SI1255751T1 - 1,3-dihydro-2h-indol-2-one derivatives and their use as ligands for v1b or v1b and v1a arginine-vasopressin receptors - Google Patents

1,3-dihydro-2h-indol-2-one derivatives and their use as ligands for v1b or v1b and v1a arginine-vasopressin receptors

Info

Publication number: SI1255751T1
Authority: SI; Slovenia
Prior art keywords: indol; dihydro; ligands; arginine; derivatives
Prior art date: 2000-01-25

Application number

SI200130155T

Other languages

English (en)

Slovenian (sl)

Inventor

Richard Roux

Gal Claudine Serradeil-Le

Bernard Tonnerre

Jean Wagnon

Original Assignee

Sanofi-Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-25

Filing date

2001-01-24

Publication date

2004-10-31

2001-01-24 Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo

2004-10-31 Publication of SI1255751T1 publication Critical patent/SI1255751T1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2

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SI200130155T 2000-01-25 2001-01-24 1,3-dihydro-2h-indol-2-one derivatives and their use as ligands for v1b or v1b and v1a arginine-vasopressin receptors SI1255751T1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0000957A FR2804114B1 (fr)	2000-01-25	2000-01-25	Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
PCT/FR2001/000226 WO2001055130A2 (fr)	2000-01-25	2001-01-24	Derives de 1,3-dihydro-2h-indol-2-one et leur utilisation en tant que ligands des recepteurs v1b ou v1b et v1a de l'arginine-vasopressine
EP01907685A EP1255751B1 (fr)	2000-01-25	2001-01-24	Derives de 1,3-dihydro-2h-indol-2-one et leur utilisation en tant que ligands des recepteurs v1b ou v1b et v1a de l'arginine-vasopressine

Publications (1)

Publication Number	Publication Date
SI1255751T1 true SI1255751T1 (en)	2004-10-31

Family

ID=8846307

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200130155T SI1255751T1 (en)	2000-01-25	2001-01-24	1,3-dihydro-2h-indol-2-one derivatives and their use as ligands for v1b or v1b and v1a arginine-vasopressin receptors

Country Status (36)

Country	Link
US (3)	US6730695B2 (zh)
EP (1)	EP1255751B1 (zh)
JP (1)	JP3992498B2 (zh)
KR (1)	KR100689922B1 (zh)
CN (1)	CN1193025C (zh)
AR (1)	AR027263A1 (zh)
AT (1)	ATE269326T1 (zh)
AU (1)	AU778196B2 (zh)
BG (1)	BG65796B1 (zh)
BR (1)	BR0107807B1 (zh)
CA (1)	CA2396814C (zh)
CZ (1)	CZ300917B6 (zh)
DE (1)	DE60103853T2 (zh)
DK (1)	DK1255751T3 (zh)
EA (1)	EA004628B1 (zh)
EE (1)	EE04779B1 (zh)
ES (1)	ES2222342T3 (zh)
FR (1)	FR2804114B1 (zh)
HK (1)	HK1050900A1 (zh)
HR (1)	HRP20020626B1 (zh)
HU (1)	HU229081B1 (zh)
IL (2)	IL150539A0 (zh)
IS (1)	IS2313B (zh)
ME (1)	MEP17308A (zh)
MX (1)	MXPA02007259A (zh)
NO (1)	NO323607B1 (zh)
PL (1)	PL204160B1 (zh)
PT (1)	PT1255751E (zh)
RS (1)	RS50290B (zh)
SI (1)	SI1255751T1 (zh)
SK (1)	SK286976B6 (zh)
TR (1)	TR200402344T4 (zh)
TW (1)	TWI283672B (zh)
UA (1)	UA74354C2 (zh)
WO (1)	WO2001055130A2 (zh)
ZA (1)	ZA200205224B (zh)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
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FR2804114B1 (fr) *	2000-01-25	2002-03-08	Sanofi Synthelabo	Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
FR2805536B1 (fr) *	2000-02-25	2002-08-23	Sanofi Synthelabo	Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
FR2842527B1 (fr) *	2002-07-19	2005-01-28	Sanofi Synthelabo	Derives d'acyloxypyrolidine, leur preparation et leur application en therapeutique
WO2005021534A1 (ja) *	2003-08-28	2005-03-10	Taisho Pharmaceutical Co., Ltd.	１，３−ジヒドロ−２ｈ−インドール−２−オン誘導体
US20050070718A1 (en) *	2003-09-30	2005-03-31	Abbott Gmbh & Co. Kg	Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US8580842B2 (en) *	2003-09-30	2013-11-12	Abbott Gmbh & Co. Kg	Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US20050165082A1 (en) *	2003-12-16	2005-07-28	Wyeth	Methods of treating vasomotor symptoms
US7517899B2 (en)	2004-03-30	2009-04-14	Wyeth	Phenylaminopropanol derivatives and methods of their use
US7414052B2 (en)	2004-03-30	2008-08-19	Wyeth	Phenylaminopropanol derivatives and methods of their use
WO2006038119A1 (en) *	2004-10-08	2006-04-13	Warner-Lambert Company Llc	Stereoselective synthesis of n-protected alkoxy prolines
WO2006070742A1 (ja) *	2004-12-27	2006-07-06	Kyoto University	麻薬性鎮痛剤の耐性形成抑制剤
CA2593044A1 (en) *	2004-12-31	2006-07-13	Abbott Gmbh & Co. Kg	Substituted oxindole derivatives, medicaments containing said derivatives and use thereof
JP5125501B2 (ja) *	2005-01-28	2013-01-23	大正製薬株式会社	１，３−ジヒドロ−２ｈ−インドール−２−オン化合物、及び芳香族複素環が縮合したピロリジン−２−オン化合物
CN101258134B (zh) *	2005-03-11	2011-10-12	欧加农股份有限公司	2-(4-氧代-4h-喹唑啉-3-基)乙酰胺衍生物及其作为加压素v3拮抗剂的用途
TW200643015A (en)	2005-03-11	2006-12-16	Akzo Nobel Nv	2-(4-oxo-4H-quinazolin-3-yl)acetamide derivatives
DE102005014904A1 (de) *	2005-03-26	2007-02-01	Abbott Gmbh & Co. Kg	Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung
CA2602194A1 (en)	2005-03-24	2006-09-28	Abbott Gmbh & Co. Kg	Substituted oxindol derivatives, drugs containing said derivatives and the use thereof
DE102005014936A1 (de)	2005-03-24	2006-12-14	Abbott Gmbh & Co. Kg	Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung
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Also Published As

Publication number	Publication date
IL150539A0 (en)	2003-02-12
ATE269326T1 (de)	2004-07-15
KR100689922B1 (ko)	2007-03-09
IS6451A (is)	2002-06-28
TR200402344T4 (tr)	2004-12-21
RS50290B (sr)	2009-09-08
US6730695B2 (en)	2004-05-04
CA2396814A1 (en)	2001-08-02
UA74354C2 (uk)	2005-12-15
KR20020067938A (ko)	2002-08-24
JP2003523351A (ja)	2003-08-05
PL204160B1 (pl)	2009-12-31
WO2001055130A2 (fr)	2001-08-02
AR027263A1 (es)	2003-03-19
MEP17308A (en)	2010-06-10
US7129240B2 (en)	2006-10-31
PL357553A1 (en)	2004-07-26
NO20023510D0 (no)	2002-07-23
AU3559401A (en)	2001-08-07
IS2313B (is)	2007-11-15
EP1255751A2 (fr)	2002-11-13
SK286976B6 (sk)	2009-08-06
CZ300917B6 (cs)	2009-09-09
ES2222342T3 (es)	2005-02-01
BG65796B1 (bg)	2009-12-31
US20070004703A1 (en)	2007-01-04
BR0107807A (pt)	2002-10-22
PT1255751E (pt)	2004-10-29
HRP20020626B1 (en)	2009-04-30
CZ20022497A3 (cs)	2002-10-16
DK1255751T3 (da)	2004-10-18
EA004628B1 (ru)	2004-06-24
FR2804114B1 (fr)	2002-03-08
TWI283672B (en)	2007-07-11
HRP20020626A2 (en)	2003-10-31
BG106947A (en)	2003-04-30
US20030114683A1 (en)	2003-06-19
NO323607B1 (no)	2007-06-18
HUP0204242A2 (en)	2003-05-28
SK10832002A3 (sk)	2003-03-04
HK1050900A1 (en)	2003-07-11
MXPA02007259A (es)	2003-01-28
YU52302A (sh)	2006-05-25
HUP0204242A3 (en)	2004-05-28
NO20023510L (no)	2002-09-25
JP3992498B2 (ja)	2007-10-17
BR0107807B1 (pt)	2014-02-25
EP1255751B1 (fr)	2004-06-16
DE60103853T2 (de)	2005-04-28
HU229081B1 (en)	2013-07-29
DE60103853D1 (de)	2004-07-22
FR2804114A1 (fr)	2001-07-27
WO2001055130A3 (fr)	2002-03-14
CN1404479A (zh)	2003-03-19
EA200200628A1 (ru)	2002-12-26
US20040209938A1 (en)	2004-10-21
CA2396814C (en)	2007-07-10
ZA200205224B (en)	2004-03-09
CN1193025C (zh)	2005-03-16
EE04779B1 (et)	2007-02-15
IL150539A (en)	2007-09-20
US7297692B2 (en)	2007-11-20
AU778196B2 (en)	2004-11-18
EE200200409A (et)	2003-12-15

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SI1255751T1 (en)	2004-10-31	1,3-dihydro-2h-indol-2-one derivatives and their use as ligands for v1b or v1b and v1a arginine-vasopressin receptors
MXPA03003246A (es)	2003-06-06	Derivados de indolina y su uso como ligandos del receptor 5-ht2.
DK1259505T3 (da)	2004-08-30	1,3-dihydro-2H-indol-2-on-derivater og deres anvendelse som ligander for arginin-vasopressin-receptorerne V1B eller V1B og V1A
AU2002232768A1 (en)	2002-09-05	Benzimidazole and pyridylimidazole derivatives as ligands for GABA receptors
DK1296976T3 (da)	2005-05-23	1,3-dihydro-2H-indol-2-on-derivater og deres anvendelse som lagander for ariginin-vasopressin-receptorerne V1B og V1A
ZA988078B (en)	2000-03-22	Substituted oxindole derivatives.
AU2001246671A1 (en)	2002-01-03	Indolin-2-one derivatives, preparation and their use as ocytocin receptor ligands
IL152085A0 (en)	2003-05-29	Indolin-2-one derivatives, preparation and their use as ocytocin receptor ligands
AP2003002818A0 (en)	2003-06-30	Benzimidazole and pyridylimidazole derivatives as ligands for gaba receptors
AU2001292898A1 (en)	2002-04-02	Substituted azepino[4,5b)indole derivatives
MXPA03005648A (es)	2003-10-06	Derivados de carbazol y su uso, como ligandos de receptor del neuropeptido y5.
HK1031873A1 (en)	2001-06-29	Imidazolyl derivatives and their use as somatostatin receptor ligands.
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ZA200207331B (en)	2003-09-12	Ethylenediamine derivatives.
EA199900303A3 (ru)	2000-04-24	Замещенные трициклические соединения.
IL151154A0 (en)	2003-04-10	Indol-3-yl derivatives
AU2001231664A1 (en)	2001-11-01	Indol-3-yl derivatives
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AU2001258601A1 (en)	2001-12-03	Peptoids as ligands for melanocortin receptors
AU4478200A (en)	2000-11-10	Death domain containing receptors
HUP0300562A3 (en)	2006-02-28	Hydroxyphenyl-piperazinyl-methyl-benzamide derivatives for the
IL140062A0 (en)	2002-02-10	Tetrahydroquinoline derivatives as glycine antagonists
AU6913100A (en)	2001-03-13	Notch receptor ligands and uses thereof