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SI2686334T2 - Ionska izmenjevalna kromatografija z izboljšano selektivnostjo za ločevanje polipeptidnih monomerov, agregatov in fragmentov s spremembo mobilne faze - Google Patents

Ionska izmenjevalna kromatografija z izboljšano selektivnostjo za ločevanje polipeptidnih monomerov, agregatov in fragmentov s spremembo mobilne faze

Info

Publication number
SI2686334T2
SI2686334T2 SI201231179T SI201231179T SI2686334T2 SI 2686334 T2 SI2686334 T2 SI 2686334T2 SI 201231179 T SI201231179 T SI 201231179T SI 201231179 T SI201231179 T SI 201231179T SI 2686334 T2 SI2686334 T2 SI 2686334T2
Authority
SI
Slovenia
Prior art keywords
aggregates
fragments
modulation
separation
ion exchange
Prior art date
Application number
SI201231179T
Other languages
English (en)
Other versions
SI2686334T1 (sl
Inventor
Sebastian Neumann
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45819216&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2686334(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of SI2686334T1 publication Critical patent/SI2686334T1/sl
Publication of SI2686334T2 publication Critical patent/SI2686334T2/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SI201231179T 2011-03-16 2012-03-14 Ionska izmenjevalna kromatografija z izboljšano selektivnostjo za ločevanje polipeptidnih monomerov, agregatov in fragmentov s spremembo mobilne faze SI2686334T2 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11158523 2011-03-16
PCT/EP2012/054449 WO2012123488A1 (en) 2011-03-16 2012-03-14 Ion exchange chromatography with improved selectivity for the separation of polypeptide monomers, aggregates and fragments by modulation of the mobile phase
EP12708546.2A EP2686334B2 (en) 2011-03-16 2012-03-14 Ion exchange chromatography with improved selectivity for the separation of polypeptide monomers, aggregates and fragments by modulation of the mobile phase

Publications (2)

Publication Number Publication Date
SI2686334T1 SI2686334T1 (sl) 2018-03-30
SI2686334T2 true SI2686334T2 (sl) 2020-10-30

Family

ID=45819216

Family Applications (2)

Application Number Title Priority Date Filing Date
SI201231907T SI3318571T1 (sl) 2011-03-16 2012-03-14 Ionska izmenjevalna kromatografija z izboljšano selektivnostjo za ločevanje polipeptidnih monomerov, agregatov in fragmentov s spremembo mobilne faze
SI201231179T SI2686334T2 (sl) 2011-03-16 2012-03-14 Ionska izmenjevalna kromatografija z izboljšano selektivnostjo za ločevanje polipeptidnih monomerov, agregatov in fragmentov s spremembo mobilne faze

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI201231907T SI3318571T1 (sl) 2011-03-16 2012-03-14 Ionska izmenjevalna kromatografija z izboljšano selektivnostjo za ločevanje polipeptidnih monomerov, agregatov in fragmentov s spremembo mobilne faze

Country Status (9)

Country Link
US (3) US9394337B2 (sl)
EP (2) EP2686334B2 (sl)
JP (3) JP5984854B2 (sl)
ES (2) ES2865449T3 (sl)
HR (2) HRP20180028T4 (sl)
PL (2) PL2686334T5 (sl)
SG (1) SG193378A1 (sl)
SI (2) SI3318571T1 (sl)
WO (1) WO2012123488A1 (sl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2865449T3 (es) 2011-03-16 2021-10-15 Hoffmann La Roche Cromatografía de intercambio iónico con selectividad mejorada para la separación de monómeros, agregados y fragmentos polipeptídicos por modulación de la fase móvil
WO2014018420A1 (en) * 2012-07-21 2014-01-30 K-Technologies, Inc. Processes for the removal and recovery of minor elements in wet-process phosphoric acid
CN105073769B (zh) 2013-03-14 2019-09-10 Emd密理博公司 利用基于a蛋白的色谱增加蛋白纯度的方法
GB2516808A (en) * 2013-05-31 2015-02-11 Innova Biosciences Ltd Antibody composition and buffer system therefor
RU2652911C2 (ru) * 2013-08-19 2018-05-03 Ф. Хоффманн-Ля Рош Аг Разделение биспецифических антител и побочных продуктов процесса получения биспецифических антител с применением гидроксиапатитной хроматографии
JP2024503996A (ja) * 2020-12-20 2024-01-30 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 生体分子中のスクランブルジスルフィドを同定するための方法
CN113388026B (zh) * 2021-08-03 2022-09-27 江西理工大学 一种螺旋藻藻蓝蛋白和藻油的同步提取方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
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US5204244A (en) 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
US5202238A (en) 1987-10-27 1993-04-13 Oncogen Production of chimeric antibodies by homologous recombination
US5429746A (en) 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
ES2228052T3 (es) 1998-06-01 2005-04-01 Genentech, Inc. Separacion demonomeros de anticuerpos de sus multimeros utilizando cromatografia de intercambio de iones.
SK288128B6 (sk) 1998-06-09 2013-10-02 Csl Behring Ag Process for purifying immunoglobulin G (IgG), liquid immunoglobulin product and use thereof for the preparation of a medicament
DK2270044T3 (en) * 1998-06-09 2015-01-26 Csl Behring Ag Liquid immunoglobulin G (IgG) product
DE19836213A1 (de) * 1998-08-11 2000-02-24 Gerhard Harry Scholz Verfahren zur Elution von Biomolekülen von Chromatographie-Materialien
AU2003257188A1 (en) 2002-08-06 2004-02-23 Akzo Nobel Patent Department Increased dynamic binding capacity in ion exchange chromatography by addition of polyethylene glycol
CN1208346C (zh) 2003-04-09 2005-06-29 中国科学院过程工程研究所 血红蛋白－人血清白蛋白偶联物制备血液代用品及其制备方法
SE0400886D0 (sv) 2004-04-02 2004-04-02 Amersham Biosciences Ab Process of purification
KR100554481B1 (ko) * 2004-06-30 2006-03-03 씨제이 주식회사 반코마이신 염산염의 정제방법
TWI320788B (en) 2005-05-25 2010-02-21 Hoffmann La Roche Method for the purification of antibodies
US8124743B2 (en) * 2006-06-01 2012-02-28 President And Fellows Of Harvard College Purification of a bivalently active antibody using a non-chromatographic method
US7691980B2 (en) 2007-01-09 2010-04-06 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
WO2009015063A2 (en) * 2007-07-23 2009-01-29 Centocor Methods and compositions for treating fibrosis related disorders using il-17 antagonists
WO2009085200A2 (en) * 2007-12-21 2009-07-09 Amgen Inc. Anti-amyloid antibodies and uses thereof
EP2287174B8 (en) 2008-01-18 2016-12-07 Bio-Rad Laboratories, Inc. Enhanced purification of antibody fragments by apatite chromatography
CA2726823A1 (en) † 2008-06-03 2009-12-10 Patrys Limited Process for purification of antibodies
MX2011003184A (es) 2008-09-29 2011-04-21 Roche Glycart Ag Anticuerpos contra il17 humana y usos de los mismos.
US8268314B2 (en) 2008-10-08 2012-09-18 Hoffmann-La Roche Inc. Bispecific anti-VEGF/anti-ANG-2 antibodies
RS57784B1 (sr) 2009-06-16 2018-12-31 Genzyme Corp Poboljšani postupci za prečišćavanje vektora rekombinantnog aav
US8394922B2 (en) * 2009-08-03 2013-03-12 Medarex, Inc. Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
TW201138821A (en) * 2010-03-26 2011-11-16 Roche Glycart Ag Bispecific antibodies
ES2865449T3 (es) 2011-03-16 2021-10-15 Hoffmann La Roche Cromatografía de intercambio iónico con selectividad mejorada para la separación de monómeros, agregados y fragmentos polipeptídicos por modulación de la fase móvil

Also Published As

Publication number Publication date
EP3318571B1 (en) 2021-02-17
PL2686334T5 (pl) 2020-10-19
US9394337B2 (en) 2016-07-19
ES2656167T3 (es) 2018-02-23
ES2656167T5 (es) 2021-03-26
EP3318571A1 (en) 2018-05-09
WO2012123488A1 (en) 2012-09-20
SI2686334T1 (sl) 2018-03-30
SI3318571T1 (sl) 2021-08-31
EP2686334A1 (en) 2014-01-22
US20200148719A1 (en) 2020-05-14
HRP20210588T1 (hr) 2021-05-28
PL2686334T3 (pl) 2018-03-30
HRP20180028T4 (hr) 2020-10-02
JP2018058900A (ja) 2018-04-12
JP5984854B2 (ja) 2016-09-06
JP6273326B2 (ja) 2018-01-31
US10377793B2 (en) 2019-08-13
US20140081000A1 (en) 2014-03-20
JP2014511829A (ja) 2014-05-19
JP2017019805A (ja) 2017-01-26
ES2865449T3 (es) 2021-10-15
PL3318571T3 (pl) 2021-07-05
EP2686334B1 (en) 2017-11-15
HRP20180028T1 (hr) 2018-02-09
US20170107249A1 (en) 2017-04-20
SG193378A1 (en) 2013-10-30
JP6523491B2 (ja) 2019-06-05
EP2686334B2 (en) 2020-07-01

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