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SI3484863T1 - Ciklični amidi kot odpiralci kalijevih kanalčkov - Google Patents

Ciklični amidi kot odpiralci kalijevih kanalčkov

Info

Publication number
SI3484863T1
SI3484863T1 SI201830113T SI201830113T SI3484863T1 SI 3484863 T1 SI3484863 T1 SI 3484863T1 SI 201830113 T SI201830113 T SI 201830113T SI 201830113 T SI201830113 T SI 201830113T SI 3484863 T1 SI3484863 T1 SI 3484863T1
Authority
SI
Slovenia
Prior art keywords
potassium channel
channel openers
cyclic amides
amides
cyclic
Prior art date
Application number
SI201830113T
Other languages
English (en)
Inventor
Michael Bos
Original Assignee
Acousia Therapeutics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acousia Therapeutics Gmbh filed Critical Acousia Therapeutics Gmbh
Publication of SI3484863T1 publication Critical patent/SI3484863T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/26Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40Y being a hydrogen or a carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43Y being a hetero atom
    • C07C323/44X or Y being nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/63Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28Halogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Fertilizers (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SI201830113T 2017-02-28 2018-02-27 Ciklični amidi kot odpiralci kalijevih kanalčkov SI3484863T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17158326.3A EP3366683A1 (en) 2017-02-28 2017-02-28 Cyclic amides, acteamides and ureas useful as potassium channel openers
EP18707374.7A EP3484863B1 (en) 2017-02-28 2018-02-27 Cyclic amides as potassium channel openers
PCT/EP2018/054820 WO2018158256A2 (en) 2017-02-28 2018-02-27 Novel compounds useful as potassium channel openers

Publications (1)

Publication Number Publication Date
SI3484863T1 true SI3484863T1 (sl) 2020-10-30

Family

ID=58192162

Family Applications (2)

Application Number Title Priority Date Filing Date
SI201830113T SI3484863T1 (sl) 2017-02-28 2018-02-27 Ciklični amidi kot odpiralci kalijevih kanalčkov
SI201830189T SI3567034T1 (sl) 2017-02-28 2018-02-27 Pentaciklotienil in indanil urea derivati kot odpiralci kalijevih kanalčkov

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI201830189T SI3567034T1 (sl) 2017-02-28 2018-02-27 Pentaciklotienil in indanil urea derivati kot odpiralci kalijevih kanalčkov

Country Status (24)

Country Link
US (2) US11034665B2 (sl)
EP (3) EP3366683A1 (sl)
JP (3) JP6795713B2 (sl)
KR (2) KR102443685B1 (sl)
CN (2) CN114105942B (sl)
AU (2) AU2018227005B2 (sl)
BR (2) BR112019017184B1 (sl)
CA (2) CA3238405A1 (sl)
CL (2) CL2019002445A1 (sl)
CY (2) CY1123114T1 (sl)
DK (2) DK3484863T3 (sl)
ES (2) ES2813064T3 (sl)
HR (2) HRP20201159T1 (sl)
HU (2) HUE052703T2 (sl)
IL (1) IL268931B (sl)
LT (2) LT3484863T (sl)
MX (2) MX2019010169A (sl)
PH (1) PH12019550146A1 (sl)
PL (2) PL3484863T3 (sl)
PT (2) PT3484863T (sl)
RS (2) RS60648B1 (sl)
SI (2) SI3484863T1 (sl)
WO (1) WO2018158256A2 (sl)
ZA (1) ZA201905198B (sl)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3366683A1 (en) * 2017-02-28 2018-08-29 Acousia Therapeutics GmbH Cyclic amides, acteamides and ureas useful as potassium channel openers
US20230136562A1 (en) 2020-04-29 2023-05-04 Idorsia Pharmaceuticals Ltd Spirourea derivatives
KR20230029813A (ko) 2020-06-25 2023-03-03 이도르시아 파마슈티컬스 리미티드 시클로부틸-우레아 유도체
US20240009149A1 (en) * 2020-11-19 2024-01-11 Acousia Therapeutics Gmbh Non-aqueous gel composition
EP4279061A1 (en) * 2022-05-18 2023-11-22 Acousia Therapeutics GmbH Aqueous gel composition

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UA89503C2 (uk) 2004-09-13 2010-02-10 Х. Луннбек А/С Заміщені похідні аніліну
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EP3366683A1 (en) * 2017-02-28 2018-08-29 Acousia Therapeutics GmbH Cyclic amides, acteamides and ureas useful as potassium channel openers

Also Published As

Publication number Publication date
MX2019010169A (es) 2019-10-21
PH12019550146A1 (en) 2020-06-08
EP3484863A2 (en) 2019-05-22
JP7474289B2 (ja) 2024-04-24
CN110312710A (zh) 2019-10-08
RU2019127116A (ru) 2021-03-30
BR112019017184B1 (pt) 2021-06-01
JP2021008479A (ja) 2021-01-28
KR102382795B1 (ko) 2022-04-05
RS61254B1 (sr) 2021-01-29
KR102443685B1 (ko) 2022-09-15
US20200157072A1 (en) 2020-05-21
JP2020510694A (ja) 2020-04-09
DK3484863T3 (da) 2020-09-07
PL3484863T3 (pl) 2020-12-14
CN110312710B (zh) 2022-02-15
HUE051854T2 (hu) 2021-03-29
JP6795713B2 (ja) 2020-12-02
BR122020025103B1 (pt) 2021-06-01
WO2018158256A2 (en) 2018-09-07
CL2019002445A1 (es) 2020-03-13
RU2019127116A3 (sl) 2021-03-31
AU2018227005A1 (en) 2019-08-22
CA3052359A1 (en) 2018-09-07
MX2020010866A (es) 2022-02-28
BR112019017184A2 (pt) 2020-04-28
CL2021001243A1 (es) 2021-10-22
CN114105942A (zh) 2022-03-01
CY1123114T1 (el) 2021-10-29
ES2846772T3 (es) 2021-07-29
ZA201905198B (en) 2020-03-25
SI3567034T1 (sl) 2021-03-31
LT3567034T (lt) 2020-12-10
PT3484863T (pt) 2020-08-27
PT3567034T (pt) 2020-12-04
WO2018158256A3 (en) 2018-12-13
EP3567034B1 (en) 2020-10-28
EP3567034A1 (en) 2019-11-13
IL268931A (en) 2019-10-31
AU2021254653B2 (en) 2022-12-08
HRP20201159T1 (hr) 2020-11-13
AU2018227005B2 (en) 2021-11-11
PL3567034T3 (pl) 2021-05-17
KR20190105058A (ko) 2019-09-11
DK3567034T3 (da) 2021-01-11
CY1123488T1 (el) 2022-03-24
US20210261518A1 (en) 2021-08-26
KR20210134826A (ko) 2021-11-10
CA3238405A1 (en) 2018-09-07
JP2022166055A (ja) 2022-11-01
RS60648B1 (sr) 2020-09-30
ES2813064T3 (es) 2021-03-22
HRP20201961T1 (hr) 2021-02-05
AU2021254653A1 (en) 2021-11-18
EP3484863B1 (en) 2020-06-17
HUE052703T2 (hu) 2021-05-28
LT3484863T (lt) 2020-07-27
US11034665B2 (en) 2021-06-15
RU2020140167A (ru) 2020-12-16
CN114105942B (zh) 2024-07-12
IL268931B (en) 2021-10-31
RU2020140167A3 (sl) 2021-04-23
EP3366683A1 (en) 2018-08-29
US11884642B2 (en) 2024-01-30

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