuromutiline pour le traitement de maladies transmises par des microbesInfo
- Publication number
- TN2009000347A1 TN2009000347A1 TNP2009000347A TN2009000347A TN2009000347A1 TN 2009000347 A1 TN2009000347 A1 TN 2009000347A1 TN P2009000347 A TNP2009000347 A TN P2009000347A TN 2009000347 A TN2009000347 A TN 2009000347A TN 2009000347 A1 TN2009000347 A1 TN 2009000347A1
- Authority
- TN
- Tunisia
- Prior art keywords
- alkyl
- microbes
- treatment
- cycloalkyl
- diseases transmitted
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/61—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/93—Spiro compounds
- C07C2603/95—Spiro compounds containing "not free" spiro atoms
- C07C2603/98—Spiro compounds containing "not free" spiro atoms containing at least one ring with more than six ring members
- C07C2603/99—Spiro compounds containing "not free" spiro atoms containing at least one ring with more than six ring members containing eight-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
L'invention porte sur un composé de formule (1), dans laquelle n vaut 0 à 4; m vaut 0 ou 1, à la condition que l'atome de soufre et R3 soient en position voisine (si m = 0, R3 est en position 2', et si m = 1, R3 est en position 1'); R représente éthyle ou vinyle; R1 représente hydrogène ou alkyle en C1-6; R2 représente hydrogène ou cycloalkyle en C3-6 ou alkyle en Cl-6 non substitué ou alkyle en Cl-6 substitué par un ou plusieurs hydroxy; de préférence un ou deux méthoxy, halogène, cycloalkyle en C3-6, ou R1 et R2, conjointement avec l'atome d'azote auquel ils sont attachés, forment un noyau hétérocyclique de 5 à 7 chaînons contenant au moins 1 atome d'azote ou 1 azote et 1 hétéroatome supplémentaire, par exemple, choisi parmi N ou 0, ou R1 représente hydroxy et R2 représente formyle; R3 représente OH, OR4, un atome d'halogène, ou à la condition que R3 soit lié en 2', R3 représente -0-(CH2)p-0-, avec p valant 2 ou 3; R4 représente alkyle en C1-6 non substitué ou cycloalkyle en C3-6.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07450053A EP1972618A1 (fr) | 2007-03-20 | 2007-03-20 | Dérivés de pleuromutilin pour le traitement des maladies médiées par des microbes |
| PCT/AT2008/000097 WO2008113089A1 (fr) | 2007-03-20 | 2008-03-19 | Dérivés de pleuromutiline pour le traitement de maladies transmises par des microbes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TN2009000347A1 true TN2009000347A1 (fr) | 2010-12-31 |
Family
ID=38668870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNP2009000347A TN2009000347A1 (fr) | 2007-03-20 | 2009-08-19 | Derives de pleuromutiline pour le traitement de maladies transmises par des microbes |
Country Status (32)
| Country | Link |
|---|---|
| US (12) | US20090118366A1 (fr) |
| EP (3) | EP1972618A1 (fr) |
| JP (2) | JP5479114B2 (fr) |
| KR (1) | KR101478593B1 (fr) |
| CN (2) | CN101668738B (fr) |
| AT (1) | ATE523486T1 (fr) |
| AU (1) | AU2008229609B2 (fr) |
| BR (1) | BRPI0809023B8 (fr) |
| CA (1) | CA2678795C (fr) |
| CY (2) | CY1117482T1 (fr) |
| DK (2) | DK2137143T3 (fr) |
| EA (1) | EA018707B1 (fr) |
| ES (2) | ES2620459T3 (fr) |
| FI (1) | FIC20200038I1 (fr) |
| HK (1) | HK1140185A1 (fr) |
| HR (1) | HRP20110869T1 (fr) |
| HU (1) | HUS2100001I1 (fr) |
| IL (1) | IL200440A (fr) |
| LT (1) | LTPA2020531I1 (fr) |
| MA (1) | MA31314B1 (fr) |
| MY (1) | MY148916A (fr) |
| NL (1) | NL301086I2 (fr) |
| NO (1) | NO2021002I1 (fr) |
| NZ (1) | NZ579011A (fr) |
| PL (1) | PL2137143T3 (fr) |
| PT (2) | PT2137143E (fr) |
| SI (1) | SI2137143T1 (fr) |
| TN (1) | TN2009000347A1 (fr) |
| TW (1) | TWI406657B (fr) |
| UA (1) | UA97836C2 (fr) |
| WO (1) | WO2008113089A1 (fr) |
| ZA (1) | ZA200905590B (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8617015B2 (en) | 2005-09-27 | 2013-12-31 | Wick Werks, LLC | Bicycle chain rings |
| US8092329B2 (en) | 2005-08-31 | 2012-01-10 | Wick Werks, LLC | Bicycle chain rings with ramps |
| EP1808431A1 (fr) * | 2006-01-16 | 2007-07-18 | Nabriva Therapeutics Forschungs GmbH | Dérivés de mutiline et leur utilisation en tant que composé pharmaceutique |
| EP1972618A1 (fr) | 2007-03-20 | 2008-09-24 | Nabriva Therapeutics AG | Dérivés de pleuromutilin pour le traitement des maladies médiées par des microbes |
| EP2159220A1 (fr) * | 2008-09-02 | 2010-03-03 | Nabriva Therapeutics AG | Composés organiques |
| WO2010056855A1 (fr) * | 2008-11-13 | 2010-05-20 | Teva Pharmaceutical Industries Ltd. | Préparation de rétapamuline par l'intermédiaire de son précurseur pleuromutiline-thiol |
| EP2390245A1 (fr) * | 2010-05-26 | 2011-11-30 | Nabriva Therapeutics AG | Amines énantiomériquement pures |
| EP2399904A1 (fr) | 2010-05-26 | 2011-12-28 | Nabriva Therapeutics AG | Procédé de préparation de pleuromutilines |
| EP2433926A1 (fr) | 2010-09-09 | 2012-03-28 | Nabriva Therapeutics AG | Dérivés de pleuromutilin pour le traitement des maladies médiées par des microbes |
| BR112014001057B1 (pt) | 2011-07-15 | 2018-07-03 | Bayer Intellectual Property Gmbh | Derivados de 2,3-difenilvaleronitrilo, processos para a sua preparação e sua utilização enquanto herbicidas e reguladores do crescimento vegetal |
| CN103265487A (zh) * | 2013-06-05 | 2013-08-28 | 北京理工大学 | 截短侧耳素扩环衍生物及其制备方法和用途 |
| CN104803911B (zh) * | 2014-01-23 | 2018-01-05 | 中国科学院上海药物研究所 | 一类截短侧耳素化合物、其药物组合物、合成方法与用途 |
| ES2553929B1 (es) * | 2014-06-11 | 2016-09-26 | Antonio Javier MORENO CASTRO | Dispositivo de modificación/destrucción selectiva de tejidos orgánicos |
| SI3310331T1 (sl) | 2015-06-17 | 2021-02-26 | Nabriva Therapeutics GmbH | Farmacevtska formulacija lefamulina, ki se jo da injicirati |
| PT3701944T (pt) | 2015-06-18 | 2022-01-11 | Estetra Srl | Dose unitária orodispersível contendo um composto de estetrol |
| JP6863547B2 (ja) | 2015-06-18 | 2021-04-21 | エステトラ ソシエテ プリーヴ ア レスポンサビリテ リミテ | エステトロール成分を含有する口腔内崩壊性投与単位 |
| TWI762573B (zh) | 2017-02-10 | 2022-05-01 | 奧地利商納畢瓦治療有限責任公司 | 截短側耳素之純化 |
| TWI801561B (zh) | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
| JOP20200260A1 (ar) | 2018-04-19 | 2019-10-19 | Estetra Sprl | مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث |
| CN111170911A (zh) * | 2019-09-29 | 2020-05-19 | 安帝康（无锡）生物科技有限公司 | 用于治疗细菌感染性疾病的截短侧耳素类化合物 |
| CN111170893B (zh) * | 2020-01-19 | 2022-04-26 | 郑州依米花手性药物研究有限公司 | Lefamulin的中间体化合物及其在Lefamulin制备中的应用 |
| TW202204337A (zh) | 2020-04-17 | 2022-02-01 | 奧地利商納畢瓦治療有限責任公司 | 截短側耳素類之醫療用途 |
| BR112022020007A2 (pt) * | 2020-04-17 | 2022-11-22 | Nabriva Therapeutics GmbH | Uso terapêutico de pleuromutilinas |
| EP4135681A1 (fr) | 2020-04-17 | 2023-02-22 | Nabriva Therapeutics GMBH | Nouvelle utilisation thérapeutique de pleuromutilines |
| WO2023152115A1 (fr) | 2022-02-09 | 2023-08-17 | Nabriva Therapeutics GmbH | Léfamuline et ses dérivés pour utilisation dans le traitement contre une bactérie en forme de spirale |
| EP4338732A1 (fr) | 2022-09-16 | 2024-03-20 | Nabriva Therapeutics GMBH | Lefamulin et ses dérivés pour leur utilisation dans le traitement de la tularémie |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4130709A (en) * | 1977-12-08 | 1978-12-19 | Eli Lilly And Company | Pleuromutilin glycoside derivatives |
| DE4023848C2 (de) | 1990-07-27 | 1994-04-21 | Huels Chemische Werke Ag | Verfahren zur Herstellung von 3-C¶1¶- bis C¶6¶-Alkoxycarbonylcyclohexanpropionsäureestern |
| GB9918037D0 (en) * | 1999-07-30 | 1999-09-29 | Biochemie Gmbh | Organic compounds |
| GB0017031D0 (en) * | 2000-07-11 | 2000-08-30 | Biochemie Gmbh | Antimicrobials |
| GB0207495D0 (en) | 2002-03-28 | 2002-05-08 | Biochemie Gmbh | Organic compounds |
| GB0209262D0 (en) | 2002-04-23 | 2002-06-05 | Biochemie Gmbh | Organic compounds |
| JP4611020B2 (ja) * | 2002-07-24 | 2011-01-12 | ナブリバ・セラピユーテイクス・アクチエンゲゼルシヤフト | 抗菌剤としてのプレウロムチリン（ｐｌｅｕｒｏｍｕｔｉｌｉｎ）誘導体 |
| GB0513058D0 (en) * | 2005-06-27 | 2005-08-03 | Sandoz Ag | Organic compounds |
| JP5373393B2 (ja) * | 2005-06-27 | 2013-12-18 | ナブリヴァ セラピュティクス アクチエンゲゼルシャフト | ヒドロキシアミノ基またはアシルオキシアミノシクロアルキル基を含むプレウロムチリン誘導体 |
| GB0515995D0 (en) * | 2005-08-03 | 2005-09-07 | Sandoz Ag | Organic compounds |
| EP1972618A1 (fr) | 2007-03-20 | 2008-09-24 | Nabriva Therapeutics AG | Dérivés de pleuromutilin pour le traitement des maladies médiées par des microbes |
-
2007
- 2007-03-20 EP EP07450053A patent/EP1972618A1/fr not_active Withdrawn
- 2007-07-25 US US11/828,224 patent/US20090118366A1/en not_active Abandoned
-
2008
- 2008-03-19 JP JP2009553863A patent/JP5479114B2/ja active Active
- 2008-03-19 EP EP11005863.3A patent/EP2380874B1/fr active Active
- 2008-03-19 CN CN200880007780.5A patent/CN101668738B/zh active Active
- 2008-03-19 ES ES11005863.3T patent/ES2620459T3/es active Active
- 2008-03-19 DK DK08714294.9T patent/DK2137143T3/da active
- 2008-03-19 PL PL08714294T patent/PL2137143T3/pl unknown
- 2008-03-19 CA CA2678795A patent/CA2678795C/fr active Active
- 2008-03-19 PT PT08714294T patent/PT2137143E/pt unknown
- 2008-03-19 UA UAA200910582A patent/UA97836C2/ru unknown
- 2008-03-19 AT AT08714294T patent/ATE523486T1/de active
- 2008-03-19 ZA ZA200905590A patent/ZA200905590B/xx unknown
- 2008-03-19 SI SI200830451T patent/SI2137143T1/sl unknown
- 2008-03-19 ES ES08714294T patent/ES2375503T3/es active Active
- 2008-03-19 US US12/531,839 patent/US8071643B2/en active Active
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