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SI3307734T1 - Modulatorji jedrnega receptorja (ROR) za zdravljenje vnetnih in avtoimunih bolezni - Google Patents

Modulatorji jedrnega receptorja (ROR) za zdravljenje vnetnih in avtoimunih bolezni

Info

Publication number
SI3307734T1
SI3307734T1 SI201630618T SI201630618T SI3307734T1 SI 3307734 T1 SI3307734 T1 SI 3307734T1 SI 201630618 T SI201630618 T SI 201630618T SI 201630618 T SI201630618 T SI 201630618T SI 3307734 T1 SI3307734 T1 SI 3307734T1
Authority
SI
Slovenia
Prior art keywords
ror
inflammatory
treatment
autoimmune diseases
receptor modulators
Prior art date
Application number
SI201630618T
Other languages
English (en)
Inventor
Maria A. Argiriadi
Eric C. Breinlinger
Kevin P. Cusack
Adrian D. Hobson
Dominique Potin
Martine Barth
Jerome Amaudrut
Olivia Poupardin
Laurent Mounier
Michael E. Kort
Original Assignee
Abbvie Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2015/001693 external-priority patent/WO2016198908A1/en
Application filed by Abbvie Inc. filed Critical Abbvie Inc.
Publication of SI3307734T1 publication Critical patent/SI3307734T1/sl

Links

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
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    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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SI201630618T 2015-06-09 2016-06-08 Modulatorji jedrnega receptorja (ROR) za zdravljenje vnetnih in avtoimunih bolezni SI3307734T1 (sl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/IB2015/001693 WO2016198908A1 (en) 2015-06-09 2015-06-09 Ror nuclear receptor modulators
US201562257806P 2015-11-20 2015-11-20
US201662343905P 2016-06-01 2016-06-01
EP16731721.3A EP3307734B1 (en) 2015-06-09 2016-06-08 Nuclear receptor modulators (ror) for the treatment of inflammatory and autoimmune diseases
PCT/US2016/036283 WO2016200851A1 (en) 2015-06-09 2016-06-08 Nuclear receptor modulators

Publications (1)

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SI3307734T1 true SI3307734T1 (sl) 2020-03-31

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SI201630618T SI3307734T1 (sl) 2015-06-09 2016-06-08 Modulatorji jedrnega receptorja (ROR) za zdravljenje vnetnih in avtoimunih bolezni

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US (4) US10106501B2 (sl)
EP (2) EP3307734B1 (sl)
JP (4) JP6549735B2 (sl)
KR (1) KR20180014433A (sl)
CN (1) CN107820494B (sl)
AU (3) AU2016276316B2 (sl)
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CA (1) CA2988502A1 (sl)
CL (1) CL2017003147A1 (sl)
CO (1) CO2017012594A2 (sl)
CR (1) CR20170594A (sl)
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DK (1) DK3307734T3 (sl)
DO (1) DOP2017000289A (sl)
EC (1) ECSP18001225A (sl)
ES (1) ES2774517T3 (sl)
HK (1) HK1248678A1 (sl)
HR (1) HRP20200064T1 (sl)
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