[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

SG11202009884YA - Growth differentiation factor 15 fusion proteins - Google Patents

Growth differentiation factor 15 fusion proteins

Info

Publication number
SG11202009884YA
SG11202009884YA SG11202009884YA SG11202009884YA SG11202009884YA SG 11202009884Y A SG11202009884Y A SG 11202009884YA SG 11202009884Y A SG11202009884Y A SG 11202009884YA SG 11202009884Y A SG11202009884Y A SG 11202009884YA SG 11202009884Y A SG11202009884Y A SG 11202009884YA
Authority
SG
Singapore
Prior art keywords
fusion proteins
differentiation factor
growth differentiation
growth
factor
Prior art date
Application number
SG11202009884YA
Inventor
Yumei Xiong
Kenneth William Walker
ELLISON Murielle Marie VENIANT
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of SG11202009884YA publication Critical patent/SG11202009884YA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/495Transforming growth factor [TGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11202009884YA 2018-04-09 2019-04-08 Growth differentiation factor 15 fusion proteins SG11202009884YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862655108P 2018-04-09 2018-04-09
PCT/US2019/026369 WO2019199685A1 (en) 2018-04-09 2019-04-08 Growth differentiation factor 15 fusion proteins

Publications (1)

Publication Number Publication Date
SG11202009884YA true SG11202009884YA (en) 2020-11-27

Family

ID=66251865

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202009884YA SG11202009884YA (en) 2018-04-09 2019-04-08 Growth differentiation factor 15 fusion proteins

Country Status (23)

Country Link
US (4) US12054527B2 (en)
EP (1) EP3773656A1 (en)
JP (2) JP7058670B2 (en)
KR (1) KR20200140878A (en)
CN (1) CN111954537A (en)
AR (1) AR114476A1 (en)
AU (1) AU2019253462A1 (en)
BR (1) BR112020020823A2 (en)
CA (1) CA3096097A1 (en)
CL (1) CL2020002585A1 (en)
CO (1) CO2020012563A2 (en)
CR (1) CR20200510A (en)
EA (1) EA202092419A1 (en)
IL (1) IL277842A (en)
JO (1) JOP20200258A1 (en)
MA (1) MA52205A (en)
MX (1) MX2020010659A (en)
PE (1) PE20201350A1 (en)
PH (1) PH12020551655A1 (en)
SG (1) SG11202009884YA (en)
TW (1) TW202003586A (en)
UY (1) UY38177A (en)
WO (1) WO2019199685A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170299608A1 (en) * 2016-03-04 2017-10-19 Ngm Biopharmaceuticals, Inc. Compositions and methods for modulating body weight
SG11202009884YA (en) 2018-04-09 2020-11-27 Amgen Inc Growth differentiation factor 15 fusion proteins
MX2021010737A (en) * 2019-03-08 2021-09-28 Amgen Inc Growth differentiation factor 15 combination therapy.
JOP20210282A1 (en) * 2019-04-23 2023-01-30 Lg Chemical Ltd Fusion polypeptide comprising fc region of immunoglobulin and gdf15
CN113366024B (en) * 2020-01-08 2024-11-05 上海翰森生物医药科技有限公司 FGF21 mutant proteins and fusion proteins thereof
WO2022092915A1 (en) * 2020-10-30 2022-05-05 가톨릭대학교 산학협력단 Composition for preventing and treating immune diseases containing gdf15 as active ingredient
WO2023025120A1 (en) * 2021-08-24 2023-03-02 Sunshine Lake Pharma Co., Ltd. Gdf15 fusion proteins and uses thereof
WO2023154953A1 (en) 2022-02-14 2023-08-17 Ngm Biopharmaceuticals, Inc. Gdf15 polypeptides for treating and preventing autoimmune diseases

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4263428A (en) 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
DE3374837D1 (en) 1982-02-17 1988-01-21 Ciba Geigy Ag Lipids in the aqueous phase
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
US4615885A (en) 1983-11-01 1986-10-07 Terumo Kabushiki Kaisha Pharmaceutical composition containing urokinase
US5470582A (en) 1992-02-07 1995-11-28 Syntex (U.S.A.) Inc. Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles
WO1999006445A1 (en) 1997-07-31 1999-02-11 The Johns Hopkins University School Of Medicine Growth differentiation factor-15
ID30327A (en) 1999-01-07 2001-11-22 Lexigen Pharm Corp EXPRESSION AND EXPORT OF ANTI OBESITY PROTEINS AS FUSION FOTIIN PROTEINS
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
US20030103978A1 (en) 2000-02-23 2003-06-05 Amgen Inc. Selective binding agents of osteoprotegerin binding protein
HU230603B1 (en) 2000-12-07 2017-03-28 Eli Lilly And Company Glp-1 fusion proteins
JP4524074B2 (en) 2001-03-09 2010-08-11 アーナソン, バリー ジー. Polymeric immunoglobulin fusion proteins targeting low affinity Fcγ receptors
JP4422949B2 (en) 2001-06-26 2010-03-03 武田薬品工業株式会社 TGF-β superfamily production / secretion promoter
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
US7101852B2 (en) 2003-05-30 2006-09-05 The Board Of Regents Of The University Of Texas System Composition and method for treatment and prevention of restenosis
US20070148170A1 (en) 2005-10-03 2007-06-28 Desjarlais John R Fc Variants With Optimized Fc Receptor Binding Properties
WO2005063815A2 (en) 2003-11-12 2005-07-14 Biogen Idec Ma Inc. Fcϝ receptor-binding polypeptide variants and methods related thereto
CN1723220A (en) 2003-11-13 2006-01-18 韩美药品工业株式会社 A pharmaceutical composition comprising an immunoglobulin FC region as a carrier
EP1697520A2 (en) 2003-12-22 2006-09-06 Xencor, Inc. Fc polypeptides with novel fc ligand binding sites
SI2441466T1 (en) 2004-04-13 2015-01-30 St Vincent's Hospital Sydney Limited Centre For Immunology MIC-1 inhibiting agent
US20090042780A1 (en) 2004-05-20 2009-02-12 Acceleron Pharma Inc Modified TGF-Beta Superfamily Polypeptides and Related Methods
US7670595B2 (en) 2004-06-28 2010-03-02 Merck Patent Gmbh Fc-interferon-beta fusion proteins
CN1974601A (en) 2005-11-28 2007-06-06 上海新生源医药研究有限公司 New-type Fc fusion protein and its production process
EP2057191A1 (en) 2006-08-18 2009-05-13 Ablynx N.V. Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling
CN101854947A (en) 2007-08-16 2010-10-06 圣文森特医院悉尼有限公司 Be used to regulate active medicament of macrophage inhibition factor (MIC-1) and method
PL2235064T3 (en) 2008-01-07 2016-06-30 Amgen Inc Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
WO2009141357A1 (en) 2008-05-20 2009-11-26 Roche Diagnostics Gmbh Gdf-15 as biomarker in type 1 diabetes
WO2010017198A2 (en) 2008-08-04 2010-02-11 Five Prime Therapeutics, Inc. Fgfr extracellular domain acidic region muteins
ES2434996T3 (en) 2008-10-31 2013-12-18 St Vincent's Hospital Sydney Limited Prognosis methods in chronic kidney disease
WO2011063348A1 (en) 2009-11-23 2011-05-26 Amgen Inc. Monomeric antibody fc
WO2011064758A2 (en) 2009-11-30 2011-06-03 Pfizer Limited Fusion protein
US8372952B2 (en) 2009-12-02 2013-02-12 Amgen Inc. Binding proteins that bind to human FGFR1C, human β-klotho and both human FGFR1C and human β-klotho
WO2011091078A2 (en) 2010-01-19 2011-07-28 Xencor, Inc. Antibody fc variants with enhanced complement activity
ES2526981T3 (en) 2010-07-12 2015-01-19 Pfizer Limited N-sulfonylbenzamides as voltage dependent sodium channel inhibitors
US8772343B2 (en) 2010-07-12 2014-07-08 Pfizer Limited Chemical compounds
JP2013532185A (en) 2010-07-12 2013-08-15 ファイザー・リミテッド Compound
CA2807213C (en) 2010-08-26 2022-06-28 F. Hoffman-La Roche Ag Use of biomarkers in the assessment of the early transition from arterial hypertension to heart failure
EP2439535A1 (en) 2010-10-07 2012-04-11 F. Hoffmann-La Roche AG Diagnosis of diabetes related heart disease and GDF-15 and Troponin as predictors for the development of type 2 diabetes mellitus
WO2012058768A1 (en) 2010-11-05 2012-05-10 Zymeworks Inc. Stable heterodimeric antibody design with mutations in the fc domain
US20140112926A1 (en) 2011-03-16 2014-04-24 Amgen Inc. Fc VARIANTS
AU2012240102C1 (en) 2011-04-08 2016-09-08 Amgen Inc. Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (GDF-15)
EA201892619A1 (en) 2011-04-29 2019-04-30 Роше Гликарт Аг IMMUNOCONJUGATES CONTAINING INTERLEUKIN-2 MUTANT POLYPETIPS
EA201491413A1 (en) * 2012-01-26 2015-03-31 Эмджен Инк. POLYPEPTIDE GROWTH FACTOR AND DIFFERENTIATION 15 (GDF-15)
US9550819B2 (en) * 2012-03-27 2017-01-24 Ngm Biopharmaceuticals, Inc. Compositions and methods of use for treating metabolic disorders
SG10201913376XA (en) 2012-04-20 2020-02-27 Merus Nv Methods and means for the production of ig-like molecules
JP6758832B2 (en) 2012-12-21 2020-09-30 アベオ ファーマシューティカルズ, インコーポレイテッド Anti-GDF15 antibody
BR112015018104A2 (en) * 2013-01-30 2017-11-21 Ngm Biopharmaceuticals Inc modified gdf15 polypeptides, their use, compositions comprising them and sterile container comprising said compositions
US9161966B2 (en) 2013-01-30 2015-10-20 Ngm Biopharmaceuticals, Inc. GDF15 mutein polypeptides
EA037355B1 (en) 2013-07-31 2021-03-17 Эмджен Инк. Growth differentiation factor 15 (gdf-15) constructs
CN112851790A (en) 2014-06-23 2021-05-28 诺华股份有限公司 Site-specific protein modification
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
EP3157947A1 (en) 2014-06-23 2017-04-26 Novartis AG Hsa-gdf-15 fusion polypeptide and use thereof
AU2015279525A1 (en) 2014-06-24 2016-12-15 Novo Nordisk A/S MIC-1 fusion proteins and uses thereof
MY192917A (en) 2014-07-30 2022-09-15 Ngm Biopharmaceuticals Inc Compositions and methods of use for treating metabolic disorders
CA2961587A1 (en) 2014-10-31 2016-05-06 Ngm Biopharmaceuticals, Inc. Compositions and methods of use for treating metabolic disorders
CN108367053A (en) 2015-12-22 2018-08-03 诺华股份有限公司 The method that metabolic disease is treated or improved using growth and differentiation factor 15 (GDF-15)
US20170299608A1 (en) 2016-03-04 2017-10-19 Ngm Biopharmaceuticals, Inc. Compositions and methods for modulating body weight
US10336812B2 (en) 2016-05-10 2019-07-02 Janssen Biotech, Inc. GDF15 fusion proteins and uses thereof
TW201741333A (en) 2016-05-24 2017-12-01 諾佛 儂迪克股份有限公司 MIC-1 compounds and uses thereof
TWI724392B (en) 2018-04-06 2021-04-11 美商美國禮來大藥廠 Growth differentiation factor 15 agonist compounds and methods of using the same
SG11202009884YA (en) 2018-04-09 2020-11-27 Amgen Inc Growth differentiation factor 15 fusion proteins
MX2021010737A (en) 2019-03-08 2021-09-28 Amgen Inc Growth differentiation factor 15 combination therapy.

Also Published As

Publication number Publication date
UY38177A (en) 2019-07-31
CL2020002585A1 (en) 2020-12-04
MA52205A (en) 2021-02-17
IL277842A (en) 2020-11-30
JP7058670B2 (en) 2022-04-22
WO2019199685A1 (en) 2019-10-17
CR20200510A (en) 2020-11-26
PE20201350A1 (en) 2020-11-30
EA202092419A1 (en) 2021-02-05
US11161889B2 (en) 2021-11-02
AR114476A1 (en) 2020-09-09
PH12020551655A1 (en) 2021-07-26
US20230143988A1 (en) 2023-05-11
US20210147500A1 (en) 2021-05-20
AU2019253462A1 (en) 2020-11-26
JP2020533271A (en) 2020-11-19
JOP20200258A1 (en) 2020-10-11
TW202003586A (en) 2020-01-16
BR112020020823A2 (en) 2021-01-19
US20220017584A1 (en) 2022-01-20
CA3096097A1 (en) 2019-10-17
US12054527B2 (en) 2024-08-06
US20240327481A1 (en) 2024-10-03
KR20200140878A (en) 2020-12-16
CO2020012563A2 (en) 2020-10-30
MX2020010659A (en) 2020-10-28
EP3773656A1 (en) 2021-02-17
CN111954537A (en) 2020-11-17
JP2022095856A (en) 2022-06-28

Similar Documents

Publication Publication Date Title
IL277842A (en) Growth differentiation factor 15 fusion proteins
SG11202011743SA (en) Fusion proteins comprising progranulin
IL281954A (en) Heterodimeric fc-fused proteins
IL282267A (en) Programmable dna base editing by nme2cas9-deaminase fusion proteins
IL281962A (en) Il-12 heterodimeric fc-fusion proteins
EP3880814A4 (en) Fusion protein
EP3743438A4 (en) Cytokine fusion proteins
EP3620474A4 (en) Human fibroblast growth factor 21 (hfgf21) fusion protein, preparation method therefor, and use thereof
SG11202012004SA (en) Rna-targeting fusion protein compositions and methods for use
EP3757218A4 (en) Fusion protein
EP3755726A4 (en) Fusion proteins for base editing
ZA202005385B (en) Growth differentiation factor 15 agonist compounds and methods of using the same
IL290660A (en) Therapeutic fusion proteins
ZA202003845B (en) Fusion proteins
SG11202101904UA (en) Spd-1 variant - fc fusion proteins
IL273271A (en) Fusion protein comprising an fgf-18 moiety
ZA202007491B (en) Stable fusion protein formulation
EP3697428A4 (en) Artificial secretion peptides for heterologous protein production
IL281088A (en) Flt3l-based chimeric proteins
EP3848388A4 (en) Fusion polypeptide comprising polypeptide region that can be o-glycosylated
EP3873918A4 (en) Insecticidal proteins
GB201816873D0 (en) Fusion protein
IL290715A (en) Nkg2d fusion proteins and uses thereof
IL291618A (en) Heterodimeric proteins
EP3897104A4 (en) Insecticidal proteins