RU2015120804A - Антагонисты активина-actrii и их применение для лечения нарушений костной ткани и других нарушений - Google Patents
Антагонисты активина-actrii и их применение для лечения нарушений костной ткани и других нарушений Download PDFInfo
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- 210000000988 bone and bone Anatomy 0.000 title claims abstract 5
- 208000026062 Tissue disease Diseases 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 208000035475 disorder Diseases 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract 40
- 239000003112 inhibitor Substances 0.000 claims abstract 16
- 208000020084 Bone disease Diseases 0.000 claims abstract 12
- 208000013725 Chronic Kidney Disease-Mineral and Bone disease Diseases 0.000 claims abstract 10
- 230000008416 bone turnover Effects 0.000 claims abstract 6
- 208000017169 kidney disease Diseases 0.000 claims abstract 5
- 201000005991 hyperphosphatemia Diseases 0.000 claims abstract 4
- 208000005475 Vascular calcification Diseases 0.000 claims abstract 3
- 208000004434 Calcinosis Diseases 0.000 claims abstract 2
- 239000004098 Tetracycline Substances 0.000 claims abstract 2
- 230000003143 atherosclerotic effect Effects 0.000 claims abstract 2
- 230000002308 calcification Effects 0.000 claims abstract 2
- 208000005368 osteomalacia Diseases 0.000 claims abstract 2
- 229960002180 tetracycline Drugs 0.000 claims abstract 2
- 229930101283 tetracycline Natural products 0.000 claims abstract 2
- 235000019364 tetracycline Nutrition 0.000 claims abstract 2
- 150000003522 tetracyclines Chemical class 0.000 claims abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 208000020832 chronic kidney disease Diseases 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 238000000502 dialysis Methods 0.000 claims 1
- 208000028208 end stage renal disease Diseases 0.000 claims 1
- 201000000523 end stage renal failure Diseases 0.000 claims 1
- 201000002793 renal fibrosis Diseases 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1796—Receptors; Cell surface antigens; Cell surface determinants for hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- Diabetes (AREA)
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- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract
1. Способ лечения адинамического нарушения костной ткани у индивидуума, где способ включает введение терапевтически эффективного количества ингибитора ActRII индивидууму, нуждающемуся в лечении адинамического нарушения костной ткани.2. Способ лечения формы CKD-MBD с адинамическим нарушением костной ткани у индивидуума, где способ включает введение терапевтически эффективного количества ингибитора ActRII индивидууму, нуждающемуся в лечении формы CKD-MBD с адинамическим нарушением костной ткани.3. Способ по п. 1 или 2, где адинамическое нарушение костной ткани характеризуется отсутствием включения тетрациклина в минерализованную костную ткань.4. Способ лечения формы CKD-MBD с низким оборотом костной ткани у индивидуума, где способ включает введение терапевтически эффективного количества ингибитора ActRII индивидууму, нуждающемуся в лечении формы CKD-MBD с низким оборотом костной ткани.5. Способ по п. 4, где форма CKD-MBD с низким оборотом костной ткани представляет собой остеомаляцию.6. Способ лечения нарушения костной ткани, характеризующегося гиперфосфатемией, у индивидуума, где способ включает введение терапевтически эффективного количества ингибитора ActRII индивидууму, нуждающемуся в лечении нарушения костной ткани, характеризующегося гиперфосфатемией.7. Способ лечения кальцификации сосудов у индивидуума, где способ включает введение терапевтически эффективного количества ингибитора ActRII индивидууму, нуждающемуся в лечении атеросклеротической кальцификации.8. Способ лечения почечного заболевания у индивидуума, где способ включает введение терапевтически эффективного количества ингибитора ActRII индивидууму, нуждающемуся в лечении заболевания почек.9. Способ по п. 8,
Claims (17)
1. Способ лечения адинамического нарушения костной ткани у индивидуума, где способ включает введение терапевтически эффективного количества ингибитора ActRII индивидууму, нуждающемуся в лечении адинамического нарушения костной ткани.
2. Способ лечения формы CKD-MBD с адинамическим нарушением костной ткани у индивидуума, где способ включает введение терапевтически эффективного количества ингибитора ActRII индивидууму, нуждающемуся в лечении формы CKD-MBD с адинамическим нарушением костной ткани.
3. Способ по п. 1 или 2, где адинамическое нарушение костной ткани характеризуется отсутствием включения тетрациклина в минерализованную костную ткань.
4. Способ лечения формы CKD-MBD с низким оборотом костной ткани у индивидуума, где способ включает введение терапевтически эффективного количества ингибитора ActRII индивидууму, нуждающемуся в лечении формы CKD-MBD с низким оборотом костной ткани.
5. Способ по п. 4, где форма CKD-MBD с низким оборотом костной ткани представляет собой остеомаляцию.
6. Способ лечения нарушения костной ткани, характеризующегося гиперфосфатемией, у индивидуума, где способ включает введение терапевтически эффективного количества ингибитора ActRII индивидууму, нуждающемуся в лечении нарушения костной ткани, характеризующегося гиперфосфатемией.
7. Способ лечения кальцификации сосудов у индивидуума, где способ включает введение терапевтически эффективного количества ингибитора ActRII индивидууму, нуждающемуся в лечении атеросклеротической кальцификации.
8. Способ лечения почечного заболевания у индивидуума, где способ включает введение терапевтически эффективного количества ингибитора ActRII индивидууму, нуждающемуся в лечении заболевания почек.
9. Способ по п. 8, где заболевание почек представляет собой фиброз почек.
10. Способ снижения уровня кальция сосудов у индивидуума с
диагнозом кальцификации сосудов, где способ включает введение терапевтически эффективного количества ингибитора ActRII индивидууму.
11. Способ по пп. 1, 2, 4, 6, 7, 8 или 10, где ингибитор ActRII представляет собой полипептид, включающий аминокислотную последовательность, выбранную из группы, состоящей из
a. последовательности, на 90% идентичной SEQ ID NO: 2;
b. последовательности, на 95% идентичной SEQ ID NO: 2;
c. последовательности, на 98% идентичной SEQ ID NO: 2;
d. SEQ ID NO: 2;
e. последовательности, на 90% идентичной SEQ ID NO: 3;
f. последовательности, на 95% идентичной SEQ ID NO: 3;
g. последовательности, на 98% идентичной SEQ ID NO: 3;
h. SEQ ID NO: 3;
i. последовательности, на 90% идентичной SEQ ID NO: 6;
j. последовательности, на 95% идентичной SEQ ID NO: 6;
k. последовательности, на 98% идентичной SEQ ID NO: 6;
l. SEQ ID NO: 6;
m. последовательности, на 90% идентичной SEQ ID NO: 7;
n. последовательности, на 95% идентичной SEQ ID NO: 7;
o. последовательности, на 98% идентичной SEQ ID NO: 7;
p. SEQ ID NO: 7;
q. последовательности, на 90% идентичной SEQ ID NO: 12;
r. последовательности, на 95% идентичной SEQ ID NO: 12;
s. последовательности, на 98% идентичной SEQ ID NO: 12;
t. SEQ ID NO: 12;
u. последовательности, на 90% идентичной SEQ ID NO: 17;
v. последовательности, на 95% идентичной SEQ ID NO: 17;
w. последовательности, на 98% идентичной SEQ ID NO: 17;
x. SEQ ID NO: 17;
y. последовательности, на 90% идентичной SEQ ID NO: 20;
z. последовательности, на 95% идентичной SEQ ID NO: 20;
aa. последовательности, на 98% идентичной SEQ ID NO: 20;
bb. SEQ ID NO: 20;
cc. последовательности, на 90% идентичной SEQ ID NO: 21;
dd. последовательности, на 95% идентичной SEQ ID NO: 21;
ee. последовательности, на 98% идентичной SEQ ID NO: 21;
ff. SEQ ID NO: 21;
gg. последовательности, на 90% идентичной SEQ ID NO: 23;
hh. последовательности, на 95% идентичной SEQ ID NO: 23;
ii. последовательности, на 98% идентичной SEQ ID NO: 23;
jj. SEQ ID NO: 23;
kk. последовательности, на 90% идентичной SEQ ID NO: 25;
ll. последовательности, на 95% идентичной SEQ ID NO: 25;
mm. последовательности, на 98% идентичной SEQ ID NO: 25; и
nn. SEQ ID NO: 25.
12. Способ по пп. 1, 2, 4, 6, 7, 8 или 10, где ингибитор ActRII представляет собой полипептид, включающий аминокислотную последовательность SEQ ID NO:7.
13. Способ по пп. 1, 2, 4, 6, 7, 8 или 10, где ингибитор ActRII вводят парентерально.
14. Способ по п. 1, 2, 4, 6, 7, 8 или 10, где возраст индивидуума меньше 18 лет.
15. Способ по пп. 1, 2, 4, 6, 7, 8 или 10, где способ увеличивает рост индивидуума.
16. Способ по пп. 1, 2, 4, 6, 7, 8 или 10, где индивидуум страдает терминальной стадией почечной недостаточности.
17. Способ по пп. 1, 2, 4, 6, 7, 8 или 10, где индивидуум подвергается диализу.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261721898P | 2012-11-02 | 2012-11-02 | |
| US61/721,898 | 2012-11-02 | ||
| US201261740665P | 2012-12-21 | 2012-12-21 | |
| US61/740,665 | 2012-12-21 | ||
| PCT/US2013/068009 WO2014071158A1 (en) | 2012-11-02 | 2013-11-01 | Activin-actrii antagonists and uses for treating bone and other disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018145985A Division RU2018145985A (ru) | 2012-11-02 | 2013-11-01 | Антагонисты активина-actrii и их применение для лечения нарушений костной ткани и других нарушений |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015120804A true RU2015120804A (ru) | 2016-12-27 |
| RU2678117C2 RU2678117C2 (ru) | 2019-01-23 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015120804A RU2678117C2 (ru) | 2012-11-02 | 2013-11-01 | Антагонисты активина-actrii и их применение для лечения нарушений костной ткани и других нарушений |
| RU2018145985A RU2018145985A (ru) | 2012-11-02 | 2013-11-01 | Антагонисты активина-actrii и их применение для лечения нарушений костной ткани и других нарушений |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018145985A RU2018145985A (ru) | 2012-11-02 | 2013-11-01 | Антагонисты активина-actrii и их применение для лечения нарушений костной ткани и других нарушений |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US10195249B2 (ru) |
| EP (3) | EP3964224A1 (ru) |
| JP (4) | JP2016504275A (ru) |
| KR (3) | KR20210091358A (ru) |
| CN (1) | CN104936605A (ru) |
| AU (3) | AU2013337677B2 (ru) |
| BR (1) | BR112015009948B1 (ru) |
| CA (2) | CA3120678A1 (ru) |
| ES (2) | ES2884095T3 (ru) |
| HK (2) | HK1214525A1 (ru) |
| IL (2) | IL238443B (ru) |
| MX (2) | MX366336B (ru) |
| NZ (1) | NZ707477A (ru) |
| RU (2) | RU2678117C2 (ru) |
| WO (1) | WO2014071158A1 (ru) |
| ZA (1) | ZA201503135B (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11834508B2 (en) | 2017-03-24 | 2023-12-05 | Novartis Ag | Method of treating structural and/or functional cardiac abnormalities by administering an anti-ActRII receptor antibody |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2631013C (en) | 2005-11-23 | 2019-06-11 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for promoting bone growth |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| TWI480048B (zh) | 2007-02-01 | 2015-04-11 | Acceleron Pharma Inc | 活化素-ＡｃｔＲＩＩａ拮抗劑及其治療或預防乳癌之用途 |
| TW201940502A (zh) | 2007-02-02 | 2019-10-16 | 美商艾瑟勒朗法瑪公司 | 衍生自ＡｃｔＲＩＩＢ的變體與其用途 |
| EP2120999B1 (en) | 2007-02-09 | 2012-08-29 | Acceleron Pharma, Inc. | Pharmaceutical compositions comprising Activin-ActRIIA antagonists and use thereof in preventing or treating multiple myeloma |
| WO2009038745A1 (en) | 2007-09-18 | 2009-03-26 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| PL3494986T3 (pl) | 2008-08-14 | 2020-11-16 | Acceleron Pharma Inc. | Pułapki GDF |
| KR20210034684A (ko) | 2009-06-12 | 2021-03-30 | 악셀레론 파마 인코포레이티드 | 절두된 ＡｃｔＲＩＩＢ-ＦＣ 융합 단백질 |
| AU2010322011B2 (en) | 2009-11-17 | 2016-03-31 | Acceleron Pharma Inc. | ActRIIB proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
| WO2012064771A1 (en) | 2010-11-08 | 2012-05-18 | Acceleron Pharma, Inc. | Actriia binding agents and uses thereof |
| ES2884095T3 (es) | 2012-11-02 | 2021-12-10 | Celgene Corp | Antagonistas de activina-actrii y usos para el tratamiento de trastornos óseos y otros trastornos |
| AU2015274277B2 (en) | 2014-06-13 | 2021-03-18 | Acceleron Pharma, Inc. | Methods and compositions for treating ulcers |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11834508B2 (en) | 2017-03-24 | 2023-12-05 | Novartis Ag | Method of treating structural and/or functional cardiac abnormalities by administering an anti-ActRII receptor antibody |
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