PT1309593E - Pirazoles substituidos - Google Patents

Pirazoles substituidos

Info

Publication number: PT1309593E
Authority: PT; Portugal
Prior art keywords: substituted pyrazoles; methods; pyrazoles; substituted; cathepsin
Prior art date: 2000-08-14

Application number

PT01965898T

Other languages

English (en)

Inventor

Christopher R Butler

Cai Hui

James P Edwards

Cheryl A Grice

Darin J Gustin

Khatuya Haripada

Steven P Meduna

Barbara A Pio

Clark A Sehon

Kevin L Tays

Jianmei Wei

Original Assignee

Ortho Mcneil Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-14

Filing date

2001-08-10

Publication date

2006-08-31

2001-08-10 Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc

2006-08-31 Publication of PT1309593E publication Critical patent/PT1309593E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

PT01965898T 2000-08-14 2001-08-10 Pirazoles substituidos PT1309593E (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US22517800P	2000-08-14	2000-08-14
US09/927,324 US6953793B2 (en)	2000-08-14	2001-08-10	Substituted pyrazoles

Publications (1)

Publication Number	Publication Date
PT1309593E true PT1309593E (pt)	2006-08-31

Family

ID=26919364

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT01965898T PT1309593E (pt)	2000-08-14	2001-08-10	Pirazoles substituidos

Country Status (20)

Country	Link
US (2)	US6953793B2 (pt)
EP (1)	EP1309593B1 (pt)
JP (1)	JP5049447B2 (pt)
KR (1)	KR100837193B1 (pt)
AT (1)	ATE320427T1 (pt)
AU (2)	AU2001286454B2 (pt)
BR (1)	BRPI0113286B8 (pt)
CA (1)	CA2419552C (pt)
CZ (1)	CZ307185B6 (pt)
DE (1)	DE60118004T2 (pt)
DK (1)	DK1309593T3 (pt)
ES (1)	ES2261463T3 (pt)
HK (1)	HK1055422A1 (pt)
HU (1)	HU230538B1 (pt)
MX (1)	MXPA03001422A (pt)
NZ (1)	NZ524191A (pt)
PL (1)	PL213103B1 (pt)
PT (1)	PT1309593E (pt)
RU (1)	RU2317988C2 (pt)
WO (1)	WO2002014315A2 (pt)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6566372B1 (en) *	1999-08-27	2003-05-20	Ligand Pharmaceuticals Incorporated	Bicyclic androgen and progesterone receptor modulator compounds and methods
US20050101587A9 (en) *	2000-08-14	2005-05-12	Butler Christopher R.	Method for treating allergies using substituted pyrazoles
DE60126286T2 (de) *	2000-08-14	2007-11-15	Ortho-Mcneil Pharmaceutical, Inc.	Substituierte pyrazole
AU2001286454B2 (en) *	2000-08-14	2006-09-14	Ortho-Mcneil Pharmaceutical, Inc.	Substituted pyrazoles
WO2002051983A2 (en) *	2000-12-22	2002-07-04	Axys Pharmaceuticals, Inc.	Novel compounds and compositions as cathepsin inhibitors
KR100722207B1 (ko) *	2001-04-18	2007-05-29	유로-셀티크 소시에떼 아노뉨	노시셉틴 유사체
CZ20032850A3 (cs) *	2001-04-18	2004-02-18	Euro-Celtique, S. A.	Analogy nociceptinu
US20040147503A1 (en) *	2002-06-04	2004-07-29	Sheila Zipfeil	Novel compounds and compositions as cathepsin inhibitors
CA2499622C (en)	2002-09-24	2012-01-03	Novartis Ag	Sphingosine-1-phosphate receptor agonists in the treatment of demyelinating disorders
US7384970B2 (en)	2003-03-24	2008-06-10	Irm Llc	Inhibitors of cathepsin S
US7109243B2 (en)	2003-03-24	2006-09-19	Irm Llc	Inhibitors of cathepsin S
US7173051B2 (en)	2003-06-13	2007-02-06	Irm, Llc	Inhibitors of cathepsin S
US7256207B2 (en)	2003-08-20	2007-08-14	Irm Llc	Inhibitors of cathepsin S
FR2885904B1 (fr) *	2005-05-19	2007-07-06	Aventis Pharma Sa	Nouveaux derives du fluorene, compositions les contenant et utilisation
KR101418024B1 (ko) *	2005-06-22	2014-07-16	케모센트릭스, 인크.	아자인다졸 화합물 및 사용방법
TW200813018A (en)	2006-06-09	2008-03-16	Astrazeneca Ab	Novel compounds
CL2007003590A1 (es) *	2006-12-12	2008-02-29	Wyeth Corp	Compuestos derivados de aril sulfamida; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en prevencion y tratamiento de sintomas vasomotrices, disfuncion sexual, transtornos gastrointestinales, transt
US20090118274A1 (en) *	2007-02-15	2009-05-07	Darin Allen	Monocyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s
US20080269241A1 (en) *	2007-02-15	2008-10-30	Darin Allen	Bicyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s
US20080207683A1 (en) *	2007-02-15	2008-08-28	Darin Allen	Biaryl-substituted tetrahydro-pyrazolo-pyridine modulators of cathepsin s
US20090099157A1 (en) *	2007-02-15	2009-04-16	Ameriks Michael K	Tetrahydro-pyrazolo-pyridine thioether modulators of cathepsin s
US20080200454A1 (en) *	2007-02-15	2008-08-21	Ameriks Michael K	Carbon-linked tetrahydro-pyrazolo-pyridine modulators of cathepsin s
US8119661B2 (en)	2007-09-11	2012-02-21	Astrazeneca Ab	Piperidine derivatives and their use as muscarinic receptor modulators
KR20110020928A (ko)	2008-06-20	2011-03-03	노파르티스 아게	다발성 경화증을 치료하기 위한 소아용 조성물
US9643922B2 (en)	2008-08-18	2017-05-09	Yale University	MIF modulators
US9540322B2 (en)	2008-08-18	2017-01-10	Yale University	MIF modulators
PE20110368A1 (es) *	2008-08-18	2011-06-13	Univ Yale	Moduladores de mif
TWI475020B (zh) *	2009-03-12	2015-03-01		The substituted nicotine amide as a KCNQ2 / 3 modifier
BR112012003270A2 (pt) *	2009-08-12	2019-09-24	Janssen Pharmaceutica Nv	processo para a preparação de inibidores de catepsina s
US8754114B2 (en)	2010-12-22	2014-06-17	Incyte Corporation	Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
US9611267B2 (en)	2012-06-13	2017-04-04	Incyte Holdings Corporation	Substituted tricyclic compounds as FGFR inhibitors
WO2014026125A1 (en)	2012-08-10	2014-02-13	Incyte Corporation	Pyrazine derivatives as fgfr inhibitors
RU2674249C2 (ru)	2012-11-05	2018-12-06	НэнтБайо, Инк.	Замещенные производные индол-5-ола и их терапевтическое применение
EP2920183B1 (en)	2012-11-14	2017-03-08	Glaxosmithkline LLC	Thieno[3,2-c]pyridin-4(5h)-ones as bet inhibitors
US9266892B2 (en)	2012-12-19	2016-02-23	Incyte Holdings Corporation	Fused pyrazoles as FGFR inhibitors
RU2017141536A (ru)	2013-03-15	2019-02-13	Нэнтбайосайенс, Инк.	Замещенные производные индол-5-ола и их терапевтические применения
EP2986610B9 (en)	2013-04-19	2018-10-17	Incyte Holdings Corporation	Bicyclic heterocycles as fgfr inhibitors
US10851105B2 (en)	2014-10-22	2020-12-01	Incyte Corporation	Bicyclic heterocycles as FGFR4 inhibitors
JP6654636B2 (ja) *	2014-12-02	2020-02-26	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	新規ピペリジン誘導体
WO2016134294A1 (en)	2015-02-20	2016-08-25	Incyte Corporation	Bicyclic heterocycles as fgfr4 inhibitors
MA41551A (fr)	2015-02-20	2017-12-26	Incyte Corp	Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
ES2895769T3 (es)	2015-02-20	2022-02-22	Incyte Corp	Heterociclos bicíclicos como inhibidores de FGFR
JP6936796B2 (ja)	2015-07-06	2021-09-22	ロダン・セラピューティクス，インコーポレーテッド	ヒストンデアセチラーゼのヘテロハロ阻害剤
EP3319968A1 (en)	2015-07-06	2018-05-16	Rodin Therapeutics, Inc.	Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase
DK3570834T3 (en)	2017-01-11	2022-02-28	Alkermes Inc	Bicyclic inhibitors of histone deacetylase
AR111960A1 (es)	2017-05-26	2019-09-04	Incyte Corp	Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
PT3664802T (pt)	2017-08-07	2022-05-24	Alkermes Inc	Inibidores bicíclicos de histona-desacetilase
JP7110360B2 (ja)	2017-10-09	2022-08-01	テルモビーシーティーバイオテクノロジーズ，エルエルシー	凍結乾燥方法
CN112566912A (zh)	2018-05-04	2021-03-26	因赛特公司	Fgfr抑制剂的盐
US11466004B2 (en)	2018-05-04	2022-10-11	Incyte Corporation	Solid forms of an FGFR inhibitor and processes for preparing the same
WO2020185532A1 (en)	2019-03-08	2020-09-17	Incyte Corporation	Methods of treating cancer with an fgfr inhibitor
EP3938741B1 (en)	2019-03-14	2024-05-01	Terumo BCT Biotechnologies, LLC	Lyophilization container fill fixture, system and method of use
WO2021007269A1 (en)	2019-07-09	2021-01-14	Incyte Corporation	Bicyclic heterocycles as fgfr inhibitors
WO2021067374A1 (en)	2019-10-01	2021-04-08	Incyte Corporation	Bicyclic heterocycles as fgfr inhibitors
JP2022552324A (ja)	2019-10-14	2022-12-15	インサイト・コーポレイション	Ｆｇｆｒ阻害剤としての二環式複素環
WO2021076728A1 (en)	2019-10-16	2021-04-22	Incyte Corporation	Bicyclic heterocycles as fgfr inhibitors
BR112022010664A2 (pt)	2019-12-04	2022-08-16	Incyte Corp	Derivados de um inibidor de fgfr
WO2021113479A1 (en)	2019-12-04	2021-06-10	Incyte Corporation	Tricyclic heterocycles as fgfr inhibitors
US12012409B2 (en)	2020-01-15	2024-06-18	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
WO2022221170A1 (en)	2021-04-12	2022-10-20	Incyte Corporation	Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent
EP4352059A1 (en)	2021-06-09	2024-04-17	Incyte Corporation	Tricyclic heterocycles as fgfr inhibitors

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US856514A (en) *	1907-03-15	1907-06-11	William T Adams	Cheese-cutter.
US3743409A (en)	1971-06-11	1973-07-03	Xerox Corp	Cutter assembly
JPS5090172A (pt)	1973-12-13	1975-07-19
US3994890A (en)	1974-01-31	1976-11-30	Chugai Seiyaku Kabushiki Kaisha	1-Aminoalkyl, 3-phenyl indazoles
JPS5640714B2 (pt) *	1974-03-04	1981-09-22
DK27383A (da)	1982-02-17	1983-08-18	Lepetit Spa	Fremgangsmaade til fremstilling af pyrazol(4,3-c)pyridiner
JPH0615542B2 (ja) *	1986-07-22	1994-03-02	吉富製薬株式会社	ピラゾロピリジン化合物
FR2642759B1 (fr)	1989-02-09	1991-05-17	Laboratorios Esteve Sa	Derives de pyrimidyl-piperazinyl-alkyl azoles avec activite anxiolytique et/ou tranquillisante
FR2673628B1 (fr)	1991-03-07	1993-07-09	Esteve Labor Dr	Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles.
US5264576A (en)	1992-10-22	1993-11-23	Hoechst-Roussel Pharmaceuticals Incorporated	Pyrazolo[4,3-c]pyridines which are intermediates
FR2705962B1 (fr)	1993-06-03	1995-07-13	Rhone Poulenc Agrochimie	Arylpyrazoles fongicides.
FR2712808B1 (fr)	1993-11-25	1996-02-16	Esteve Labor Dr	Utilisation des dérivés de 1-{4-[4-aryl(ou hétéroaryl)-1-pipérazinyl]-butyl}-1-H-azole pour la préparation de médicaments destinés au traitement des troubles de la sécrétion gastrique .
IL112759A0 (en)	1994-02-25	1995-05-26	Khepri Pharmaceuticals Inc	Novel cysteine protease inhibitors
US5776718A (en)	1995-03-24	1998-07-07	Arris Pharmaceutical Corporation	Reversible protease inhibitors
EP0817778A1 (en)	1995-03-24	1998-01-14	Arris Pharmaceutical Corporation	Reversible protease inhibitors
TW438591B (en)	1995-06-07	2001-06-07	Arris Pharm Corp	Reversible cysteine protease inhibitors
FR2742052B1 (fr)	1995-12-12	1998-04-10	Esteve Labor Dr	Utilisation des derives 1-(4-(4-aryl (ou heteroaryl)-1-piper azinyl)-buty)-1h-azole pour le traitement de la depression, des troubles obsessifs compulsifs, l'apnee du sommeil, les dysfonctions sexuelles, l'emese et le mal des transports
PT912601E (pt)	1996-04-22	2004-04-30	Massachusetts Inst Technology	Supressao da resposta imune via inibicao da catepsina s
WO1998056785A1 (fr)	1997-06-12	1998-12-17	Sumitomo Pharmaceuticals Co., Ltd.	Derives de pyrazole
WO1999024460A2 (en)	1997-11-05	1999-05-20	Novartis Ag	Dipeptide nitriles
GB9806287D0 (en)	1998-03-24	1998-05-20	Synphar Lab Inc	Monobactam enzyme inhibitors
WO1999058153A1 (en)	1998-05-08	1999-11-18	Brigham & Women's Hospital	Methods of diagnosing and modulating autoimmunity
WO2000049008A1 (en)	1999-02-20	2000-08-24	Astrazeneca Ab	Di- and tripeptide nitrile derivatives as inhibitors of cathepsin l and cathepsin s
JP2002538151A (ja)	1999-03-02	2002-11-12	ベーリンガーインゲルハイムファーマシューティカルズインコーポレイテッド	カテプシンの可逆的インヒビターとして有用な化合物
TW200404789A (en)	1999-03-15	2004-04-01	Axys Pharm Inc	Novel compounds and compositions as protease inhibitors
WO2001009110A1 (en)	1999-07-30	2001-02-08	Boehringer Ingelheim Pharmaceuticals, Inc.	Novel succinate derivative compounds useful as cysteine protease inhibitors
AU7490900A (en)	1999-09-16	2001-04-17	Axys Pharmaceuticals, Inc.	Chemical compounds and compositions and their use as cathepsin s inhibitors
WO2001040204A1 (fr)	1999-12-03	2001-06-07	Ono Pharmaceutical Co., Ltd.	Derives de 1.3.4-oxadiazoline et medicaments contenant ces derives utiles comme ingredients actifs
AU2001286454B2 (en) *	2000-08-14	2006-09-14	Ortho-Mcneil Pharmaceutical, Inc.	Substituted pyrazoles

2001
- 2001-08-10 AU AU2001286454A patent/AU2001286454B2/en not_active Expired
- 2001-08-10 NZ NZ524191A patent/NZ524191A/en not_active IP Right Cessation
- 2001-08-10 DK DK01965898T patent/DK1309593T3/da active
- 2001-08-10 EP EP01965898A patent/EP1309593B1/en not_active Expired - Lifetime
- 2001-08-10 AT AT01965898T patent/ATE320427T1/de active
- 2001-08-10 KR KR1020037002163A patent/KR100837193B1/ko active IP Right Grant
- 2001-08-10 CZ CZ2003-429A patent/CZ307185B6/cs not_active IP Right Cessation
- 2001-08-10 JP JP2002519455A patent/JP5049447B2/ja not_active Expired - Lifetime
- 2001-08-10 HU HU0303108A patent/HU230538B1/hu not_active IP Right Cessation
- 2001-08-10 WO PCT/US2001/025290 patent/WO2002014315A2/en active IP Right Grant
- 2001-08-10 MX MXPA03001422A patent/MXPA03001422A/es active IP Right Grant
- 2001-08-10 BR BRPI0113286A patent/BRPI0113286B8/pt not_active IP Right Cessation
- 2001-08-10 RU RU2003107016/04A patent/RU2317988C2/ru not_active Application Discontinuation
- 2001-08-10 CA CA2419552A patent/CA2419552C/en not_active Expired - Lifetime
- 2001-08-10 US US09/927,324 patent/US6953793B2/en not_active Expired - Lifetime
- 2001-08-10 DE DE60118004T patent/DE60118004T2/de not_active Expired - Lifetime
- 2001-08-10 AU AU8645401A patent/AU8645401A/xx active Pending
- 2001-08-10 ES ES01965898T patent/ES2261463T3/es not_active Expired - Lifetime
- 2001-08-10 PL PL360696A patent/PL213103B1/pl unknown
- 2001-08-10 PT PT01965898T patent/PT1309593E/pt unknown
2003
- 2003-07-10 HK HK03104996A patent/HK1055422A1/xx not_active IP Right Cessation
2005
- 2005-06-30 US US11/174,077 patent/US20050245576A1/en not_active Abandoned

Also Published As

Publication number	Publication date
KR100837193B1 (ko)	2008-06-13
CA2419552A1 (en)	2002-02-21
DE60118004T2 (de)	2006-11-16
RU2003107016A (ru)	2004-11-27
DK1309593T3 (da)	2006-07-17
HUP0303108A3 (en)	2012-10-29
HUP0303108A2 (hu)	2004-01-28
CZ307185B6 (cs)	2018-03-07
HU230538B1 (hu)	2016-11-28
JP2004511440A (ja)	2004-04-15
BR0113286B1 (pt)	2013-04-16
PL360696A1 (en)	2004-09-20
ATE320427T1 (de)	2006-04-15
KR20030060876A (ko)	2003-07-16
RU2317988C2 (ru)	2008-02-27
WO2002014315A2 (en)	2002-02-21
BRPI0113286B8 (pt)	2021-05-25
NZ524191A (en)	2004-11-26
BR0113286A (pt)	2003-09-09
DE60118004D1 (de)	2006-05-11
MXPA03001422A (es)	2004-01-26
AU2001286454B2 (en)	2006-09-14
JP5049447B2 (ja)	2012-10-17
PL213103B1 (pl)	2013-01-31
EP1309593A2 (en)	2003-05-14
WO2002014315A3 (en)	2002-06-13
EP1309593B1 (en)	2006-03-15
CA2419552C (en)	2010-10-12
US20030078419A1 (en)	2003-04-24
US6953793B2 (en)	2005-10-11
US20050245576A1 (en)	2005-11-03
HK1055422A1 (en)	2004-01-09
AU8645401A (en)	2002-02-25
ES2261463T3 (es)	2006-11-16
CZ2003429A3 (cs)	2003-12-17

Publication	Publication Date	Title
DK1309593T3 (da)	2006-07-17	Substituerede pyrazoler
DK1309592T3 (da)	2006-08-21	Substituerede pyrazoler
WO2002014314A3 (en)	2002-06-06	Substituted pyrazoles
NO20030845D0 (no)	2003-02-24	Utvalgte fusjonerte pyrrolokarbazoler
BG66084B1 (bg)	2011-03-31	Циклопентаноиндоли, състави,съдържащи такива съединения и използването им
BG66080B1 (bg)	2011-03-31	Заместени тиоацетамиди
SG149045A1 (en)	2009-01-29	Novel fused pyrrolocarbazoles
SG149042A1 (en)	2009-01-29	Novel fused pyrrolocarbazoles
RS94603A (en)	2007-02-05	Novel compounds and compositions as cathepsin inhibitors
TR200402030T4 (tr)	2004-09-21	İkame edilen I-aminobutan-3-ol-türevleri
UA87829C2 (en)	2009-08-25	Fused pyrrolocarbazoles
CY1111290T1 (el)	2015-08-05	Παραγωγα 9-αλκυλαμινo-1-νιτρoακριδινης
ATE423780T1 (de)	2009-03-15	Makrozyclen zur behandlung von krebserkrankungen
SE0001631D0 (sv)	2000-05-04	New use