SK279339B6 - Racemické alebo opticky aktívne bis-aza-bicyklické - Google Patents

Racemické alebo opticky aktívne bis-aza-bicyklické Download PDF

Info

Publication number: SK279339B6
Authority: SK; Slovakia
Prior art keywords: formula; group; compound; preparation; optically active
Prior art date: 1989-01-23

Application number

SK299-90A

Other languages

English (en)

Slovak (sk)

Inventor

Kishor A. Desai

Gene M. Bright

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-01-23

Filing date

1990-01-22

Publication date

1998-10-07

1990-01-22 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

1998-10-07 Publication of SK279339B6 publication Critical patent/SK279339B6/sk

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

SK299-90A 1989-01-23 1990-01-22 Racemické alebo opticky aktívne bis-aza-bicyklické SK279339B6 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/US1989/000275 WO1990008148A1 (en)	1989-01-23	1989-01-23	Bis-aza-bicyclic anxiolytic agents
PCT/US1989/003811 WO1990008144A1 (en)	1989-01-23	1989-09-01	Bis-aza-bicyclic anxiolytic agents

Publications (1)

Publication Number	Publication Date
SK279339B6 true SK279339B6 (sk)	1998-10-07

Family

ID=22214801

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK299-90A SK279339B6 (sk)	1989-01-23	1990-01-22	Racemické alebo opticky aktívne bis-aza-bicyklické

Country Status (38)

Country	Link
US (1)	US5122525A (ko)
EP (1)	EP0380217B1 (ko)
JP (1)	JPH0643427B2 (ko)
KR (1)	KR910009289B1 (ko)
CN (1)	CN1022186C (ko)
AP (1)	AP128A (ko)
AR (1)	AR246969A1 (ko)
AT (1)	ATE82574T1 (ko)
AU (1)	AU614214B2 (ko)
BA (1)	BA98302A (ko)
BG (1)	BG51046A3 (ko)
CA (1)	CA2008108C (ko)
CZ (1)	CZ277698B6 (ko)
DD (1)	DD291560A5 (ko)
DE (1)	DE69000467T2 (ko)
DK (1)	DK0380217T3 (ko)
EG (1)	EG19306A (ko)
ES (1)	ES2053094T3 (ko)
FI (1)	FI95381C (ko)
GR (1)	GR3006925T3 (ko)
HU (1)	HU215154B (ko)
IE (1)	IE62670B1 (ko)
IL (1)	IL93073A (ko)
IS (1)	IS1667B (ko)
MA (1)	MA21735A1 (ko)
MX (1)	MX19222A (ko)
MY (1)	MY104861A (ko)
NO (1)	NO175978C (ko)
NZ (1)	NZ232168A (ko)
OA (1)	OA10041A (ko)
PL (1)	PL163836B1 (ko)
PT (1)	PT92919B (ko)
RO (1)	RO110142B1 (ko)
RU (1)	RU2015977C1 (ko)
SK (1)	SK279339B6 (ko)
WO (2)	WO1990008148A1 (ko)
YU (1)	YU47554B (ko)
ZA (1)	ZA90430B (ko)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX19222A (es) *	1989-01-23	1993-12-01	Pfizer	Agentes ansioliticos bis-aza-biciclicos
WO1992000075A1 (en) *	1990-06-29	1992-01-09	Pfizer Inc.	Pyridopyrazine derivatives for treating substance abuse and addiction
ES2072141T3 (es) *	1991-01-31	1995-07-01	Pfizer	Resolucion de trans-2-(2-pirimidinil)-7-(hidroximetil)octahidro-2h-pirido(1,2a)pirazina.
US5157034A (en) *	1991-02-27	1992-10-20	Pfizer Inc.	Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines
US5185449A (en) *	1991-02-27	1993-02-09	Pfizer Inc.	Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
DK0573464T3 (da) *	1991-02-27	1997-09-01	Pfizer	Fremgangsmåde til fremstilling af trans-piperidin-2,5-dicarboxylater
US5311195A (en) *	1991-08-30	1994-05-10	Etak, Inc.	Combined relative and absolute positioning method and apparatus
WO1993006101A1 (en) *	1991-09-25	1993-04-01	Pfizer Inc.	NEUROLEPTIC 2-SUBSTITUTED PERHYDRO-1-H-PYRIDO[1,2a]PYRAZINES
US5719286A (en) *	1992-06-16	1998-02-17	Pfizer Inc.	Process and intermediates for bis-aza-bicyclic anxiolytic agents
AU5291793A (en) *	1992-09-24	1994-04-12	National Institutes Of Health	Aralkyl diazabicycloalkane derivatives for cns disorders
IL104506A (en) *	1993-01-25	1997-11-20	Israel State	Fast changing heating- cooling device and method, particularly for cryogenic and/or surgical use
US5637713A (en) *	1993-08-20	1997-06-10	Pfizer Inc.	Process for preparing trans-piperidine-2,5-dicarboxylates
US5455350A (en) *	1993-10-13	1995-10-03	Pfizer Inc.	Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
IL107460A (en) *	1993-11-01	1999-06-20	Israel State	Controlled cryogenic contact system
KR100244848B1 (ko) *	1994-09-30	2000-03-02	디. 제이. 우드, 스피겔 알렌 제이	2,7-치환된 옥타하이드로-1H-피리도[1,2-a] 피라진 유도체
US6231833B1 (en)	1999-08-05	2001-05-15	Pfizer Inc	2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
WO1996010570A1 (en) *	1994-09-30	1996-04-11	Pfizer Inc.	NEUROLEPTIC 2,7-DISUBSTITUTED PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES
EP0874849B1 (en) *	1995-12-21	2001-09-19	Pfizer Inc.	2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives
CN1221418A (zh) *	1996-07-01	1999-06-30	辉瑞大药厂	(7s,反)－2－(2－嘧啶基)－7－(羟甲基)八氢－2h－吡啶并[1,2－a)吡嗪的制备
PA8469101A1 (es) *	1998-04-09	2000-09-29	Pfizer Prod Inc	Ligandos azabiciclicos de receptores 5ht1
US6251893B1 (en) *	1998-06-15	2001-06-26	Nps Allelix Corp.	Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
HN1999000146A (es) *	1998-09-21	2000-11-11	Pfizer Prod Inc	Agentes farmaceuticos para el tratamiento de la enfermedad de parkinson, adhd y microadenomas.
US20020016334A1 (en) *	2000-07-31	2002-02-07	Coe Jotham Wadsworth	Pharmaceutical composition for the treatment of attention deficit hyperactivity disorder (ADHD)
US6670476B2 (en)	2000-11-29	2003-12-30	Pfizer Inc.	Resolution of trans-7-(hydroxy-methyl)octa-hydro-2H-pyrido[1,2-a]pyrazine
KR20070074667A (ko) *	2003-03-12	2007-07-12	화이자 프로덕츠 인크.	피리딜옥시메틸 및 벤즈이속사졸 아자비시클릭 유도체
WO2004092173A2 (en)	2003-04-09	2004-10-28	Biogen Idec Ma Inc.	A2a adenosine receptor antagonists
CA2547283C (en) *	2003-11-26	2010-11-09	Pfizer Products Inc.	Aminopyrazole derivatives as gsk-3 inhibitors
CA2566154A1 (en) *	2004-05-27	2005-12-08	Warner-Lambert Company Llc	Combination of atomoxetine and a 5t1a receptor agonist for treating adhd and other disorders
US7658206B2 (en)	2006-12-05	2010-02-09	Kohler Co.	Plumbing valve with stick control handle

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3388128A (en) *	1965-09-03	1968-06-11	Allan R. Day	Substituted 1, 4-diazabicyclo [4. 4. 9] decanes
US4182763A (en) *	1978-05-22	1980-01-08	Mead Johnson & Company	Buspirone anti-anxiety method
US4339579A (en) *	1980-12-29	1982-07-13	American Home Products Corporation	2,6-Bis-(pyrrolopyrazinyl)pyrazines
US4400511A (en) *	1982-05-07	1983-08-23	American Home Products Corporation	2-Substituted octahydropyrrolo(1,2-A)-pyrazine-3-carboxylic acids
US4414389A (en) *	1982-05-25	1983-11-08	American Home Products Corporation	4-Substituted-piperidino carboxamides
US4517187A (en) *	1982-10-18	1985-05-14	Pennwalt Corporation	1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants
DE3321969A1 (de) *	1983-06-18	1984-12-20	Troponwerke GmbH & Co KG, 5000 Köln	2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3409440A1 (de) *	1984-03-15	1985-09-26	Bayer Ag, 5090 Leverkusen	Imidazo(1,5-a)pyridyl-methan- und imidazo(1,5-b)pyridazinylmethan-derivate, ihre herstellung und sie enthaltende aufzeichnungsmaterialien
IT1204803B (it) *	1986-02-17	1989-03-10	Acraf	Composto farmacologicamente attivo e composizioni farmaceutiche che lo contengono,procedimento per prepararlo e intermedio utile in detto procedimento
US4788290A (en) *	1987-12-11	1988-11-29	American Home Products Corporation	Serotonergic pyrazine derivatives
JP2668259B2 (ja) *	1988-02-18	1997-10-27	塩野義製薬株式会社	複素環化合物および抗潰瘍剤
MX19222A (es) *	1989-01-23	1993-12-01	Pfizer	Agentes ansioliticos bis-aza-biciclicos

1989
- 1989-01-23 MX MX1922290A patent/MX19222A/es unknown
- 1989-01-23 WO PCT/US1989/000275 patent/WO1990008148A1/en unknown
- 1989-09-01 WO PCT/US1989/003811 patent/WO1990008144A1/en active IP Right Grant
- 1989-09-01 RO RO148053A patent/RO110142B1/ro unknown
- 1989-09-01 HU HU40/90A patent/HU215154B/hu not_active IP Right Cessation
- 1989-12-13 IS IS3529A patent/IS1667B/is unknown
1990
- 1990-01-12 DE DE9090300362T patent/DE69000467T2/de not_active Expired - Fee Related
- 1990-01-12 AT AT90300362T patent/ATE82574T1/de not_active IP Right Cessation
- 1990-01-12 DK DK90300362.2T patent/DK0380217T3/da active
- 1990-01-12 EP EP90300362A patent/EP0380217B1/en not_active Expired - Lifetime
- 1990-01-12 ES ES90300362T patent/ES2053094T3/es not_active Expired - Lifetime
- 1990-01-16 IL IL9307390A patent/IL93073A/en not_active IP Right Cessation
- 1990-01-18 BG BG090949A patent/BG51046A3/xx unknown
- 1990-01-19 NZ NZ232168A patent/NZ232168A/xx unknown
- 1990-01-19 AR AR90315971A patent/AR246969A1/es active
- 1990-01-19 MY MYPI90000101A patent/MY104861A/en unknown
- 1990-01-19 CA CA002008108A patent/CA2008108C/en not_active Expired - Fee Related
- 1990-01-21 EG EG3290A patent/EG19306A/xx active
- 1990-01-22 AP APAP/P/1990/000158A patent/AP128A/en active
- 1990-01-22 IE IE22590A patent/IE62670B1/en not_active IP Right Cessation
- 1990-01-22 SK SK299-90A patent/SK279339B6/sk unknown
- 1990-01-22 KR KR1019900000701A patent/KR910009289B1/ko not_active IP Right Cessation
- 1990-01-22 ZA ZA90430A patent/ZA90430B/xx unknown
- 1990-01-22 DD DD90337249A patent/DD291560A5/de not_active IP Right Cessation
- 1990-01-22 CN CN90100291A patent/CN1022186C/zh not_active Expired - Fee Related
- 1990-01-22 MA MA21996A patent/MA21735A1/fr unknown
- 1990-01-22 CZ CS90299A patent/CZ277698B6/cs not_active IP Right Cessation
- 1990-01-22 AU AU48679/90A patent/AU614214B2/en not_active Ceased
- 1990-01-22 PT PT92919A patent/PT92919B/pt not_active IP Right Cessation
- 1990-01-22 YU YU11190A patent/YU47554B/sh unknown
- 1990-01-22 PL PL90283395A patent/PL163836B1/pl not_active IP Right Cessation
- 1990-01-23 OA OA59727A patent/OA10041A/en unknown
- 1990-01-23 JP JP2013459A patent/JPH0643427B2/ja not_active Expired - Fee Related
1991
- 1991-07-09 US US07/721,537 patent/US5122525A/en not_active Expired - Lifetime
- 1991-07-22 NO NO912863A patent/NO175978C/no unknown
- 1991-07-22 RU SU915001279A patent/RU2015977C1/ru not_active IP Right Cessation
- 1991-07-22 FI FI913510A patent/FI95381C/fi not_active IP Right Cessation
1993
- 1993-01-28 GR GR930400172T patent/GR3006925T3/el unknown
1998
- 1998-03-30 BA BA980302A patent/BA98302A/bs unknown

Also Published As

Publication number	Publication date
FI913510A0 (fi)	1991-07-22
FI95381C (fi)	1996-01-25
IS3529A7 (is)	1990-07-24
DE69000467T2 (de)	1993-04-01
PT92919A (pt)	1990-07-31
DK0380217T3 (da)	1992-12-14
NO175978C (no)	1995-01-11
CS29990A3 (en)	1992-11-18
IS1667B (is)	1997-11-14
HU215154B (hu)	2000-09-28
YU47554B (sh)	1995-10-03
KR900011774A (ko)	1990-08-02
BA98302A (bs)	2001-09-14
ES2053094T3 (es)	1994-07-16
US5122525A (en)	1992-06-16
IE62670B1 (en)	1995-03-08
EG19306A (en)	1995-01-31
YU11190A (sh)	1993-05-28
IE900225L (en)	1990-07-23
FI95381B (fi)	1995-10-13
OA10041A (en)	1996-10-14
NO912863L (no)	1991-07-22
WO1990008148A1 (en)	1990-07-26
NO175978B (no)	1994-10-03
CN1044464A (zh)	1990-08-08
HUT63163A (en)	1993-07-28
AR246969A1 (es)	1994-10-31
PL163836B1 (pl)	1994-05-31
CA2008108A1 (en)	1990-07-23
ZA90430B (en)	1991-08-28
RO110142B1 (ro)	1995-10-30
NO912863D0 (no)	1991-07-22
AU4867990A (en)	1990-07-26
DD291560A5 (de)	1991-07-04
EP0380217B1 (en)	1992-11-19
RU2015977C1 (ru)	1994-07-15
PT92919B (pt)	1995-12-29
GR3006925T3 (ko)	1993-06-30
AP128A (en)	1991-03-20
WO1990008144A1 (en)	1990-07-26
EP0380217A1 (en)	1990-08-01
DE69000467D1 (de)	1992-12-24
MA21735A1 (fr)	1990-10-01
MX19222A (es)	1993-12-01
ATE82574T1 (de)	1992-12-15
CN1022186C (zh)	1993-09-22
JPH0643427B2 (ja)	1994-06-08
CZ277698B6 (en)	1993-03-17
AU614214B2 (en)	1991-08-22
KR910009289B1 (ko)	1991-11-09
IL93073A (en)	1994-05-30
JPH02233681A (ja)	1990-09-17
MY104861A (en)	1994-06-30
BG51046A3 (en)	1993-01-15
AP9000158A0 (en)	1990-01-31
CA2008108C (en)	1995-08-08
NZ232168A (en)	1991-08-27

Publication	Publication Date	Title
SK279339B6 (sk)	1998-10-07	Racemické alebo opticky aktívne bis-aza-bicyklické
EP0017484B1 (en)	1983-04-06	2-imidazoline derivatives, process for the preparation thereof and the pharmaceutical composition of the same
EP0132375B1 (en)	1989-06-21	Dihydropyridine anti-ischaemic and antihypertensive agents
DE69329654T2 (de)	2001-03-15	3-oxo-pyrido [1,2-a] benzimidazol-4-carboxyl und 4-oxo-azepino [1,2-a] benzimidazol-5-carboxyl derivate geeignet für die behandlung von zentralnervensystemerkrankungen
EP0222474B1 (en)	1990-10-03	Gamma-carbolines
KR890000706B1 (ko)	1989-03-27	1,6-나프티리딘 유도체의 제조방법
AU651977B2 (en)	1994-08-11	Pyridopyrazine derivatives for treating substance abuse and addiction
EP0174136B1 (en)	1989-03-22	Derivatives of dihydro-1h-pyrrolo(1,2-c)imidazol-3,5-dione as cognition activators
EP0254527B1 (en)	1993-01-27	Tetracyclic indole derivatives
AU761391B2 (en)	2003-06-05	Process for preparing 8-cyclopentyl-6-ethyl-3-(substituted) -5,8- dihydro-4H-1,2,3A,7,8-pentazza-as indacenes and intermediates useful therein
WO2023213525A1 (en)	2023-11-09	2-(5-FLUORO-1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-b]PYRIDIN-3-YL)-5-NITROSOPYRIMIDIN-4,6-DIAMINE OR A SALT THEREOF, METHOD FOR THE PREPARATION THEREOF, AND USE THEREOF IN THE SYNTHESIS OF VERICIGUAT
EP1380585B1 (en)	2004-11-10	Pyrazolopyridinone as intermediate
LU83251A1 (fr)	1981-10-29	Derives d'imidazo(4,5-b)pyridine,leur preparation et leur utilisation comme agents cardiotoniques
HU211986A9 (hu)	1996-01-29	Szorongásoldó hatású bisz-azabiciklo-vegyületek
NL8302297A (nl)	1984-01-16	E-homoeburnaanderivaten, werkwijze voor hun bereiding, alsmede farmaceutische samenstellingen welke deze verbindingen bevatten.