[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

SE0400501D0 - Antibody purification - Google Patents

Antibody purification

Info

Publication number
SE0400501D0
SE0400501D0 SE0400501A SE0400501A SE0400501D0 SE 0400501 D0 SE0400501 D0 SE 0400501D0 SE 0400501 A SE0400501 A SE 0400501A SE 0400501 A SE0400501 A SE 0400501A SE 0400501 D0 SE0400501 D0 SE 0400501D0
Authority
SE
Sweden
Prior art keywords
cation
aromatic
solution
modal
exchanging group
Prior art date
Application number
SE0400501A
Other languages
English (en)
Inventor
Bo-Lennart Johansson
Hans J Johansson
Anders Ljungloef
Jean-Luc Maloisel
Nicolas Thevenin
Original Assignee
Amersham Biosciences Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Biosciences Ab filed Critical Amersham Biosciences Ab
Priority to SE0400501A priority Critical patent/SE0400501D0/sv
Publication of SE0400501D0 publication Critical patent/SE0400501D0/sv
Priority to EP05722174A priority patent/EP1718668B1/en
Priority to NZ548127A priority patent/NZ548127A/en
Priority to AU2005217348A priority patent/AU2005217348B2/en
Priority to PCT/SE2005/000292 priority patent/WO2005082926A1/en
Priority to US10/589,718 priority patent/US7385040B2/en
Priority to DE602005016220T priority patent/DE602005016220D1/de
Priority to CN2005800062670A priority patent/CN1926146B/zh
Priority to JP2007500724A priority patent/JP4776615B2/ja
Priority to KR1020067017115A priority patent/KR101149969B1/ko
Priority to AT05722174T priority patent/ATE440858T1/de
Priority to CA2552823A priority patent/CA2552823C/en
Priority to KR1020067017113A priority patent/KR101150050B1/ko
Priority to AU2005216847A priority patent/AU2005216847B2/en
Priority to CA2552639A priority patent/CA2552639C/en
Priority to PCT/SE2005/000293 priority patent/WO2005082483A1/en
Priority to US10/589,717 priority patent/US7750129B2/en
Priority to NZ548126A priority patent/NZ548126A/en
Priority to JP2007500725A priority patent/JP4848356B2/ja
Priority to CN200580006276XA priority patent/CN1925898B/zh
Priority to EP05722175A priority patent/EP1718386A1/en
Priority to IL176635A priority patent/IL176635A/en
Priority to IL176745A priority patent/IL176745A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3847—Multimodal interactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/04—Processes using organic exchangers
    • B01J39/07—Processes using organic exchangers in the weakly acidic form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/26—Cation exchangers for chromatographic processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J47/00—Ion-exchange processes in general; Apparatus therefor
    • B01J47/014—Ion-exchange processes in general; Apparatus therefor in which the adsorbent properties of the ion-exchanger are involved, e.g. recovery of proteins or other high-molecular compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SE0400501A 2004-02-27 2004-02-27 Antibody purification SE0400501D0 (sv)

Priority Applications (23)

Application Number Priority Date Filing Date Title
SE0400501A SE0400501D0 (sv) 2004-02-27 2004-02-27 Antibody purification
CA2552823A CA2552823C (en) 2004-02-27 2005-02-24 Antibody purification
AT05722174T ATE440858T1 (de) 2004-02-27 2005-02-24 Aufreinigung von antikírpern
NZ548127A NZ548127A (en) 2004-02-27 2005-02-24 Method for antibody purification
AU2005217348A AU2005217348B2 (en) 2004-02-27 2005-02-24 Antibody purification
PCT/SE2005/000292 WO2005082926A1 (en) 2004-02-27 2005-02-24 Antibody purification
US10/589,718 US7385040B2 (en) 2004-02-27 2005-02-24 Antibody purification
DE602005016220T DE602005016220D1 (de) 2004-02-27 2005-02-24 Aufreinigung von antikörpern
CN2005800062670A CN1926146B (zh) 2004-02-27 2005-02-24 抗体纯化
JP2007500724A JP4776615B2 (ja) 2004-02-27 2005-02-24 抗体精製
KR1020067017115A KR101149969B1 (ko) 2004-02-27 2005-02-24 항체 정제
EP05722174A EP1718668B1 (en) 2004-02-27 2005-02-24 Antibody purification
EP05722175A EP1718386A1 (en) 2004-02-27 2005-02-25 A process for the purification of antibodies
KR1020067017113A KR101150050B1 (ko) 2004-02-27 2005-02-25 항체 정제 방법
AU2005216847A AU2005216847B2 (en) 2004-02-27 2005-02-25 A process for the purification of antibodies
CA2552639A CA2552639C (en) 2004-02-27 2005-02-25 A process for the purification of antibodies
PCT/SE2005/000293 WO2005082483A1 (en) 2004-02-27 2005-02-25 A process for the purification of antibodies
US10/589,717 US7750129B2 (en) 2004-02-27 2005-02-25 Process for the purification of antibodies
NZ548126A NZ548126A (en) 2004-02-27 2005-02-25 A process for the purification of antibodies involving addition of a second resin
JP2007500725A JP4848356B2 (ja) 2004-02-27 2005-02-25 抗体精製法
CN200580006276XA CN1925898B (zh) 2004-02-27 2005-02-25 纯化抗体的工艺
IL176635A IL176635A (en) 2004-02-27 2006-06-29 Method of purification of antibodies from one or more contaminants by chromatography and a system for such purification
IL176745A IL176745A (en) 2004-02-27 2006-07-06 Process for the purification of antibodies

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0400501A SE0400501D0 (sv) 2004-02-27 2004-02-27 Antibody purification

Publications (1)

Publication Number Publication Date
SE0400501D0 true SE0400501D0 (sv) 2004-02-27

Family

ID=32067281

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0400501A SE0400501D0 (sv) 2004-02-27 2004-02-27 Antibody purification

Country Status (13)

Country Link
US (1) US7385040B2 (sv)
EP (1) EP1718668B1 (sv)
JP (1) JP4776615B2 (sv)
KR (1) KR101149969B1 (sv)
CN (2) CN1926146B (sv)
AT (1) ATE440858T1 (sv)
AU (1) AU2005217348B2 (sv)
CA (1) CA2552823C (sv)
DE (1) DE602005016220D1 (sv)
IL (1) IL176635A (sv)
NZ (1) NZ548127A (sv)
SE (1) SE0400501D0 (sv)
WO (1) WO2005082926A1 (sv)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160279239A1 (en) 2011-05-02 2016-09-29 Immunomedics, Inc. Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease
US20160355591A1 (en) 2011-05-02 2016-12-08 Immunomedics, Inc. Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies
US7589183B2 (en) * 2006-11-28 2009-09-15 Bio-Rad Laboratories, Inc. Prevention of leaching of ligands from affinity-based purification systems
US7999085B2 (en) * 2007-01-09 2011-08-16 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of protein by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
US7691980B2 (en) * 2007-01-09 2010-04-06 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
US8092683B2 (en) * 2007-01-10 2012-01-10 Ge Healthcare Bio-Sciences Ab Multi-modal ion exchange chromatography resins
JP5888481B2 (ja) 2007-03-28 2016-03-22 ディーピーエックス ホールディングス ビー．ブイ． 膨張床カラムおよび使い捨て可能なクロマトグラフィー
US9493548B2 (en) * 2007-06-01 2016-11-15 Hoffmann-La Roche Inc. Immunoglobulin purification
US9433922B2 (en) * 2007-08-14 2016-09-06 Emd Millipore Corporation Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
EP2027875A1 (en) 2007-08-23 2009-02-25 Octapharma AG A Process for Isolation and Purification of a Target Protein free of Prion Protein (PrPSC)
KR101163307B1 (ko) 2007-10-26 2012-07-05 아사히 가세이 케미칼즈 가부시키가이샤 단백질의 정제 방법
US8158405B2 (en) * 2008-06-30 2012-04-17 General Electric Company Process for concentrating and processing fluid samples
US8546127B2 (en) * 2008-06-30 2013-10-01 General Electric Company Bacteria/RNA extraction device
US8753868B2 (en) 2008-08-04 2014-06-17 General Electric Company Method and system for selective isolation of target biological molecules in a general purpose system
US20100051554A1 (en) * 2008-08-28 2010-03-04 Dong June Ahn Molecular basket coated micro particles
US8497358B2 (en) 2008-12-19 2013-07-30 Takeda Pharmaceutical Company Limited Antibody purification method
CN101797493B (zh) * 2009-02-06 2014-05-21 上海抗体药物国家工程研究中心有限公司 一种在反应釜中制备亲和层析介质的方法
DE102009057993A1 (de) 2009-06-13 2011-01-20 Sartorius Stedim Biotech Gmbh Polysaccharidmatrix mit aufgepfropftem Polymer, Verfahren zu ihrer Herstellung und Verwendung
JPWO2011001963A1 (ja) * 2009-07-03 2012-12-13 旭化成ケミカルズ株式会社 多孔質基材に固定されたグラフト鎖に結合しているアミノ基及びアルキル基を有する多孔膜を用いた抗体の精製方法
WO2011049798A1 (en) * 2009-10-20 2011-04-28 Merck Sharp & Dohme Corp. Use of mixed mode chromatography for the capture and purification of basic antibody products
US8277649B2 (en) * 2009-12-14 2012-10-02 General Electric Company Membranes and associated methods for purification of antibodies
US20130178608A1 (en) * 2009-12-29 2013-07-11 Samir Kulkarni Protein purification by ion exchange
KR101152036B1 (ko) 2010-04-27 2012-06-08 (주)셀트리온 컬럼 순환 및 시료 연속주입법을 이용한 단백질 ａ 크로마토그래피 정제 방법
WO2012015908A2 (en) 2010-07-30 2012-02-02 Millipore Corporation Chromatography media and method
AU2012250924B2 (en) 2011-05-02 2017-05-25 Immunomedics, Inc. Ultrafiltration concentration of allotype selected antibodies for small-volume administration
US9783570B2 (en) 2011-07-01 2017-10-10 Hoffmann-La Roche Inc. Method for separation of monomeric polypeptides from aggregated polypeptides
US20130109807A1 (en) * 2011-10-26 2013-05-02 Bio-Rad Laboratories, Inc. Removal of virucidal agents in mixed mode chromatography
GB201202762D0 (en) 2012-02-17 2012-04-04 Autology Health Ltd High efficiency cell capture
CN103506079B (zh) * 2012-06-19 2016-04-06 汪志友 一种用于分离纯化抗体的介质及其制备方法
SG11201501597VA (en) * 2012-09-03 2015-04-29 Kaneka Corp Mix-mode antibody affinity separation matrix and purification method using same, and target molecule
CA2885263C (en) 2012-09-17 2021-11-16 W. R. Grace & Co.-Conn. Chromatography media and devices
EP2919902B1 (en) 2012-11-13 2020-01-01 GE Healthcare BioProcess R&D AB Multimodal anion exchange matrices
JP6639236B2 (ja) 2013-02-26 2020-02-05 ナトリックス セパレイションズ インコーポレーテッド 混合モードクロマトグラフィー膜
TWI596107B (zh) 2013-06-25 2017-08-21 卡地拉保健有限公司 單株抗體之新穎純化方法
WO2015041218A1 (ja) * 2013-09-17 2015-03-26 株式会社カネカ 新規抗体精製方法及びそれから得られる抗体（Ｎｏｖｅｌ Ａｎｔｉｂｏｄｙ Ｐｕｒｉｆｉｃａｔｉｏｎ Ｍｅｔｈｏｄ ａｎｄ Ａｎｔｉｂｏｄｙ ｏｂｔａｉｎｅｄ ｔｈｅｒｅｆｒｏｍ）、並びに陽イオン交換基を用いた新規抗体精製法及びそれから得られる抗体（Ｎｏｖｅｌ Ａｎｔｉｂｏｄｙ Ｐｕｒｉｆｉｃａｔｉｏｎ ｍｅｔｈｏｄ ｕｓｉｎｇ Ｃａｔｉｏｎ Ｅｘｃｈａｎｇｅｒ ａｎｄ Ａｎｔｉｂｏｄｙ ｏｂｔａｉｎｅｄ ｔｈｅｒｅｆｒｏｍ）
CA2967901A1 (en) * 2013-11-17 2015-05-21 New Proteintech Inc. Method of preparing chromatographic materials
WO2015109068A1 (en) 2014-01-16 2015-07-23 W. R. Grace & Co.-Conn. Affinity chromatography media and chromatography devices
EP3137209B1 (en) 2014-05-02 2022-10-05 W.R. Grace & CO. - CONN. Functionalized support material and methods of making and using functionalized support material
DE102014010353B4 (de) 2014-07-10 2024-09-12 Sartorius Stedim Biotech Gmbh Vorrichtung, Verwendung dieser Vorrichtung und Verfahren für die Stofftrennung mit verbesserter Ausnutzung der Kapazität chromatographischer Medien
WO2016013609A1 (ja) 2014-07-25 2016-01-28 旭化成メディカル株式会社 陽イオン交換クロマトグラフィー担体及びその使用方法
AR102198A1 (es) 2014-10-09 2017-02-08 Regeneron Pharma Proceso para reducir partículas subvisibles en una formulación farmacéutica
CA2960797A1 (en) 2014-11-06 2016-05-12 F. Hoffmann-La Roche Ag Fc-region variants with modified fcrn-binding and methods of use
EP3230299A1 (en) 2014-12-08 2017-10-18 EMD Millipore Corporation Mixed bed ion exchange adsorber
BR112017026193B1 (pt) 2015-06-05 2021-09-14 W.R. Grace & Co-Conn Adsorventes, método de produção dos adsorventes e uso dos adsorventes
JP2019070528A (ja) * 2016-02-26 2019-05-09 Jsr株式会社 多孔質担体、アフィニティクロマトグラフィー用多孔質担体、標的物の精製方法、及び抗体
JP6846434B2 (ja) * 2016-04-29 2021-03-24 クレオプティクス・アーゲーＣｒｅｏｐｔｉｘ Ａｇ 分子を回収するための方法およびアセンブリ
EP4183414A1 (en) 2016-08-16 2023-05-24 Regeneron Pharmaceuticals, Inc. Methods for quantitating individual antibodies from a mixture
IL295211B2 (en) 2016-10-25 2024-09-01 Regeneron Pharma Methods and systems for analysis of chromatography data
EP3606964A4 (en) 2017-04-03 2020-12-09 Immunomedics, Inc. SUBCUTANE ADMINISTRATION OF ANTIBODY DRUG CONJUGATES FOR CANCER THERAPY
KR20200054980A (ko) 2017-09-19 2020-05-20 리제너론 파아마슈티컬스, 인크. 입자 형성을 감소시키는 방법 및 그것에 의해 형성된 조성물
EP3762120A4 (en) * 2018-03-08 2021-09-01 Bio-Rad Laboratories, Inc. MIXED MODE ANIONIC-HYDROPHOBIC EXCHANGE CHROMATOGRAPHY RESIN
US11155575B2 (en) 2018-03-21 2021-10-26 Waters Technologies Corporation Non-antibody high-affinity-based sample preparation, sorbent, devices and methods
EP3816177A4 (en) * 2018-06-29 2021-12-01 Mitsubishi Chemical Corporation POLYPEPTIDE ISOLATION PROCESS, POLYPEPTIDE PRODUCTION PROCESS AND POLYPEPTIDE PURIFICATION APPARATUS
AU2019299321A1 (en) 2018-07-02 2021-01-07 Regeneron Pharmaceuticals, Inc. Use of multiple hydrophobic interaction chromatography for preparing a polypeptide from a mixture
CN114040815B (zh) 2019-09-05 2024-06-28 生物辐射实验室股份有限公司 阴离子交换-疏水混合模式色谱树脂

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE462046C (sv) 1982-08-23 1998-04-27 Pharmacia Biotech Ab Hybrid-DNA-vektor innehållande DNA-sekvens från Staphylococcus aureus, förfarande för dess framställning och bakterie innehållande densamma
US5151350A (en) 1982-10-27 1992-09-29 Repligen Corporation Cloned genes encoding recombinant protein a
US4983722A (en) 1988-06-08 1991-01-08 Miles Inc. Removal of protein A from antibody preparations
US5429746A (en) 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
US6117996A (en) * 1995-09-20 2000-09-12 Novo Nordisk A/S Triazine based ligands and use thereof
GB9519197D0 (en) * 1995-09-20 1995-11-22 Affinity Chromatography Ltd Novel affinity ligands and their use
CA2264177C (en) * 1996-08-30 2015-03-17 Upfront Chromatography A/S Isolation of immunoglobulins
SE0002688D0 (sv) * 2000-07-17 2000-07-17 Amersham Pharm Biotech Ab Adsorption method and ligands
WO2002053288A2 (en) * 2000-12-31 2002-07-11 Amersham Biosciences Ab A method for the manufacture of compositions containing low concentrations of salts
JP2004517310A (ja) * 2001-01-05 2004-06-10 プロ・ケム インク 精製器具及び方法
SE0103084D0 (sv) 2001-09-14 2001-09-14 Amersham Pharm Biotech Ab Generation of ion exchange media
DE10155984A1 (de) 2001-11-15 2003-05-28 Boehringer Ingelheim Pharma Verfahren zur Reduktion des Liganden-leakage von Affinitätschromatographie-Matrices
DK1472275T3 (da) 2002-02-05 2009-04-14 Genentech Inc Proteinoprensning
PT1601697E (pt) 2003-02-28 2007-09-04 Lonza Biologics Plc Purificação de anticorpos através de proteína a e cromatografia de troca iónica.

Also Published As

Publication number Publication date
ATE440858T1 (de) 2009-09-15
US20070112178A1 (en) 2007-05-17
CA2552823A1 (en) 2005-09-09
CN1926146B (zh) 2010-06-16
JP4776615B2 (ja) 2011-09-21
EP1718668A1 (en) 2006-11-08
NZ548127A (en) 2009-09-25
DE602005016220D1 (de) 2009-10-08
IL176635A (en) 2011-07-31
KR20070001969A (ko) 2007-01-04
US7385040B2 (en) 2008-06-10
KR101149969B1 (ko) 2012-07-05
CA2552823C (en) 2013-11-19
IL176635A0 (en) 2006-10-31
EP1718668B1 (en) 2009-08-26
AU2005217348A1 (en) 2005-09-09
CN1925898A (zh) 2007-03-07
CN1925898B (zh) 2010-09-01
JP2008505851A (ja) 2008-02-28
CN1926146A (zh) 2007-03-07
WO2005082926A1 (en) 2005-09-09
AU2005217348B2 (en) 2011-03-31

Similar Documents

Publication Publication Date Title
SE0400501D0 (sv) Antibody purification
WO2006138737A8 (en) Methods of purifying anti a beta antibodies
EA200970230A1 (ru) СПОСОБ ОЧИСТКИ Fc-СЛИТЫХ БЕЛКОВ
ATE384742T1 (de) Verfahren zur reinigung von preproinsulin
WO2004024866A3 (en) Protein purification
EA200702210A1 (ru) Способ очистки белков
DE69932944D1 (de) Kolonne und mit dieser durchgeführtes chromatographisches verfahren
EP1568710A3 (en) Antibody purification method
WO2008087184A3 (en) Process for the purification of fc-containing proteins
WO2002088306A3 (en) Humanized antibodies
WO2003066662A3 (en) Protein purification
ATE409047T1 (de) Humanisierte antikörper
DE602004006157D1 (de) Verfahren zur aufreinigung von il-18-bindendem protein
DE602006020333D1 (de) Multimere fc-rezeptor-polypeptide
FR2892820B1 (fr) Procede magnetique d'immunodiagnostic pour la mise en evidence de complexe anticorps/antigene, en particulier de groupe sanguin
ATE417056T1 (de) Verfahren zur proteinreinigung
DE602004007250D1 (de) Verfahren für volumen mit hohem durchsatz bei der fraktionierung von biomolekülen durch chromatographische systeme
DE69931645D1 (de) Reinigung von fibrinogen aus flüssigkeiten mittels ausfällung und hydrophobischer-interaktion-chromatographie
MY157846A (en) Process for the purification of fc-containing proteins
SE0402558D0 (sv) A process for the purification of antibodies
SE0502649L (sv) Aktiverad fast stödfas och metod
Savane et al. Molecular insight in the purification of immunoglobulin by pseudobiospecific ligand l-histidine and histidyl moieties in histidine ligand affinity chromatography (HLAC) by molecular docking
JP5067917B2 (ja) Ａｄａｍｔｓ１３の分離精製方法
Gallant Immunoaffinity chromatography of proteins
Subramanian et al. Use of modified chitosan macrospheres in the selective removal of immunoglobulins