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SI1176964T1 - Uporaba et743 za zdravljenje raka - Google Patents

Uporaba et743 za zdravljenje raka

Info

Publication number
SI1176964T1
SI1176964T1 SI200030905T SI200030905T SI1176964T1 SI 1176964 T1 SI1176964 T1 SI 1176964T1 SI 200030905 T SI200030905 T SI 200030905T SI 200030905 T SI200030905 T SI 200030905T SI 1176964 T1 SI1176964 T1 SI 1176964T1
Authority
SI
Slovenia
Prior art keywords
treating cancer
cancer
treating
Prior art date
Application number
SI200030905T
Other languages
English (en)
Inventor
Angela Dept Of Clinical Bowman
Esteban Cvitkovic
George Daniel Dept Of Demetri
Cecilia Pharma Mar S A Guzman
Jose Pharma Mar S A Jimeno
Lazaro Luis Pharma Mar S Lopez
Jean Louis Service D On Misset
C Uni Of Glasgow Crc B Twelves
Hoff Daniel D Arizona Canc Von
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9911183.3A external-priority patent/GB9911183D0/en
Priority claimed from GBGB9911346.6A external-priority patent/GB9911346D0/en
Priority claimed from GBGB9918534.0A external-priority patent/GB9918534D0/en
Priority claimed from GBGB9927005.0A external-priority patent/GB9927005D0/en
Priority claimed from GBGB9927106.6A external-priority patent/GB9927106D0/en
Priority claimed from GB0007637A external-priority patent/GB0007637D0/en
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Publication of SI1176964T1 publication Critical patent/SI1176964T1/sl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995Pyrazines or piperazines forming part of bridged ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
SI200030905T 1999-05-13 2000-05-15 Uporaba et743 za zdravljenje raka SI1176964T1 (sl)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB9911183.3A GB9911183D0 (en) 1999-05-13 1999-05-13 Treatment of cancers
GBGB9911346.6A GB9911346D0 (en) 1999-05-14 1999-05-14 Treatment of cancers
GBGB9918534.0A GB9918534D0 (en) 1999-08-05 1999-08-05 Treatment of cancers
GBGB9927005.0A GB9927005D0 (en) 1999-11-15 1999-11-15 Treatment of cancers
GBGB9927106.6A GB9927106D0 (en) 1999-11-16 1999-11-16 Cancer treatment
GB0007637A GB0007637D0 (en) 2000-03-29 2000-03-29 Antitumour compound
PCT/GB2000/001857 WO2000069441A1 (en) 1999-05-13 2000-05-15 Compositions and uses of et743 for treating cancer

Publications (1)

Publication Number Publication Date
SI1176964T1 true SI1176964T1 (sl) 2007-02-28

Family

ID=27546594

Family Applications (3)

Application Number Title Priority Date Filing Date
SI200031067T SI1716853T1 (sl) 1999-05-13 2000-05-15 Zdravljenje rakov äśloveĺ kega telesa z uporabo et743
SI200030905T SI1176964T1 (sl) 1999-05-13 2000-05-15 Uporaba et743 za zdravljenje raka
SI200030977T SI1702618T1 (sl) 1999-05-13 2000-05-15 Uporaba et743 v kombinirani terapiji z deksametazonom za zdravljenje raka

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI200031067T SI1716853T1 (sl) 1999-05-13 2000-05-15 Zdravljenje rakov äśloveĺ kega telesa z uporabo et743

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200030977T SI1702618T1 (sl) 1999-05-13 2000-05-15 Uporaba et743 v kombinirani terapiji z deksametazonom za zdravljenje raka

Country Status (32)

Country Link
US (1) US8119638B2 (sl)
EP (3) EP1702618B1 (sl)
JP (2) JP2002544231A (sl)
KR (1) KR20020019914A (sl)
CN (2) CN1360503A (sl)
AR (1) AR028476A1 (sl)
AT (3) ATE375795T1 (sl)
AU (2) AU777417B2 (sl)
BG (1) BG65680B1 (sl)
BR (1) BR0010531A (sl)
CA (1) CA2373794C (sl)
CY (4) CY1105818T1 (sl)
CZ (1) CZ301482B6 (sl)
DE (4) DE60030554T8 (sl)
DK (3) DK1716853T3 (sl)
ES (2) ES2294756T3 (sl)
FR (1) FR08C0013I2 (sl)
HU (2) HU229866B1 (sl)
IL (2) IL146434A0 (sl)
LU (1) LU91418I2 (sl)
MX (1) MXPA01011562A (sl)
MY (1) MY164077A (sl)
NL (1) NL300337I2 (sl)
NO (2) NO324564B1 (sl)
NZ (1) NZ515423A (sl)
PL (1) PL198185B1 (sl)
PT (3) PT1176964E (sl)
SI (3) SI1716853T1 (sl)
SK (1) SK287580B6 (sl)
TR (1) TR200103819T2 (sl)
UA (1) UA74782C2 (sl)
WO (1) WO2000069441A1 (sl)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
CN100374162C (zh) * 2000-11-06 2008-03-12 法马马有限公司 海鞘素-743在制备用于治疗肿瘤的药剂中的应用
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
CA2462502A1 (en) * 2001-10-19 2003-05-15 Pharma Mar, S.A. Improved use of antitumoral compound in cancer therapy
GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
PL1689404T3 (pl) * 2003-11-13 2009-02-27 Pharma Mar Sau Połączenie ET-743 z pro lekami 5-fluorouracylu do leczenia raka
EP1691809A1 (en) * 2003-11-14 2006-08-23 Pharma Mar, S.A. Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
US20080293725A1 (en) * 2004-07-09 2008-11-27 Rafael Rosell Costa Prognostic Molecular Markers
UA87877C2 (en) * 2004-10-26 2009-08-25 Фарма Мар С.А., Сосьедад Униперсональ Pegylated liposomal doxorubicin in combination with ecteinescidin 743
DK1658848T3 (da) * 2004-10-29 2007-11-26 Pharma Mar Sa Formuleringer omfattende ecteinascidin og et disaccharid
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
US20100009906A1 (en) * 2006-05-12 2010-01-14 Pharma Mar, S.A. Anticancer Treatments
JP2011500046A (ja) * 2007-10-19 2011-01-06 ファルマ・マール・ソシエダード・アノニマ Et−743治療のための予後分子マーカー
BR112018015118A2 (pt) * 2016-02-04 2018-12-18 Jiangsu Hengrui Medicine Co., Ltd. composição farmacêutica injetável inclusiva de trabectedina para uso externo gastrointestinal e método de fabricação da mesma
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
WO2020239478A1 (en) 2019-05-28 2020-12-03 Pharma Mar, S.A. Trabectedin for treating sarcomas based on genomic markers
CN112574234B (zh) * 2019-09-27 2022-05-24 江苏恒瑞医药股份有限公司 一种海鞘素衍生物的制备方法
AU2021256746A1 (en) 2020-04-15 2022-11-03 Ever Valinject Gmbh Composition comprising trabectedin and an amino acid
US20230226051A1 (en) 2022-01-20 2023-07-20 Extrovis Ag Trabectedin composition

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US5089273A (en) 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5256663A (en) 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
ATE69234T1 (de) * 1986-06-09 1991-11-15 Univ Illinois Ekteinascidine 729, 743, 745, 759a, 759b and 770.
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
DE3635711A1 (de) 1986-10-21 1988-04-28 Knoll Ag 5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung
GB8805268D0 (en) * 1988-03-04 1988-04-07 Glaxo Group Ltd Medicaments
GB9101221D0 (en) * 1991-01-19 1991-02-27 Smithkline Beecham Plc Pharmaceuticals
US5721352A (en) 1991-02-19 1998-02-24 University Of Florida Research Foundation Entomopoxvirus expression system
FR2697752B1 (fr) 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
US5891704A (en) * 1992-11-19 1999-04-06 Anticancer, Inc. Method to produce high levels of methioninase
JPH09503743A (ja) * 1993-05-14 1997-04-15 デポテック コーポレーション 神経学的疾患の治療方法
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US20040059112A1 (en) 1994-02-18 2004-03-25 Rinehart Kenneth L. Ecteinascidins
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US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
EP2298300A1 (en) * 1996-11-05 2011-03-23 The Children's Medical Center Corporation Compositions for inhibition of anglogenesis comprising thalidomide and aspirin
IL123740A0 (en) * 1997-03-28 1998-10-30 Pfizer NK-1 receptor antagonists for the treatment of delayed emesis
US5985876A (en) 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
DE19720312A1 (de) * 1997-05-15 1998-11-19 Hoechst Ag Zubereitung mit erhöhter in vivo Verträglichkeit
GB9801231D0 (en) * 1997-06-05 1998-03-18 Merck & Co Inc A method of treating cancer
KR100603219B1 (ko) 1998-04-06 2006-07-20 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 반합성 엑테이나시딘
KR100643092B1 (ko) * 1998-05-11 2006-11-10 파르마 마르, 에스.에이. 엑테인아시딘 743의 대사산물
US6124292A (en) 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
AR035842A1 (es) 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
WO2001077115A1 (en) 2000-04-12 2001-10-18 Pharma Mar, S.A. Antitumoral ecteinascidin derivatives
US7247892B2 (en) 2000-04-24 2007-07-24 Taylor Geoff W Imaging array utilizing thyristor-based pixel elements
US7420051B2 (en) 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
EP1356097A2 (en) 2000-08-11 2003-10-29 City of Hope The anti-neoplastic agent et-743 inhibits trans activation by sxr
CN100374162C (zh) 2000-11-06 2008-03-12 法马马有限公司 海鞘素-743在制备用于治疗肿瘤的药剂中的应用
EP1360337A1 (en) 2001-02-09 2003-11-12 The Regents Of The University Of California Ecteinascidin family compounds: compositions and methods
AU2002242561A1 (en) 2001-03-30 2002-10-15 Shire Biochem Inc. Methods of treating cancer using cyplastin combined with a dioxolane nucleoside such as troxacitabine
GB0121285D0 (en) 2001-09-03 2001-10-24 Cancer Res Ventures Ltd Anti-cancer combinations
CA2462502A1 (en) 2001-10-19 2003-05-15 Pharma Mar, S.A. Improved use of antitumoral compound in cancer therapy
US20040019027A1 (en) 2002-04-12 2004-01-29 Barry Forman Method of treating cerebrotendinous xanthomatosis
GB0312407D0 (en) 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
PL1689404T3 (pl) 2003-11-13 2009-02-27 Pharma Mar Sau Połączenie ET-743 z pro lekami 5-fluorouracylu do leczenia raka
GB0326486D0 (en) 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
EP1691809A1 (en) 2003-11-14 2006-08-23 Pharma Mar, S.A. Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
US20080293725A1 (en) 2004-07-09 2008-11-27 Rafael Rosell Costa Prognostic Molecular Markers
CA2583464A1 (en) 2004-09-29 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
UA87877C2 (en) 2004-10-26 2009-08-25 Фарма Мар С.А., Сосьедад Униперсональ Pegylated liposomal doxorubicin in combination with ecteinescidin 743
DK1658848T3 (da) 2004-10-29 2007-11-26 Pharma Mar Sa Formuleringer omfattende ecteinascidin og et disaccharid
DE602006020335D1 (de) 2005-11-25 2011-04-07 Pharma Mar Sa Verwendung von parp-1-hemmern
US20100009906A1 (en) 2006-05-12 2010-01-14 Pharma Mar, S.A. Anticancer Treatments

Also Published As

Publication number Publication date
DE60030554D1 (de) 2006-10-19
AU777417B2 (en) 2004-10-14
HUS1500001I1 (hu) 2016-08-29
CY2008007I1 (el) 2009-11-04
BG65680B1 (bg) 2009-06-30
CY1112753T1 (el) 2016-02-10
HUP0201187A3 (en) 2002-11-28
EP1716853A2 (en) 2006-11-02
EP1716853B9 (en) 2011-09-28
JP5777562B2 (ja) 2015-09-09
ATE500830T1 (de) 2011-03-15
EP1716853A3 (en) 2006-11-15
NO324564B1 (no) 2007-11-19
CN1679631A (zh) 2005-10-12
WO2000069441A1 (en) 2000-11-23
CY2008007I2 (el) 2009-11-04
NO20015516D0 (no) 2001-11-12
NL300337I1 (nl) 2008-05-01
EP1716853B1 (en) 2011-03-09
DK1176964T3 (da) 2007-01-15
NO20015516L (no) 2002-01-11
DK1702618T3 (da) 2008-02-25
NO2008005I2 (sl) 2010-09-27
EP1176964A1 (en) 2002-02-06
ES2272279T3 (es) 2007-05-01
CY1105818T1 (el) 2011-02-02
US8119638B2 (en) 2012-02-21
DE60030554T2 (de) 2007-09-13
EP1176964B8 (en) 2007-10-10
UA74782C2 (uk) 2006-02-15
PT1716853E (pt) 2011-05-12
CA2373794A1 (en) 2000-11-23
JP2002544231A (ja) 2002-12-24
EP1702618A2 (en) 2006-09-20
CZ20014081A3 (cs) 2002-11-13
LU91418I9 (sl) 2019-01-02
LU91418I2 (fr) 2008-05-13
CA2373794C (en) 2005-10-11
SK16442001A3 (sk) 2002-03-05
SK287580B6 (sk) 2011-03-04
NO2008005I1 (no) 2008-06-09
NZ515423A (en) 2004-04-30
PL198185B1 (pl) 2008-06-30
CN1360503A (zh) 2002-07-24
BG106171A (en) 2002-06-28
CY1107143T1 (el) 2010-07-28
PL352931A1 (en) 2003-09-22
AU2005200180A1 (en) 2005-02-10
ATE338552T1 (de) 2006-09-15
AR028476A1 (es) 2003-05-14
TR200103819T2 (tr) 2002-04-22
MXPA01011562A (es) 2002-07-30
DE60030554T8 (de) 2008-01-10
DE60036826D1 (de) 2007-11-29
HU229866B1 (en) 2014-10-28
EP1702618A3 (en) 2006-12-27
DE122008000013I1 (de) 2008-08-07
IL146434A0 (en) 2002-07-25
US20070275942A1 (en) 2007-11-29
CZ301482B6 (cs) 2010-03-17
JP2012149095A (ja) 2012-08-09
DK1716853T3 (da) 2011-06-27
SI1702618T1 (sl) 2008-02-29
NL300337I2 (nl) 2008-09-01
SI1716853T1 (sl) 2011-10-28
EP1702618B1 (en) 2007-10-17
KR20020019914A (ko) 2002-03-13
PT1702618E (pt) 2008-01-11
CN100477993C (zh) 2009-04-15
EP1176964B1 (en) 2006-09-06
FR08C0013I1 (sl) 2008-05-30
AU2005200180B9 (en) 2008-05-29
FR08C0013I2 (fr) 2009-10-30
PT1176964E (pt) 2007-01-31
AU4597500A (en) 2000-12-05
ATE375795T1 (de) 2007-11-15
BR0010531A (pt) 2002-06-04
HUP0201187A2 (en) 2002-09-28
AU2005200180B2 (en) 2007-12-13
DE60045720D1 (de) 2011-04-21
DE60036826T2 (de) 2008-08-28
MY164077A (en) 2017-11-30
IL146434A (en) 2008-03-20
ES2294756T3 (es) 2008-04-01

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