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RU93005013A - 1-AMINOSPIRO [IZOHINOLIN-4 (1H) 3-PYRROLIDIN-1,2,3,5 '(2H) -TETRONS] AND THEIR ANALOGUES, METHOD OF THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITION - Google Patents

1-AMINOSPIRO [IZOHINOLIN-4 (1H) 3-PYRROLIDIN-1,2,3,5 '(2H) -TETRONS] AND THEIR ANALOGUES, METHOD OF THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITION

Info

Publication number
RU93005013A
RU93005013A RU93005013/04A RU93005013A RU93005013A RU 93005013 A RU93005013 A RU 93005013A RU 93005013/04 A RU93005013/04 A RU 93005013/04A RU 93005013 A RU93005013 A RU 93005013A RU 93005013 A RU93005013 A RU 93005013A
Authority
RU
Russia
Prior art keywords
tetrons
izohinolin
aminospiro
pyrrolidin
analogues
Prior art date
Application number
RU93005013/04A
Other languages
Russian (ru)
Other versions
RU2110518C1 (en
Inventor
Сотирпос Маламас Майкл
Original Assignee
Американ Хоум Продактс Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/596,266 external-priority patent/US5102886A/en
Application filed by Американ Хоум Продактс Корпорейшн filed Critical Американ Хоум Продактс Корпорейшн
Publication of RU93005013A publication Critical patent/RU93005013A/en
Application granted granted Critical
Publication of RU2110518C1 publication Critical patent/RU2110518C1/en

Links

Claims (1)

Изобретение относится к 1-аминоспиро[изохинолин-4(1Н) 3-пирролидин-1,2,3,5'(2Н)-тетронам и их фармацевтически приемлемым солям, к способам их получения, способам использования этих соединений и фармацевтическим препаратам на их основе. Указанные соединения обладают фармацевтическими свойствами, которые делают их полезными для предотвращения или лечения осложнений, связанных с сахарным диабетом.The invention relates to 1-amino-spiro [isoquinolin-4 (1H) 3-pyrrolidine-1,2,3,5 '(2H) -tetrons and their pharmaceutically acceptable salts, to methods for their preparation, to methods for using these compounds and to pharmaceutical preparations thereof. basis. These compounds have pharmaceutical properties that make them useful for the prevention or treatment of complications associated with diabetes.
RU93005013A 1990-10-12 1991-10-10 Derivatives of spiro-[isoquinoline-4-(1h)-3-pyrrolidine]-1,2',3,5'-(2h)-tetr- -one, method of their synthesis and pharmaceutical composition used for prevention or treatment of diabetes mellitus-related complications RU2110518C1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US596266 1990-10-12
US596.266 1990-10-12
US07/596,266 US5102886A (en) 1990-10-12 1990-10-12 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
PCT/US1991/007473 WO1992006975A1 (en) 1990-10-12 1991-10-10 1'-aminospiro[isoquinoline-4(1h),3'-pyrrolidine]-1,2',3,5'(2h)-tetrones and analogs thereof useful as aldose reductase inhibitors

Publications (2)

Publication Number Publication Date
RU93005013A true RU93005013A (en) 1996-05-10
RU2110518C1 RU2110518C1 (en) 1998-05-10

Family

ID=24386645

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93005013A RU2110518C1 (en) 1990-10-12 1991-10-10 Derivatives of spiro-[isoquinoline-4-(1h)-3-pyrrolidine]-1,2',3,5'-(2h)-tetr- -one, method of their synthesis and pharmaceutical composition used for prevention or treatment of diabetes mellitus-related complications

Country Status (19)

Country Link
US (1) US5102886A (en)
EP (1) EP0553263B1 (en)
JP (1) JP3115598B2 (en)
KR (1) KR100228842B1 (en)
AT (1) ATE169300T1 (en)
AU (1) AU645865B2 (en)
CA (1) CA2093794C (en)
DE (1) DE69129941T2 (en)
DK (1) DK0553263T3 (en)
ES (1) ES2120966T3 (en)
FI (1) FI103045B (en)
HK (1) HK1009601A1 (en)
HU (2) HU214874B (en)
MX (1) MX9101543A (en)
PT (1) PT99179B (en)
RU (1) RU2110518C1 (en)
SG (1) SG47809A1 (en)
TW (1) TW200484B (en)
WO (1) WO1992006975A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5189168A (en) * 1991-11-25 1993-02-23 American Home Products Corporation 1'-amino-2[(benzothiazolyl)methyl]spiro-[isoquinoline-4(1H),3'-pyrrolidine]-1,2'3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
CA2122916A1 (en) * 1991-11-25 1993-06-10 Michael S. Malamas 1-amino-2-[(benzothiazolyl)methyl] spiro [isoquinoline-4(1h),3'-pyrrolidine]-1,2',3,5'(2h)- tetrones and analogs thereof useful as aldose reductase inhibitors
EP1400244A1 (en) 2002-09-17 2004-03-24 Warner-Lambert Company LLC New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors
CL2008001839A1 (en) 2007-06-21 2009-01-16 Incyte Holdings Corp Compounds derived from 2,7-diazaspirocycles, inhibitors of 11-beta hydroxyl steroid dehydrogenase type 1; pharmaceutical composition comprising said compounds; Useful to treat obesity, diabetes, glucose intolerance, type II diabetes, among other diseases.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200642A (en) * 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones
IE52879B1 (en) * 1981-05-12 1988-03-30 Ici Plc Pharmaceutical spiro-hydantoin derivatives
US4927831A (en) * 1988-10-20 1990-05-22 American Home Products Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
AU617541B2 (en) * 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
JPH0426510A (en) * 1990-05-18 1992-01-29 Tonen Corp Carbon particle, its production and its application
US5068332A (en) * 1990-10-12 1991-11-26 American Home Products Corporation Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors

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