SV2005001840A - Compuestos de oxazol para el tratamiento de trastornos neurodegenerativos - docket 17005 - Google Patents
Compuestos de oxazol para el tratamiento de trastornos neurodegenerativos - docket 17005Info
- Publication number
- SV2005001840A SV2005001840A SV2004001840A SV2004001840A SV2005001840A SV 2005001840 A SV2005001840 A SV 2005001840A SV 2004001840 A SV2004001840 A SV 2004001840A SV 2004001840 A SV2004001840 A SV 2004001840A SV 2005001840 A SV2005001840 A SV 2005001840A
- Authority
- SV
- El Salvador
- Prior art keywords
- compounds
- formula
- docket
- treatment
- neurodegenerative disorders
- Prior art date
Links
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 2
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical class C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/48—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
COMPUESTOS DE FORMULA (VER FORMULA) EN DONDE R3, R5, R6, R7 Y Z, ASI COMO OTROS VALORES ENUMERADOS CON RELACION A R3, R5, R6, R7 Y Z SON COMO SE LOS DEFINE. LOS COMPUESTOS DE FORMULA I PRESENTAN ACTIVIDAD INHIBIDORA DE LA PRODUCCION DE PEPTIDO ABETA. ESTA INVENCION SE REFIERE ADEMAS A COMPOSICIONES FARMACEUTICAS Y METODOS PARA TRATAR ENFERMEDADES, POR EJEMPLO, ENFERMEDADES NEURODEGENERATIVAS, I.E. ENFERMEDAD DE ALZHEIMER, EN UN MAMIFERO, QUE COMPRENDEN COMPUESTOS DE FORMULA I.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49288403P | 2003-08-06 | 2003-08-06 | |
| US49802803P | 2003-08-27 | 2003-08-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SV2005001840A true SV2005001840A (es) | 2005-11-04 |
Family
ID=34197958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SV2004001840A SV2005001840A (es) | 2003-08-06 | 2004-08-09 | Compuestos de oxazol para el tratamiento de trastornos neurodegenerativos - docket 17005 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7112599B2 (es) |
| EP (1) | EP1653952A4 (es) |
| JP (1) | JP2007501244A (es) |
| AR (1) | AR046327A1 (es) |
| BR (1) | BRPI0413349A (es) |
| CA (1) | CA2534529A1 (es) |
| MX (1) | MXPA06001480A (es) |
| PA (1) | PA8608601A1 (es) |
| PE (1) | PE20050337A1 (es) |
| SV (1) | SV2005001840A (es) |
| TW (1) | TW200510351A (es) |
| UY (1) | UY28458A1 (es) |
| WO (1) | WO2005016267A2 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ549331A (en) * | 2004-03-23 | 2010-08-27 | Pfizer Prod Inc | Imidazole compounds for the treatment of neurodegenerative disorders |
| US20050222227A1 (en) * | 2004-04-01 | 2005-10-06 | Pfizer Inc | Oxazole-amine compounds for the treatment of neurodegenerative disorders |
| RS20080139A (en) * | 2005-09-22 | 2009-05-06 | Pfizer Products Inc., | Imidazole coumpounds for the treatment of neurological disorders |
| CA2676944C (en) | 2007-02-15 | 2016-01-19 | F. Hoffmann-La Roche Ag | 2-aminooxazolines as taar1 ligands |
| AU2010204118B2 (en) | 2009-01-12 | 2012-12-20 | Icagen, Inc. | Sulfonamide derivatives |
| SG11201407919WA (en) * | 2012-05-31 | 2014-12-30 | Phenex Pharmaceuticals Ag | Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ror[gamma] |
| BR112020019191A2 (pt) | 2018-03-23 | 2021-01-05 | Yumanity Therapeutics, Inc. | Compostos e seus usos |
| KR20220007845A (ko) | 2019-01-24 | 2022-01-19 | 유마니티 테라퓨틱스, 인크. | 화합물 및 이의 용도 |
| EA202192047A1 (ru) | 2019-11-13 | 2021-12-08 | Юманити Терапьютикс, Инк. | Соединения и их применение |
| CN113651805B (zh) * | 2021-07-19 | 2023-07-25 | 安徽医科大学 | 一种1,2,4-噁二唑-吡啶类化合物及其在治疗阿尔茨海默症中的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3094462A (en) * | 1961-09-18 | 1963-06-18 | Mcneilab Inc | Therapeutic reaction complex for muscle relaxation |
| US3591584A (en) * | 1968-08-27 | 1971-07-06 | Pfizer | Benzothiazine dioxides |
| GB1264258A (es) * | 1970-10-10 | 1972-02-16 | ||
| GB9320660D0 (en) * | 1993-10-07 | 1993-11-24 | British Bio Technology | Inhibition of cytokine production |
| US6169102B1 (en) * | 1996-06-25 | 2001-01-02 | Takeda Chemical Industries, Ltd. | Oxazolone derivatives and their use as anti-Helicobacter pylori agent |
| US20020002199A1 (en) * | 1998-03-12 | 2002-01-03 | Lone Jeppesen | Modulators of protein tyrosine phosphatases (ptpases) |
| EP1165546A2 (en) * | 1999-04-02 | 2002-01-02 | Du Pont Pharmaceuticals Company | Novel lactam inhibitors of matrix metalloproteinases, tnf-alpha, and aggrecanase |
| TW593241B (en) * | 1999-04-20 | 2004-06-21 | Hoffmann La Roche | Carbamic acid derivatives |
| AR039059A1 (es) * | 2001-08-06 | 2005-02-09 | Sanofi Aventis | Compuesto derivado de acilaminotiazol, su utilizacion, procedimientos para prepararlo, composicion farmaceutica que lo comprende, y compuestos intermediarios |
| JP2006504725A (ja) * | 2002-10-09 | 2006-02-09 | ファイザー・プロダクツ・インク | 神経変性障害治療用ピラゾール化合物 |
| MXPA05002420A (es) * | 2002-10-09 | 2005-10-05 | Pfizer Prod Inc | Compuestos de tiazol para el tratamiento de trastornos neurodegenerativos. |
| BR0317714A (pt) * | 2002-12-23 | 2005-11-22 | Hoffmann La Roche | Oxazóis como realçadores de mglur1 |
| WO2004063177A1 (en) * | 2003-01-13 | 2004-07-29 | F. Hoffmann-La Roche Ag | Benzoxazole derivatives and their use as adenosine receptor ligands |
-
2004
- 2004-08-04 BR BRPI0413349-8A patent/BRPI0413349A/pt not_active IP Right Cessation
- 2004-08-04 MX MXPA06001480A patent/MXPA06001480A/es active IP Right Grant
- 2004-08-04 JP JP2006522669A patent/JP2007501244A/ja not_active Withdrawn
- 2004-08-04 CA CA002534529A patent/CA2534529A1/en not_active Abandoned
- 2004-08-04 WO PCT/US2004/025023 patent/WO2005016267A2/en active Application Filing
- 2004-08-04 EP EP04779943A patent/EP1653952A4/en not_active Withdrawn
- 2004-08-05 TW TW093123538A patent/TW200510351A/zh unknown
- 2004-08-05 US US10/911,869 patent/US7112599B2/en not_active Expired - Fee Related
- 2004-08-06 PE PE2004000763A patent/PE20050337A1/es not_active Application Discontinuation
- 2004-08-06 PA PA20048608601A patent/PA8608601A1/es unknown
- 2004-08-06 AR ARP040102804A patent/AR046327A1/es unknown
- 2004-08-06 UY UY28458A patent/UY28458A1/es not_active Application Discontinuation
- 2004-08-09 SV SV2004001840A patent/SV2005001840A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PE20050337A1 (es) | 2005-06-06 |
| TW200510351A (en) | 2005-03-16 |
| CA2534529A1 (en) | 2005-02-24 |
| UY28458A1 (es) | 2005-03-31 |
| US20050032859A1 (en) | 2005-02-10 |
| BRPI0413349A (pt) | 2006-10-10 |
| WO2005016267A3 (en) | 2005-04-21 |
| PA8608601A1 (es) | 2005-03-03 |
| AR046327A1 (es) | 2005-12-07 |
| MXPA06001480A (es) | 2006-05-15 |
| JP2007501244A (ja) | 2007-01-25 |
| EP1653952A4 (en) | 2007-04-04 |
| EP1653952A2 (en) | 2006-05-10 |
| WO2005016267A2 (en) | 2005-02-24 |
| US7112599B2 (en) | 2006-09-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PA8608301A1 (es) | Compuestos heteroarilo de 6 miembros de heteroarilo para el tratamiento de enfermedades neurogenerativas | |
| CR7785A (es) | Compuestos de tiazol para el tratamiento de trastornos neurodegenerativos | |
| SV2006002055A (es) | Compuestos de imidazol para el tratamiento de trastornos neurodegenerativos ref. pc32054a | |
| DOP2004000888A (es) | 2-hidroxi-3-diaminoalcanos de benzamida (benzamide 2-hydroxy-3-diaminoalkanes | |
| UY28144A1 (es) | Agentes terapéuticos | |
| UY28484A1 (es) | Compuestos para el tratamiento de trastornos neurodegenerativos | |
| GT200400076A (es) | Ligandos de receptores de cannabinoides y sus usos | |
| PA8601001A1 (es) | Fenacilo 2-hidroxi-3-diaminoalcanos | |
| BRPI0418181A (pt) | emprego de 2-aminotetralinas substituìdas para prevenção do tratamento de morbus parkinson | |
| UY30377A1 (es) | Inhibidores triciclicos fusionados de sulfonamida de gama-secretasa | |
| DOP2003000765A (es) | Ureas substituidas y carbamatos utiles para el tratamiento de la enfermedad de alzheimer (substituted ureas and carbamates useful in the treatment of alzheimer`s disease | |
| ECSP066888A (es) | Compuestos de sulfonamidas para el tratamiento de trastornos neurodegenerativos | |
| ATE371724T1 (de) | Behandlung neurodegenerativer krankheiten | |
| SV2005001840A (es) | Compuestos de oxazol para el tratamiento de trastornos neurodegenerativos - docket 17005 | |
| BR0306855A (pt) | Método para o tratamento de distúrbios cognitivos | |
| CR9815A (es) | Compuestos de imidazol para el tratamiento de transtornos neurologicos | |
| DOP2004000970A (es) | Compuestos de oxazol para el tratamiento de trastornos neurodegenerativos | |
| DOP2004000982A (es) | Compuestos para el tratamiento de trastornos neurodegenerativos | |
| DOP2004000966A (es) | Compuestos heteroarilo de 6 miembros para el tratamiento de trastornos neurodegenerativos | |
| PA8601101A1 (es) | 2-hidroxi-3-diaminoalcanos de benzamida | |
| BRPI0402756A (pt) | método para o tratamento de distúrbios cognitivos | |
| DOP2006000200A (es) | Compuestos de imidazol para el tratamiento de trastonos neurologicos | |
| EA200500382A1 (ru) | Соединения тиазола для лечения нейродегенеративных расстройств |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Lapse |