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RU93004860A - HETEROCYCLIC COMPOUNDS, METHOD FOR THEIR PRODUCTION, USE AND PHARMACEUTICAL COMPOSITION - Google Patents

HETEROCYCLIC COMPOUNDS, METHOD FOR THEIR PRODUCTION, USE AND PHARMACEUTICAL COMPOSITION

Info

Publication number
RU93004860A
RU93004860A RU93004860/04A RU93004860A RU93004860A RU 93004860 A RU93004860 A RU 93004860A RU 93004860/04 A RU93004860/04 A RU 93004860/04A RU 93004860 A RU93004860 A RU 93004860A RU 93004860 A RU93004860 A RU 93004860A
Authority
RU
Russia
Prior art keywords
production
pharmaceutical composition
heterocyclic compounds
pharmaceutically acceptable
acceptable esters
Prior art date
Application number
RU93004860/04A
Other languages
Russian (ru)
Other versions
RU2114860C1 (en
Inventor
Энтони Кренитский Томас
Рэндольф Эверетт Деврон
Дуглас Вильсон Джеффри
Рэй Мурман Аллан
Доуэс Чэмбэрлэйн Стенли
Вальтер Косзалка Джордж
Портер Дэвид
Уолберг Джеральд
Original Assignee
Дзе Веллкам Фаундейшн Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909015914A external-priority patent/GB9015914D0/en
Application filed by Дзе Веллкам Фаундейшн Лимитед filed Critical Дзе Веллкам Фаундейшн Лимитед
Publication of RU93004860A publication Critical patent/RU93004860A/en
Application granted granted Critical
Publication of RU2114860C1 publication Critical patent/RU2114860C1/en

Links

Claims (1)

Описаны 6-алкоксипроизводные ara G и фармацевтически приемлемые его сложные эфиры в качестве полезных средств для лечения опухолей. Описаны также новые фармацевтически приемлемые сложные эфиры, их получение и фармацевтические формы, содержащие их.The 6-alkoxy derivatives of ara G and its pharmaceutically acceptable esters as useful agents for the treatment of tumors are described. Also described are new pharmaceutically acceptable esters, their preparation and pharmaceutical forms containing them.
RU93004860A 1990-07-19 1991-07-18 MONO-, DI- OR TRICOMPLEX ESTERS OF 2-AMINO-6-(C1-C5-ALKOXY)-9-(β-D-ARABINOFURANOSYL)-9H-PURINE, METHOD OF THEIR SYNTHESIS, USING AND PHARMACEUTICAL COMPOSITION RU2114860C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB909015914A GB9015914D0 (en) 1990-07-19 1990-07-19 Heterocyclic compounds
GB9015914.6 1990-07-19
GB9015914,6 1990-07-19

Publications (2)

Publication Number Publication Date
RU93004860A true RU93004860A (en) 1995-11-27
RU2114860C1 RU2114860C1 (en) 1998-07-10

Family

ID=10679359

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93004860A RU2114860C1 (en) 1990-07-19 1991-07-18 MONO-, DI- OR TRICOMPLEX ESTERS OF 2-AMINO-6-(C1-C5-ALKOXY)-9-(β-D-ARABINOFURANOSYL)-9H-PURINE, METHOD OF THEIR SYNTHESIS, USING AND PHARMACEUTICAL COMPOSITION

Country Status (23)

Country Link
US (3) US5492897A (en)
EP (1) EP0539479B1 (en)
JP (1) JP2873086B2 (en)
KR (1) KR100187326B1 (en)
AT (1) ATE151637T1 (en)
CA (1) CA2087543C (en)
CY (1) CY2165B1 (en)
DE (1) DE69125715T2 (en)
DK (1) DK0539479T3 (en)
ES (1) ES2103311T3 (en)
GB (1) GB9015914D0 (en)
GR (1) GR3023776T3 (en)
HU (2) HU9300115D0 (en)
IE (1) IE912513A1 (en)
IL (1) IL98881A (en)
MC (1) MC2289A1 (en)
MY (1) MY111871A (en)
NZ (1) NZ239025A (en)
PT (1) PT98371B (en)
RU (1) RU2114860C1 (en)
TW (1) TW208655B (en)
WO (1) WO1992001456A1 (en)
ZA (1) ZA915656B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds
WO1998042352A1 (en) * 1997-03-24 1998-10-01 Glaxo Group Ltd. Method for treating b-cell tumors with ara-g nucleoside derivatives
CA2336412C (en) * 1998-07-02 2007-11-27 Junichi Shimada Medicament for treatment of diabetes
US6753322B2 (en) * 2000-06-06 2004-06-22 Pfizer Inc 2-aminocarbonyl-9H-purine derivatives
US7321033B2 (en) * 2001-11-27 2008-01-22 Anadys Pharmaceuticals, Inc. 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
NZ533628A (en) 2001-11-27 2006-07-28 Anadys Pharmaceuticals Inc 3-beta-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and uses thereof
AU2003261354A1 (en) * 2002-08-02 2004-02-23 The Regents Of The University Of California New uses for inhibitors of inosine monophosphate dehydrogenase
EA200600540A1 (en) * 2003-09-05 2006-08-25 Анадис Фармасьютикалз, Инк. INTRODUCTION OF TLR7 LIGANDS AND THEIR TREATMENTS FOR THE TREATMENT OF HEPATITIS C VIRUS INFECTION
GB0321613D0 (en) * 2003-09-15 2003-10-15 Drug Discovery Lab As Compounds
US20080103110A1 (en) * 2004-09-15 2008-05-01 Drug Discovery Laboratory As Compounds
CA2596543A1 (en) * 2004-11-12 2006-05-18 Northwestern University Methods of treating hematological malignancies with nucleoside analog drugs
SI1824482T1 (en) 2004-12-17 2014-06-30 Anadys Pharmaceuticals, Inc. 3, 5-DISUBSTITUTED AND 3,5,7-TRISUBSTITUTED-3H-OXAZOLO AND 3H-THIAZOLO Š4,5-dĆPYRIMIDIN-2-ONE COMPOUNDS AND PRODRUGS THEREOF
US20060189543A1 (en) * 2005-02-23 2006-08-24 Rosenbloom Richard A Compositions and methods for the treatment of leukemia
CN101365705A (en) 2005-11-21 2009-02-11 安那迪斯药品股份有限公司 Process for the preparation of 5-amino-3h-thiazolo[4,5-d]pyrimidin-2-one
MX2008016518A (en) * 2006-06-22 2009-01-19 Anadys Pharmaceuticals Inc PRODRUGS OF 5-AMINO-3-(3'-DEOXY-beta-D-RIBOFURANOSYL)-THIAZOLO[4,5- d] PYRIMIDIN-2,7-DIONE.
BRPI0714831A2 (en) 2006-07-18 2013-04-02 Anadys Pharmaceuticals Inc compound, pharmaceutical composition and methods of modulating cytokine immune activities in a patient, treating hepatitis virus infection and in a patient, and proliferation-related disorder in a mammal in need thereof
CN101768197A (en) * 2008-12-29 2010-07-07 北京德众万全药物技术开发有限公司 Preparation method for nelarabine
EP2658857B1 (en) 2010-12-29 2016-11-02 Inhibitex, Inc. Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections
WO2018230479A1 (en) * 2017-06-13 2018-12-20 大原薬品工業株式会社 5'-position silyl ether derivative for nucleoside anti-cancer agent or anti-virus agent
JP2024503755A (en) * 2020-12-30 2024-01-26 サウザン・ユニバーシティ・オブ・サイエンス・アンド・テクノロジー Nucleoside compounds for the treatment of viral infections and their uses

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2152486A1 (en) * 1970-11-20 1972-06-29 Akad Wissenschaften Ddr 6-methylmercapto-purine 5'-desoxy-5'-fluoro-riboside - with cytostati activity
US3872084A (en) * 1972-10-10 1975-03-18 Syntex Inc Purine nucleoside 3,5-cyclicphosphate compounds
US4081534A (en) * 1973-09-11 1978-03-28 Burroughs Wellcome Co. Amino purine nucleosides as autoimmune suppressant agents
GB1573777A (en) * 1977-11-03 1980-08-28 Wellcome Found 9-d-arabinonucleosides and an enzymatic process for their preparation
JPS61233696A (en) * 1985-04-08 1986-10-17 Kanegafuchi Chem Ind Co Ltd 7-hydroxyguanine derivative, production thereof, and antitumor agent comprising same as active ingredient
GB8712745D0 (en) * 1987-05-30 1987-07-01 Wellcome Found Antiviral compounds
CA1317291C (en) * 1987-12-14 1993-05-04 Naeem Botros Hanna Antitumor 6-sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides and related compounds
US5352669A (en) * 1990-03-13 1994-10-04 The Of The United States Of America As Represented By The Department Of Health And Human Services O6 -benzylated guanine, guanosine and 2'-deoxyguanosine compounds possessing O6 -alkylguanine-DNA alkyltransferase depleting activity
GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds

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