SG11201906225PA - Maintenance and expansion of pancreatic progenitor cells - Google Patents
Maintenance and expansion of pancreatic progenitor cellsInfo
- Publication number
- SG11201906225PA SG11201906225PA SG11201906225PA SG11201906225PA SG11201906225PA SG 11201906225P A SG11201906225P A SG 11201906225PA SG 11201906225P A SG11201906225P A SG 11201906225PA SG 11201906225P A SG11201906225P A SG 11201906225PA SG 11201906225P A SG11201906225P A SG 11201906225PA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- singapore
- pct
- rule
- pancreatic progenitor
- Prior art date
Links
- 210000000130 stem cell Anatomy 0.000 title abstract 3
- 238000012423 maintenance Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 4
- 210000004027 cell Anatomy 0.000 abstract 3
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 229930002330 retinoic acid Natural products 0.000 abstract 2
- 229960001727 tretinoin Drugs 0.000 abstract 2
- 108010071289 Factor XIII Proteins 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 239000011148 porous material Substances 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 abstract 1
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
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- C12N2500/00—Specific components of cell culture medium
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
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- Health & Medical Sciences (AREA)
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- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
FigW O 20 18/ 136005 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 26 July 2018 (26.07.2018) WIPO I PCT omit VIII °nolo oilimioonsomo oimIE (10) International Publication Number WO 2018/136005 Al (51) International Patent Classification: C12N 5/071 (2010.01) (21) International Application Number: PCT/SG2018/050029 (22) International Filing Date: 17 January 2018 (17.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201700390Q 17 January 2017 (17.01.2017) SG (71) Applicant: AGENCY FOR SCIENCE, TECHNOLO- GY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10 Connexis North Tower, Singapore 138632 (SG). (72) Inventors: TROTT, Jamie; c/o Institute of Medical Biol- ogy, 8A Biomedical Grove, #06-06 Immunos, Singapore 138648 (SG). DUNN, Norris Ray; c/o Institute of Medical Biology, 8A Biomedical Grove, #06-06 Immunos, Singa- pore 138648 (SG). (74) Agent: SPRUSON & FERGUSON (ASIA) PTE LTD; P.O. Box 1531, Robinson Road Post Office, Singapore 903031 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: of inventorship (Rule 4.17(iv)) (54) Title: MAINTENANCE AND EXPANSION OF PANCREATIC PROGENITOR CELLS (57) : The present invention relates to a method of culturing a pancreatic progenitor cell. The method comprises contacting the cell with epidermal growth factor (EGF), retinoic acid (RA) and an inhibitor of transforming growth factor-13 (TGF-13) and 3T3-J2 feeder cells. A cell produced by the method of the invention and a kit when used in the method are also provided. C. [Continued on next page] WO 2018/136005 Al MIDEDIMOHNOBEIEDEMIIMINNIMMENDIS Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG10201700390Q | 2017-01-17 | ||
| PCT/SG2018/050029 WO2018136005A1 (en) | 2017-01-17 | 2018-01-17 | Maintenance and expansion of pancreatic progenitor cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201906225PA true SG11201906225PA (en) | 2019-08-27 |
Family
ID=62909288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201906225PA SG11201906225PA (en) | 2017-01-17 | 2018-01-17 | Maintenance and expansion of pancreatic progenitor cells |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20200140826A1 (en) |
| EP (1) | EP3571291A4 (en) |
| JP (1) | JP2020506679A (en) |
| CN (1) | CN110392735A (en) |
| SG (1) | SG11201906225PA (en) |
| WO (1) | WO2018136005A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019060548A1 (en) * | 2017-09-20 | 2019-03-28 | Mora Sergio | Method of expansion of human pancreas progenitor cells from stem cells using feeder-conditioned media |
| KR20210077698A (en) * | 2018-10-15 | 2021-06-25 | 사이니티 가부시키가이샤 | Method for producing stem/progenitor cells from endoderm tissue or organ-derived cells using low molecular weight compounds |
| WO2021221104A1 (en) * | 2020-04-30 | 2021-11-04 | 国立大学法人京都大学 | Method for proliferation of pancreatic progenitor cells |
| CN111808795A (en) * | 2020-06-28 | 2020-10-23 | 广东省医疗器械研究所 | Hepatocyte in-vitro co-culture system and construction method and application thereof |
| CN112961823B (en) * | 2021-03-19 | 2024-01-23 | 上海爱萨尔生物科技有限公司 | Culture solution for preparing islet beta cells by inducing directional differentiation of pluripotent stem cells |
| CN113046299B (en) * | 2021-03-19 | 2024-06-28 | 上海爱萨尔生物科技有限公司 | Additive for preparing islet beta cells by inducing directional differentiation of pluripotent stem cells |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2460602A1 (en) * | 2004-03-05 | 2005-09-05 | Raewyn Seaberg | Pancreatic multipotent progenitor cells |
| JP2011520470A (en) * | 2008-05-22 | 2011-07-21 | ヴェスタ セラピューティクス，インコーポレーテッド | Method for differentiating mammalian progenitor cells into insulin-producing islet cells |
| KR20160027219A (en) * | 2012-05-23 | 2016-03-09 | 에프. 호프만-라 로슈 아게 | Compositions and methods of obtaining and using endoderm and hepatocyte cells |
| GB201216796D0 (en) * | 2012-09-20 | 2012-11-07 | Cambridge Entpr Ltd | In vitro pancreatic differentiation |
| SG11201503045YA (en) * | 2012-10-19 | 2015-05-28 | Agency Science Tech & Res | Methods of differentiating stem cells into one or more cell lineages |
| US8859286B2 (en) * | 2013-03-14 | 2014-10-14 | Viacyte, Inc. | In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells |
| SG11201700874SA (en) * | 2014-08-04 | 2017-03-30 | Takeda Pharmaceuticals Co | Method for proliferation of pancreatic progenitor cells |
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2018
- 2018-01-17 SG SG11201906225PA patent/SG11201906225PA/en unknown
- 2018-01-17 US US16/478,307 patent/US20200140826A1/en not_active Abandoned
- 2018-01-17 JP JP2019537346A patent/JP2020506679A/en active Pending
- 2018-01-17 WO PCT/SG2018/050029 patent/WO2018136005A1/en unknown
- 2018-01-17 CN CN201880017313.4A patent/CN110392735A/en active Pending
- 2018-01-17 EP EP18741578.1A patent/EP3571291A4/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018136005A1 (en) | 2018-07-26 |
| EP3571291A4 (en) | 2020-08-19 |
| CN110392735A (en) | 2019-10-29 |
| EP3571291A1 (en) | 2019-11-27 |
| JP2020506679A (en) | 2020-03-05 |
| US20200140826A1 (en) | 2020-05-07 |
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