RS50600B - Kristalni oblik gama - d ivabradin hlorhidrata, postupak njegove izrade i farmaceutske smeše koje ga sadrže - Google Patents
Kristalni oblik gama - d ivabradin hlorhidrata, postupak njegove izrade i farmaceutske smeše koje ga sadržeInfo
- Publication number
- RS50600B RS50600B RSP-2008/0367A RSP20080367A RS50600B RS 50600 B RS50600 B RS 50600B RS P20080367 A RSP20080367 A RS P20080367A RS 50600 B RS50600 B RS 50600B
- Authority
- RS
- Serbia
- Prior art keywords
- degrees
- expressed
- numbers
- line
- height
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Medicinal Preparation (AREA)
- Seasonings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
γd kristalni oblik ivabradin hlorhidrata formule (I):naznačen time stoje dijagram difrakcije X zraka na prašku, u nastavku, izmeren na difraktometru PANalytical X'Pert Pro sa detektorom X'Celerator i, izražen je u vidu položaja linije (ugao Bragg 2 teta, izražen u stepenima), visinom linije (izražena u brojevima), površinom linije (izražena kao brojevi x stepeni), širinom linija u sredini visine ("FWHM", izražena u stepenima) i inter-retikularnom udaljenošću d (izražena u A):Linija n° Ugao 2 teta (stepeni) Visina (brojevi) Površina (brojevi x stepeni) FWHM (stepeni) Inter-retikularna udaljenost (A)1 4,3 1077 124 0,1171 20,6332 6,9 132 70 0,5353 12,7873 8,4 269 35 0,1338 10,4824 10,6 322 26 0,0836 8,3105 11,9 733 97 0,1338 7,4146 12,5 1406 278 0,2007 7,0697 13,4 2975 442 0,1506 6,6198 14,4 825 122 0,1506 6,1349 15,8 1036 205 0,2007 5,59810 16,3 540 107 0,2007 5,45011 16,9 1007 183 0,184 5,233Linija n° Ugao 2 teta (stepeni) Visina (brojevi) Površina (brojevi x stepeni) FWHM (stepeni) Inter-retikularna udaljenost (A)12 17,8 499 58 0,1171 4,97813 18,9 1062 140 0,1338 4,68614 19,8 570 85 0,1506 4,48515 20,2 549 63 0,1171 4,39916 20,9 2565 635 0,2509 4,24117 21,6 531 105 0,2007 4,10418 22,3 213 35 0,1673 3,98119 23,4 278 27 0,1004 3,80720 24,1 1404 185 0,1338 3,69421 24,4 1526 176 0,1171 3,65022 24,8 676 100 0,1506 3,59123 25,4 702 139 0,2007 3,50424 26,2 1737 401 0,2342 3,40325 26,8 258 51 0,2007 3,33126 27,2 182 24 0,1338 3,28227 27,9 838 249 0,3011 3,19328 29,1 152 20 0,1338 3,071Prijava sadrži još 5 patentnih zahteva.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0501990A FR2882556B1 (fr) | 2005-02-28 | 2005-02-28 | Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS50600B true RS50600B (sr) | 2010-05-07 |
Family
ID=34954879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RSP-2008/0367A RS50600B (sr) | 2005-02-28 | 2006-02-28 | Kristalni oblik gama - d ivabradin hlorhidrata, postupak njegove izrade i farmaceutske smeše koje ga sadrže |
Country Status (43)
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2868777B1 (fr) * | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2882555B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| FR2882554B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| FR2882556B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| FR2882553B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| FR2891826B1 (fr) * | 2005-10-11 | 2007-12-28 | Servier Lab | Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
| FR2891827B1 (fr) * | 2005-10-11 | 2007-12-28 | Servier Lab | Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| FR2894825B1 (fr) * | 2005-12-21 | 2010-12-03 | Servier Lab | Nouvelle association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion et les compositions pharmaceutiques qui la contiennent |
| EP2097383B1 (en) | 2006-11-30 | 2012-02-08 | Cadila Healthcare Limited | Process for preparation of ivabradine hydrochloride |
| CN101353325B (zh) * | 2007-07-27 | 2011-11-09 | 上海优拓医药科技有限公司 | 稳定型盐酸伊伐布雷定结晶及其制备方法 |
| PT2471780E (pt) | 2007-05-30 | 2015-02-24 | Ind Swift Lab Ltd | Sais oxalato de ivabradina cristalinos e seus polimorfos |
| CN102264689B (zh) | 2008-12-22 | 2014-12-31 | 新梅斯托克尔卡公司 | 制备伊伐布雷定的方法 |
| CN101774969B (zh) | 2009-01-13 | 2012-07-04 | 江苏恒瑞医药股份有限公司 | 硫酸伊伐布雷定及其i型结晶的制备方法 |
| EP2534135A2 (en) | 2010-02-12 | 2012-12-19 | KRKA, D.D., Novo Mesto | Novel forms of ivabradine hydrochloride |
| HUP1000245A2 (en) | 2010-05-07 | 2011-11-28 | Richter Gedeon Nyrt | Industrial process for the production ivabradin salts |
| WO2012025940A1 (en) | 2010-08-25 | 2012-03-01 | Cadila Healthcare Limited | Polymorphic form of ivabradine hydrochloride and process for preparation thereof |
| EP2726462B1 (en) * | 2011-08-02 | 2017-03-22 | Sandoz AG | Acetone solvate of ivabradine hydrochloride |
| EP2773621B1 (en) | 2011-11-04 | 2015-12-30 | Synthon BV | A process for making crystalline delta-form of ivabradine hydrochloride |
| EP2589594A1 (en) | 2011-11-04 | 2013-05-08 | Urquima S.A. | Ivabradine hydrochloride Form IV |
| EP3156399A1 (en) | 2011-11-14 | 2017-04-19 | Cadila Healthcare Limited | Polymorphic forms of ivabradine hydrochloride |
| EP2948432B1 (en) | 2013-01-24 | 2018-09-19 | Synthon BV | Process for making ivabradine |
| CZ2013767A3 (cs) | 2013-10-02 | 2015-04-29 | Zentiva, K.S. | Pevná forma Ivabradin hydrochloridu a (S)-mandlové kyseliny a její farmaceutická kompozice |
| MX363389B (es) | 2013-12-12 | 2019-03-20 | Synthon Bv | Composicion farmaceutica que comprende ivabradina amorfa. |
| EP2774606B1 (en) | 2014-02-14 | 2019-01-30 | Synthon B.V. | Pharmaceutical composition comprising ivabradine hydrochloride polymorph IV |
| CZ2014478A3 (cs) | 2014-07-10 | 2015-09-16 | Zentiva, K.S. | Pevná forma Ivabradin hydrochloridu a (R)-mandlové kyseliny a její farmaceutická kompozice |
| TWI598360B (zh) * | 2016-12-19 | 2017-09-11 | 義守大學 | Ｆｓｂｍ重組蛋白及其用途 |
| TR201703066A2 (tr) | 2017-02-28 | 2018-09-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | İvabradi̇ni̇n kati oral farmasöti̇k kompozi̇syonlari |
| EP3366282A1 (en) | 2017-02-28 | 2018-08-29 | Sanovel Ilac Sanayi ve Ticaret A.S. | Solid oral pharmaceutical compositions of ivabradine |
| IT202000025312A1 (it) | 2020-10-26 | 2022-04-26 | Cambrex Profarmaco Milano S R L | Processi per la preparazione di polimorfi di ivabradina hcl |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US534859A (en) * | 1895-02-26 | Condenser for ice-machines | ||
| DE3119874A1 (de) * | 1981-05-19 | 1982-12-09 | Dr. Karl Thomae Gmbh, 7950 Biberach | "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel" |
| DE3418270A1 (de) * | 1984-05-17 | 1985-11-21 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE69133158T2 (de) | 1990-08-29 | 2003-07-17 | Humanetics Corp | Behandlungsverfahren zur förderung des gewichtsverlustes unter verwendung eines substituierten delta-5-androstens |
| FR2681862B1 (fr) * | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
| FR2818552B1 (fr) | 2000-12-26 | 2003-02-07 | Servier Lab | Compositions pharmaceutique solide thermoformable pour la liberation controlee d'ivabradine |
| FR2868777B1 (fr) * | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2882554B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| FR2882556B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| FR2882553B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| FR2882555B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| FR2891826B1 (fr) * | 2005-10-11 | 2007-12-28 | Servier Lab | Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
| FR2891827B1 (fr) * | 2005-10-11 | 2007-12-28 | Servier Lab | Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
-
2005
- 2005-02-28 FR FR0501990A patent/FR2882556B1/fr not_active Expired - Fee Related
-
2006
- 2006-02-13 MA MA28793A patent/MA28132A1/fr unknown
- 2006-02-14 PE PE2006000170A patent/PE20061070A1/es active IP Right Grant
- 2006-02-15 EC EC2006006376A patent/ECSP066376A/es unknown
- 2006-02-21 CR CR8246A patent/CR8246A/es not_active Application Discontinuation
- 2006-02-21 SG SG200601157A patent/SG125233A1/en unknown
- 2006-02-22 CU CU20060038A patent/CU23615B7/es active IP Right Grant
- 2006-02-22 GT GT200600086A patent/GT200600086A/es unknown
- 2006-02-22 US US11/359,262 patent/US7361651B2/en active Active
- 2006-02-22 TW TW095105985A patent/TWI314142B/zh active
- 2006-02-22 AP AP2006003522A patent/AP2112A/xx active
- 2006-02-23 BR BRPI0600696-5A patent/BRPI0600696A/pt not_active Application Discontinuation
- 2006-02-24 CA CA2537404A patent/CA2537404C/fr active Active
- 2006-02-24 UY UY29407A patent/UY29407A1/es not_active Application Discontinuation
- 2006-02-27 GE GEAP20069266A patent/GEP20084468B/en unknown
- 2006-02-27 SA SA06270041A patent/SA06270041B1/ar unknown
- 2006-02-27 KR KR1020060018727A patent/KR100827503B1/ko active IP Right Grant
- 2006-02-27 UA UAA200602125A patent/UA81340C2/uk unknown
- 2006-02-27 NO NO20060949A patent/NO338482B1/no unknown
- 2006-02-27 EA EA200600323A patent/EA008532B1/ru unknown
- 2006-02-27 NZ NZ545579A patent/NZ545579A/en unknown
- 2006-02-27 IL IL173960A patent/IL173960A0/en active IP Right Grant
- 2006-02-27 MY MYPI20060822A patent/MY157933A/en unknown
- 2006-02-28 DE DE602006001411T patent/DE602006001411D1/de active Active
- 2006-02-28 DK DK06290327T patent/DK1695709T3/da active
- 2006-02-28 AU AU2006200855A patent/AU2006200855B2/en active Active
- 2006-02-28 JP JP2006051650A patent/JP4628975B2/ja active Active
- 2006-02-28 PT PT06290327T patent/PT1695709E/pt unknown
- 2006-02-28 ME MEP-2008-924A patent/ME02750B/me unknown
- 2006-02-28 SI SI200630054T patent/SI1695709T1/sl unknown
- 2006-02-28 ME MEP-2008-367A patent/ME01394B/me unknown
- 2006-02-28 AR ARP060100731A patent/AR056931A1/es not_active Application Discontinuation
- 2006-02-28 WO PCT/FR2006/000445 patent/WO2006092494A1/fr not_active Application Discontinuation
- 2006-02-28 ES ES06290327T patent/ES2308688T3/es active Active
- 2006-02-28 CN CNB200610058077XA patent/CN100432057C/zh active Active
- 2006-02-28 AT AT06290327T patent/ATE397933T1/de active
- 2006-02-28 PL PL06290327T patent/PL1695709T3/pl unknown
- 2006-02-28 ZA ZA2006/01760A patent/ZA200601760B/en unknown
- 2006-02-28 RS RSP-2008/0367A patent/RS50600B/sr unknown
- 2006-02-28 EP EP06290327A patent/EP1695709B1/fr active Active
- 2006-02-28 CO CO06019920A patent/CO5770095A1/es not_active Application Discontinuation
-
2007
- 2007-02-01 HK HK07101193.6A patent/HK1096660A1/xx unknown
-
2008
- 2008-02-28 US US12/072,887 patent/US20080153804A1/en not_active Abandoned
- 2008-07-28 CY CY20081100784T patent/CY1108220T1/el unknown
- 2008-08-27 HR HR20080417T patent/HRP20080417T5/xx unknown
-
2009
- 2009-08-27 US US12/583,917 patent/US7872001B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RS50600B (sr) | Kristalni oblik gama - d ivabradin hlorhidrata, postupak njegove izrade i farmaceutske smeše koje ga sadrže | |
| RS50599B (sr) | KRISTALNI OBLIK BETA-d IVABRADIN HLORHIDRATA, POSTUPAK NJEGOVE IZRADE I FARMACEUTSKE SMEŠE KOJE GA SADRŽE | |
| RS50598B (sr) | Kristalni oblik gama ivabradin hlorhidrata, postupak njegove izrade i farmaceutske smeše koje ga sadrže | |
| RS50661B (sr) | Beta kristalni oblik ivabradin hidrohlorida, postupak njegove izrade i farmaceutske smeše koje ga sadrže | |
| TW200738596A (en) | Benzamide and heteroarene derivatives | |
| ECSP066914A (es) | FORMA CRISTALINA dd DEL CLORHIDRATO DE LA IVABRADINA, SU PROCEDIMIENTO DE PREPARACIÓN Y LAS COMPOSICIONES FARMACÉUTICAS QUE LA CONTIENEN | |
| UA90265C2 (ru) | Дельта-кристаллическая форма гидрохлорида ивабрадина, способ ее получения и фармацевтическая композиция, которая ее содержит | |
| IL177962A0 (en) | Compounds and methods for treating dyslipidemia | |
| GEP20115359B (en) | Fused cyclic compounds | |
| TW200633712A (en) | Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof | |
| JO3360B1 (ar) | الشكل البلوري الجديد 3 للأغوميلاتين وعملية تحضيره والمكونات الصيدلانية التي تحتويه | |
| MX2009010552A (es) | Antagonistas de receptor de opioide periferico y usos de los mismos. | |
| MY150990A (en) | Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands | |
| TW200702330A (en) | 3,4,5-Substituted piperidines | |
| TW200714598A (en) | Urea derivatives, methods for their manufacture, and uses therefor | |
| TW200740781A (en) | Novel compounds | |
| UA89904C2 (ru) | β КРИСТАЛЛИЧЕСКАЯ ФОРМА АРГИНИНОВОЙ СОЛИ ПЕРИНДОПРИЛА, СПОСОБ ЕЕ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, КОТОРАЯ ЕЕ СОДЕРЖИТ | |
| RS51110B (sr) | Alfa kristalni oblik stroncijum ranelata, postupak njegove izrade i farmaceutske smeše koje ga sadrže | |
| UA94242C2 (ru) | Производные бензотиазолциклобутиламина и их применение как лигандов рецепторов гистамина-3 | |
| JO2501B1 (en) | The crystalline form of gamma-D of ivabradine hydrochloride, its preparation process and its pharmaceutical ingredients | |
| TN2011000508A1 (en) | Substituted piperidines as ccr3 antagonists | |
| TH82143B (th) | พหุสัณฐานแบบผลึกของเกลือไบซัลเฟทของสารต้านตัวรับธรอมบิน | |
| TH81392A (sr) |