SE8003351L - Forfarande for framstellning av heterocykliska foreningar med terapeutisk verkan - Google Patents
Forfarande for framstellning av heterocykliska foreningar med terapeutisk verkanInfo
- Publication number
- SE8003351L SE8003351L SE8003351A SE8003351A SE8003351L SE 8003351 L SE8003351 L SE 8003351L SE 8003351 A SE8003351 A SE 8003351A SE 8003351 A SE8003351 A SE 8003351A SE 8003351 L SE8003351 L SE 8003351L
- Authority
- SE
- Sweden
- Prior art keywords
- formula
- preparation
- given above
- heterocyclic
- societies
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- -1 methoxyphenyl Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- NHPWIWAGVOXDPU-UHFFFAOYSA-N 2-methylidene-1-azabicyclo[2.2.2]octan-3-one Chemical compound C1CC2CCN1C(=C)C2=O NHPWIWAGVOXDPU-UHFFFAOYSA-N 0.000 claims 1
- 102100035593 POU domain, class 2, transcription factor 1 Human genes 0.000 claims 1
- 101710084414 POU domain, class 2, transcription factor 1 Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000068 chlorophenyl group Chemical group 0.000 claims 1
- 150000002391 heterocyclic compounds Chemical class 0.000 claims 1
- 150000002440 hydroxy compounds Chemical class 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 229910000033 sodium borohydride Inorganic materials 0.000 claims 1
- 239000012279 sodium borohydride Substances 0.000 claims 1
- 125000003944 tolyl group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (4)
- Patent krav Forfarande fOr framstdllning av heterocykliska foreningar med den allmdfina formeln (I) dad, R betecknar fenyl, metylfenyl, metoxifenyl eller klorfenyl, samt fysiologiskt godtagbara salter ddrav,kdnnetecknat av alt.
- 2-metylenkinuklidin-
- 3-on med formeln omsRttes and ett alkylarylacetat med formeln RCH2 - COOR,(III) ddr R tar den ovan angivna betydelsen Oct R1 betecknar en alkylgrupp, i ndrvaro an en natriumalkoxid till bildning av en fOrening med formeln OH 1.
- 4. CH2 - CU - COOR, ddr R och R, bar de ovan angivna betydelserna, varefter denna fore-fling reduceras med natriumborhydrid till motsvarande hydroxifOrening med formeln 2. - CH - ODOR, dar R och R, har de ovan angivna betydelserna, varefter denna litre-fling ringslutes genom behandling med en koneentrerad mineralsyra, varefter den erhAllna foreningen med formeln I eventuellt omvandlas till ett fysiologodtagbartddrav.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL48453A IL48453A (en) | 1975-11-11 | 1975-11-11 | Substituted 6-oxa-1-azatricyclo-(6.2.2.0 )dodecan-5-ones and 1,4-ethano-5-oxo octa (or decahydro)quinoline,their preparation and pharmaceutical compositions containing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8003351L true SE8003351L (sv) | 1980-05-05 |
| SE435929B SE435929B (sv) | 1984-10-29 |
Family
ID=11048546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8003351A SE435929B (sv) | 1975-11-11 | 1980-05-05 | Forfarande for framstellning av 6-oxa-1-azatricyklo (4.2.2.0?722,7)-dodekan-5-oner med terapeutisk verkan |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4083985A (sv) |
| JP (2) | JPS6045198B2 (sv) |
| AR (1) | AR213184A1 (sv) |
| AT (1) | AT355035B (sv) |
| AU (1) | AU511347B2 (sv) |
| BE (1) | BE848227A (sv) |
| CA (1) | CA1078385A (sv) |
| CH (2) | CH635102A5 (sv) |
| DE (1) | DE2650876A1 (sv) |
| DK (1) | DK507376A (sv) |
| ES (1) | ES453162A1 (sv) |
| FI (1) | FI60013C (sv) |
| FR (1) | FR2331339A1 (sv) |
| GB (1) | GB1571511A (sv) |
| IL (1) | IL48453A (sv) |
| IN (1) | IN145202B (sv) |
| MX (1) | MX4767E (sv) |
| NL (1) | NL7612427A (sv) |
| NO (1) | NO144927C (sv) |
| NZ (1) | NZ182556A (sv) |
| SE (1) | SE435929B (sv) |
| ZA (1) | ZA766663B (sv) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4183938A (en) * | 1975-11-11 | 1980-01-15 | The Purdue Frederick Company | 1,8-Ethano-5-oxo-octa- and -decahydroquinolines and mydriatic compositions thereof |
| US4855290A (en) | 1985-05-10 | 1989-08-08 | State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research | Derivatives of quinuclidine |
| US4876260A (en) * | 1987-10-28 | 1989-10-24 | State Of Israel, Israel Institute Of Biological Research | Oxathiolanes |
| JPH0523864Y2 (sv) * | 1989-09-05 | 1993-06-17 | ||
| US5852029A (en) * | 1990-04-10 | 1998-12-22 | Israel Institute For Biological Research | Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity |
| US5407938A (en) * | 1990-04-10 | 1995-04-18 | Israel Institute For Biological Research | Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines) |
| JPH0518551U (ja) * | 1991-08-28 | 1993-03-09 | 亀吉 立花 | ぶら下がり健康器 |
| US5280028A (en) * | 1992-06-24 | 1994-01-18 | G. D. Searle & Co. | Benzimidazole compounds |
| US5521193A (en) * | 1992-06-24 | 1996-05-28 | G. D. Searle & Co. | Benzimidazole compounds |
| US5534521A (en) * | 1993-06-23 | 1996-07-09 | G. D. Searle & Co. | Benzimidazole compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3857837A (en) * | 1968-07-02 | 1974-12-31 | Hoffmann La Roche | Processes and intermediated for quinine, quinidine, isomers and derivatives thereof |
-
1975
- 1975-11-11 IL IL48453A patent/IL48453A/xx unknown
-
1976
- 1976-02-06 US US05/655,650 patent/US4083985A/en not_active Expired - Lifetime
- 1976-10-28 AR AR265267A patent/AR213184A1/es active
- 1976-11-03 FI FI763152A patent/FI60013C/fi not_active IP Right Cessation
- 1976-11-06 DE DE19762650876 patent/DE2650876A1/de not_active Ceased
- 1976-11-08 NZ NZ182556A patent/NZ182556A/xx unknown
- 1976-11-08 ZA ZA766663A patent/ZA766663B/xx unknown
- 1976-11-09 NL NL7612427A patent/NL7612427A/xx not_active Application Discontinuation
- 1976-11-10 ES ES453162A patent/ES453162A1/es not_active Expired
- 1976-11-10 BE BE172272A patent/BE848227A/xx not_active IP Right Cessation
- 1976-11-10 CH CH1417776A patent/CH635102A5/de not_active IP Right Cessation
- 1976-11-10 FR FR7634034A patent/FR2331339A1/fr active Granted
- 1976-11-10 DK DK507376A patent/DK507376A/da not_active Application Discontinuation
- 1976-11-10 IN IN2028/CAL/1976A patent/IN145202B/en unknown
- 1976-11-10 GB GB46748/76A patent/GB1571511A/en not_active Expired
- 1976-11-10 NO NO763820A patent/NO144927C/no unknown
- 1976-11-10 CA CA265,344A patent/CA1078385A/en not_active Expired
- 1976-11-11 MX MX765119U patent/MX4767E/es unknown
- 1976-11-11 AT AT839476A patent/AT355035B/de not_active IP Right Cessation
- 1976-11-11 JP JP51136167A patent/JPS6045198B2/ja not_active Expired
- 1976-11-11 AU AU19552/76A patent/AU511347B2/en not_active Expired
-
1980
- 1980-05-05 SE SE8003351A patent/SE435929B/sv not_active IP Right Cessation
-
1982
- 1982-04-30 CH CH267282A patent/CH640234A5/de not_active IP Right Cessation
-
1984
- 1984-08-10 JP JP59166668A patent/JPS6043348B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE848227A (fr) | 1977-03-01 |
| FR2331339B1 (sv) | 1980-04-04 |
| CH635102A5 (de) | 1983-03-15 |
| US4083985A (en) | 1978-04-11 |
| ES453162A1 (es) | 1977-11-01 |
| JPS5283396A (en) | 1977-07-12 |
| FI763152A (sv) | 1977-05-12 |
| AU511347B2 (en) | 1980-08-14 |
| DK507376A (da) | 1977-05-12 |
| GB1571511A (en) | 1980-07-16 |
| NO763820L (sv) | 1977-05-12 |
| FI60013C (fi) | 1981-11-10 |
| FR2331339A1 (fr) | 1977-06-10 |
| SE435929B (sv) | 1984-10-29 |
| ZA766663B (en) | 1977-10-26 |
| NO144927B (no) | 1981-08-31 |
| IN145202B (sv) | 1978-09-09 |
| DE2650876A1 (de) | 1977-05-18 |
| AR213184A1 (es) | 1978-12-29 |
| JPS60120876A (ja) | 1985-06-28 |
| MX4767E (es) | 1982-09-08 |
| ATA839476A (de) | 1979-07-15 |
| IL48453A (en) | 1980-06-30 |
| IL48453A0 (en) | 1976-01-30 |
| CA1078385A (en) | 1980-05-27 |
| NZ182556A (en) | 1979-10-25 |
| NL7612427A (nl) | 1977-05-13 |
| AT355035B (de) | 1980-02-11 |
| AU1955276A (en) | 1978-05-18 |
| CH640234A5 (de) | 1983-12-30 |
| JPS6043348B2 (ja) | 1985-09-27 |
| JPS6045198B2 (ja) | 1985-10-08 |
| NO144927C (no) | 1981-12-09 |
| FI60013B (fi) | 1981-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
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