SU72463A2 - Method for producing apomorphine - Google Patents
Method for producing apomorphineInfo
- Publication number
- SU72463A2 SU72463A2 SU98A SU356578A SU72463A2 SU 72463 A2 SU72463 A2 SU 72463A2 SU 98 A SU98 A SU 98A SU 356578 A SU356578 A SU 356578A SU 72463 A2 SU72463 A2 SU 72463A2
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- apomorphine
- producing
- ether
- hydrochloric acid
- reaction mass
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
В осиовно.м авт. св. Ль 40981 описываетс способ получени апо .морфина при нагревании морфина с фосфорной кислотой до 145-150 ири одновременном иропускаими через раствор хлористого водорода. После добавлени к реакционной массе поваренной соли и соды и отделени образуюидегос осадка смол раствор нейтрализуют сульфитом до полного выделени осадка апоморфина, который извлекают этиловым эфиром.In axis m auth. St. A 40981 describes a method for producing apo morphine by heating morphine with phosphoric acid to 145-150 or simultaneously using an emulsion through a solution of hydrogen chloride. After adding sodium chloride and soda to the reaction mass and separating the formation of a suitable sludge resin, the solution is neutralized with sulphite until apomorphine precipitate is completely separated, which is extracted with ethyl ether.
В описываемом изобретении предлагаетс дл извлечени аиоморфина B iecTO этилового эфира примен ть изоиропиловы эфир.In the present invention, it is proposed to use the isoyl propyl ether to extract the iomomorphine B i ethyl ethyl.
С этой нелыо к реакиионной массе, получеиной описанным способом , после нейтрализации ее сульфитом добавл ют равный объем изопроиилового эфира и нолучеиную выт жку обрабатывают сол ной кислотой. Одна и та же норци эфира примен етс до 12 раз, Апомор Ьиli . выиадактций к осадок при добав,:;еи11:1 сол ной кислоты, отфильтровываетс и промываетс разбавленной сол ной кислотой. Полученный продукт не допольиттельной очистки.From this bed, an equal volume of isopropyl ether is added to the reaction mass obtained by the method described above, after neutralizing it with sulphite, and the batch extract is treated with hydrochloric acid. The same ether rate is applied up to 12 times, Apomor bli. With the addition of::; 11/1 hydrochloric acid, the precipitate is filtered and washed with dilute hydrochloric acid. The resulting product is not additional purification.
Предмет изобретени Subject invention
Способ получени апоморфина ио авт. св. N° 40981, отличаюИ1 и и с тем, что, с целью уменьшени расхода органического растворител , апоморфин извлекают из реакционной массы изопропиловымA method for producing apomorphine io auth. St. N ° 40981, distinguishing II with the fact that, in order to reduce the consumption of organic solvent, apomorphine is extracted from the reaction mass with isopropyl
эфиром.by ether.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU98A SU72463A2 (en) | 1947-07-03 | 1947-07-03 | Method for producing apomorphine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU98A SU72463A2 (en) | 1947-07-03 | 1947-07-03 | Method for producing apomorphine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU72463A2 true SU72463A2 (en) | 1947-11-30 |
Family
ID=52785310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU98A SU72463A2 (en) | 1947-07-03 | 1947-07-03 | Method for producing apomorphine |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU72463A2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10525134B2 (en) | 2012-06-05 | 2020-01-07 | Neuroderm, Ltd. | Compositions comprising apomorphine and organic acids and uses thereof |
-
1947
- 1947-07-03 SU SU98A patent/SU72463A2/en active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10525134B2 (en) | 2012-06-05 | 2020-01-07 | Neuroderm, Ltd. | Compositions comprising apomorphine and organic acids and uses thereof |
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