PT1216250E - Derivados propilicos substituidos de tienoisoxazolil- e tienilpirrazolil-fenoxi uteis como antagonistas d4 - Google Patents
Derivados propilicos substituidos de tienoisoxazolil- e tienilpirrazolil-fenoxi uteis como antagonistas d4Info
- Publication number
- PT1216250E PT1216250E PT00964969T PT00964969T PT1216250E PT 1216250 E PT1216250 E PT 1216250E PT 00964969 T PT00964969 T PT 00964969T PT 00964969 T PT00964969 T PT 00964969T PT 1216250 E PT1216250 E PT 1216250E
- Authority
- PT
- Portugal
- Prior art keywords
- tienylpyrazolyl
- tienoisoxazolyl
- propolic
- antagonists
- phenoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39608199A | 1999-09-14 | 1999-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1216250E true PT1216250E (pt) | 2004-04-30 |
Family
ID=23565772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT00964969T PT1216250E (pt) | 1999-09-14 | 2000-09-13 | Derivados propilicos substituidos de tienoisoxazolil- e tienilpirrazolil-fenoxi uteis como antagonistas d4 |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1216250B1 (pt) |
| JP (1) | JP4847662B2 (pt) |
| KR (1) | KR20020027647A (pt) |
| AR (1) | AR032134A1 (pt) |
| AT (1) | ATE254621T1 (pt) |
| AU (1) | AU7577400A (pt) |
| BR (1) | BR0014515A (pt) |
| CA (1) | CA2383340C (pt) |
| CY (1) | CY1101692T1 (pt) |
| CZ (1) | CZ2002897A3 (pt) |
| DE (1) | DE60006699T2 (pt) |
| DK (1) | DK1216250T3 (pt) |
| EA (1) | EA200200355A1 (pt) |
| EE (1) | EE200200135A (pt) |
| ES (1) | ES2209995T3 (pt) |
| HR (1) | HRP20020220A2 (pt) |
| HU (1) | HUP0203526A3 (pt) |
| IL (1) | IL148623A0 (pt) |
| MX (1) | MXPA02002695A (pt) |
| NO (1) | NO20021251L (pt) |
| PL (1) | PL354515A1 (pt) |
| PT (1) | PT1216250E (pt) |
| SK (1) | SK3512002A3 (pt) |
| TW (1) | TW530060B (pt) |
| WO (1) | WO2001019833A1 (pt) |
| ZA (1) | ZA200201762B (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7125903B1 (en) | 1999-09-14 | 2006-10-24 | Aventis Pharmaceuticals Inc. | Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists |
| US7253165B2 (en) | 1999-09-14 | 2007-08-07 | Aventis Pharmaceuticals Inc. | Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists |
| US7091199B1 (en) | 1999-09-14 | 2006-08-15 | Aventis Pharmaceuticals Inc. | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists |
| MXPA03006524A (es) * | 2001-02-16 | 2003-09-25 | Aventis Pharma Inc | Derivados heterociclicos novedosos de amidas y su uso como ligandos para receptor d3 de dopamina. |
| KR20040007497A (ko) | 2001-04-16 | 2004-01-24 | 에자이 가부시키가이샤 | 신규 1ｈ-인다졸 화합물 |
| KR20040020457A (ko) * | 2002-08-30 | 2004-03-09 | 주식회사 대웅 | 3-｛2-[4-(6-플루오로벤조[ｄ]이속사졸-3-일)피페리디노]에틸｝-2-메틸-6,7,8,9-테트라하이드로-4Ｈ-피리도[1,2-ａ]피리미딘-4-온 또는 그 산부가염의 제조방법 |
| EP1583751A1 (en) * | 2003-01-17 | 2005-10-12 | Cv Therapeutics, Inc. | Substituted heterocyclic compounds useful in the treatment of cardiovascular diseases |
| JP2007297321A (ja) * | 2006-04-28 | 2007-11-15 | Daiso Co Ltd | アリール２−メチルグリシジルエーテル類の製造法 |
| JP2007297330A (ja) * | 2006-04-28 | 2007-11-15 | Daiso Co Ltd | ２−メチルグリシジル誘導体の製造法 |
| US9745291B2 (en) | 2012-12-21 | 2017-08-29 | Epizyme, Inc. | PRMT5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof |
| US10118918B2 (en) | 2012-12-21 | 2018-11-06 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| JP2016505000A (ja) | 2012-12-21 | 2016-02-18 | エピザイム，インコーポレイティド | Ｐｒｍｔ５阻害剤およびその使用 |
| US9611257B2 (en) | 2012-12-21 | 2017-04-04 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| WO2014100719A2 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| WO2015200680A2 (en) * | 2014-06-25 | 2015-12-30 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| WO2016022605A1 (en) | 2014-08-04 | 2016-02-11 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4728651A (en) * | 1985-10-24 | 1988-03-01 | Hoechst-Roussel Pharmaceuticals Inc. | Antihypertensive thieno-isoxazoles and -pyrazoles |
| US6187774B1 (en) * | 1996-03-04 | 2001-02-13 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused heterocyclic compounds and pharmaceutical applications thereof |
| HUP9603001A3 (en) * | 1996-10-30 | 1999-07-28 | Richter Gedeon Vegyeszet | Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same |
| EP1054885B1 (en) * | 1998-02-09 | 2007-07-18 | Duphar International Research B.V | Benzisoxazole derivatives having d4-antagonistic activity |
-
2000
- 2000-09-13 AR ARP000104793A patent/AR032134A1/es not_active Application Discontinuation
- 2000-09-13 AU AU75774/00A patent/AU7577400A/en not_active Abandoned
- 2000-09-13 BR BR0014515-7A patent/BR0014515A/pt not_active IP Right Cessation
- 2000-09-13 DE DE60006699T patent/DE60006699T2/de not_active Expired - Lifetime
- 2000-09-13 IL IL14862300A patent/IL148623A0/xx unknown
- 2000-09-13 MX MXPA02002695A patent/MXPA02002695A/es active IP Right Grant
- 2000-09-13 DK DK00964969T patent/DK1216250T3/da active
- 2000-09-13 CA CA2383340A patent/CA2383340C/en not_active Expired - Fee Related
- 2000-09-13 CZ CZ2002897A patent/CZ2002897A3/cs unknown
- 2000-09-13 JP JP2001523410A patent/JP4847662B2/ja not_active Expired - Fee Related
- 2000-09-13 EE EEP200200135A patent/EE200200135A/xx unknown
- 2000-09-13 PL PL00354515A patent/PL354515A1/xx unknown
- 2000-09-13 ES ES00964969T patent/ES2209995T3/es not_active Expired - Lifetime
- 2000-09-13 KR KR1020027003366A patent/KR20020027647A/ko not_active Application Discontinuation
- 2000-09-13 AT AT00964969T patent/ATE254621T1/de not_active IP Right Cessation
- 2000-09-13 SK SK351-2002A patent/SK3512002A3/sk unknown
- 2000-09-13 EA EA200200355A patent/EA200200355A1/ru unknown
- 2000-09-13 WO PCT/US2000/024962 patent/WO2001019833A1/en not_active Application Discontinuation
- 2000-09-13 PT PT00964969T patent/PT1216250E/pt unknown
- 2000-09-13 HU HU0203526A patent/HUP0203526A3/hu unknown
- 2000-09-13 EP EP00964969A patent/EP1216250B1/en not_active Expired - Lifetime
- 2000-09-14 TW TW089118850A patent/TW530060B/zh not_active IP Right Cessation
-
2002
- 2002-03-12 HR HR20020220A patent/HRP20020220A2/hr not_active Application Discontinuation
- 2002-03-13 NO NO20021251A patent/NO20021251L/no not_active Application Discontinuation
- 2002-03-21 ZA ZA200201762A patent/ZA200201762B/en unknown
-
2004
- 2004-02-12 CY CY20041100175T patent/CY1101692T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE254621T1 (de) | 2003-12-15 |
| IL148623A0 (en) | 2002-09-12 |
| NO20021251D0 (no) | 2002-03-13 |
| CZ2002897A3 (cs) | 2002-07-17 |
| AR032134A1 (es) | 2003-10-29 |
| EP1216250B1 (en) | 2003-11-19 |
| ES2209995T3 (es) | 2004-07-01 |
| CA2383340A1 (en) | 2001-03-22 |
| WO2001019833A1 (en) | 2001-03-22 |
| CA2383340C (en) | 2010-06-15 |
| TW530060B (en) | 2003-05-01 |
| KR20020027647A (ko) | 2002-04-13 |
| CY1101692T1 (el) | 2010-07-28 |
| DE60006699T2 (de) | 2004-09-30 |
| EP1216250A1 (en) | 2002-06-26 |
| PL354515A1 (en) | 2004-01-26 |
| HRP20020220A2 (en) | 2004-02-29 |
| JP2003509432A (ja) | 2003-03-11 |
| MXPA02002695A (es) | 2002-07-30 |
| DK1216250T3 (da) | 2004-02-23 |
| HUP0203526A2 (hu) | 2003-01-28 |
| AU7577400A (en) | 2001-04-17 |
| JP4847662B2 (ja) | 2011-12-28 |
| DE60006699D1 (en) | 2003-12-24 |
| NO20021251L (no) | 2002-05-10 |
| HUP0203526A3 (en) | 2004-12-28 |
| SK3512002A3 (en) | 2003-03-04 |
| BR0014515A (pt) | 2002-06-25 |
| ZA200201762B (en) | 2003-08-27 |
| EA200200355A1 (ru) | 2002-10-31 |
| EE200200135A (et) | 2003-04-15 |
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