RU2012149618A - Менингококковые полипептиды fhbp - Google Patents
Менингококковые полипептиды fhbp Download PDFInfo
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- RU2012149618A RU2012149618A RU2012149618/10A RU2012149618A RU2012149618A RU 2012149618 A RU2012149618 A RU 2012149618A RU 2012149618/10 A RU2012149618/10 A RU 2012149618/10A RU 2012149618 A RU2012149618 A RU 2012149618A RU 2012149618 A RU2012149618 A RU 2012149618A
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- 229920001184 polypeptide Polymers 0.000 title claims abstract 27
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract 27
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract 27
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 10
- 239000012634 fragment Substances 0.000 claims abstract 8
- 150000001413 amino acids Chemical class 0.000 claims abstract 4
- 239000013612 plasmid Substances 0.000 claims abstract 4
- 230000002163 immunogen Effects 0.000 claims abstract 3
- 241000894006 Bacteria Species 0.000 claims abstract 2
- 239000012528 membrane Substances 0.000 claims abstract 2
- 102000039446 nucleic acids Human genes 0.000 claims abstract 2
- 108020004707 nucleic acids Proteins 0.000 claims abstract 2
- 150000007523 nucleic acids Chemical class 0.000 claims abstract 2
- 239000002773 nucleotide Substances 0.000 claims abstract 2
- 125000003729 nucleotide group Chemical group 0.000 claims abstract 2
- 241000124008 Mammalia Species 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 230000008348 humoral response Effects 0.000 claims 2
- 241001174901 Neisseria meningitidis alpha275 Species 0.000 claims 1
- 241000921898 Neisseria meningitidis serogroup A Species 0.000 claims 1
- 241000947238 Neisseria meningitidis serogroup C Species 0.000 claims 1
- 241001573069 Neisseria meningitidis serogroup Y Species 0.000 claims 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1. Полипептид, содержащий аминокислотную последовательность, выбранную из группы, состоящей из последовательностей SEQ ID NO: 20, 23, 76, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 21, 22, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74 и 75.2. Полипептид по п.1, содержащий аминокислотную последовательность SEQ ID NO: 20.3. Полипептид по п.2, содержащий последовательность SEQ ID NO: 79.4. Полипептид по п.1, содержащий аминокислотную последовательность SEQ ID NO: 23.5. Полипептид по п.4, содержащий последовательность SEQ ID NO: 80.6. Полипептид по п.1, содержащий аминокислотную последовательность SEQ ID NO: 76.7. Полипептид по п.6, содержащий последовательность SEQ ID NO: 77.8. Полипептид, содержащий аминокислотную последовательность (i) которая имеет по меньшей мере 90% идентичность с последовательностью SEQ ID NO: 76 и/или (ii) содержит первый фрагмент и второй фрагмент последовательности SEQ ID NO: 76, где указанный первый фрагмент включает эпитоп, находящийся в пределах аминокислот 89-154 последовательности SEQ ID NO: 76, и указанный второй фрагмент включает эпитоп, находящийся в пределах аминокислот 187-248 последовательности SEQ ID NO: 76.9. Нуклеиновая кислота, кодирующая полипептид по любому из предшествующих пунктов.10. Плазмида, содержащая нуклеотидную последовательность, кодирующую полипептид по любому из пп.1-8.11. Клетка-хозяин, трансформированная плазмидой по п.10.12. Клетка-хозяин по п.11, где клетка является менингококковой бактерией.13. Мембранные везикулы, полученные из клетки-хозяина по п.12, где везикулы включают полипептид по любому из пп.1-8.14. Иммуногенная композиция, содержащая полипептид по любому из пп.1-8 или везикулу по п.13.15. Компо�
Claims (20)
1. Полипептид, содержащий аминокислотную последовательность, выбранную из группы, состоящей из последовательностей SEQ ID NO: 20, 23, 76, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 21, 22, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74 и 75.
2. Полипептид по п.1, содержащий аминокислотную последовательность SEQ ID NO: 20.
3. Полипептид по п.2, содержащий последовательность SEQ ID NO: 79.
4. Полипептид по п.1, содержащий аминокислотную последовательность SEQ ID NO: 23.
5. Полипептид по п.4, содержащий последовательность SEQ ID NO: 80.
6. Полипептид по п.1, содержащий аминокислотную последовательность SEQ ID NO: 76.
7. Полипептид по п.6, содержащий последовательность SEQ ID NO: 77.
8. Полипептид, содержащий аминокислотную последовательность (i) которая имеет по меньшей мере 90% идентичность с последовательностью SEQ ID NO: 76 и/или (ii) содержит первый фрагмент и второй фрагмент последовательности SEQ ID NO: 76, где указанный первый фрагмент включает эпитоп, находящийся в пределах аминокислот 89-154 последовательности SEQ ID NO: 76, и указанный второй фрагмент включает эпитоп, находящийся в пределах аминокислот 187-248 последовательности SEQ ID NO: 76.
9. Нуклеиновая кислота, кодирующая полипептид по любому из предшествующих пунктов.
10. Плазмида, содержащая нуклеотидную последовательность, кодирующую полипептид по любому из пп.1-8.
11. Клетка-хозяин, трансформированная плазмидой по п.10.
12. Клетка-хозяин по п.11, где клетка является менингококковой бактерией.
13. Мембранные везикулы, полученные из клетки-хозяина по п.12, где везикулы включают полипептид по любому из пп.1-8.
14. Иммуногенная композиция, содержащая полипептид по любому из пп.1-8 или везикулу по п.13.
15. Композиция по п.14, включающая адъювант.
16. Композиция по п.15, в которой адъювант содержит соль алюминия.
17. Композиция по любому из пп.14-16, дополнительно содержащая второй полипептид, который при введении млекопитающему вызывает гуморальный ответ в виде антител, которые являются бактерицидными против менингококка, при условии, что второй полипептид не является менингококковым fHBP.
18. Композиция по любому из пп.14-16, дополнительно содержащая конъюгированный капсулярный сахарид N. meningitidis серогруппы A, C, W135 и/или Y.
19. Композиция по любому из пп.14-16, дополнительно содержащая конъюгированный пневмококковый капсулярный сахарид.
20. Способ индуцирования гуморального ответа у млекопитающего, включающий введение иммуногенной композиции по любому из пп.14-19.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6671108P | 2008-02-21 | 2008-02-21 | |
| US61/066,711 | 2008-02-21 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010138815/10A Division RU2475496C2 (ru) | 2008-02-21 | 2009-02-20 | МЕНИНГОКОККОВЫЕ ПОЛИПЕПТИДЫ fHBP |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2012149618A true RU2012149618A (ru) | 2014-05-27 |
| RU2567003C2 RU2567003C2 (ru) | 2015-10-27 |
Family
ID=40775198
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010138815/10A RU2475496C2 (ru) | 2008-02-21 | 2009-02-20 | МЕНИНГОКОККОВЫЕ ПОЛИПЕПТИДЫ fHBP |
| RU2012149618/10A RU2567003C2 (ru) | 2008-02-21 | 2012-11-21 | МЕНИНГОКОККОВЫЕ ПОЛИПЕПТИДЫ fHBP |
| RU2015139827A RU2015139827A (ru) | 2008-02-21 | 2015-09-18 | МЕНИНГОКОККОВЫЕ ПОЛИПЕПТИДЫ fHBP |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010138815/10A RU2475496C2 (ru) | 2008-02-21 | 2009-02-20 | МЕНИНГОКОККОВЫЕ ПОЛИПЕПТИДЫ fHBP |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015139827A RU2015139827A (ru) | 2008-02-21 | 2015-09-18 | МЕНИНГОКОККОВЫЕ ПОЛИПЕПТИДЫ fHBP |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9579372B2 (ru) |
| EP (3) | EP2245048B1 (ru) |
| CN (1) | CN102356089B (ru) |
| AU (1) | AU2009215364B2 (ru) |
| BR (1) | BRPI0907843A2 (ru) |
| CA (1) | CA2716212A1 (ru) |
| ES (1) | ES2532946T3 (ru) |
| NZ (2) | NZ587382A (ru) |
| RU (3) | RU2475496C2 (ru) |
| WO (1) | WO2009104097A2 (ru) |
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| PT2275551E (pt) | 1999-10-29 | 2015-06-29 | Novartis Vaccines & Diagnostic | Péptidos antigénicos de neisseria |
| ES2391153T3 (es) | 2000-02-28 | 2012-11-22 | Novartis Vaccines And Diagnostics S.R.L. | Expresión heteróloga de proteínas de Neisseria |
| GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
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- 2009-02-20 WO PCT/IB2009/005038 patent/WO2009104097A2/en active Application Filing
- 2009-02-20 AU AU2009215364A patent/AU2009215364B2/en not_active Ceased
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- 2009-02-20 RU RU2010138815/10A patent/RU2475496C2/ru not_active IP Right Cessation
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- 2009-02-20 EP EP14200294.8A patent/EP2886551A3/en not_active Withdrawn
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| Publication number | Publication date |
|---|---|
| WO2009104097A3 (en) | 2009-12-03 |
| RU2015139827A (ru) | 2017-03-23 |
| ES2532946T3 (es) | 2015-04-06 |
| AU2009215364B2 (en) | 2014-09-18 |
| US20110020390A1 (en) | 2011-01-27 |
| EP3263591B1 (en) | 2019-03-27 |
| EP2245048B1 (en) | 2014-12-31 |
| US20130115238A1 (en) | 2013-05-09 |
| EP2886551A3 (en) | 2015-09-23 |
| RU2010138815A (ru) | 2012-03-27 |
| CN102356089A (zh) | 2012-02-15 |
| AU2009215364A1 (en) | 2009-08-27 |
| BRPI0907843A2 (pt) | 2015-08-04 |
| RU2567003C2 (ru) | 2015-10-27 |
| US9468673B2 (en) | 2016-10-18 |
| CN102356089B (zh) | 2014-02-19 |
| NZ596805A (en) | 2013-06-28 |
| US9579372B2 (en) | 2017-02-28 |
| NZ587382A (en) | 2012-01-12 |
| RU2475496C2 (ru) | 2013-02-20 |
| WO2009104097A2 (en) | 2009-08-27 |
| EP3263591A1 (en) | 2018-01-03 |
| EP2245048A2 (en) | 2010-11-03 |
| CA2716212A1 (en) | 2009-08-27 |
| EP2886551A2 (en) | 2015-06-24 |
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