SE9000050L - LOW-DOSAGE COMPOSITION OF BENAZEPRIL / TIAZID DIETERIC - Google Patents
LOW-DOSAGE COMPOSITION OF BENAZEPRIL / TIAZID DIETERICInfo
- Publication number
- SE9000050L SE9000050L SE9000050A SE9000050A SE9000050L SE 9000050 L SE9000050 L SE 9000050L SE 9000050 A SE9000050 A SE 9000050A SE 9000050 A SE9000050 A SE 9000050A SE 9000050 L SE9000050 L SE 9000050L
- Authority
- SE
- Sweden
- Prior art keywords
- bezenapril
- diuretic agent
- tiazid
- dieteric
- benazepril
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To prepare a composition, comprising bezenapril or its salt and a thiazide diuretic agent and capable of treating a lesser degree to a medium degree of hypertension in a lower dose than that when used alone. CONSTITUTION: This composition comprises bezenapril in about 4-6mg, preferably about 5mg dose at a time or its pharmaceutically permissible salt and a thiazide diuretic agent in an amount of 80-120%, preferably 100% based on 1/8 of the minimal antihyopertensive initial dose recommended when used alone. Bendroflumethiazide, Chlorthalidone, Chlorothiazide, hydrochlorothiazide, hydroflumethiazide, methylchlorothiazide, polythiazide, trichloromethiazide, benzthiazide and dichloroazide are cited as the thiazide diuretic agent. The most preferred composition comprises bezenapril hydrochloride and hydrochlorothiazide at about 0.8-1 weight ratio.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30038389A | 1989-01-23 | 1989-01-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE9000050L true SE9000050L (en) | 1990-07-24 |
| SE506179C2 SE506179C2 (en) | 1997-11-17 |
Family
ID=23158879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE9000050A SE506179C2 (en) | 1989-01-23 | 1990-01-08 | Pharmaceutical low composition of benazepril and a thiazide diuretic |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JP3009694B2 (en) |
| KR (1) | KR0141479B1 (en) |
| AT (1) | AT401728B (en) |
| AU (1) | AU629288B2 (en) |
| BE (1) | BE1002736A4 (en) |
| CA (1) | CA2008126C (en) |
| CH (1) | CH680568A5 (en) |
| CY (1) | CY1835A (en) |
| DE (2) | DE10199041I1 (en) |
| DK (1) | DK175204B1 (en) |
| FR (1) | FR2641971B1 (en) |
| GB (1) | GB2227172B (en) |
| HK (1) | HK98995A (en) |
| IE (1) | IE61784B1 (en) |
| IL (1) | IL93117A0 (en) |
| IT (1) | IT1239744B (en) |
| LU (1) | LU87660A1 (en) |
| MX (1) | MX9203362A (en) |
| NL (1) | NL194958C (en) |
| NZ (1) | NZ232182A (en) |
| SA (1) | SA90100151B1 (en) |
| SE (1) | SE506179C2 (en) |
| SG (1) | SG176194G (en) |
| ZA (1) | ZA90429B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100221695B1 (en) * | 1991-08-12 | 1999-09-15 | 그린 마틴, 브라이언 쥐 테슬리 | Pharmaceutical spheroid formulation |
| DK9200258U4 (en) * | 1992-03-11 | 1993-07-23 | Merck & Co Inc | Pharmaceutical preparation containing enalapril for use in hypertension |
| GB9613470D0 (en) | 1996-06-27 | 1996-08-28 | Ciba Geigy Ag | Small solid oral dosage form |
| CN102579346B (en) * | 2012-03-02 | 2013-09-25 | 海南美兰史克制药有限公司 | Liposome solid preparation of benazepril/hydrochlorothiazide medicine combination |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4217347A (en) * | 1977-12-27 | 1980-08-12 | E. R. Squibb & Sons, Inc. | Method of treating hypertension and medicaments therefor |
| IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
| US4410520A (en) * | 1981-11-09 | 1983-10-18 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
| ZA833903B (en) * | 1982-06-01 | 1984-11-28 | Merck & Co Inc | Benzofused lactams as antihypertensives |
| US4520021A (en) * | 1982-07-02 | 1985-05-28 | Merck & Co., Inc. | Substituted caprolactam derivatives as antihypertensives |
-
1990
- 1990-01-08 SE SE9000050A patent/SE506179C2/en not_active IP Right Cessation
- 1990-01-15 CH CH112/90A patent/CH680568A5/de not_active IP Right Cessation
- 1990-01-17 GB GB9001054A patent/GB2227172B/en not_active Expired - Lifetime
- 1990-01-18 LU LU87660A patent/LU87660A1/en unknown
- 1990-01-19 DE DE2001199041 patent/DE10199041I1/en active Pending
- 1990-01-19 CA CA002008126A patent/CA2008126C/en not_active Expired - Lifetime
- 1990-01-19 IT IT47548A patent/IT1239744B/en active IP Right Grant
- 1990-01-19 DE DE4001496A patent/DE4001496C2/en not_active Expired - Lifetime
- 1990-01-19 NZ NZ232182A patent/NZ232182A/en unknown
- 1990-01-19 FR FR909000612A patent/FR2641971B1/en not_active Expired - Lifetime
- 1990-01-22 AT AT0013590A patent/AT401728B/en not_active IP Right Cessation
- 1990-01-22 DK DK199000174A patent/DK175204B1/en not_active IP Right Cessation
- 1990-01-22 BE BE9000074A patent/BE1002736A4/en not_active IP Right Cessation
- 1990-01-22 IL IL93117A patent/IL93117A0/en not_active IP Right Cessation
- 1990-01-22 KR KR1019900000697A patent/KR0141479B1/en not_active IP Right Cessation
- 1990-01-22 IE IE23390A patent/IE61784B1/en not_active IP Right Cessation
- 1990-01-22 ZA ZA90429A patent/ZA90429B/en unknown
- 1990-01-22 NL NL9000158A patent/NL194958C/en not_active IP Right Cessation
- 1990-01-22 JP JP2010782A patent/JP3009694B2/en not_active Expired - Lifetime
- 1990-01-22 AU AU48703/90A patent/AU629288B2/en not_active Expired
- 1990-04-04 SA SA90100151A patent/SA90100151B1/en unknown
-
1992
- 1992-06-25 MX MX9203362A patent/MX9203362A/en unknown
-
1994
- 1994-12-16 SG SG176194A patent/SG176194G/en unknown
-
1995
- 1995-06-22 HK HK98995A patent/HK98995A/en not_active IP Right Cessation
- 1995-12-01 CY CY183595A patent/CY1835A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |