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SI3347360T1 - Spojine uporabne pri inhibiciji ROR-GAMMA-T - Google Patents

Spojine uporabne pri inhibiciji ROR-GAMMA-T

Info

Publication number
SI3347360T1
SI3347360T1 SI201630481T SI201630481T SI3347360T1 SI 3347360 T1 SI3347360 T1 SI 3347360T1 SI 201630481 T SI201630481 T SI 201630481T SI 201630481 T SI201630481 T SI 201630481T SI 3347360 T1 SI3347360 T1 SI 3347360T1
Authority
SI
Slovenia
Prior art keywords
gamma
compounds useful
inhibiting ror
ror
inhibiting
Prior art date
Application number
SI201630481T
Other languages
English (en)
Inventor
John Richard Morphy
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of SI3347360T1 publication Critical patent/SI3347360T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI201630481T 2015-09-09 2016-09-06 Spojine uporabne pri inhibiciji ROR-GAMMA-T SI3347360T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562215929P 2015-09-09 2015-09-09
EP16766765.8A EP3347360B1 (en) 2015-09-09 2016-09-06 Compounds useful for inhibiting ror-gamma-t
PCT/US2016/050374 WO2017044410A1 (en) 2015-09-09 2016-09-06 Compounds useful for inhibiting ror-gamma-t

Publications (1)

Publication Number Publication Date
SI3347360T1 true SI3347360T1 (sl) 2019-12-31

Family

ID=56940418

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201630481T SI3347360T1 (sl) 2015-09-09 2016-09-06 Spojine uporabne pri inhibiciji ROR-GAMMA-T

Country Status (41)

Country Link
US (1) US9598431B1 (sl)
EP (1) EP3347360B1 (sl)
JP (1) JP6282789B1 (sl)
KR (1) KR102048780B1 (sl)
CN (1) CN108026112B (sl)
AR (1) AR105821A1 (sl)
AU (1) AU2016318593B2 (sl)
BR (1) BR112018001451B1 (sl)
CA (1) CA2994732C (sl)
CL (1) CL2018000558A1 (sl)
CO (1) CO2018002440A2 (sl)
CR (1) CR20180089A (sl)
CY (1) CY1122287T1 (sl)
DK (1) DK3347360T3 (sl)
DO (1) DOP2018000066A (sl)
EA (1) EA033882B1 (sl)
EC (1) ECSP18018793A (sl)
ES (1) ES2760992T3 (sl)
HK (1) HK1249901B (sl)
HR (1) HRP20192235T1 (sl)
HU (1) HUE047950T2 (sl)
IL (1) IL257202B (sl)
JO (1) JO3638B1 (sl)
LT (1) LT3347360T (sl)
MA (1) MA42776B1 (sl)
MD (1) MD3347360T2 (sl)
MX (1) MX2018002898A (sl)
MY (1) MY195903A (sl)
NZ (1) NZ739518A (sl)
PE (1) PE20181274A1 (sl)
PH (1) PH12018500504A1 (sl)
PL (1) PL3347360T3 (sl)
PT (1) PT3347360T (sl)
RS (1) RS59655B1 (sl)
SI (1) SI3347360T1 (sl)
SV (1) SV2018005647A (sl)
TN (1) TN2018000057A1 (sl)
TW (1) TWI597284B (sl)
UA (1) UA118824C2 (sl)
WO (1) WO2017044410A1 (sl)
ZA (1) ZA201800515B (sl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11008336B2 (en) 2017-03-02 2021-05-18 Eli Lilly And Company Compounds useful for inhibiting RORγt
JP6766274B2 (ja) 2017-03-02 2020-10-07 イーライ リリー アンド カンパニー Ror−ガンマ−tを阻害するのに有用な化合物
WO2018193297A1 (en) 2017-04-21 2018-10-25 Cadila Healthcare Limited Novel compounds as ror-gamma modulators
JP2020142989A (ja) * 2017-06-21 2020-09-10 Meiji Seikaファルマ株式会社 イミダゾール誘導体及びそれを含有する医薬
WO2022122740A1 (en) 2020-12-07 2022-06-16 Diaccurate Ror-gamma inhibitors for the treatment of ror-gamma-dependent cancer
WO2023232870A1 (en) 2022-05-31 2023-12-07 Immunic Ag Rorg/rorgt modulators for the treatment of virus infections like covid-19

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005016913A1 (en) * 2003-08-19 2005-02-24 Pfizer Japan, Inc. Tetrahydroisoquinoline or isochroman compounds as orl-1 receptor ligands for the treatment of pain and cns disorders
JP3790250B2 (ja) * 2004-01-16 2006-06-28 新日鐵化学株式会社 両面導体ポリイミド積層体の連続製造方法
ES2436241T3 (es) * 2009-11-16 2013-12-27 Eli Lilly And Company Compuestos de espiropiperidina como antagonistas de receptor oral-1
UA107943C2 (en) 2009-11-16 2015-03-10 Lilly Co Eli Compounds of spiropiperidines as antagonists of the orl-1 receptors
KR102505085B1 (ko) * 2009-12-04 2023-02-28 선오비온 파마슈티컬스 인코포레이티드 다환형 화합물 및 이의 사용 방법
TWI582096B (zh) * 2011-12-06 2017-05-11 美國禮來大藥廠 用於酒精依賴及濫用處理之4',5'-二氫螺[哌啶-4,7'-噻吩并[2,3-c]哌喃]化合物
MX367341B (es) * 2012-05-08 2019-08-14 Merck Sharp & Dohme Tetrahidronaftiridina y compuestos biciclicos relacionados para la inhibicion de la actividad de rorgamma y el tratamiento de enfermedades.
SG11201407919WA (en) * 2012-05-31 2014-12-30 Phenex Pharmaceuticals Ag Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ror[gamma]
WO2014026328A1 (en) * 2012-08-15 2014-02-20 Merck Sharp & Dohme Corp. 3-cyclohexenyl substituted indole and indazole compounds as rorgammat inhibitors and uses thereof
WO2014179564A1 (en) 2013-05-01 2014-11-06 Vitae Pharmaceuticals, Inc. Thiazalopyrrolidine inhibitors of ror-gamma
US9745297B2 (en) 2013-07-30 2017-08-29 Boehringer Ingelheim International Gmbh Compounds as modulators of RORC
WO2015101928A1 (en) * 2013-12-31 2015-07-09 Aurigene Discovery Technologies Limited Fused thiophene and thiazole derivatives as ror gamma modulators

Also Published As

Publication number Publication date
DOP2018000066A (es) 2018-03-30
AU2016318593A1 (en) 2018-02-15
PH12018500504A1 (en) 2018-09-24
DK3347360T3 (da) 2020-01-02
CN108026112A (zh) 2018-05-11
ZA201800515B (en) 2019-06-26
EA033882B1 (ru) 2019-12-05
HUE047950T2 (hu) 2020-05-28
RS59655B1 (sr) 2020-01-31
CR20180089A (es) 2018-02-27
UA118824C2 (uk) 2019-03-11
CO2018002440A2 (es) 2018-07-10
WO2017044410A1 (en) 2017-03-16
MX2018002898A (es) 2018-06-18
KR20180031777A (ko) 2018-03-28
US9598431B1 (en) 2017-03-21
PL3347360T3 (pl) 2020-04-30
JP6282789B1 (ja) 2018-02-21
IL257202B (en) 2020-02-27
AU2016318593B2 (en) 2018-10-04
SV2018005647A (es) 2018-07-23
ES2760992T3 (es) 2020-05-18
MA42776B1 (fr) 2020-02-28
MY195903A (en) 2023-02-27
HRP20192235T1 (hr) 2020-03-20
AR105821A1 (es) 2017-11-15
TN2018000057A1 (en) 2019-07-08
NZ739518A (en) 2019-06-28
KR102048780B1 (ko) 2019-11-27
CL2018000558A1 (es) 2018-08-10
TWI597284B (zh) 2017-09-01
HK1249901B (zh) 2020-06-19
CA2994732C (en) 2020-06-30
EA201890364A1 (ru) 2018-08-31
IL257202A (en) 2018-03-29
PE20181274A1 (es) 2018-08-03
JP2018507203A (ja) 2018-03-15
TW201722964A (zh) 2017-07-01
EP3347360A1 (en) 2018-07-18
CY1122287T1 (el) 2020-11-25
JO3638B1 (ar) 2020-08-27
BR112018001451B1 (pt) 2023-10-10
LT3347360T (lt) 2020-01-27
MD3347360T2 (ro) 2020-03-31
US20170066781A1 (en) 2017-03-09
BR112018001451A2 (pt) 2018-09-11
CN108026112B (zh) 2020-04-10
ECSP18018793A (es) 2018-04-30
EP3347360B1 (en) 2019-10-23
CA2994732A1 (en) 2017-03-16
PT3347360T (pt) 2020-01-07

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