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PT1307423E - Processos de produção da fexofenadina - Google Patents

Processos de produção da fexofenadina Download PDF

Info

Publication number
PT1307423E
PT1307423E PT01947748T PT01947748T PT1307423E PT 1307423 E PT1307423 E PT 1307423E PT 01947748 T PT01947748 T PT 01947748T PT 01947748 T PT01947748 T PT 01947748T PT 1307423 E PT1307423 E PT 1307423E
Authority
PT
Portugal
Prior art keywords
sub
compound
formula
fexofenadine
alkyl
Prior art date
Application number
PT01947748T
Other languages
English (en)
Inventor
Federico Junquera Milla
William Paul Jackson
Original Assignee
Texcontor Ets
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texcontor Ets filed Critical Texcontor Ets
Publication of PT1307423E publication Critical patent/PT1307423E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/313—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of doubly bound oxygen containing functional groups, e.g. carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Catalysts (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Glass Compositions (AREA)
PT01947748T 2000-07-28 2001-07-19 Processos de produção da fexofenadina PT1307423E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0018691.6A GB0018691D0 (en) 2000-07-28 2000-07-28 Process

Publications (1)

Publication Number Publication Date
PT1307423E true PT1307423E (pt) 2008-06-09

Family

ID=9896639

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01947748T PT1307423E (pt) 2000-07-28 2001-07-19 Processos de produção da fexofenadina

Country Status (9)

Country Link
US (1) US7176318B2 (pt)
EP (1) EP1307423B1 (pt)
AT (1) ATE389631T1 (pt)
AU (1) AU2001269388A1 (pt)
DE (1) DE60133288T2 (pt)
ES (1) ES2302737T3 (pt)
GB (1) GB0018691D0 (pt)
PT (1) PT1307423E (pt)
WO (1) WO2002010115A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7700779B2 (en) 2001-06-18 2010-04-20 Dr. Reddy's Laboratories Limited Crystalline forms of fexofenadine and its hydrochloride
HUP0401546A2 (hu) * 2001-06-18 2004-12-28 Dr. Reddy's Laboratories Ltd. A 4-[4-[4-(hidroxi-difenil-metil)-1-piperidinil]-1-hidroxi-butil]-alfa,alfa-dimetil-benzol-ecetsavnak és hidrokloridjának új kristályformái és eljárás az előállításukra
EP1616861A3 (en) * 2004-06-15 2006-02-08 Dipharma S.p.A. A process for the preparation of keto compounds
US7498443B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of carebastine
US7498345B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
CN101952273B (zh) 2008-02-12 2014-11-12 柳韩洋行 2-甲基2’-苯基丙酸衍生物的制备方法和中间体化合物
CN102070512B (zh) * 2009-11-21 2014-11-19 浙江华海药业股份有限公司 一种高纯度非索非那定及其中间体的合成路线与制备方法
CN102070490B (zh) * 2009-11-21 2014-07-30 浙江华海药业股份有限公司 一种非索非那定中间体2-(4-(4-羟基丁酰基)苯基)-2-甲基丙氰的制备方法
ITMI20120589A1 (it) * 2012-04-12 2013-10-13 Chemelectiva S R L Intermedi utili per la sintesi di fexofenadina, processo per la loro preparazione e per la preparazione di fexofenadina
US20130237709A1 (en) * 2012-03-02 2013-09-12 Chemelectiva S.R.L. Intermediates useful for the synthesis of fexofenadine, processes for their preparation and for the preparation of fexofenadine
WO2016116555A1 (en) 2015-01-22 2016-07-28 Sanofi-Aventis Deutschland Gmbh Process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile
CA3002425C (en) * 2015-10-22 2023-10-17 Sanofi-Aventis Deutschland Gmbh Process for the preparation of fexofenadine and of intermediates used therein
CN107782804B (zh) * 2016-08-25 2020-11-13 人福普克药业（武汉）有限公司 检测盐酸非索非那定样品中有关物质的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5499135A (en) * 1990-12-24 1996-03-12 Alcatel N.V. Optical amplifier
KR100387347B1 (ko) * 1993-06-24 2003-11-28 알바니 몰레큘라 리써치, 인크. 피페리딘 유도체 및 그의 제조 방법
ES2190442T3 (es) * 1993-06-25 2003-08-01 Merrell Pharma Inc Nuevos productos intermedios para la preparacion de derivados de 4-difenilmetil/difenilmetoxi piperidina antihistaminicos.
IT1271417B (it) * 1993-10-15 1997-05-28 Erregierre Ind Chim Composti ad attivita' antiistaminica procedimento per la loro preperazione e composizioni farmaceutiche che li contengono.
JPH08237203A (ja) * 1995-02-23 1996-09-13 Fujitsu Ltd 光フィルタアレイ、光送信機及び光送信システム
US6101200A (en) * 1997-12-24 2000-08-08 Nortel Networks Corporation Laser module allowing simultaneous wavelength and power control
US6134253A (en) * 1998-02-19 2000-10-17 Jds Uniphase Corporation Method and apparatus for monitoring and control of laser emission wavelength
FR2776302B1 (fr) 1998-03-19 2002-04-12 Hoechst Marion Roussel Inc Nouveau procede de preparation de la fexofenadine
JP3197869B2 (ja) * 1998-03-31 2001-08-13 アンリツ株式会社 波長可変レーザ光源装置
US6018536A (en) * 1998-11-20 2000-01-25 Sarnoff Corporation Multiple-wavelength mode-locked laser

Also Published As

Publication number Publication date
EP1307423B1 (en) 2008-03-19
EP1307423A1 (en) 2003-05-07
WO2002010115A1 (en) 2002-02-07
DE60133288T2 (de) 2009-04-16
AU2001269388A1 (en) 2002-02-13
DE60133288D1 (de) 2008-04-30
ATE389631T1 (de) 2008-04-15
ES2302737T3 (es) 2008-08-01
US20030166682A1 (en) 2003-09-04
US7176318B2 (en) 2007-02-13
GB0018691D0 (en) 2000-09-20

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