SK283552B6 - 2-Azetidinóny substituované cukrovými zvyškami, farmaceutický prípravok, kombinovaný farmaceutický prípravok a ich použitie - Google Patents

2-Azetidinóny substituované cukrovými zvyškami, farmaceutický prípravok, kombinovaný farmaceutický prípravok a ich použitie Download PDF

Info

Publication number: SK283552B6
Authority: SK; Slovakia
Prior art keywords: alkyl; phenyl; independently selected; group; substituted
Prior art date: 1995-10-31

Application number

SK483-98A

Other languages

English (en)

Slovak (sk)

Other versions

SK48398A3 (en

Inventor

Nathan P. Yumibe

Kevin B. Alton

Heek Margaret Van

Harry R. Davis

Wayne D. Vaccaro

Original Assignee

Schering Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-31

Filing date

1996-10-29

Publication date

2003-09-11

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26677904&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK283552(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-10-29 Application filed by Schering Corporation filed Critical Schering Corporation

1998-11-04 Publication of SK48398A3 publication Critical patent/SK48398A3/sk

2003-09-11 Publication of SK283552B6 publication Critical patent/SK283552B6/sk

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)

SK483-98A 1995-10-31 1996-10-29 2-Azetidinóny substituované cukrovými zvyškami, farmaceutický prípravok, kombinovaný farmaceutický prípravok a ich použitie SK283552B6 (sk)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US818595P	1995-10-31	1995-10-31
US57084795A	1995-12-12	1995-12-12
PCT/US1996/016823 WO1997016455A1 (en)	1995-10-31	1996-10-29	Sugar-substituted 2-azetidinones useful as hypocholesterolemic a gents

Publications (2)

Publication Number	Publication Date
SK48398A3 SK48398A3 (en)	1998-11-04
SK283552B6 true SK283552B6 (sk)	2003-09-11

Family

ID=26677904

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK483-98A SK283552B6 (sk)	1995-10-31	1996-10-29	2-Azetidinóny substituované cukrovými zvyškami, farmaceutický prípravok, kombinovaný farmaceutický prípravok a ich použitie

Country Status (28)

Country	Link
EP (1)	EP0877750B1 (ko)
JP (2)	JP3385031B2 (ko)
KR (1)	KR100311554B1 (ko)
CN (1)	CN1103780C (ko)
AR (1)	AR004701A1 (ko)
AT (1)	ATE219495T1 (ko)
AU (1)	AU712158B2 (ko)
BR (2)	BR9612998B1 (ko)
CA (1)	CA2235943C (ko)
CY (1)	CY2353B1 (ko)
CZ (1)	CZ293957B6 (ko)
DE (1)	DE69621952T2 (ko)
DK (1)	DK0877750T3 (ko)
ES (1)	ES2175141T3 (ko)
GE (1)	GEP20033006B (ko)
HK (1)	HK1012507A1 (ko)
HU (1)	HU226822B1 (ko)
ID (1)	ID16177A (ko)
IL (1)	IL124268A (ko)
MX (1)	MX9803447A (ko)
MY (1)	MY114803A (ko)
NO (1)	NO311692B1 (ko)
NZ (1)	NZ321766A (ko)
PL (1)	PL184698B1 (ko)
PT (1)	PT877750E (ko)
SK (1)	SK283552B6 (ko)
TW (1)	TW448181B (ko)
WO (1)	WO1997016455A1 (ko)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5633246A (en) *	1994-11-18	1997-05-27	Schering Corporation	Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
DE10042447A1 (de) *	2000-08-29	2002-03-28	Aventis Pharma Gmbh	Protein aus dem Darm von Wirbeltieren, welches Cholesterin absorbiert, sowie Verwendung dieses Proteins zur Identifizierung von Inhibitoren des intestinalen Cholesterintransports
DK1593670T3 (da) *	2000-12-20	2007-11-05	Schering Corp	Hydroxysubstituerede 2-azetidinoner, der er anvendelige som hypokolesterolæmiske midler
EP1510521A1 (en) *	2000-12-20	2005-03-02	Schering Corporation	Sugar-substituted 2-Azetidinones useful as hypocholesterolemic agents
WO2002050027A1 (de) *	2000-12-21	2002-06-27	Aventis Pharma Deutschland Gmbh	Neue diphenzylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung zur behandlung von lipidstoffwechselstörungen
AU2002243557B2 (en) *	2001-01-26	2006-01-05	Merck Sharp & Dohme Corp.	The use of substituted azetidinone compounds for the treatment of sitosterolemia
BR0206639A (pt) *	2001-01-26	2004-02-25	Schering Corp	Combinações de inibidor(es) da absorção do esterol com modificador(es) do sangue para o tratamento de condições vasculares
AU2005246926B2 (en) *	2001-01-26	2008-02-28	Merck Sharp & Dohme Corp.	The use of substituted azetidinone compounds for the treatment of sitosterolemia
TWI291957B (en)	2001-02-23	2008-01-01	Kotobuki Pharmaceutical Co Ltd	Beta-lactam compounds, process for repoducing the same and serum cholesterol-lowering agents containing the same
US6627757B2 (en)	2001-03-28	2003-09-30	Schering Corporation	Enantioselective synthesis of azetidinone intermediate compounds
DK1429756T3 (da) *	2001-09-21	2007-03-19	Schering Corp	Behandling af xanthoma med azetidinonderivater som sterolabsorptionsinhibitorer
DE10227506A1 (de) *	2002-06-19	2004-01-08	Aventis Pharma Deutschland Gmbh	Ringsubstituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
US7671047B2 (en)	2002-06-19	2010-03-02	Sanofi-Aventis Deutschland Gmbh	Cationically substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
US7176194B2 (en)	2002-06-19	2007-02-13	Sanofi-Aventis Deutschland Gmbh	Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
US7176193B2 (en)	2002-06-19	2007-02-13	Sanofi-Aventis Deutschland Gmbh	Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
GB0215579D0 (en)	2002-07-05	2002-08-14	Astrazeneca Ab	Chemical compounds
AR040588A1 (es)	2002-07-26	2005-04-13	Schering Corp	Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
AR041089A1 (es)	2003-05-15	2005-05-04	Merck & Co Inc	Procedimiento y composiciones farmaceutiicas para tratar aterosclerosis, dislipidemias y afecciones relacionadas
JP2005015434A (ja)	2003-06-27	2005-01-20	Kotobuki Seiyaku Kk	血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤
EP1522541A1 (en)	2003-10-07	2005-04-13	Lipideon Biotechnology AG	Novel hypocholesterolemic compounds
EP1682117A1 (en) *	2003-10-30	2006-07-26	Merck & Co., Inc.	2-azetidinones as anti-hypercholesterolemic agents
SA04250427A (ar)	2003-12-23	2005-12-03	استرازينيكا ايه بي	مشتقات ثاني فينيل أزيتيدون
US20060211752A1 (en)	2004-03-16	2006-09-21	Kohn Leonard D	Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
EP1877067A1 (en) *	2005-04-26	2008-01-16	Microbia, Inc.	4-biarylyl-1-phenylazetidin-2-one glucuronide derivatives for hypercholesterolemia
SA06270191B1 (ar)	2005-06-22	2010-03-29	استرازينيكا ايه بي	مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
KR20080059233A (ko)	2005-10-21	2008-06-26	노파르티스 아게	레닌 억제제, 및 항이상지질혈증제 및/또는 항비만제의조합물
TW200811098A (en)	2006-04-27	2008-03-01	Astrazeneca Ab	Chemical compounds
US20080319221A1 (en)	2007-06-22	2008-12-25	Bernd Junker	Esters of Pentahydroxyhexylcarbamoyl Alkanoic Acids
DE102007063671A1 (de)	2007-11-13	2009-06-25	Sanofi-Aventis Deutschland Gmbh	Neue kristalline Diphenylazetidinonhydrate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
CA2754384A1 (en)	2009-03-06	2010-09-10	Lipideon Biotechnology Ag	Pharmaceutical hypocholesterolemic compositions
CN101993403B (zh)	2009-08-11	2012-07-11	浙江海正药业股份有限公司	氮杂环丁酮类化合物及医药应用
CN103102297A (zh) *	2012-09-28	2013-05-15	北京赛林泰医药技术有限公司	一种新的依折麦布的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LT3595B (en) *	1993-01-21	1995-12-27	Schering Corp	Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents
CA2120221A1 (en) *	1993-04-23	1994-10-24	Allan W. Rey	N-substituted 2-azetidinones
US5631365A (en) *	1993-09-21	1997-05-20	Schering Corporation	Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents

1996
- 1996-10-29 HU HU9802539A patent/HU226822B1/hu unknown
- 1996-10-29 BR BRPI9612998-0A patent/BR9612998B1/pt not_active IP Right Cessation
- 1996-10-29 BR BRPI9611401-0A patent/BR9611401B1/pt not_active IP Right Cessation
- 1996-10-29 ES ES96937702T patent/ES2175141T3/es not_active Expired - Lifetime
- 1996-10-29 PT PT96937702T patent/PT877750E/pt unknown
- 1996-10-29 AT AT96937702T patent/ATE219495T1/de active
- 1996-10-29 DE DE69621952T patent/DE69621952T2/de not_active Expired - Lifetime
- 1996-10-29 WO PCT/US1996/016823 patent/WO1997016455A1/en active IP Right Grant
- 1996-10-29 CZ CZ19981294A patent/CZ293957B6/cs not_active IP Right Cessation
- 1996-10-29 AR ARP960104954A patent/AR004701A1/es not_active Application Discontinuation
- 1996-10-29 AU AU75179/96A patent/AU712158B2/en not_active Ceased
- 1996-10-29 GE GEAP19966589A patent/GEP20033006B/en unknown
- 1996-10-29 EP EP96937702A patent/EP0877750B1/en not_active Expired - Lifetime
- 1996-10-29 NZ NZ321766A patent/NZ321766A/xx not_active IP Right Cessation
- 1996-10-29 CN CN96199226A patent/CN1103780C/zh not_active Expired - Lifetime
- 1996-10-29 TW TW085113142A patent/TW448181B/zh not_active IP Right Cessation
- 1996-10-29 MY MYPI96004488A patent/MY114803A/en unknown
- 1996-10-29 DK DK96937702T patent/DK0877750T3/da active
- 1996-10-29 IL IL12426896A patent/IL124268A/xx not_active IP Right Cessation
- 1996-10-29 JP JP51738697A patent/JP3385031B2/ja not_active Expired - Fee Related
- 1996-10-29 PL PL96327987A patent/PL184698B1/pl not_active IP Right Cessation
- 1996-10-29 SK SK483-98A patent/SK283552B6/sk not_active IP Right Cessation
- 1996-10-29 CA CA002235943A patent/CA2235943C/en not_active Expired - Lifetime
- 1996-10-29 KR KR1019980703155A patent/KR100311554B1/ko not_active IP Right Cessation
- 1996-10-30 ID IDP963136A patent/ID16177A/id unknown
1998
- 1998-04-29 NO NO19981950A patent/NO311692B1/no not_active IP Right Cessation
- 1998-04-30 MX MX9803447A patent/MX9803447A/es unknown
- 1998-12-18 HK HK98114029A patent/HK1012507A1/xx unknown
2000
- 2000-07-17 JP JP2000216704A patent/JP2001048895A/ja not_active Withdrawn
2003
- 2003-01-29 CY CY0300007A patent/CY2353B1/xx unknown

Also Published As

Publication number	Publication date
TW448181B (en)	2001-08-01
PL327987A1 (en)	1999-01-04
KR100311554B1 (ko)	2002-06-20
ES2175141T3 (es)	2002-11-16
NZ321766A (en)	1999-07-29
NO311692B1 (no)	2002-01-07
CA2235943C (en)	2002-10-01
ID16177A (id)	1997-09-11
PT877750E (pt)	2002-09-30
ATE219495T1 (de)	2002-07-15
HUP9802539A3 (en)	1999-12-28
MY114803A (en)	2003-01-31
JPH10512592A (ja)	1998-12-02
IL124268A (en)	2005-08-31
PL184698B1 (pl)	2002-12-31
WO1997016455A1 (en)	1997-05-09
BR9612998B1 (pt)	2010-03-23
GEP20033006B (en)	2003-07-10
CN1205707A (zh)	1999-01-20
MX9803447A (es)	1998-09-30
BR9611401A (pt)	1999-01-05
DE69621952T2 (de)	2003-01-16
AR004701A1 (es)	1999-03-10
DE69621952D1 (de)	2002-07-25
CN1103780C (zh)	2003-03-26
NO981950L (no)	1998-06-26
HK1012507A1 (en)	1999-08-06
CZ293957B6 (cs)	2004-08-18
CZ129498A3 (cs)	1998-10-14
JP3385031B2 (ja)	2003-03-10
EP0877750A1 (en)	1998-11-18
JP2001048895A (ja)	2001-02-20
KR19990067202A (ko)	1999-08-16
CY2353B1 (en)	2004-06-04
SK48398A3 (en)	1998-11-04
CA2235943A1 (en)	1997-05-09
HU226822B1 (en)	2009-11-30
NO981950D0 (no)	1998-04-29
HUP9802539A2 (hu)	1998-11-30
AU7517996A (en)	1997-05-22
AU712158B2 (en)	1999-10-28
EP0877750B1 (en)	2002-06-19
BR9611401B1 (pt)	2010-08-10
DK0877750T3 (da)	2002-07-15

Publication	Publication Date	Title
SK283552B6 (sk)	2003-09-11	2-Azetidinóny substituované cukrovými zvyškami, farmaceutický prípravok, kombinovaný farmaceutický prípravok a ich použitie
US5756470A (en)	1998-05-26	Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
JP4351842B2 (ja)	2009-10-28	低コレステロール血症剤として有用な糖置換２−アゼチジノン
EP0681569B1 (en)	2001-03-21	Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents
US6982251B2 (en)	2006-01-03	Substituted 2-azetidinones useful as hypocholesterolemic agents
SK286744B6 (sk)	2009-04-06	Deriváty 1,4-benzotiazepín-1,1-dioxidu substituované cukornými zvyškami, spôsob ich prípravy, liečivá, ktoré ich obsahujú, a ich použitie
EP1593670B1 (en)	2007-08-08	Hydroxy-substituted 2-azetidinones useful as hypocholesterolemic agents
EP1510521A1 (en)	2005-03-02	Sugar-substituted 2-Azetidinones useful as hypocholesterolemic agents

Legal Events

Date	Code	Title	Description
2013-01-02	TC4A	Change of owner's name	Owner name: MERCK SHARP & DOHME CORP., RAHWAY, NJ, US Effective date: 20121108
2015-07-01	MM4A	Patent lapsed due to non-payment of maintenance fees	Effective date: 20141029

Date

Code

Title

Description

2013-01-02

TC4A

Change of owner's name

Owner name: MERCK SHARP & DOHME CORP., RAHWAY, NJ, US

Effective date: 20121108

2015-07-01

MM4A

Patent lapsed due to non-payment of maintenance fees

Effective date: 20141029