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SE9901530D0 - Novel compounds - Google Patents

Novel compounds

Info

Publication number
SE9901530D0
SE9901530D0 SE9901530A SE9901530A SE9901530D0 SE 9901530 D0 SE9901530 D0 SE 9901530D0 SE 9901530 A SE9901530 A SE 9901530A SE 9901530 A SE9901530 A SE 9901530A SE 9901530 D0 SE9901530 D0 SE 9901530D0
Authority
SE
Sweden
Prior art keywords
novel compounds
compounds
tautomers
prophylaxis
enantiomers
Prior art date
Application number
SE9901530A
Other languages
Swedish (sv)
Inventor
David Cheshire
Stephen Connolly
David Cox
Peter Hamley
Antonio Mete
Austen Pimm
Michael Stocks
Original Assignee
Astra Pharma Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharma Prod filed Critical Astra Pharma Prod
Priority to SE9901530A priority Critical patent/SE9901530D0/en
Publication of SE9901530D0 publication Critical patent/SE9901530D0/en
Priority to AU44465/00A priority patent/AU4446500A/en
Priority to PCT/SE2000/000796 priority patent/WO2000064904A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

There are provided novel compounds of formula (I), wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<12>, A, B, D and X are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and tautomers thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.
SE9901530A 1999-04-28 1999-04-28 Novel compounds SE9901530D0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SE9901530A SE9901530D0 (en) 1999-04-28 1999-04-28 Novel compounds
AU44465/00A AU4446500A (en) 1999-04-28 2000-04-26 5,7-bicyclic amidine derivatives useful as nitric oxide synthase inhibitors
PCT/SE2000/000796 WO2000064904A1 (en) 1999-04-28 2000-04-26 5,7-bicyclic amidine derivatives useful as nitric oxide synthase inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9901530A SE9901530D0 (en) 1999-04-28 1999-04-28 Novel compounds

Publications (1)

Publication Number Publication Date
SE9901530D0 true SE9901530D0 (en) 1999-04-28

Family

ID=20415385

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9901530A SE9901530D0 (en) 1999-04-28 1999-04-28 Novel compounds

Country Status (3)

Country Link
AU (1) AU4446500A (en)
SE (1) SE9901530D0 (en)
WO (1) WO2000064904A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200808810A (en) * 2006-02-23 2008-02-16 Novartis Ag Organic compounds
EP2018863B9 (en) 2006-05-16 2015-02-18 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854234A (en) * 1993-10-21 1998-12-29 G. D. Searle & Co. Amidino dervatives useful as nitric oxide synthase inhibitors
US5629322A (en) * 1994-11-15 1997-05-13 Merck & Co., Inc. Cyclic amidine analogs as inhibitors of nitric oxide synthase
WO1996014842A1 (en) * 1994-11-15 1996-05-23 Merck & Co., Inc. Substituted heterocycles as inhibitors of nitric oxide synthase
AU712995B2 (en) * 1995-05-10 1999-11-18 G.D. Searle & Co. Nitric oxide synthase inhibitors derived from cyclic amidines
EP0861238A4 (en) * 1995-11-01 2000-03-01 Merck & Co Inc Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
CA2251681A1 (en) * 1996-04-13 1997-10-23 Peter Hamley Aminoisoquinolines and aminothienopyridine derivatives and their use as anti-inflammatory agents
SE9701304D0 (en) * 1997-04-09 1997-04-09 Astra Pharma Prod Compounds

Also Published As

Publication number Publication date
WO2000064904A1 (en) 2000-11-02
AU4446500A (en) 2000-11-10

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