PT3723858T - Anticorpo biespecífico fixaxfx com cadeia leve comum - Google Patents
Anticorpo biespecífico fixaxfx com cadeia leve comumInfo
- Publication number
- PT3723858T PT3723858T PT198368060T PT19836806T PT3723858T PT 3723858 T PT3723858 T PT 3723858T PT 198368060 T PT198368060 T PT 198368060T PT 19836806 T PT19836806 T PT 19836806T PT 3723858 T PT3723858 T PT 3723858T
- Authority
- PT
- Portugal
- Prior art keywords
- fixaxfx
- light chain
- bispecific antibody
- common light
- common
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1820977.5A GB201820977D0 (en) | 2018-12-21 | 2018-12-21 | Fixaxfx bispecific antibody with commomn light chain |
| GBGB1906816.2A GB201906816D0 (en) | 2019-05-15 | 2019-05-15 | FIXaxFX bispecific antibody with common light chain |
| GBGB1908190.0A GB201908190D0 (en) | 2019-06-07 | 2019-06-07 | Fixaxfx bispecific antibody with common light chain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3723858T true PT3723858T (pt) | 2022-02-02 |
Family
ID=69167786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT198368060T PT3723858T (pt) | 2018-12-21 | 2019-12-20 | Anticorpo biespecífico fixaxfx com cadeia leve comum |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US20220064327A1 (pt) |
| EP (2) | EP3723858B1 (pt) |
| JP (1) | JP7530362B2 (pt) |
| KR (1) | KR20210118085A (pt) |
| CN (1) | CN113453757B (pt) |
| BR (1) | BR112021012065A2 (pt) |
| CA (1) | CA3123177A1 (pt) |
| DK (1) | DK3723858T3 (pt) |
| ES (1) | ES2901683T3 (pt) |
| HR (1) | HRP20220088T1 (pt) |
| HU (1) | HUE057634T2 (pt) |
| LT (1) | LT3723858T (pt) |
| PL (1) | PL3723858T3 (pt) |
| PT (1) | PT3723858T (pt) |
| RS (1) | RS62848B1 (pt) |
| SI (1) | SI3723858T1 (pt) |
| TW (1) | TWI772724B (pt) |
| WO (1) | WO2020128049A1 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201709970D0 (en) | 2017-06-22 | 2017-08-09 | Kymab Ltd | Bispecific antigen-binding molecules |
| PL3723858T3 (pl) | 2018-12-21 | 2022-03-07 | Kymab Limited | Przeciwciało dwuswoiste fixaxfx o wspólnym łańcuchu lekkim |
| CN115728433B (zh) * | 2021-08-27 | 2024-11-15 | 联邦生物科技(珠海横琴)有限公司 | IgG4型单克隆抗体电荷异质性的离子交换色谱检测方法 |
| WO2023111018A1 (en) * | 2021-12-17 | 2023-06-22 | F. Hoffmann-La Roche Ag | Antibodies against coagulation factor x and uses thereof |
| EP4473008A2 (en) * | 2022-01-31 | 2024-12-11 | The Children's Hospital Of Philadelphia | Compositions and methods for treating factor ix deficiency |
| JP7459354B2 (ja) | 2022-07-08 | 2024-04-01 | ノヴォ ノルディスク アー／エス | ＦＶＩＩＩ（ａ）の代わりとなることができる非常に効力があるＩＳＶＤ化合物 |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| MA24512A1 (fr) | 1996-01-17 | 1998-12-31 | Univ Vermont And State Agrienl | Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose |
| CA2288600C (en) | 1997-05-02 | 2010-06-01 | Genentech, Inc. | A method for making multispecific antibodies having heteromultimeric and common components |
| AT411997B (de) | 1999-09-14 | 2004-08-26 | Baxter Ag | Faktor ix/faktor ixa aktivierende antikörper und antikörper-derivate |
| AU2002248184C1 (en) | 2000-12-12 | 2018-01-04 | Board Of Regents, The University Of Texas System | Molecules with extended half-lives, compositions and uses thereof |
| US7297336B2 (en) | 2003-09-12 | 2007-11-20 | Baxter International Inc. | Factor IXa specific antibodies displaying factor VIIIa like activity |
| WO2005035754A1 (ja) | 2003-10-14 | 2005-04-21 | Chugai Seiyaku Kabushiki Kaisha | 機能蛋白質を代替する二重特異性抗体 |
| WO2005035753A1 (ja) * | 2003-10-10 | 2005-04-21 | Chugai Seiyaku Kabushiki Kaisha | 機能蛋白質を代替する二重特異性抗体 |
| US10011858B2 (en) | 2005-03-31 | 2018-07-03 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
| PL1876236T3 (pl) | 2005-04-08 | 2015-01-30 | Chugai Pharmaceutical Co Ltd | Przeciwciała zastępujące czynność czynnika krzepnięcia VIII |
| AU2006265276B2 (en) | 2005-07-05 | 2011-10-13 | Glaxo Group Limited | Humanised antibodies specific for NOGO-A and pharmaceutical uses thereof |
| WO2007110205A2 (en) | 2006-03-24 | 2007-10-04 | Merck Patent Gmbh | Engineered heterodimeric protein domains |
| AU2007238705A1 (en) * | 2006-04-14 | 2007-10-25 | Amgen Inc. | Agonist erythropoietin receptor antibodies |
| MY152963A (en) | 2009-06-26 | 2014-12-15 | Regeneron Pharma | Readily isolated bispecific antibodies with native immunoglobulin format |
| KR102103093B1 (ko) * | 2009-12-25 | 2020-04-21 | 추가이 세이야쿠 가부시키가이샤 | 폴리펩티드 다량체를 정제하기 위한 폴리펩티드의 개변방법 |
| EP2569337A1 (en) | 2010-05-14 | 2013-03-20 | Rinat Neuroscience Corp. | Heterodimeric proteins and methods for producing and purifying them |
| AU2011330184B2 (en) * | 2010-11-17 | 2016-03-10 | Chugai Seiyaku Kabushiki Kaisha | Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor VIII |
| US20140356377A1 (en) | 2011-08-25 | 2014-12-04 | Umc Utrecht Holding B.V. | Compounds for use in boosting coagulation |
| CA2871068C (en) | 2012-04-20 | 2022-06-14 | Merus B.V. | Methods and means for the production of ig-like molecules |
| SG11201502816YA (en) | 2012-10-12 | 2015-05-28 | Agency Science Tech & Res | Optimised heavy chain and light chain signal peptides for the production of recombinant antibody therapeutics |
| CA2904805A1 (en) * | 2013-04-29 | 2014-11-06 | F. Hoffmann-La Roche Ag | Fc-receptor binding modified asymmetric antibodies and methods of use |
| EP3065768B1 (en) | 2013-11-04 | 2020-09-23 | The Regents of the University of California | Composition for use in treatment or prevention of conditions associated with bleeding or hypocoagulationcompostion |
| BR112016015140A2 (pt) | 2013-12-30 | 2018-01-23 | Epimab Biotherapeutics Inc. | imunoglobulina com fabs in-tandem e usos das mesmas |
| TW201625299A (zh) | 2014-06-20 | 2016-07-16 | Chugai Pharmaceutical Co Ltd | 用於因第ｖｉｉｉ凝血因子及／或活化的第ｖｉｉｉ凝血因子的活性降低或欠缺而發病及／或進展的疾病之預防及／或治療之醫藥組成物 |
| TWI700300B (zh) | 2014-09-26 | 2020-08-01 | 日商中外製藥股份有限公司 | 中和具有第ｖｉｉｉ凝血因子（ｆｖｉｉｉ）機能替代活性的物質之抗體 |
| CN107454906B (zh) | 2015-04-17 | 2022-05-27 | 豪夫迈·罗氏有限公司 | 使用凝固因子和多特异性抗体的联合治疗 |
| JP2018123055A (ja) | 2015-04-24 | 2018-08-09 | 公立大学法人奈良県立医科大学 | 血液凝固第ｖｉｉｉ因子（ｆｖｉｉｉ）の機能を代替する多重特異性抗原結合分子を含有する、血液凝固第ｘｉ因子（ｆｘｉ）異常症の予防および／または治療に用いられる医薬組成物 |
| WO2016207402A1 (en) * | 2015-06-26 | 2016-12-29 | Institute For Research In Biomedicine | Proteins comprising a mutated lair-1 fragment and uses thereof |
| US10618952B2 (en) | 2015-10-30 | 2020-04-14 | Medimmune Limited | Prevention of N-terminal truncation in IgG light chains |
| EP3395835B1 (en) | 2015-12-25 | 2021-02-03 | Chugai Seiyaku Kabushiki Kaisha | Antibody having enhanced activity, and method for modifying same |
| WO2017132827A1 (en) * | 2016-02-02 | 2017-08-10 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibodies |
| AU2017214692B2 (en) | 2016-02-06 | 2021-11-04 | Epimab Biotherapeutics, Inc. | Fabs-in-tandem immunoglobulin and uses thereof |
| RU2770006C2 (ru) | 2016-05-16 | 2022-04-14 | Такеда Фармасьютикал Компани Лимитед | Антитела к фактору ix padua |
| MX2018015721A (es) | 2016-07-29 | 2019-05-27 | Chugai Pharmaceutical Co Ltd | Anticuerpos biespecificos que exhiben actividad de funcion de cofactor fviii alternativa mejorada. |
| AU2017325240B9 (en) | 2016-09-06 | 2025-02-13 | Chugai Seiyaku Kabushiki Kaisha | Methods of using a bispecific antibody that recognizes coagulation factor IX and/or activated coagulation factor IX and coagulation factor X and/or activated coagulation factor X |
| BR112019010349A2 (pt) * | 2016-11-23 | 2019-10-08 | Bioverativ Therapeutics Inc | Anticorpos anti-fixa, anti-fxz e antifxa, molécula biespecífica, ácido nulceico, composiçãofarmacêutica e uso dos anteriores |
| CA3051639A1 (en) | 2017-02-01 | 2018-08-09 | Novo Nordisk A/S | Procoagulant antibodies |
| US20210284715A1 (en) | 2017-02-06 | 2021-09-16 | Applied Stemcell, Inc. | Coagulation factor viii mimetic protein and uses thereof |
| SG10201913582XA (en) * | 2017-04-26 | 2020-02-27 | Eureka Therapeutics Inc | Constructs specifically recognizing glypican 3 and uses thereof |
| EP3621643A4 (en) | 2017-05-11 | 2021-07-21 | Atreca, Inc. | ANTIBODY ANTI-MALARIA BOUND WITH CIRCUMSPOROZOID PROTEIN |
| GB201709970D0 (en) | 2017-06-22 | 2017-08-09 | Kymab Ltd | Bispecific antigen-binding molecules |
| CA3071236A1 (en) | 2017-09-29 | 2019-04-04 | Chugai Seiyaku Kabushiki Kaisha | Multispecific antigen-binding molecule having blood coagulation factor viii (fviii) cofactor function-substituting activity, and pharmaceutical formulation containing said molecule as active ingredient |
| MA50893A (fr) | 2017-11-15 | 2020-09-23 | Novo Nordisk As | Liants de facteur x renforçant l'activation fx |
| PL3723858T3 (pl) | 2018-12-21 | 2022-03-07 | Kymab Limited | Przeciwciało dwuswoiste fixaxfx o wspólnym łańcuchu lekkim |
-
2019
- 2019-12-20 PL PL19836806T patent/PL3723858T3/pl unknown
- 2019-12-20 US US17/311,595 patent/US20220064327A1/en active Pending
- 2019-12-20 SI SI201930150T patent/SI3723858T1/sl unknown
- 2019-12-20 WO PCT/EP2019/086808 patent/WO2020128049A1/en unknown
- 2019-12-20 PT PT198368060T patent/PT3723858T/pt unknown
- 2019-12-20 US US16/722,452 patent/US10815308B2/en active Active
- 2019-12-20 CN CN201980091786.3A patent/CN113453757B/zh active Active
- 2019-12-20 JP JP2021535950A patent/JP7530362B2/ja active Active
- 2019-12-20 HU HUE19836806A patent/HUE057634T2/hu unknown
- 2019-12-20 TW TW108146911A patent/TWI772724B/zh active
- 2019-12-20 EP EP19836806.0A patent/EP3723858B1/en active Active
- 2019-12-20 HR HRP20220088TT patent/HRP20220088T1/hr unknown
- 2019-12-20 CA CA3123177A patent/CA3123177A1/en active Pending
- 2019-12-20 RS RS20220069A patent/RS62848B1/sr unknown
- 2019-12-20 BR BR112021012065A patent/BR112021012065A2/pt not_active Application Discontinuation
- 2019-12-20 ES ES19836806T patent/ES2901683T3/es active Active
- 2019-12-20 DK DK19836806.0T patent/DK3723858T3/da active
- 2019-12-20 KR KR1020217022770A patent/KR20210118085A/ko unknown
- 2019-12-20 LT LTEPPCT/EP2019/086808T patent/LT3723858T/lt unknown
- 2019-12-20 EP EP21204339.2A patent/EP4015538A1/en active Pending
-
2020
- 2020-10-06 US US17/063,905 patent/US11976135B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP4015538A1 (en) | 2022-06-22 |
| LT3723858T (lt) | 2022-02-10 |
| TW202039584A (zh) | 2020-11-01 |
| SI3723858T1 (sl) | 2022-04-29 |
| EP3723858B1 (en) | 2021-10-27 |
| JP7530362B2 (ja) | 2024-08-07 |
| HRP20220088T1 (hr) | 2022-04-15 |
| KR20210118085A (ko) | 2021-09-29 |
| BR112021012065A2 (pt) | 2021-12-07 |
| EP3723858A1 (en) | 2020-10-21 |
| DK3723858T3 (da) | 2022-01-24 |
| JP2022515770A (ja) | 2022-02-22 |
| US10815308B2 (en) | 2020-10-27 |
| TWI772724B (zh) | 2022-08-01 |
| US20210101997A1 (en) | 2021-04-08 |
| CA3123177A1 (en) | 2020-06-25 |
| PL3723858T3 (pl) | 2022-03-07 |
| CN113453757A (zh) | 2021-09-28 |
| RS62848B1 (sr) | 2022-02-28 |
| ES2901683T3 (es) | 2022-03-23 |
| US11976135B2 (en) | 2024-05-07 |
| US20220064327A1 (en) | 2022-03-03 |
| HUE057634T2 (hu) | 2022-05-28 |
| US20200199250A1 (en) | 2020-06-25 |
| CN113453757B (zh) | 2024-06-28 |
| WO2020128049A1 (en) | 2020-06-25 |
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