RU2198698C2 - Method for forming bone regenerate in bone defects - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: method involves acting upon bone defect After performing operation including pathologic bone fragment resection within the limits of healthy tissues, resection area is treated with external electromagnetic field daily during 30 min. the field is built using amplitude-modulated sinusoid signal which carrying frequency belongs to 10-1000 kHz interval and modulation frequency belongs to 10-1000 Hz interval. The signal is sent to magnetic coil winding. The coil is included into chip circuit and set on the bone resection area. Winding current is not greater than 7 mcA. First, modulation frequency is varied within the limits of 10-100 Hz with 2-3 s long period. Calcium salt preparation is administered to skin covering bone defect beginning from the tenth day after the surgical intervention before every procedure. The treatment is carried out with modulation frequency varied within the limits of 10-100 Hz with 10-12 s long period. The procedures are applied during 25-45 days. EFFECT: enhanced effectiveness of treatment.

Description

 The invention relates to medicine, namely to traumatology and orthopedics.

 The stimulating effect of a weak electric current on bone tissue regeneration is known [1].

 Electrical stimulation increases the amount of adenosine triphosphoric acid, which is a universal source of biological energy in regenerating bone tissue, improves the energy supply of the healing process of bone wounds.

 A known method of replacing a bone defect by the method of monolocal compression-distraction osteosynthesis with an Ilizarov apparatus [2].

 However, the complete replacement of the defect in this way requires a long time. The disadvantage is that when implementing the method requires multiple surgical interventions (dissection of the bone to replace the defect and fixation of the bone with knitting needles after replacing the defect).

 The closest analogue is the method of forming a bone regenerator for bone defects, which consists in influencing the area of the bone defect with a physiological factor [3].

 A known method of stimulating the regeneration of bone tissue is carried out by repeated exposure to the affected area of the limb with low-frequency electric pulses using metal electrodes.

 The disadvantage of this method is that the effect is carried out by the contact method, as well as the use of a low-frequency pulse signal, which reduces the effectiveness of the impact.

 The technical result is to increase the effectiveness of exposure to bone defects.

 This is achieved by the fact that in the method of forming a bone regenerate with bone defects, including exposure to the area of the bone defect by a physical factor after an operation containing the reaction of the pathological area of the bone within healthy tissues, an external electromagnetic high-frequency field is exposed to the bone resection area daily for 30 minutes , the formation of which uses an amplitude-modulated sinusoidal signal with a carrier frequency in the range of 100-1000 kHz, modulation frequency in the range e 10-1000 Hz, which is fed into the winding of the inductor installed on the bone resection area and included in the LC circuit, the current in the winding is not more than 7 mAA, while at the beginning of the procedure the modulation frequency is changed from 10 to 100 Hz with a period of 2-3 s, starting from the 10th day after the operation, preparations with calcium salts are applied to the skin over the resection zone before each procedure, and the effect is carried out with a modulation frequency varying from 10 to 1000 Hz with a period of equal to 10-12 s, and the procedures are carried out in echenie 25-45 days.

 The method of formation of bone regenerate is carried out as follows. An operation is performed - closed osteosynthesis by an external fixation apparatus with subsequent resection of the pathological area of the bone within healthy tissues. From the first days after the operation (2nd – 3rd day), an external influence element is installed on the bone resection zone, the role of which is performed by the winding of the inductor, which is an integral part of the oscillatory circuit. The coil is made with a detachable winding [4, 5]. An amplitude-modulated sinusoidal signal with a carrier frequency of 100-1000 kHz and a modulation frequency in the range of 10-1000 Hz is supplied to the winding terminals. The frequency of the generator is equal to the resonant frequency of the oscillatory circuit of the exposure element. During the procedure, the modulation frequency changes (sways) within 10-100 Hz. The swing period is 2-3 seconds. The duration of the procedure is 30 minutes, the current flowing through the oscillatory circuit is not more than 7 μA. The procedure is carried out daily. After the procedure, the coil is removed from the limb of the patient. From the 10th day after the operation, preparations with calcium salts (calcium chloride, calcium gluconate) are applied to the skin over the resection zone. The tissue wipe is wetted in the solution and wraps around the limb in the resection zone. A napkin is wrapped with a plastic film on top. An inductance coil is put on a limb, to which an amplitude-modulated sinusoidal signal with a carrier frequency in the range of 100-1000 kHz is supplied, the modulation frequency oscillates within 10-1000 Hz, the swing period is 10-12 seconds. The duration of the procedure is 30 minutes, the current flowing through the oscillating circuit is not more than 7 μA. The procedure is carried out daily for 24-45 days, depending on the size of the bone defect.

 During the procedure, blood pressure and pulse are measured 15-20 minutes after the end of the procedure and every day following the procedure before the next session of exposure to the electromagnetic field. The proposed method allows to create a mode of optimal formation of bone regenerate. The method was tested experimentally at the trauma unit of the Omsk city emergency hospital 2. Positive results were obtained.

Sources of information
1. V.A. Landa et al. On the mechanism of the stimulating effect of electric current on the reparative regeneration of bone tissue. - Bulletin of experimental biology and medicine, 1978, 9, p. 363-362.

 2. RF patent 538710, cl. A 61 B 17/18, bull. 46, 1976

 3. RF patent 554870 A1, publ. 04/25/1977.

 4. RF patent 1772830, cl. H 01 F 17/02.

 5. RF patent 2103758, cl. H 01 F 17/02.

Claims (1)

 A method of forming a bone regenerate in case of bone defects, including exposure to the area of the bone defect with a physical factor, characterized in that after the operation, containing a resection of the pathological area of the bone within healthy tissues, an external electromagnetic high-frequency field is exposed to the area of bone resection daily for 30 minutes, in the formation of which an amplitude-modulated sinusoidal signal is used with a carrier frequency in the range of 100-1000 kHz, a modulation frequency in the range of 10-1000 Hz, which is fed into the winding of an inductor installed on the bone resection area and included in the LC circuit, the current in the winding is no more than 7 μA, while at the beginning of the procedure, the modulation frequency is changed from 10 to 100 Hz with a period equal to 2-3 s, starting from the 10th day after the operation, preparations with calcium salts are applied to the skin over the resection zone before each procedure, and the effect is carried out with a modulation frequency varying from 10 to 1000 Hz with a period of 10-12 c, moreover, the procedures are carried out over e 25-45 days.