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RS50287B - Postupak za pripremanje citaloprama - Google Patents

Postupak za pripremanje citaloprama

Info

Publication number
RS50287B
RS50287B YUP-115/03A YUP11503A RS50287B RS 50287 B RS50287 B RS 50287B YU P11503 A YUP11503 A YU P11503A RS 50287 B RS50287 B RS 50287B
Authority
RS
Serbia
Prior art keywords
citalopram
preparation
compound
formula
converting
Prior art date
Application number
YUP-115/03A
Other languages
English (en)
Inventor
Hans Petersen
Haleh Ahmadian
Original Assignee
H. Lundbeck A/S.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S., filed Critical H. Lundbeck A/S.,
Publication of YU11503A publication Critical patent/YU11503A/sh
Publication of RS50287B publication Critical patent/RS50287B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)

Abstract

Postupak za pripremanje citaloprama, naznačen time, što obuhvata pretvaranje jedinjenja sa Formulom VIII Gde je Z halogen, U jedinjenje sa Formulom IV praćeno pretvaranjem jedinjenja sa Formulom IV u citalopram. Prijava sadrži još 11 patentnih zahteva.
YUP-115/03A 2000-08-18 2001-08-14 Postupak za pripremanje citaloprama RS50287B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200001231 2000-08-18

Publications (2)

Publication Number Publication Date
YU11503A YU11503A (sh) 2006-05-25
RS50287B true RS50287B (sr) 2009-09-08

Family

ID=8159660

Family Applications (2)

Application Number Title Priority Date Filing Date
YU6903A RS50258B (sr) 2000-08-18 2001-08-14 Postupak za pripremanje citaloprama
YUP-115/03A RS50287B (sr) 2000-08-18 2001-08-14 Postupak za pripremanje citaloprama

Family Applications Before (1)

Application Number Title Priority Date Filing Date
YU6903A RS50258B (sr) 2000-08-18 2001-08-14 Postupak za pripremanje citaloprama

Country Status (41)

Country Link
US (2) US6509483B2 (sr)
EP (2) EP1309582B1 (sr)
JP (2) JP2004506729A (sr)
KR (2) KR100887206B1 (sr)
CN (3) CN1239490C (sr)
AR (3) AR029597A1 (sr)
AT (4) ATE281448T1 (sr)
AU (6) AU2001279609B2 (sr)
BE (2) BE1013443A6 (sr)
BG (2) BG65964B1 (sr)
CA (2) CA2354877C (sr)
CH (2) CH691969A5 (sr)
CL (2) CL2008002412A1 (sr)
CZ (2) CZ295863B6 (sr)
DE (4) DE60106933T2 (sr)
DK (4) DK200101219A (sr)
EA (2) EA005811B1 (sr)
ES (4) ES2230347T3 (sr)
FI (2) FI20011622A (sr)
FR (2) FR2813078B1 (sr)
GB (2) GB2362647B (sr)
GR (1) GR1004074B (sr)
HK (3) HK1044538B (sr)
HR (2) HRP20030064A2 (sr)
HU (2) HUP0103291A3 (sr)
IE (2) IES20010761A2 (sr)
IL (2) IL144817A0 (sr)
IS (2) IS2121B (sr)
ME (2) MEP2208A (sr)
MX (2) MXPA03001329A (sr)
NL (2) NL1018775C1 (sr)
NO (2) NO326570B1 (sr)
NZ (2) NZ523853A (sr)
PL (2) PL359969A1 (sr)
PT (2) PT1309581E (sr)
RS (2) RS50258B (sr)
SI (2) SI1309581T1 (sr)
SK (2) SK287236B6 (sr)
UA (2) UA72340C2 (sr)
WO (2) WO2002016341A1 (sr)
ZA (1) ZA200106683B (sr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
IL145615A0 (en) 1999-04-14 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
NZ512406A (en) 1999-10-25 2004-01-30 H Method for the preparation of citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
IL150335A0 (en) 1999-12-28 2002-12-01 Lundbeck & Co As H Method for the preparation of citalopram
SK11052002A3 (sk) 1999-12-30 2003-01-09 H. Lundbeck A/S Spôsob prípravy medziproduktu pri príprave citalopramu
HUP0300343A2 (hu) * 2000-01-14 2003-06-28 H. Lundbeck A/S Eljárás 5-cianoftalid előállítására
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
HUP0300274A2 (hu) * 2000-03-13 2003-06-28 H. Lundbeck A/S Eljárás citalopram előállítására
BR0109364A (pt) * 2000-03-13 2002-12-24 Lundbeck & Co As H Métodos para fabricação de citalopram através de alquilação escalonada de 5-substituìda 1- (4-fluorofenil) - 1,3- diidroisobenzofuranos e citalopram
JP2003527386A (ja) 2000-03-14 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
EA200200982A1 (ru) * 2000-03-16 2003-02-27 Х.Лундбекк А/С Способ получения 5-циано-1-(4-фторфенил)-1,3-дигидроизобензофуранов
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
FI20011622A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
EP1462447A3 (en) 2000-12-22 2004-11-17 H. Lundbeck A/S Method for the preparation of pure citalopram
US7148364B2 (en) * 2002-01-07 2006-12-12 Sun Pharmaceutical Industries Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
TWI306846B (en) * 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
US9339500B2 (en) * 2008-03-04 2016-05-17 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms
US20100087664A1 (en) * 2008-10-07 2010-04-08 Ravindra Vedantham Preparation of citalopram and salts thereof
JP6222973B2 (ja) * 2013-04-19 2017-11-01 日本テルペン化学株式会社 ジベンジルトリチオカーボネート誘導体
CN103936702A (zh) * 2014-05-07 2014-07-23 成都诺维尔生物医药有限公司 艾司西酞普兰杂质j的合成方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (sr) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DE3926765A1 (de) 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DK213290D0 (da) 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
CN1206207C (zh) 1997-07-08 2005-06-15 H.隆德贝克有限公司 氰酞氟苯胺的制备方法
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
DE1042310T1 (de) 1997-11-11 2001-04-19 Lundbeck & Co As H Verfahren zur herstellung von citaloprame
CZ299920B6 (cs) * 1998-10-20 2008-12-29 H. Lundbeck A/S Zpusob výroby citalopramu
CN1149208C (zh) 1998-12-23 2004-05-12 H.隆德贝克有限公司 制备5-氰基2-苯并[c]呋喃酮的方法
AR022329A1 (es) * 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
IL145615A0 (en) 1999-04-14 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ES2229774T3 (es) 1999-10-25 2005-04-16 H. Lundbeck A/S Metodo para la preparacion de citalopram.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) * 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
FI20011622A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
EP1462447A3 (en) 2000-12-22 2004-11-17 H. Lundbeck A/S Method for the preparation of pure citalopram
TR200200018T1 (tr) 2000-12-28 2002-06-21 H. Lundbeck A/S Saf sitalopram hazırlanması için yöntem.

Also Published As

Publication number Publication date
AU2001279609B2 (en) 2007-09-06
JP2004506730A (ja) 2004-03-04
FI20011622A (fi) 2002-02-19
GB2362647B (en) 2002-09-18
MXPA03000913A (es) 2003-06-24
SK3202003A3 (en) 2003-08-05
DE60106932D1 (de) 2004-12-09
MEP2308A (xx) 2010-02-10
DK200101219A (da) 2002-02-19
CN1339435A (zh) 2002-03-13
SK287008B6 (sk) 2009-09-07
AU2001279608B2 (en) 2006-10-05
YU6903A (sh) 2006-05-25
UA71676C2 (en) 2004-12-15
GR20010100398A (el) 2002-05-24
NO20013942L (no) 2002-02-19
BG65964B1 (bg) 2010-07-30
NZ523877A (en) 2004-08-27
ES2170734B2 (es) 2003-09-16
MXPA03001329A (es) 2003-06-06
UA72340C2 (uk) 2005-02-15
AT4946U1 (de) 2002-01-25
HUP0103295A2 (hu) 2002-05-29
AU2001100278B4 (en) 2001-11-29
CZ20012958A3 (cs) 2002-04-17
NZ523853A (en) 2004-07-30
NO20013943D0 (no) 2001-08-14
DE60106933D1 (de) 2004-12-09
ES2170734A1 (es) 2002-08-01
KR100887207B1 (ko) 2009-03-06
HK1068069A1 (en) 2005-04-22
HK1047086A1 (en) 2003-02-07
AU7960801A (en) 2002-03-04
ATE281448T1 (de) 2004-11-15
GB0119734D0 (en) 2001-10-03
BE1013443A6 (fr) 2002-01-15
ATE281447T1 (de) 2004-11-15
CN1222517C (zh) 2005-10-12
BG65965B1 (bg) 2010-07-30
NO20013943L (no) 2002-02-19
PT1309582E (pt) 2005-03-31
AR029597A1 (es) 2003-07-10
FR2813078B1 (fr) 2004-04-02
DK1309581T3 (da) 2005-03-14
HK1047086B (zh) 2005-04-22
DE10140029A1 (de) 2002-05-02
CN1339436A (zh) 2002-03-13
CL2008002412A1 (es) 2009-01-02
EP1309582A1 (en) 2003-05-14
DK200101216A (da) 2002-02-19
CL2008002673A1 (es) 2009-01-02
CH691968A5 (de) 2001-12-14
CN1239490C (zh) 2006-02-01
IES20010760A2 (en) 2002-02-20
GB2362647A (en) 2001-11-28
HUP0103291A2 (hu) 2002-05-29
EP1309581A1 (en) 2003-05-14
IS6048A (is) 2001-10-19
US20020026062A1 (en) 2002-02-28
IS2120B (is) 2006-06-15
WO2002016342A1 (en) 2002-02-28
US6509483B2 (en) 2003-01-21
CZ295863B6 (cs) 2005-11-16
CZ294746B6 (cs) 2005-03-16
DE60106932T2 (de) 2005-11-03
JP2004506729A (ja) 2004-03-04
FR2813078A1 (fr) 2002-02-22
SK287236B6 (sk) 2010-04-07
CH691969A5 (de) 2001-12-14
DK1309582T3 (da) 2005-03-14
FI20011621A (fi) 2002-02-19
ES2228920T3 (es) 2005-04-16
HUP0103291A3 (en) 2003-02-28
EA200300279A1 (ru) 2003-08-28
US6426422B1 (en) 2002-07-30
SK3222003A3 (en) 2003-08-05
ES2170735B2 (es) 2003-09-16
FI20011621A0 (fi) 2001-08-09
GB2365865B (en) 2002-07-17
AU7960901A (en) 2002-03-04
EA200300277A1 (ru) 2003-08-28
ES2170735A1 (es) 2002-08-01
ZA200106683B (en) 2002-08-05
NO326570B1 (no) 2009-01-12
EP1309581B1 (en) 2004-11-03
DE60106933T2 (de) 2005-12-01
IS6047A (is) 2001-10-20
HRP20030065A2 (en) 2005-02-28
CN1159307C (zh) 2004-07-28
EA005946B1 (ru) 2005-08-25
IL144817A0 (en) 2002-06-30
BG107583A (bg) 2004-01-30
AT5026U1 (de) 2002-02-25
PT1309581E (pt) 2005-03-31
BE1013444A6 (fr) 2002-01-15
GR1004074B (el) 2002-11-26
BG107584A (bg) 2004-01-30
SI1309581T1 (en) 2005-04-30
FR2813077B1 (fr) 2004-08-20
EP1309582B1 (en) 2004-11-03
NL1018776C1 (nl) 2001-10-24
RS50258B (sr) 2009-07-15
SI1309582T1 (en) 2005-06-30
US20020025982A1 (en) 2002-02-28
CA2354880C (en) 2003-06-03
GB2365865A (en) 2002-02-27
DE10140028A1 (de) 2002-04-18
AU2001100271A4 (en) 2001-09-13
HK1044538B (zh) 2006-07-07
EA005811B1 (ru) 2005-06-30
CZ20012959A3 (cs) 2002-04-17
AR029598A1 (es) 2003-07-10
PL359969A1 (en) 2004-09-06
NO326772B1 (no) 2009-02-16
AR066694A2 (es) 2009-09-09
IS2121B (is) 2006-06-15
IL144816A (en) 2005-09-25
NL1018775C1 (nl) 2001-10-24
PL359825A1 (en) 2004-09-06
WO2002016341A1 (en) 2002-02-28
AU2001100278A4 (en) 2001-09-13
IL144816A0 (en) 2002-06-30
KR20030022378A (ko) 2003-03-15
ES2230347T3 (es) 2005-05-01
NO20013942D0 (no) 2001-08-14
HUP0103295A3 (en) 2005-01-28
CA2354877C (en) 2006-05-02
MEP2208A (xx) 2010-02-10
FR2813077A1 (fr) 2002-02-22
KR100887206B1 (ko) 2009-03-06
CA2354877A1 (en) 2002-02-18
AU2001100271B4 (en) 2001-11-29
YU11503A (sh) 2006-05-25
FI20011622A0 (fi) 2001-08-09
HRP20030064A2 (en) 2005-02-28
GB0119733D0 (en) 2001-10-03
HU0103291D0 (en) 2001-10-28
CN1515564A (zh) 2004-07-28
CA2354880A1 (en) 2002-01-22
KR20030022385A (ko) 2003-03-15
HK1044538A1 (en) 2002-10-25
IES20010761A2 (en) 2002-02-20

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