[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

SG10201401681PA - Novel antigen binding proteins - Google Patents

Novel antigen binding proteins

Info

Publication number
SG10201401681PA
SG10201401681PA SG10201401681PA SG10201401681PA SG10201401681PA SG 10201401681P A SG10201401681P A SG 10201401681PA SG 10201401681P A SG10201401681P A SG 10201401681PA SG 10201401681P A SG10201401681P A SG 10201401681PA SG 10201401681P A SG10201401681P A SG 10201401681PA
Authority
SG
Singapore
Prior art keywords
antigen binding
binding proteins
novel antigen
novel
proteins
Prior art date
Application number
SG10201401681PA
Inventor
Neil James Clarke
Kyung Oh Johanson
Zdenka Ludmila Jonak
Alexander H Taylor
Christopher B Hopson
Stephen H Trulli
Zdenka Haskova
Judithann M Lee
John R White
Yu Xue
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45773540&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201401681P(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of SG10201401681PA publication Critical patent/SG10201401681PA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG10201401681PA 2010-09-03 2011-09-02 Novel antigen binding proteins SG10201401681PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37984010P 2010-09-03 2010-09-03
US201161440460P 2011-02-08 2011-02-08

Publications (1)

Publication Number Publication Date
SG10201401681PA true SG10201401681PA (en) 2014-07-30

Family

ID=45773540

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201401681PA SG10201401681PA (en) 2010-09-03 2011-09-02 Novel antigen binding proteins
SG2013013057A SG187930A1 (en) 2010-09-03 2011-09-02 Novel antigen binding proteins

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG2013013057A SG187930A1 (en) 2010-09-03 2011-09-02 Novel antigen binding proteins

Country Status (20)

Country Link
US (1) US9085622B2 (en)
EP (1) EP2611829A4 (en)
JP (1) JP2013544492A (en)
KR (1) KR20130101047A (en)
CN (1) CN103189391A (en)
AU (1) AU2011295726B2 (en)
BR (1) BR112013005242A2 (en)
CA (1) CA2809443A1 (en)
CL (1) CL2013000566A1 (en)
CO (1) CO6690769A2 (en)
CR (1) CR20130128A (en)
EA (1) EA201390328A1 (en)
MA (1) MA34555B1 (en)
MX (1) MX2013002535A (en)
NZ (1) NZ607680A (en)
PE (1) PE20140133A1 (en)
SG (2) SG10201401681PA (en)
TW (1) TW201302793A (en)
UY (1) UY33591A (en)
WO (1) WO2012031198A2 (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA107821C2 (en) 2009-12-22 2015-02-25 Roche Glycart Ag Antibody her3 and its application
UA114883C2 (en) 2010-08-20 2017-08-28 Новартіс Аг Antibodies for epidermal growth factor receptor 3 (her3)
WO2013078191A1 (en) 2011-11-23 2013-05-30 Medimmune, Llc Binding molecules specific for her3 and uses thereof
US9192663B2 (en) 2011-12-05 2015-11-24 Novartis Ag Antibodies for epidermal growth factor receptor 3 (HER3)
BR112014013495A8 (en) * 2011-12-05 2017-06-13 Novartis Ag antibodies to epidermal growth factor receptor 3 (her3) targeting her3 domain iii and domain iv
EP2807272A1 (en) * 2012-01-27 2014-12-03 Ventana Medical Systems, Inc. Devices and methods for detecting bio-analytes using optically decipherable patterns
PE20150955A1 (en) 2012-11-08 2015-06-20 Hoffmann La Roche ANTI-HER3 / HER4 ANTIGEN BINDING PROTEINS BINDING TO HER3 BETA FORK AND HER4 BETA FORK
CN104755500B (en) 2012-11-08 2020-10-02 霍夫曼-拉罗奇有限公司 HER3 antigen binding proteins that bind to the HER3 beta-hairpin
AR094403A1 (en) 2013-01-11 2015-07-29 Hoffmann La Roche ANTI-HER3 ANTIBODY COMBINATION THERAPY
WO2015048008A2 (en) 2013-09-24 2015-04-02 Medimmune, Llc Binding molecules specific for her3 and uses thereof
CA2924386C (en) * 2013-10-04 2021-07-20 F. Hoffmann-La Roche Ag Antibodies specifically binding to her3
ES2816624T3 (en) 2014-02-28 2021-04-05 Merus Nv Antibodies that bind EGFR and ERBB3
SI3110849T1 (en) * 2014-02-28 2021-01-29 Merus N.V. Antibody that binds erbb-2 and erbb-3
US10745490B2 (en) 2014-04-11 2020-08-18 Celldex Therapeutics, Inc. Anti-ErbB antibodies and methods of use thereof
EP3134115A4 (en) * 2014-04-25 2017-10-25 The Trustees Of The University Of Pennsylvania Methods and compositions for treating metastatic breast cancer and other cancers in the brain
MX2016014416A (en) 2014-05-14 2017-02-23 Hoffmann La Roche Anti-her3 antibodies binding to the beta-hairpin of her3.
KR20190143491A (en) 2014-06-30 2019-12-30 타베다 세라퓨틱스, 인코포레이티드 Targeted conjugates and particles and formulations thereof
US11254933B2 (en) * 2014-07-14 2022-02-22 The Regents Of The University Of California CRISPR/Cas transcriptional modulation
WO2016038610A1 (en) 2014-09-08 2016-03-17 Yeda Research And Development Co. Ltd. Compositions and methods for treating cancer resistant to a tyrosine kinase inhibitor (tki)
CA2959716A1 (en) 2014-09-08 2016-03-17 Yeda Research And Development Co. Ltd. Anti-her3 antibodies and uses of same
WO2016059602A2 (en) * 2014-10-16 2016-04-21 Glaxo Group Limited Methods of treating cancer and related compositions
JP7296728B2 (en) 2015-10-23 2023-06-23 メルス ナムローゼ フェンノートシャップ Binding molecules that suppress cancer growth
US11160871B2 (en) 2015-10-28 2021-11-02 Tarveda Therapeutics, Inc. SSTR-targeted conjugates and particles and formulations thereof
TWI778491B (en) 2015-11-30 2022-09-21 美商輝瑞股份有限公司 Site specific her2 antibody drug conjugates
CN108602890A (en) 2015-12-11 2018-09-28 瑞泽恩制药公司 Method for reducing or preventing the tumour growth resistant to EGFR and/or ERBB3 retarding agents
EP3429623A1 (en) 2016-03-15 2019-01-23 Merrimack Pharmaceuticals, Inc. Methods for treating er+, her2-, hrg+ breast cancer using combination therapies comprising an anti-erbb3 antibody
SI3468621T1 (en) * 2016-06-10 2023-01-31 Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts The core domain of annexins and uses thereof in antigen delivery and vaccination
CN106543286A (en) * 2016-12-07 2017-03-29 上海邦耀生物科技有限公司 One kind goes fucose Anti-HER 2 and its application
BR112019020508A2 (en) 2017-03-31 2020-08-04 Merus N.V. bispecific antibodies binding to erbb-2 and erbb3 for use in the treatment of cells that have an nrg1 fusion gene
EP3630830A1 (en) * 2017-05-23 2020-04-08 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Novel cd73 antibody, preparation and uses thereof
EA202090215A1 (en) 2017-08-09 2020-07-01 Мерус Н.В. ANTIBODIES BINDING EGFR AND cMET
WO2019173417A1 (en) * 2018-03-08 2019-09-12 Phanes Therapeutics, Inc. Anti-tip-1 antibodies and uses thereof
WO2019185164A1 (en) * 2018-03-29 2019-10-03 Hummingbird Bioscience Holdings Pte. Ltd. Her3 antigen-binding molecules
US20210130495A1 (en) * 2019-09-27 2021-05-06 Agenus Inc. Heterodimeric proteins
WO2023196658A2 (en) * 2022-04-08 2023-10-12 Cz Biohub Sf, Llc Antibody compositions and optimization methods
CN116286828B (en) * 2023-05-12 2023-08-18 中国人民解放军军事科学院军事医学研究院 Oligonucleotide siRNA and application thereof in preparation of drugs for preventing and treating liver cancer
CN117903311B (en) * 2024-03-20 2024-10-25 湖南卓润生物科技有限公司 SST2 specific binding protein, and preparation method and application thereof

Family Cites Families (238)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5183884A (en) 1989-12-01 1993-02-02 United States Of America Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
US6639061B1 (en) 1999-07-07 2003-10-28 Isis Pharmaceuticals, Inc. C3′-methylene hydrogen phosphonate oligomers and related compounds
US5804396A (en) 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
AU4155696A (en) 1994-11-09 1996-06-06 Regents Of The University Of California, The Immunoliposomes that optimize internalization into target cells
CA2589421C (en) 1996-03-27 2012-12-18 Genentech, Inc. Erbb3 antibodies
EP1728802A3 (en) 1996-03-27 2006-12-13 Genentech, Inc. ErbB3 antibodies
US5968511A (en) 1996-03-27 1999-10-19 Genentech, Inc. ErbB3 antibodies
US5922845A (en) 1996-07-11 1999-07-13 Medarex, Inc. Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
JP4274581B2 (en) 1996-07-12 2009-06-10 ジェネンテック・インコーポレーテッド Chimera heteromultimer adhering body
US20020002276A1 (en) 1997-02-10 2002-01-03 Genentech, Inc. Chimeric heteromultimer adhesins
US6723694B1 (en) 1997-05-21 2004-04-20 The Children's Medical Center Corp. Short peptides which selectively modulate intracellular signalling
US6416168B1 (en) 1997-07-15 2002-07-09 Silverbrook Research Pty Ltd Pump action refill ink jet printing mechanism
ZA9811162B (en) 1997-12-12 2000-06-07 Genentech Inc Treatment with anti-ERBB2 antibodies.
AU2003203831B2 (en) 1998-02-04 2006-08-10 Genentech, Inc. Use of heregulin as an epithelial cell growth factor
US20010023241A1 (en) 1998-02-04 2001-09-20 Sliwkowski Mark X. Use of heregulin as a growth factor
AU2581599A (en) 1998-02-04 1999-08-23 Genentech Inc. Use of heregulin as an epithelial cell growth factor
US6417168B1 (en) 1998-03-04 2002-07-09 The Trustees Of The University Of Pennsylvania Compositions and methods of treating tumors
EP2016951B1 (en) 1998-03-17 2012-06-27 Genentech, Inc. Polypeptides homologous to VEGF and BMP1
WO1999054342A1 (en) 1998-04-20 1999-10-28 Pablo Umana Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
AU2004200705A1 (en) 1998-05-15 2004-03-18 Imclone Systems Incorporated Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases
ZA200007412B (en) 1998-05-15 2002-03-12 Imclone Systems Inc Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases.
JP2002515511A (en) 1998-05-15 2002-05-28 イムクローン システムズ インコーポレイティド Treatment of human tumors using inhibitors of radiation and growth factor receptor tyrosine kinase
WO2000027426A1 (en) 1998-11-07 2000-05-18 Genentech, Inc. Method for enhancing proliferation of inner ear hair cells using ligands for her2 and/or her3 receptors
US7183387B1 (en) 1999-01-15 2007-02-27 Genentech, Inc. Polypeptide variants with altered effector function
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
JP2002544123A (en) * 1999-04-14 2002-12-24 スミスクライン・ビーチャム・コーポレイション Erythropoietin receptor antibody
US7534866B2 (en) 2005-10-19 2009-05-19 Ibc Pharmaceuticals, Inc. Methods and compositions for generating bioactive assemblies of increased complexity and uses
CA2370466C (en) 1999-06-25 2011-02-08 Sharon Erickson Methods of treatment using anti-erbb antibody-maytansinoid conjugates
US6710186B2 (en) 1999-06-14 2004-03-23 Wisconsin Alumni Research Foundation Oligomers and polymers of di-substituted cyclic imino carboxylic acids
AUPQ105799A0 (en) 1999-06-18 1999-07-08 Victor Chang Cardiac Research Institute, The Cell growth inhibition
CH694589A5 (en) 1999-06-25 2005-04-15 Genentech Inc Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies.
US6949245B1 (en) 1999-06-25 2005-09-27 Genentech, Inc. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
IL148114A0 (en) 1999-08-27 2002-09-12 Genentech Inc DOSAGES FOR TREATMENT WITH ANTI-ErbB2 ANTIBODIES
US7390632B2 (en) 1999-09-30 2008-06-24 Tumor Biology Investment Group, Inc. Soluble ErbB3 receptor isoforms
US7732157B1 (en) 1999-09-30 2010-06-08 Tumor Biology Investment Group Soluble epidermal growth factor receptor-like proteins and their uses in cancer detection methods
US7651703B2 (en) 1999-10-15 2010-01-26 Genentech, Inc. Injection vehicle for polymer-based formulations
ATE271691T1 (en) 2000-01-12 2004-08-15 Ventana Med Syst Inc METHOD FOR DETECTING THE EFFECTIVENESS OF CANCER THERAPY
DE60028830T2 (en) 2000-02-16 2007-01-18 Genentech, Inc., South San Francisco ANTI-APRIL ANTIBODIES AND HYBRIDOMA CELLS
US7097840B2 (en) 2000-03-16 2006-08-29 Genentech, Inc. Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
US6632979B2 (en) 2000-03-16 2003-10-14 Genentech, Inc. Rodent HER2 tumor model
AU2007216733A1 (en) 2000-04-11 2007-09-27 Genentech, Inc. Multivalent antibodies and uses therefor
HUP0300369A2 (en) 2000-04-11 2003-06-28 Genentech, Inc. Multivalent antibodies and uses therefor
FR2807767B1 (en) 2000-04-12 2005-01-14 Lab Francais Du Fractionnement MONOCLONAL ANTIBODIES ANTI-D
AUPQ903400A0 (en) 2000-07-27 2000-08-17 Oh, Young June Navigable search engine
US6277640B1 (en) 2000-07-31 2001-08-21 Isis Pharmaceuticals, Inc. Antisense modulation of Her-3 expression
AU2002221891A1 (en) 2000-11-24 2002-06-03 Carl Freudenberg Kg Floor mop
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
AU2008200400B2 (en) 2001-01-17 2012-06-07 Aptevo Research And Development Llc Binding domain-immunoglobulin fusion proteins
EP1228766A1 (en) 2001-01-31 2002-08-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. PYK2 phosphorylation by HER3 induces tumor invasion
CA2437814C (en) 2001-02-12 2008-05-13 Medarex, Inc. Human monoclonal antibodies to fc alpha receptor (cd89)
WO2002081649A2 (en) 2001-04-06 2002-10-17 The Trustees Of The University Of Pennsylvania ErbB INTERFACE PEPTIDOMIMETICS AND METHODS OF USE THEREOF
WO2002087618A1 (en) 2001-04-27 2002-11-07 Takeda Chemical Industries, Ltd. Preventive/therapeutic method for cancer
AU2002310012A1 (en) 2001-05-21 2002-12-03 Monogram Biosciences, Inc. Methods and compositions for analyzing proteins
US7744882B2 (en) 2001-05-31 2010-06-29 Tumor Biology Investment Group, Inc. Soluble ErbB3 methods of detection and antibodies
US7745398B2 (en) 2001-05-31 2010-06-29 Tumor Biology Investment Group, Inc. Soluble ErbB3 and treatment of cancer
EP1423428B2 (en) 2001-06-20 2012-11-14 Fibron Ltd. Antibodies that block fgfr3 activation, methods of screening for and uses thereof
WO2003001602A2 (en) 2001-06-21 2003-01-03 Akzo Nobel N.V. Manufacturing a solar cell foil connected in series via a temporary substrate
WO2003011897A1 (en) 2001-07-27 2003-02-13 The Regents Of The University Of California Modulation of heregulin and her3 interaction
DE10137374A1 (en) 2001-07-31 2003-02-27 Ipk Inst Fuer Pflanzengenetik Process for the production of arachidonic acid in transgenic organisms
US7662374B2 (en) 2001-08-03 2010-02-16 The Trustees Of The University Of Pennsylvania Monoclonal antibodies to activated erbB family members and methods of use thereof
AU2008200654B2 (en) 2001-08-09 2010-04-29 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Inhibitors of HER3 activity
EP1283053A1 (en) 2001-08-09 2003-02-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibitors of HER3 activity
WO2005063299A2 (en) 2003-12-24 2005-07-14 Genentech, Inc. Compositions and methods for the treatment of tumor of hematopoietic origin
US8877901B2 (en) 2002-12-13 2014-11-04 Immunomedics, Inc. Camptothecin-binding moiety conjugates
US7591994B2 (en) 2002-12-13 2009-09-22 Immunomedics, Inc. Camptothecin-binding moiety conjugates
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
JP4132912B2 (en) 2002-03-26 2008-08-13 日東電工株式会社 Gel electrolyte, its production method and its use
CA2480099C (en) 2002-03-26 2019-01-08 Zensun (Shanghai) Sci-Tech. Ltd. Erbb3 based methods and compositions for treating neoplasms
US7332585B2 (en) 2002-04-05 2008-02-19 The Regents Of The California University Bispecific single chain Fv antibody molecules and methods of use thereof
US7332580B2 (en) 2002-04-05 2008-02-19 The Regents Of The University Of California Bispecific single chain Fv antibody molecules and methods of use thereof
JP4319979B2 (en) 2002-04-26 2009-08-26 ジェネンテック・インコーポレーテッド Non-affinity purification of proteins
US20040229294A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US20040229380A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB heterodimers as biomarkers
US20040229293A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui Surface receptor complexes as biomarkers
US20040229299A1 (en) 2002-05-21 2004-11-18 Badal M. Youssouf Intracellular complexes as biomarkers
WO2004000102A2 (en) 2002-06-19 2003-12-31 Abgenix, Inc. Method for predicting response to epidermal growth factor receptor-directed therapy
ES2392525T3 (en) 2002-07-15 2012-12-11 F. Hoffmann-La Roche Ag Cancer treatment with the antibody directed against ErbB2 rhuMAb 2C4
JP4443407B2 (en) 2002-07-25 2010-03-31 アクララ バイオサイエンシーズ， インコーポレイテッド Detection of receptor oligomer formation
GB0225282D0 (en) 2002-10-31 2002-12-11 Astrazeneca Ab assay
CA2513113A1 (en) 2003-01-23 2004-08-05 Genentech, Inc. Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture
US20060233808A1 (en) 2003-04-04 2006-10-19 David Deperthes Peptabody for cancer treatment
US7189694B2 (en) 2003-04-18 2007-03-13 University Of Florida Research Foundation, Inc. Inhibitors of autophosphorylation protein kinases
MXPA05012939A (en) 2003-05-30 2006-05-17 Astrazeneca Uk Ltd Process.
DK1636593T5 (en) 2003-06-06 2009-07-27 Genentech Inc Modulating the interaction between HGF-beta chain and c-met
WO2005001048A2 (en) 2003-06-13 2005-01-06 Oncomax Acquisition Corp. Preparation and application of anti-tumor bifunctional fusion proteins
US20040254108A1 (en) 2003-06-13 2004-12-16 Jing Ma Preparation and application of anti-tumor bifunctional fusion proteins
US20050232931A1 (en) 2003-06-13 2005-10-20 Oncomax Acquisition Corp. Preparation and application of anti-tumor bifunctional fusion proteins
US6836094B1 (en) 2003-07-01 2004-12-28 International Truck Intellectual Property Company, Llc Motor vehicle battery disconnect switch circuits
WO2005040339A2 (en) 2003-07-18 2005-05-06 The Regents Of The University Of California Aptamers to human epidermal growth factor receptor-3
EP3095793B1 (en) 2003-07-28 2020-03-25 Genentech, Inc. Reducing protein a leaching during protein a affinity chromatography
CA2534362A1 (en) 2003-08-05 2005-02-17 Euro-Celtique S.A. Erbb receptor methods and kits for monitoring chemotherapy resistance
US20050079184A1 (en) 2003-08-08 2005-04-14 Immunomedics, Inc. Bispecific antibodies for inducing apoptosis of tumor and diseased cells
JP2007502417A (en) 2003-08-11 2007-02-08 モノグラム バイオサイエンシズ，インコーポレーテッド Detection and characterization of molecular complexes
US8399618B2 (en) 2004-10-21 2013-03-19 Xencor, Inc. Immunoglobulin insertions, deletions, and substitutions
EP1681983A4 (en) 2003-10-14 2008-12-10 Monogram Biosciences Inc Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy
WO2005045058A2 (en) 2003-10-27 2005-05-19 Monogram Biosciences, Inc. Detecting human anti-therapeutic antibodies
CA2544863A1 (en) 2003-11-06 2005-05-19 Pfizer Products Inc. Selective erbb2 inhibitor/anti-erbb antibody combinations in the treatment of cancer
US7754441B2 (en) 2003-11-17 2010-07-13 Genentech, Inc. Compositions and methods for the treatment of tumor of hematopoietic origin
US7235641B2 (en) 2003-12-22 2007-06-26 Micromet Ag Bispecific antibodies
WO2006107617A2 (en) 2005-04-06 2006-10-12 Ibc Pharmaceuticals, Inc. Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses
WO2005079434A2 (en) 2004-02-17 2005-09-01 The University Of North Carolina At Chapel Hill Modulation of epidermal growth factor heterodimer activity
US7906624B2 (en) 2004-02-20 2011-03-15 The Trustees Of The University Of Pennsylvania Binding peptidomimetics and uses of the same
WO2005112969A2 (en) 2004-04-22 2005-12-01 Oregon Health And Science University Herstatin or intron 8-encoded domain thereof for modulating signaling mediated by igf-1 receptor and erbb receptors
JP2007536254A (en) 2004-05-05 2007-12-13 メリマック ファーマシューティカルズ インコーポレーティッド Bispecific binding agents for modulating biological activity
KR20070039911A (en) 2004-06-01 2007-04-13 도만티스 리미티드 Bispecific fusion antibodies with enhanced serum half-life
CA2567520A1 (en) 2004-06-01 2005-12-15 Genentech, Inc. Maytansinoid-antibody conjugates
SV2006002143A (en) 2004-06-16 2006-01-26 Genentech Inc USE OF AN ANTIBODY FOR THE TREATMENT OF CANCER RESISTANT TO PLATINUM
NZ551934A (en) 2004-06-24 2009-09-25 Inst Medical W & E Hall Conjugates comprising a targeting moiety and a peptide that mimics the apoptosis-inducing BH3-only proteins
PT1771482E (en) 2004-07-22 2014-11-03 Genentech Inc Her2 antibody composition
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
EP3088004B1 (en) 2004-09-23 2018-03-28 Genentech, Inc. Cysteine engineered antibodies and conjugates
AU2005294347A1 (en) 2004-10-05 2006-04-20 Oregon Health And Science University Compositions and methods for treating disease
CN102746404B (en) 2004-11-12 2016-01-20 赞科股份有限公司 To FcRn in conjunction with reformed Fc variant
US20060122185A1 (en) 2004-11-22 2006-06-08 Jeremy Green Bicyclic inhibitors of Rho kinase
US7947839B2 (en) 2004-12-01 2011-05-24 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
ES2356830T3 (en) * 2004-12-03 2011-04-13 Schering Corporation BIOMARCATORS FOR PRESELECTION OF PATIENTS FOR ANTI-IGF-1R THERAPY.
RU2007125644A (en) 2004-12-07 2009-01-20 Дженентек Инк. (Us) SELECTION OF PATIENTS FOR THERAPY WITH HER INHIBITOR
US7807789B2 (en) 2004-12-21 2010-10-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in EGFR-signaling pathways
WO2006068640A1 (en) 2004-12-21 2006-06-29 Cell Signaling Technology, Inc. Protein phosphorylation in egfr-signaling pathways
EP1699826B1 (en) 2005-01-05 2009-03-11 f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions
CN101365712A (en) 2005-01-11 2009-02-11 莫勒丘尔洛吉克斯有限公司 Pan-her antagonists and methods of use
WO2006078307A1 (en) 2005-01-21 2006-07-27 Genentech, Inc. Fixed dosing of her antibodies
WO2006084018A2 (en) 2005-02-02 2006-08-10 Monogram Biosciences, Inc. Methods for determining responsiveness to cancer therapy
CN101115773B (en) 2005-02-07 2015-06-10 罗氏格黎卡特股份公司 Antigen binding molecules that bind egfr, vectors encoding same, and uses thereof
US7718626B2 (en) 2005-02-17 2010-05-18 University Of Maryland, Baltimore ErbB3 binding protein compositions and methods of use
BRPI0606542A8 (en) 2005-02-23 2018-03-20 Genentech Inc methods to increase the time to disease progression (ttp)
RU2007135216A (en) 2005-02-23 2009-03-27 Мерримак Фармасьютикалз, Инк. (Us) BSPECIFIC BINDING AGENTS FOR MODULATION OF BIOLOGICAL ACTIVITY
US7210618B2 (en) 2005-03-03 2007-05-01 Nokia Corporation Mobile communication terminal
KR20080004480A (en) 2005-03-07 2008-01-09 타게티드 몰레큘라 다이아그노스틱스, 엘엘씨 Tyrosine kinase inhibitor compositions and methods for manufacturing and using them in the treatment of disease
TW200642695A (en) 2005-03-08 2006-12-16 Genentech Inc Methods for identifying tumors responsive to treatment with her dimerization inhibitors (HDIs)
DK1874821T3 (en) 2005-04-26 2013-07-08 Trion Pharma Gmbh Combination of antibodies with glycocorticoids to treat cancer
WO2007015935A2 (en) 2005-07-29 2007-02-08 Bayer Healthcare Llc Diagnostic methods for the prediction of therapeutic success, recurrence free and overall survival in cancer therapy
CN101291954B (en) 2005-08-26 2013-03-27 罗氏格黎卡特股份公司 Modified antigen binding molecules with altered cell signaling activity
CA2624086A1 (en) 2005-09-28 2007-04-05 H. Lee Moffitt Cancer Center Individualized cancer treatments
AU2006299429B2 (en) 2005-10-03 2012-02-23 Xencor, Inc. Fc variants with optimized Fc receptor binding properties
US20090252681A1 (en) 2005-10-11 2009-10-08 Ablynx N.V. Nanobodies and Polypeptides Against EGFR and IGF-IR
WO2007050495A2 (en) 2005-10-26 2007-05-03 Children's Medical Center Corporation Method to prognose response to anti-egfr therapeutics
EP1792622A1 (en) 2005-11-11 2007-06-06 GPC Biotech AG Anti-proliferative combination therapy comprising a platinum-based chemotherapeutic agent and EGFR inhibitors or pyrimidine analogues
JP5063612B2 (en) * 2005-12-13 2012-10-31 イーライ リリー アンド カンパニー Anti-IL-17 antibody
EP1800695A1 (en) 2005-12-21 2007-06-27 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Immuno-RNA-constructs
AR056857A1 (en) 2005-12-30 2007-10-24 U3 Pharma Ag DIRECTED ANTIBODIES TO HER-3 (RECEIVER OF THE HUMAN EPIDERMAL GROWTH FACTOR-3) AND ITS USES
US7498142B2 (en) 2006-01-31 2009-03-03 Yeda Research And Development Co., Ltd. Methods of identifying combinations of antibodies with an improved anti-tumor activity and compositions and methods using the antibodies
RU2008135318A (en) 2006-02-01 2010-03-10 Дзе Джонс Хопкинс Юниверсити (Us) POLYEPEPTIDE-NUCLEIC ACID CONJUGATE FOR IMMUNOPROPHYLAXIS OR IMMUNOTHERAPY OF NEOPLASTIC OR INFECTIOUS DISEASES
MX2008011874A (en) 2006-03-17 2009-01-07 Biogen Idec Inc Stabilized polypeptide compositions.
EP2049568A2 (en) 2006-04-07 2009-04-22 Københavns Universitet Erbb receptor-derived peptide fragments
JP2009539836A (en) 2006-06-05 2009-11-19 ジェネンテック・インコーポレーテッド Prolonged survival of cancer patients with elevated levels of EGF or TGF-α
CN101627053A (en) * 2006-06-12 2010-01-13 西福根有限公司 Pan-cell surface receptor- specific therapeutics
CA2654317A1 (en) 2006-06-12 2007-12-21 Trubion Pharmaceuticals, Inc. Single-chain multivalent binding proteins with effector function
WO2007145832A2 (en) 2006-06-13 2007-12-21 Shulman Zachary J Infant harness support
AR062223A1 (en) 2006-08-09 2008-10-22 Glycart Biotechnology Ag MOLECULES OF ADHESION TO THE ANTIGEN THAT ADHER TO EGFR, VECTORS THAT CODE THEM, AND THEIR USES OF THESE
US20100316626A1 (en) 2006-08-11 2010-12-16 The Government Of The United States Of America As Represented By The Secretary Methods for treatment and diagnosis of psychiatric disorders
US10118970B2 (en) 2006-08-30 2018-11-06 Genentech, Inc. Multispecific antibodies
US8936780B2 (en) 2006-08-30 2015-01-20 Advanced Cardiovascular Systems, Inc. Stimuli responsive polyester amide particles
EP2059530B1 (en) 2006-08-31 2012-08-29 F.Hoffmann-La Roche Ag Method for the production of insulin-like growth factor-i
BRPI0717416A2 (en) 2006-09-21 2013-11-12 Prometheus Lab Inc METHOD FOR PERFORMING A HIGH PRODUCTIVITY COMPLEX IMMUNOASON, AND
US20080076139A1 (en) 2006-09-21 2008-03-27 Sharat Singh Methods and compositions for detecting the activation states of multiple signal transducers in rare circulating cells
CN104198705B (en) 2006-09-21 2017-06-09 雀巢产品技术援助有限公司 Detect the array based on antibody of multiple signal transducers in rare circulating cells
US20080112961A1 (en) 2006-10-09 2008-05-15 Macrogenics, Inc. Identification and Engineering of Antibodies with Variant Fc Regions and Methods of Using Same
AU2007328427A1 (en) 2006-11-06 2008-06-12 Source Precision Medicine, Inc. Gene expression profiling for identification, monitoring and treatment of melanoma
AU2007353412A1 (en) 2006-11-21 2008-11-20 Fox Chase Cancer Center Anti-EGFR family antibodies, bispecific anti-EGFR family antibodies and methods of use thereof
WO2008064884A1 (en) 2006-11-28 2008-06-05 U3 Pharma Gmbh Activated her3 as a marker for predicting therapeutic efficacy
JP2010511382A (en) 2006-12-01 2010-04-15 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ Cancer-related protein kinase
WO2008140603A2 (en) 2006-12-08 2008-11-20 Macrogenics, Inc. METHODS FOR THE TREATMENT OF DISEASE USING IMMUNOGLOBULINS HAVING FC REGIONS WITH ALTERED AFFINITIES FOR FCγR ACTIVATING AND FCγR INHIBITING
US8569464B2 (en) 2006-12-21 2013-10-29 Emd Millipore Corporation Purification of proteins
US8362217B2 (en) 2006-12-21 2013-01-29 Emd Millipore Corporation Purification of proteins
WO2008079280A1 (en) 2006-12-21 2008-07-03 Millipore Corporation Purification of proteins
DE102007001370A1 (en) 2007-01-09 2008-07-10 Curevac Gmbh RNA-encoded antibodies
JP2010516675A (en) 2007-01-17 2010-05-20 イミューノメディクス、インコーポレイテッド Recognition moieties for polymer carriers of therapeutic agents and antibody-based targeting of disease sites
WO2008100624A2 (en) 2007-02-16 2008-08-21 Merrimack Pharmaceuticals, Inc. Antibodies against erbb3 and uses thereof
ES2477497T3 (en) 2007-03-02 2014-07-17 Genentech, Inc. Prediction of the response to an HER dimerization inhibitor based on low HER3 expression
PE20090190A1 (en) 2007-03-23 2009-03-22 Smithkline Beecham Corp COMBINATION OF ANTI-CD20 ANTIBODIES AND IL-18 POLYPEPTIDES
CN101636412A (en) 2007-03-30 2010-01-27 霍夫曼-拉罗奇有限公司 Mark and composition cold monoclonal antibody
EP2851091B1 (en) 2007-04-13 2017-12-27 Dana-Farber Cancer Institute, Inc. Methods for treating cancer resistant to ERBB therapeutics
FR2915115B1 (en) 2007-04-23 2010-09-10 Sames Technologies SPRAYING DEVICE, PROJECTION DEVICE COMPRISING SUCH AN ORGAN, PROJECTION PLANT AND METHOD OF CLEANING SUCH AN ORGAN
NZ599214A (en) 2007-06-01 2013-12-20 Univ California Multigene prognostic assay for lung cancer
MX2009012838A (en) 2007-06-06 2009-12-11 Hoffmann La Roche Composition of a first non-labeled monoclonal antibody binding to a tumor antigen and a non-cross reactive second monoclonal antibody labeled with a nir fluorescence label.
US20100183504A1 (en) 2007-06-14 2010-07-22 Fanqing Frank Chen Multimodal imaging probes for in vivo targeted and non-targeted imaging and therapeutics
US20110038865A1 (en) 2007-06-26 2011-02-17 University Of Miami Antibody- endostatin fusion protein and its variants
US8501417B2 (en) 2007-06-26 2013-08-06 Vanderbilt University Immunological compositions as cancer biomarkers and/or therapeutics
KR20100061442A (en) 2007-07-09 2010-06-07 제넨테크, 인크. Prevention of disulfide bond reduction during recombinant production of polypeptides
JP5352585B2 (en) 2007-07-13 2013-11-27 ネステク ソシエテ アノニム Drug selection for the treatment of lung cancer using antibody arrays
WO2009023266A1 (en) 2007-08-14 2009-02-19 Ludwig Institute For Cancer Research Generation of antibodies to cell-surface receptors and cancer-associated proteins including egfr family members
KR101759460B1 (en) 2007-09-21 2017-07-18 더 리전트 오브 더 유니버시티 오브 캘리포니아 Targeted interferon demonstrates potent apoptotic and anti-tumor activities
WO2009052830A1 (en) 2007-10-22 2009-04-30 Genmab A/S Novel antibody therapies
EP2230300A4 (en) 2007-10-24 2012-08-08 Otsuka Chemical Holdings Co Ltd Polypeptide having enhanced effector function
NZ617520A (en) 2008-02-25 2015-05-29 Nestec Sa Drug selection for breast cancer therapy using antibody-based arrays
EP2260056A1 (en) 2008-03-06 2010-12-15 Genentech, Inc. Combination therapy with c-met and her antagonists
EP2106806A1 (en) 2008-03-31 2009-10-07 Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung e.V. Nanoparticles for targeted delivery of active agents to the lung
CN102057054B (en) 2008-04-11 2015-06-10 梅里麦克制药股份有限公司 Human serum albumin linkers and conjugates thereof
NZ588554A (en) 2008-04-29 2013-03-28 Abbott Lab Dual variable domain immunoglobulins and uses thereof
BRPI0911442A2 (en) 2008-04-30 2019-03-12 Immunogen, Inc. potent conjugates and hydrophilic binders
WO2009134870A1 (en) 2008-04-30 2009-11-05 Immunogen, Inc. Potent cell-binding agent drug conjugates
UY31800A (en) 2008-05-05 2009-11-10 Smithkline Beckman Corp CANCER TREATMENT METHOD USING A CMET AND AXL INHIBITOR AND AN ERBB INHIBITOR
NZ589880A (en) 2008-06-16 2012-10-26 Immunogen Inc Use of synergistic anti-cancer compositions comprising lenalidomide, at least one corticosteroid and at least one immunoconjugate
EP2138511A1 (en) 2008-06-27 2009-12-30 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. HER3 as a determinant for the prognosis of melanoma
NZ603698A (en) * 2008-07-08 2014-03-28 Abbvie Inc Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
JP2011529172A (en) 2008-07-25 2011-12-01 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Method for measuring receptor binding saturation by monoclonal antibodies
US8056451B2 (en) 2008-07-28 2011-11-15 Irwin Industrial Tool Company Locking pliers
US20100033482A1 (en) 2008-08-11 2010-02-11 Interactive Relighting of Dynamic Refractive Objects Interactive Relighting of Dynamic Refractive Objects
JP2012500008A (en) 2008-08-15 2012-01-05 メリマック ファーマシューティカルズ インコーポレーティッド Methods and systems for predicting cellular responses to therapeutic agents
EP2340305A1 (en) 2008-09-26 2011-07-06 Eureka Therapeutics, Inc. Cell lines and proteins with variant glycosylation pattern
EP2361098B1 (en) 2008-10-31 2019-08-28 The General Hospital Corporation Compositions and methods for delivering a substance to a biological target
CA2779436A1 (en) 2008-10-31 2010-05-06 Biogen Idec Ma Inc. Light targeting molecules and uses thereof
WO2010059315A1 (en) 2008-11-18 2010-05-27 Merrimack Pharmaceuticals, Inc. Human serum albumin linkers and conjugates thereof
US20100169729A1 (en) 2008-12-30 2010-07-01 Datta Shamanna M Enabling an integrated memory controller to transparently work with defective memory devices
US20110306514A1 (en) 2009-01-14 2011-12-15 United States Department of Health and Human Services Ratio based biomarkers and methods of use thereof
CA2749817A1 (en) 2009-01-15 2010-07-22 Laboratory Corporation Of America Holdings Methods of determining patient response by measurement of her-2 expression
SG172983A1 (en) 2009-01-15 2011-08-29 Lab Corp America Holdings Methods of determining patient response by measurement of her-3
PL2396036T3 (en) 2009-02-13 2017-12-29 Immunomedics, Inc. Immunoconjugates with an intracellularly-cleavable linkage
WO2010097186A1 (en) 2009-02-24 2010-09-02 Roche Diagnostic Gmbh Use of s-erbb-3 as a marker for cancer
EP2400984A4 (en) 2009-02-25 2013-01-23 Merck Sharp & Dohme Her2 antibody compositions
AU2010226453B2 (en) 2009-03-20 2013-11-21 Genentech, Inc. Bispecific anti-HER antibodies
EP2425009A4 (en) 2009-04-29 2013-01-23 Trellis Bioscience Llc Improved antibodies immunoreactive with heregulin-coupled her3
WO2010136569A1 (en) 2009-05-29 2010-12-02 F. Hoffmann-La Roche Ag Modulators for her2 signaling in her2 expressing patients with gastric cancer
EP2711018A1 (en) 2009-06-22 2014-03-26 MedImmune, LLC Engineered Fc regions for site-specific conjugation
CA2768013C (en) 2009-07-15 2018-08-21 Prometheus Laboratories Inc. Drug selection for gastric cancer therapy using antibody-based arrays
KR20180035936A (en) 2009-08-06 2018-04-06 제넨테크, 인크. Method to improve virus removal in protein purification
US20110039300A1 (en) 2009-08-10 2011-02-17 Robert Bayer Antibodies with enhanced adcc functions
KR20120059568A (en) 2009-08-21 2012-06-08 메리맥 파마슈티컬즈, 인크. Antibodies against the ectodomain of erbb3 and uses thereof
WO2011031840A1 (en) 2009-09-09 2011-03-17 Quintiles Transnational Corp. Methods and compositions for the treatment of receptor tyrosine kinase mediated diseases or disorders
WO2011044368A1 (en) 2009-10-07 2011-04-14 Macrogenics, Inc. Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use
US20120195831A1 (en) 2009-10-09 2012-08-02 Ningyan Zhang Generation, characterization and uses thereof of anti-her3 antibodies
JP2013507926A (en) 2009-10-14 2013-03-07 メリマック ファーマシューティカルズ インコーポレーティッド Bispecific binding agents targeting IGF-1R and ErbB3 signaling and uses thereof
PT3351558T (en) 2009-11-13 2020-04-09 Daiichi Sankyo Europe Gmbh Material and methods for treating or preventing her-3 associated diseases
PL2536748T3 (en) 2010-02-18 2015-01-30 Genentech Inc Neuregulin antagonists and use thereof in treating cancer
US20130225424A1 (en) 2010-03-03 2013-08-29 Targeted Molecular Diagnostics, Llc Methods for determining responsiveness to a drug based upon determination of ras mutation and/or ras amplification
MX344355B (en) 2010-03-11 2016-12-14 Merrimack Pharmaceuticals Inc * Use of erbb3 inhibitors in the treatment of triple negative and basal-like breast cancers.
US8481687B2 (en) 2010-04-09 2013-07-09 Aveo Pharmaceuticals, Inc. Anti-ErbB3 antibodies
WO2011139629A2 (en) 2010-04-26 2011-11-10 Biogen Idec Ma Inc. Light targeting molecules and uses thereof
WO2011143414A1 (en) 2010-05-13 2011-11-17 Fox Chase Cancer Center RECOMBINANTLY PRODUCED ANTIBODIES TARGETING ErbB SIGNALING MOLECULES AND METHODS OF USE THEREOF FOR THE DIAGNOSIS AND TREATMENT OF DISEASE
WO2011146568A1 (en) 2010-05-19 2011-11-24 Genentech, Inc. Predicting response to a her inhibitor
CN102906118B (en) 2010-05-20 2017-07-28 埃博灵克斯股份有限公司 The biomaterial related to HER3
AU2012211258A1 (en) 2011-01-27 2013-03-21 Merrimack Pharmaceuticals, Inc. Treatment of advanced solid stage tumors using anti-ErbB3 antibodies
WO2012106578A1 (en) 2011-02-04 2012-08-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services HIV NEUTRALIZING ANTIBODIES HAVING MUTATIONS IN CONSTANT DOMAIN (Fc)
CA2825064C (en) 2011-02-04 2022-08-30 Genentech, Inc. Fc variants and methods for their production
EP2673299B1 (en) 2011-02-07 2017-05-10 Research Development Foundation Engineered immunoglobulin fc polypeptides
CN109797138A (en) 2011-03-06 2019-05-24 默克雪兰诺有限公司 Low fucose cell line and its application
CA2830501C (en) 2011-03-17 2023-10-17 Cernostics, Inc. Systems and compositions for diagnosing barrett's esophagus and methods of using the same

Also Published As

Publication number Publication date
JP2013544492A (en) 2013-12-19
EA201390328A1 (en) 2013-08-30
PE20140133A1 (en) 2014-02-09
EP2611829A4 (en) 2014-05-07
AU2011295726B2 (en) 2014-11-06
SG187930A1 (en) 2013-03-28
TW201302793A (en) 2013-01-16
CR20130128A (en) 2013-06-28
CA2809443A1 (en) 2012-03-08
US20130156779A1 (en) 2013-06-20
WO2012031198A3 (en) 2012-05-18
MX2013002535A (en) 2013-06-03
CO6690769A2 (en) 2013-06-17
BR112013005242A2 (en) 2016-06-28
US9085622B2 (en) 2015-07-21
NZ607680A (en) 2015-02-27
KR20130101047A (en) 2013-09-12
CL2013000566A1 (en) 2014-01-24
MA34555B1 (en) 2013-09-02
CN103189391A (en) 2013-07-03
UY33591A (en) 2012-03-30
EP2611829A2 (en) 2013-07-10
AU2011295726A1 (en) 2013-03-21
WO2012031198A2 (en) 2012-03-08

Similar Documents

Publication Publication Date Title
IL282226A (en) St2 antigen binding proteins
SG10201401681PA (en) Novel antigen binding proteins
EP2681239B8 (en) Antigen binding proteins
HK1170506A1 (en) Bispecific antigen binding proteins
HK1199042A1 (en) Cd27l antigen binding proteins cd27l
ZA201300975B (en) Binding proteins for hepcidin
ZA201304905B (en) TNF-a BINDING PROTEINS
ZA201208906B (en) Humanised antigen binding proteins to myostatin6
HK1174645A1 (en) Bispecific, tetravalent antigen binding proteins
IL222980A0 (en) Il-1 binding proteins
ZA201205624B (en) Cd127 binding proteins
IL226157A0 (en) Antigen binding proteins