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SU1187720A3 - Способ получени производных пиперидина или их кислотноаддитивных солей - Google Patents

Способ получени производных пиперидина или их кислотноаддитивных солей Download PDF

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Publication number
SU1187720A3
SU1187720A3 SU833641410A SU3641410A SU1187720A3 SU 1187720 A3 SU1187720 A3 SU 1187720A3 SU 833641410 A SU833641410 A SU 833641410A SU 3641410 A SU3641410 A SU 3641410A SU 1187720 A3 SU1187720 A3 SU 1187720A3
Authority
SU
USSR - Soviet Union
Prior art keywords
general formula
piperidine derivatives
acid
compound
carbon atoms
Prior art date
Application number
SU833641410A
Other languages
English (en)
Inventor
Ментруп Антон
Рент Эрнст-Отто
Шромм Курт
Хефке Вольфганг
Гаида Вольфрам
Original Assignee
Берингер Ингельгейм Кг (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Берингер Ингельгейм Кг (Фирма) filed Critical Берингер Ингельгейм Кг (Фирма)
Application granted granted Critical
Publication of SU1187720A3 publication Critical patent/SU1187720A3/ru

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Способ получени  производных пиперидина общей формулы СО-( N -л ,. N 1Нг R2 где R и Rj - одинаковые или различные и означают водород, алкил с числом атомов углерода 1-4, бензил или вместе - группа . -(сн,), или их кислотно-аддитивных со ей, отличающи   тем, что соединение общей формулы CHjO v-x fN NH2 S где X - хлор, бром или алкилтио с числом атомов углерода 1-4, подвергают взаимодействию с соединением общей формулы - C(bC-R, 2 где R, и Rj имеют указанные значени , с последующим вьщелением целевого продукта в свободном виде или в виде кислотно-аддитивной соли.

Description

Таблица 1
СНз223
СН,
Н
сн.
СН,
CjHj135
4
80
Н
-(CHj)-140
6C.HS
. H-CjH,
Н
CjHj-CHjН
92
90
88
89,5
91.5
90
92,5
89

Claims (1)

  1. Способ получения производных пиперидина общей формулы nh2 или алкилтио с числом атомов углерода 1-4, подвергают взаимодействию с соединением общей формулы н/у^С0“?
    4CO-C-Rt *2 где R, и R2 имеют указанные значения, с последующим вьщелением целевого продукта в свободном виде или в виде кислотно-аддитивной соли.
    где X - хлор, бром
SU833641410A 1982-09-25 1983-09-13 Способ получени производных пиперидина или их кислотноаддитивных солей SU1187720A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823235565 DE3235565A1 (de) 1982-09-25 1982-09-25 Piperidinderivate, ihre herstellung und verwendung

Publications (1)

Publication Number Publication Date
SU1187720A3 true SU1187720A3 (ru) 1985-10-23

Family

ID=6174159

Family Applications (1)

Application Number Title Priority Date Filing Date
SU833641410A SU1187720A3 (ru) 1982-09-25 1983-09-13 Способ получени производных пиперидина или их кислотноаддитивных солей

Country Status (23)

Country Link
US (1) US4539323A (ru)
EP (1) EP0104445A3 (ru)
JP (1) JPS5978187A (ru)
KR (1) KR840006222A (ru)
AU (1) AU561118B2 (ru)
CA (1) CA1215981A (ru)
CS (1) CS235342B2 (ru)
DD (1) DD212517A5 (ru)
DE (1) DE3235565A1 (ru)
DK (1) DK436583A (ru)
ES (4) ES8501762A1 (ru)
FI (1) FI833292A (ru)
GR (1) GR78973B (ru)
HU (1) HU191637B (ru)
IL (1) IL69777A (ru)
NO (1) NO833423L (ru)
NZ (1) NZ205716A (ru)
PH (1) PH20015A (ru)
PL (1) PL139590B1 (ru)
PT (1) PT77380B (ru)
SU (1) SU1187720A3 (ru)
YU (1) YU192183A (ru)
ZA (1) ZA837081B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4601897A (en) * 1985-11-06 1986-07-22 Pfizer Inc. Prazosin-pirbuterol combination for bronchodilation
JPS62212385A (ja) * 1986-03-13 1987-09-18 Kotobuki Seiyaku Kk キナゾリン誘導体並びに血圧降下剤及びその製法
DE60137635D1 (de) * 2000-06-28 2009-03-26 Merck & Co Inc Verwendung von allopurinol zur behandlung von bluthochdruck
ATE397669T1 (de) 2002-07-01 2008-06-15 Tibotec Pharm Ltd Mit phänotypischer medikamentenresistenz korrelierte mutationsprofile in hiv-1-reverse- transkriptase
FR2854633B1 (fr) * 2003-05-07 2005-06-24 Sanofi Synthelabo Derives de piperidinyl-et piperazinyl-alkylcarbamates, leur preparation et leur application en therapeutique
FR2866885B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives de piperidinylalkylcarbamates, leur prepation et leur application en therapeutique

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4309541A (en) * 1978-09-20 1982-01-05 Ciba-Geigy Corporation Piperidinyl-lactams
EP0009465A1 (de) * 1978-09-20 1980-04-02 Ciba-Geigy Ag N-(1-(4-Amino-2-chinazolinyl)-3- oder -4-piperidyl-lactame, Verfahren zu ihrer Herstellung, sowie pharmazeutische Präparate enthaltend diese Verbindungen
FR2483920A1 (fr) * 1980-06-09 1981-12-11 Synthelabo Nouveaux derives de quinazoline, leur procede de preparation et leur application en therapeutique

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Патент GB 1156973, кл. С 2 С, 1969. Бншер К., Пирсон Д. Органические синтезы. -М.: Мир, 1973, с. 504. *

Also Published As

Publication number Publication date
PT77380A (de) 1983-10-01
IL69777A (en) 1986-09-30
EP0104445A3 (de) 1985-07-10
DD212517A5 (de) 1984-08-15
FI833292A (fi) 1984-03-26
FI833292A0 (fi) 1983-09-15
ZA837081B (en) 1985-05-29
PL243878A1 (en) 1985-01-02
KR840006222A (ko) 1984-11-22
ES534351A0 (es) 1985-04-01
DK436583A (da) 1984-03-26
GR78973B (ru) 1984-10-02
ES525876A0 (es) 1984-12-01
US4539323A (en) 1985-09-03
ES534350A0 (es) 1985-04-01
ES8504180A1 (es) 1985-04-01
NO833423L (no) 1984-03-26
DE3235565A1 (de) 1984-03-29
PH20015A (en) 1986-08-28
PT77380B (de) 1986-03-20
HU191637B (en) 1987-03-30
EP0104445A2 (de) 1984-04-04
JPS5978187A (ja) 1984-05-04
DK436583D0 (da) 1983-09-23
NZ205716A (en) 1985-08-30
ES534349A0 (es) 1985-04-01
PL139590B1 (en) 1987-02-28
AU1939683A (en) 1984-03-29
AU561118B2 (en) 1987-04-30
ES8501762A1 (es) 1984-12-01
CA1215981A (en) 1986-12-30
ES8504182A1 (es) 1985-04-01
CS235342B2 (en) 1985-05-15
YU192183A (ru) 1986-12-31
ES8504181A1 (es) 1985-04-01

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