PT946507E - Compostos de pirrolilo substituidos para o tratamento da inflamacao - Google Patents
Compostos de pirrolilo substituidos para o tratamento da inflamacaoInfo
- Publication number
- PT946507E PT946507E PT97950891T PT97950891T PT946507E PT 946507 E PT946507 E PT 946507E PT 97950891 T PT97950891 T PT 97950891T PT 97950891 T PT97950891 T PT 97950891T PT 946507 E PT946507 E PT 946507E
- Authority
- PT
- Portugal
- Prior art keywords
- inflammation
- compounds
- pyrrolylic
- substituted
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3268896P | 1996-12-10 | 1996-12-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT946507E true PT946507E (pt) | 2004-02-27 |
Family
ID=21866300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97950891T PT946507E (pt) | 1996-12-10 | 1997-12-09 | Compostos de pirrolilo substituidos para o tratamento da inflamacao |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5935990A (pt) |
| EP (1) | EP0946507B1 (pt) |
| AT (1) | ATE250576T1 (pt) |
| AU (1) | AU5377698A (pt) |
| CA (1) | CA2273836A1 (pt) |
| DE (1) | DE69725171T2 (pt) |
| DK (1) | DK0946507T3 (pt) |
| ES (1) | ES2208964T3 (pt) |
| PT (1) | PT946507E (pt) |
| WO (1) | WO1998025896A1 (pt) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1211361C (zh) * | 1996-03-18 | 2005-07-20 | 卫材株式会社 | 含有稠环的羧酸衍生物 |
| US5908858A (en) * | 1996-04-05 | 1999-06-01 | Sankyo Company, Limited | 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses |
| US6887893B1 (en) | 1997-12-24 | 2005-05-03 | Sankyo Company, Limited | Methods and compositions for treatment and prevention of tumors, tumor-related disorders and cachexia |
| US6649645B1 (en) * | 1998-12-23 | 2003-11-18 | Pharmacia Corporation | Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia |
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| DE19953025A1 (de) | 1999-11-04 | 2001-05-10 | Merck Patent Gmbh | Pyrrolderivate als Phosphodiesterase VII-Hemmer |
| EP1525883A1 (en) * | 1999-12-08 | 2005-04-27 | Pharmacia Corporation | Ciclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect |
| KR20020067574A (ko) * | 1999-12-23 | 2002-08-22 | 니트로메드 인코포레이티드 | 니트로소화 및 니트로실화된 사이클로옥시게나아제-2억제제, 조성물 및 그 이용방법 |
| DE19963174A1 (de) * | 1999-12-27 | 2001-07-12 | Gruenenthal Gmbh | Substituierte Pyrrol-Mannichbasen |
| EP1253921A4 (en) | 2000-01-28 | 2004-10-13 | Merck & Co Inc | TREATMENT AND PROPHYLAXIS OF PROSTATE CANCER WITH COX-2 SELECTIVE INHIBITORS |
| JP2003531202A (ja) * | 2000-04-25 | 2003-10-21 | ファルマシア・コーポレーション | ３，４−ジ（カルボシクリルまたはヘテロシクリル）チオフェンの位置選択的合成 |
| EP1299123A2 (en) * | 2000-07-13 | 2003-04-09 | Pharmacia Corporation | Use of cox-2 inhibitors in the treatment and prevention of ocular cox-2 mediated disorders |
| US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
| US7695736B2 (en) | 2001-04-03 | 2010-04-13 | Pfizer Inc. | Reconstitutable parenteral composition |
| US6673818B2 (en) | 2001-04-20 | 2004-01-06 | Pharmacia Corporation | Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation |
| UA80682C2 (en) * | 2001-08-06 | 2007-10-25 | Pharmacia Corp | Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition |
| JP2005522477A (ja) | 2002-04-08 | 2005-07-28 | グラクソ グループ リミテッド | （２−（（２−アルコキシ）−フェニル）−シクロペント−１−エニル）芳香族炭素環式および複素環式酸および誘導体 |
| US7622117B2 (en) * | 2002-04-17 | 2009-11-24 | Dynamis Therapeutics, Inc. | 3-deoxyglucosone and skin |
| GB0212785D0 (en) * | 2002-05-31 | 2002-07-10 | Glaxo Group Ltd | Compounds |
| JP4601274B2 (ja) * | 2002-08-20 | 2010-12-22 | 第一三共株式会社 | γ−ケトアセタール類の製造方法 |
| AU2003257568A1 (en) * | 2002-08-20 | 2004-03-11 | Sankyo Company, Limited | PROCESS FOR THE PRODUCTION OF Gamma-KETO ACETALS |
| GB0225548D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Compounds |
| AU2003291227A1 (en) | 2002-11-05 | 2004-06-07 | Smithkline Beecham Corporation | Antibacterial agents |
| DE10261130A1 (de) * | 2002-12-20 | 2004-07-01 | Grünenthal GmbH | Arzneimittel enthaltend substituierte 2,5-Diaminomethyl-1H-pyrrole |
| JP4354984B2 (ja) * | 2003-05-07 | 2009-10-28 | オステオロジックス エイ／エス | 水溶性ストロンチウム塩を用いる軟骨／骨症状の治療 |
| AU2004237438B2 (en) * | 2003-05-07 | 2011-01-20 | Osteologix A/S | Strontium combinations for prophylaxis/treatment of cartilage and/or bone conditions |
| US20050131028A1 (en) * | 2003-09-11 | 2005-06-16 | Pharmacia Corporation | Methods and compositions for the extended duration treatment of pain, inflammation and inflammation-related disorders |
| US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| GB0328024D0 (en) * | 2003-12-03 | 2004-01-07 | Glaxo Group Ltd | Compounds |
| MX2007008227A (es) * | 2005-01-05 | 2007-09-11 | Novacea Inc | Prevencion de trastornos tromboticos con compuestos de vitamina d activa o mimeticos de los mismos. |
| FR2887548B1 (fr) * | 2005-06-27 | 2007-09-21 | Sanofi Aventis Sa | Derives de 4,5-diarylpyrrole, leur preparation et leur application en therapeutique |
| JP2009510090A (ja) * | 2005-09-27 | 2009-03-12 | ミリアド ジェネティックス インコーポレーティッド | 治療化合物としてのピロール誘導体 |
| WO2007074176A1 (es) * | 2005-12-27 | 2007-07-05 | Universidad Del Pais Vasco - Euskal Herriko Unibertsitatea (Upv-Ehu) | Nuevos derivados pirrólicos con actividad inhibidora de desacetilasas de histonas |
| CN101479262A (zh) | 2006-06-27 | 2009-07-08 | 艾博特公司 | 噻唑啉和唑啉衍生物及其应用方法 |
| EP2059504B1 (en) | 2006-08-03 | 2015-09-09 | Rottapharm Biotech S.r.l. | 3-substituted-1,5-diarly-2-alkyl-pyrroles highly selective and orally effective cox-2 inhibitors |
| AU2007294553A1 (en) * | 2006-09-07 | 2008-03-13 | Myriad Genetics, Inc. | Therapeutic compounds for diseases and disorders |
| JP2010533205A (ja) | 2007-07-12 | 2010-10-21 | トラガラ ファーマシューティカルズ，インク． | 癌、腫瘍、および腫瘍関連障害を治療するための方法および組成物 |
| US8642628B2 (en) * | 2008-08-15 | 2014-02-04 | N30 Pharmaceuticals, Inc. | Pyrrole inhibitors of S-nitrosoglutathione reductase |
| WO2010019905A1 (en) * | 2008-08-15 | 2010-02-18 | N30 Pharmaceuticals, Llc | Novel pyrrole inhibitors of s-nitrosoglutathione reductase as therapeutic agents |
| JP2012500216A (ja) | 2008-08-15 | 2012-01-05 | エヌサーティー・ファーマシューティカルズ，エルエルシー | 治療薬剤としての、ｓ−ニトロソグルタチオンレダクターゼの新規ピロール阻害剤 |
| WO2016149126A1 (en) | 2015-03-13 | 2016-09-22 | The Board Of Trustees Of The Leland Stanford Junior University | Ltb4 inhibition to prevent and treat human lymphedema |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3168531A (en) * | 1963-06-12 | 1965-02-02 | Parke Davis & Co | 1-aryl-5-(p-lower alkoxyphenyl)-pyrrole-2-propionic acid compounds |
| BE633582A (pt) * | 1963-06-13 | |||
| US3427305A (en) * | 1966-11-01 | 1969-02-11 | Searle & Co | 5 - ((halo/alkoxy)phenyl) - 1 - (p - sulfonamido(phenyl/benzyl)) - 2 - pyrrolepropionic acids |
| US3531497A (en) * | 1967-02-21 | 1970-09-29 | Upjohn Co | 2,4,5 - triphenyl - (and substituted triphenyl) - 3 - acetonitriles of pyrrole |
| DE1938904A1 (de) * | 1968-08-02 | 1970-02-05 | Innothera Lab Sa | 1-Phenylpyrrole |
| US5187185A (en) * | 1988-12-09 | 1993-02-16 | Rhone-Poulenc Ag Company | Pesticidal 1-arylpyrroles |
| DE2261965A1 (de) * | 1971-12-23 | 1973-06-28 | Continental Pharma | Derivate der pyrrolessigsaeure und deren salze sowie von pyrrolacetonitril, verfahren zur herstellung dieser verbindungen, diese verbindungen enthaltende pharmazeutische produkte und verwendung dieser verbindungen und produkte |
| US4267184A (en) * | 1979-02-08 | 1981-05-12 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-2-(substituted-thio)pyrroles and their corresponding sulfoxides and sulfones |
| US4267190A (en) * | 1980-04-18 | 1981-05-12 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-α,α-bis(polyfluoromethyl)-1H-pyrrole-2-methanethiols |
| US4335136A (en) * | 1980-04-18 | 1982-06-15 | E. I. Du Pont De Nemours And Company | Anti-inflammatory 4,5-diaryl-α-(polyfluoroalkyl)-1H-pyrrole-2-methanamines |
| US4652582A (en) * | 1985-01-09 | 1987-03-24 | E. I. Du Pont De Nemours And Company | Antiinflammatory-2-halo-4,5-diarylpyrroles |
| US4694018A (en) * | 1985-11-29 | 1987-09-15 | G. D. Serale & Co. | Substituted 1,5-diphenyl-2-pyrrolepropionic acids and derivatives |
| DE3739882A1 (de) * | 1987-11-25 | 1989-06-08 | Bayer Ag | Substituierte hydroxylamine |
| AU641905B2 (en) * | 1988-12-09 | 1993-10-07 | Rhone-Poulenc Agrochimie | 1-substituted-phenyl pyrrole derivatives as insecticides and methods for their production |
| US5096919A (en) * | 1989-01-05 | 1992-03-17 | Ciba-Geigy Corporation | Pyrrolylphenyl-substituted hydroxamic acid derivatives |
| DE4036706A1 (de) * | 1990-11-17 | 1992-05-21 | Hoechst Ag | Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie |
| US5128485A (en) * | 1990-12-17 | 1992-07-07 | American Cyanamid Company | Synthesis of 2-aryl-5-(trifluoromethyl)pyrroles useful as pesticidal agents and as intermediates for the preparation of said agents |
| ATE177734T1 (de) * | 1990-12-26 | 1999-04-15 | American Cyanamid Co | Verfahren zur herstellung von 2-aryl-1- substituierten-5-(trifluormethyl)-pyrrolen als insektizide, akarizide und nematizide wirkstoffe sowie als zwischenprodukte zur herstellung dieser wirkstoffe |
| US5144041A (en) * | 1990-12-26 | 1992-09-01 | American Cyanamid Company | Process for the preparation of 2-aryl-1-substituted-5-(trifluoromethyl) pyrrole compounds useful as insecticidal, acaricidal and nematocidal agents and as intermediates for the manufacture of said agents |
| US5219856A (en) * | 1992-04-06 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Angiotensin-II receptor blocking, heterocycle substituted imidazoles |
| ATE160345T1 (de) * | 1993-01-15 | 1997-12-15 | Searle & Co | 3,4-diarylthiophene und analoga davon, sowie deren verwendung als entzündungshemmende mittel |
| US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5908858A (en) * | 1996-04-05 | 1999-06-01 | Sankyo Company, Limited | 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses |
-
1997
- 1997-12-09 AU AU53776/98A patent/AU5377698A/en not_active Abandoned
- 1997-12-09 PT PT97950891T patent/PT946507E/pt unknown
- 1997-12-09 EP EP97950891A patent/EP0946507B1/en not_active Expired - Lifetime
- 1997-12-09 AT AT97950891T patent/ATE250576T1/de not_active IP Right Cessation
- 1997-12-09 US US08/987,356 patent/US5935990A/en not_active Expired - Fee Related
- 1997-12-09 DK DK97950891T patent/DK0946507T3/da active
- 1997-12-09 ES ES97950891T patent/ES2208964T3/es not_active Expired - Lifetime
- 1997-12-09 CA CA002273836A patent/CA2273836A1/en not_active Abandoned
- 1997-12-09 WO PCT/US1997/022488 patent/WO1998025896A1/en active IP Right Grant
- 1997-12-09 DE DE69725171T patent/DE69725171T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2208964T3 (es) | 2004-06-16 |
| EP0946507A1 (en) | 1999-10-06 |
| ATE250576T1 (de) | 2003-10-15 |
| DE69725171D1 (de) | 2003-10-30 |
| AU5377698A (en) | 1998-07-03 |
| US5935990A (en) | 1999-08-10 |
| DE69725171T2 (de) | 2004-07-15 |
| CA2273836A1 (en) | 1998-06-18 |
| WO1998025896A1 (en) | 1998-06-18 |
| EP0946507B1 (en) | 2003-09-24 |
| DK0946507T3 (da) | 2004-01-26 |
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