SI0736009T1 - N-oxides of 4-arylpiperazines and 4-arylpiperidines as antipsychotic drugs - Google Patents

N-oxides of 4-arylpiperazines and 4-arylpiperidines as antipsychotic drugs

Info

Publication number: SI0736009T1
Authority: SI; Slovenia
Prior art keywords: arylpiperidines; arylpiperazines; oxides; antipsychotic drugs; antipsychotic
Prior art date: 1993-12-23

Application number

SI9430427T

Other languages

English (en)

Slovenian (sl)

Inventor

Allen B. Reitz

Mark E. Mcdonnell

Original Assignee

Ortho-Mcneil Pharmaceutical, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-23

Filing date

1994-12-22

Publication date

2003-04-30

1994-12-22 Application filed by Ortho-Mcneil Pharmaceutical, Inc. filed Critical Ortho-Mcneil Pharmaceutical, Inc.

2003-04-30 Publication of SI0736009T1 publication Critical patent/SI0736009T1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/24—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SI9430427T 1993-12-23 1994-12-22 N-oxides of 4-arylpiperazines and 4-arylpiperidines as antipsychotic drugs SI0736009T1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US17338293A	1993-12-23	1993-12-23
EP95906100A EP0736009B1 (en)	1993-12-23	1994-12-22	N-oxides of 4-arylpiperazines and 4-arylpiperidines as antipsychotic drugs
PCT/US1994/014850 WO1995017385A1 (en)	1993-12-23	1994-12-22	N-oxides of 4-arylpiperazines and 4-arylpiperidines as antipsychotic drugs

Publications (1)

Publication Number	Publication Date
SI0736009T1 true SI0736009T1 (en)	2003-04-30

Family

ID=22631753

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI9430427T SI0736009T1 (en)	1993-12-23	1994-12-22	N-oxides of 4-arylpiperazines and 4-arylpiperidines as antipsychotic drugs

Country Status (16)

Country	Link
EP (1)	EP0736009B1 (da)
JP (1)	JPH09507077A (da)
AT (1)	ATE223898T1 (da)
AU (1)	AU687501B2 (da)
CA (1)	CA2179735A1 (da)
DE (1)	DE69431360T2 (da)
DK (1)	DK0736009T3 (da)
ES (1)	ES2183862T3 (da)
IL (1)	IL112099A (da)
MX (1)	MX9500228A (da)
NZ (1)	NZ278261A (da)
PT (1)	PT736009E (da)
RU (1)	RU2123001C1 (da)
SI (1)	SI0736009T1 (da)
WO (1)	WO1995017385A1 (da)
ZA (1)	ZA9410287B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
USRE46117E1 (en)	1999-12-22	2016-08-23	Teva Pharmaceuticals International Gmbh	Modulators of dopamine neurotransmission
MXPA03001276A (es) *	2000-08-11	2003-09-05	Ono Pharmaceutical Co	Derivados de piperidina y farmacos que contienen esos derivados como el ingrediente activo.
ES2278321T3 (es)	2003-06-12	2007-08-01	Btg International Limited	Hidroxilamina ciclica como compuestos psicoactivos.
NZ580856A (en) *	2007-04-12	2011-11-25	Nsab Af Neurosearch Sweden Ab	N-oxide and/or di-n-oxide derivatives of dopamine receptor stabilizers/modulators displaying improved cardiovascular side-effects profiles
US9012476B2 (en)	2011-12-08	2015-04-21	IVAX International GmbH	Hydrobromide salt of pridopidine
WO2013152105A1 (en)	2012-04-04	2013-10-10	IVAX International GmbH	Pharmaceutical compositions for combination therapy
EP3236964A4 (en)	2014-12-22	2018-09-19	Teva Pharmaceuticals International GmbH	L-tartrate salt of pridopidine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE914218A1 (en) *	1991-09-11	1993-03-24	Mcneilab Inc	Novel 4-arylpiperazines and 4-arylpiperidines
FR2697251B1 (fr) *	1992-10-22	1994-12-02	Synthelabo	N-oxydes de dérivés de 1-(4-chlorophényl)-2-[4-[(4-fluorophényl)méthyl] pipéridin-1-yl]éthanol, leur procédé de préparation et leur application en thérapeutique.

1994
- 1994-12-21 IL IL11209994A patent/IL112099A/xx not_active IP Right Cessation
- 1994-12-22 CA CA002179735A patent/CA2179735A1/en not_active Abandoned
- 1994-12-22 NZ NZ278261A patent/NZ278261A/en unknown
- 1994-12-22 SI SI9430427T patent/SI0736009T1/xx unknown
- 1994-12-22 ZA ZA9410287A patent/ZA9410287B/xx unknown
- 1994-12-22 DK DK95906100T patent/DK0736009T3/da active
- 1994-12-22 AU AU14446/95A patent/AU687501B2/en not_active Ceased
- 1994-12-22 EP EP95906100A patent/EP0736009B1/en not_active Expired - Lifetime
- 1994-12-22 ES ES95906100T patent/ES2183862T3/es not_active Expired - Lifetime
- 1994-12-22 WO PCT/US1994/014850 patent/WO1995017385A1/en active IP Right Grant
- 1994-12-22 AT AT95906100T patent/ATE223898T1/de not_active IP Right Cessation
- 1994-12-22 RU RU96115155A patent/RU2123001C1/ru not_active IP Right Cessation
- 1994-12-22 JP JP7517623A patent/JPH09507077A/ja not_active Ceased
- 1994-12-22 PT PT95906100T patent/PT736009E/pt unknown
- 1994-12-22 DE DE69431360T patent/DE69431360T2/de not_active Expired - Fee Related
1995
- 1995-01-02 MX MX9500228A patent/MX9500228A/es not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0736009A1 (en)	1996-10-09
AU1444695A (en)	1995-07-10
DE69431360D1 (de)	2002-10-17
MX9500228A (es)	1997-02-28
JPH09507077A (ja)	1997-07-15
ZA9410287B (en)	1996-06-24
AU687501B2 (en)	1998-02-26
PT736009E (pt)	2003-01-31
CA2179735A1 (en)	1995-06-29
ATE223898T1 (de)	2002-09-15
NZ278261A (en)	1998-08-26
RU2123001C1 (ru)	1998-12-10
DK0736009T3 (da)	2002-10-07
WO1995017385A1 (en)	1995-06-29
EP0736009B1 (en)	2002-09-11
IL112099A0 (en)	1995-03-15
DE69431360T2 (de)	2003-01-23
IL112099A (en)	1999-07-14
ES2183862T3 (es)	2003-04-01

Publication	Publication Date	Title
SG70980A1 (en)	2000-03-21	Novel 4-arylpiperazines and 4-arylpiperidines
MY111201A (en)	1999-09-30	New imidazopyridines
AU6787390A (en)	1991-06-13	Nitrogen-containing spirocycles
EP0528858A4 (en)	1993-04-28	Inhibitors of dipeptidyl-aminopeptidase type iv
EP0776327A4 (en)	1997-12-10	NEW MULTIMERIZATION AGENTS
AU6613896A (en)	1996-10-30	Chemical compounds
CY2543B1 (en)	2006-06-28	9-Ä(Substituted glycyl)amidoÜ-6-(substituted)-5-hydroxy-6-deoxytetracyclines
PH30006A (en)	1996-10-29	9-¬(Substituted glycol)amido¾-6.demethyl-6-deoxytetra-cyclines
AU4461393A (en)	1994-02-17	Novel 7-(substituted)-8-(substituted-9-{(substituted glycyl) amido}-6-demethyl-6-deoxytetracyclines
MX9700557A (es)	1997-12-31	Dihidrobenzofuranos.
DE69333062D1 (de)	2003-07-31	4-mercaptoacetylamino-[2]benzazepinon(3)- derivate, und verwendung als enkephalinase-inhibitoren
HRP930239A2 (en)	1996-06-30	Anti-inflamatory 4-aminophenol derivatives
GR3031781T3 (en)	2000-02-29	Antifungal sordaridin derivatives
SI0736009T1 (en)	2003-04-30	N-oxides of 4-arylpiperazines and 4-arylpiperidines as antipsychotic drugs
HU9502989D0 (en)	1995-12-28	Herbicidal substituted 1-phenyl or 1-pyridinyl benzotriazoles
GR3023757T3 (en)	1997-09-30	Cyclic benzylamino, benzylamido and benzylimido derivatives as antipsychotic agents.
IN172911B (da)	1994-01-01
IL111246A0 (en)	1994-12-29	Tricyclic compounds and pharmaceutical compositions containing them
HU9500944D0 (en)	1995-05-29	N,n-substituted amino-methylen-imidazolinone derivatives as intermediates of 2-substituted 5-chloro-imidazol-4-carbaldeydes
PL299531A1 (en)	1995-01-09	Novel derivative of pyrol-3,4-dicarboxylic imide
PL299529A1 (en)	1995-01-09	Novel derivative of pyrol-3,4-dicarboxylic imide