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PT3227675T - Antagonistas da ativina-actrii e utilizações para tratamento da síndrome mielodisplásica - Google Patents

Antagonistas da ativina-actrii e utilizações para tratamento da síndrome mielodisplásica

Info

Publication number
PT3227675T
PT3227675T PT158652131T PT15865213T PT3227675T PT 3227675 T PT3227675 T PT 3227675T PT 158652131 T PT158652131 T PT 158652131T PT 15865213 T PT15865213 T PT 15865213T PT 3227675 T PT3227675 T PT 3227675T
Authority
PT
Portugal
Prior art keywords
activin
treating anemia
actrii antagonists
actrii
antagonists
Prior art date
Application number
PT158652131T
Other languages
English (en)
Original Assignee
Celgene Corp
Acceleron Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp, Acceleron Pharma Inc filed Critical Celgene Corp
Publication of PT3227675T publication Critical patent/PT3227675T/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Ecology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PT158652131T 2014-12-03 2015-12-03 Antagonistas da ativina-actrii e utilizações para tratamento da síndrome mielodisplásica PT3227675T (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462086977P 2014-12-03 2014-12-03
US201462088478P 2014-12-05 2014-12-05
US201562153872P 2015-04-28 2015-04-28
US201562173782P 2015-06-10 2015-06-10
US201562218728P 2015-09-15 2015-09-15

Publications (1)

Publication Number Publication Date
PT3227675T true PT3227675T (pt) 2023-05-30

Family

ID=56092426

Family Applications (1)

Application Number Title Priority Date Filing Date
PT158652131T PT3227675T (pt) 2014-12-03 2015-12-03 Antagonistas da ativina-actrii e utilizações para tratamento da síndrome mielodisplásica

Country Status (24)

Country Link
US (1) US11471510B2 (pt)
EP (2) EP3227675B1 (pt)
JP (2) JP2018501307A (pt)
KR (1) KR102556991B1 (pt)
CN (2) CN114675039A (pt)
AU (2) AU2015358469B2 (pt)
BR (1) BR112017011722A2 (pt)
CA (1) CA2969572A1 (pt)
CY (1) CY1126033T1 (pt)
DK (1) DK3227675T3 (pt)
ES (1) ES2946160T3 (pt)
FI (1) FI3227675T3 (pt)
HK (2) HK1245397A1 (pt)
HR (1) HRP20230504T1 (pt)
HU (1) HUE062189T2 (pt)
IL (1) IL252631B2 (pt)
LT (1) LT3227675T (pt)
MD (1) MD4801C1 (pt)
PL (1) PL3227675T3 (pt)
PT (1) PT3227675T (pt)
RS (1) RS64214B1 (pt)
SI (1) SI3227675T1 (pt)
TW (2) TWI773117B (pt)
WO (1) WO2016090077A1 (pt)

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DK3638243T3 (da) 2017-06-14 2024-10-28 Celgene Corp Fremgangsmåder til behandling af myeloproliferativ neoplasma-forbundet myelofibrose og anæmi
WO2019094751A1 (en) 2017-11-09 2019-05-16 Keros Therapeutics, Inc. Activin receptor type iia variants and methods of use thereof
JP7510875B2 (ja) 2018-01-12 2024-07-04 ケロス セラピューティクス インコーポレイテッド アクチビンiib型受容体変異体および同変異体を含む医薬組成物
US20210252106A1 (en) * 2018-04-30 2021-08-19 The Children's Hospital Of Philadelphia Methods of improving anemias by combining agents
CN112969471A (zh) * 2018-10-31 2021-06-15 细胞基因公司 使用激活素-actrii配体陷阱治疗具有环状铁粒幼细胞的受试者中由极低、低或中等风险的骨髓增生异常综合征引起的贫血
WO2021189006A1 (en) * 2020-03-20 2021-09-23 Keros Therapeutics, Inc. Methods of using activin receptor type iia variants
EP4121088A4 (en) * 2020-03-20 2024-07-03 Keros Therapeutics Inc METHODS OF USING ACTIVIN TYPE IIB RECEPTOR VARIANTS
JP2023523568A (ja) * 2020-04-13 2023-06-06 セルジーン コーポレーション ActRIIBリガンドトラップ及びフェドラチニブを使用して貧血を治療するための方法
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